TWI376381B - Boron compounds - Google Patents
Boron compounds Download PDFInfo
- Publication number
- TWI376381B TWI376381B TW095130337A TW95130337A TWI376381B TW I376381 B TWI376381 B TW I376381B TW 095130337 A TW095130337 A TW 095130337A TW 95130337 A TW95130337 A TW 95130337A TW I376381 B TWI376381 B TW I376381B
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- TW
- Taiwan
- Prior art keywords
- tumor
- compound
- boron
- formula
- therapy
- Prior art date
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- 229910052796 boron Inorganic materials 0.000 claims description 51
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0501847 | 2005-08-19 | ||
| SE0501903A SE528407C2 (sv) | 2005-08-19 | 2005-08-30 | Borföreningar användbara vid BNCT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200740833A TW200740833A (en) | 2007-11-01 |
| TWI376381B true TWI376381B (en) | 2012-11-11 |
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|---|---|---|---|
| TW095130337A TWI376381B (en) | 2005-08-19 | 2006-08-18 | Boron compounds |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8183247B2 (https=) |
| EP (1) | EP1915381B1 (https=) |
| JP (1) | JP5053277B2 (https=) |
| CN (1) | CN101268085B (https=) |
| RU (1) | RU2423368C2 (https=) |
| SE (1) | SE528407C2 (https=) |
| TW (1) | TWI376381B (https=) |
| WO (1) | WO2007021234A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI721200B (zh) * | 2016-07-28 | 2021-03-11 | 日商史鐵勒製藥股份有限公司 | 含硼化合物 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026701A1 (de) * | 2007-06-01 | 2008-12-04 | Universität Leipzig | Neue chemische Verbindungen, deren Herstellung und deren Verwendung |
| CN101713740B (zh) * | 2009-12-31 | 2012-05-02 | 中国原子能科学研究院 | 分光光度测量生物样品中bnct药物里硼含量的方法 |
| CN104151339B (zh) * | 2013-05-17 | 2017-05-03 | 中国科学院近代物理研究所 | 含硼吖啶衍生物、其制备方法和应用 |
| KR101903693B1 (ko) * | 2016-11-28 | 2018-10-04 | 가천대학교 산학협력단 | BSH 합성을 위한 티오피롤리딘을 이용한 Na2[B12H12] 반응 |
| JP7154528B2 (ja) * | 2017-08-25 | 2022-10-18 | 国立大学法人東京工業大学 | ホウ素含有葉酸誘導体 |
| WO2020180390A1 (en) * | 2019-03-04 | 2020-09-10 | TAE Life Sciences | Borylated amino acid compositions for use in boron neutron capture therapy and methods thereof |
| CN112358494B (zh) * | 2020-04-09 | 2021-09-28 | 南京大学 | 一种基于吖啶的碳硼烷衍生物及其在生物显影中的应用 |
| CN112442095B (zh) * | 2020-12-01 | 2022-07-22 | 上海科黛生物科技有限公司 | 一种维生素b12的精制方法及所得产品的应用 |
| CN112979686B (zh) * | 2021-02-08 | 2022-04-08 | 北京大学 | 一种新型硼携带剂、制备方法及其药物制剂 |
| CN116874515B (zh) * | 2023-05-10 | 2025-03-14 | 重庆高硼生物科技有限公司 | 一种氨基酸-bsh靶向杂合体化合物及其制备方法和应用 |
| WO2025165163A1 (ko) * | 2024-01-31 | 2025-08-07 | (주)클리켐바이오 | 붕소중성자포획치료용 알부민 나노플랫폼 및 이를 포함하는 붕소중성자포획치료용 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272250A (en) | 1992-07-10 | 1993-12-21 | Spielvogel Bernard F | Boronated phosphoramidate compounds |
| US6180766B1 (en) | 1993-12-02 | 2001-01-30 | Raymond F. Schinazi | Nucleosides and oligonucleotides containing boron clusters |
| CN1124821A (zh) * | 1994-02-14 | 1996-06-19 | 肖冠英 | 同步齿带半潜传动全贯流水电机组 |
| US5630786A (en) * | 1994-06-27 | 1997-05-20 | Ionix Corporation | Boron neutron capture enhancement of fast neutron therapy |
| JP2685128B2 (ja) * | 1995-07-21 | 1997-12-03 | 東北大学長 | カルボラン含有ガドリニウム−ｄｔｐａ錯体、その中間体、およびこれらの製造方法 |
| US6093382A (en) * | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| DE19905094C1 (de) | 1999-02-01 | 2000-10-12 | Schering Ag | Gadolinium (III)-Komplexe sowie ihre Verwendung für Zweischritt Strahlentherapieformen und diese enthaltende pharmazeutische Mittel |
| JP2001233883A (ja) * | 2000-02-22 | 2001-08-28 | Okayama Pref Gov Shin Gijutsu Shinko Zaidan | カゴ状ホウ素化合物担持ポルフィリン錯体 |
| EP1364954A4 (en) | 2001-02-09 | 2009-10-28 | Hiroyuki Kagechika | Dicarba closo DODECARBORANDERIVATE |
| CA2555597C (en) * | 2004-02-13 | 2016-06-14 | The University Of British Columbia | Radiolabeled compounds and compositions, their precursors and methods for their production |
| JP2005343858A (ja) * | 2004-06-07 | 2005-12-15 | Mebiopharm Co Ltd | ホウ素イオンクラスター脂質及びこれを用いたリポソーム |
| JP2006096870A (ja) * | 2004-09-29 | 2006-04-13 | Stella Chemifa Corp | ホウ素含有化合物 |
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- 2006-08-17 WO PCT/SE2006/000952 patent/WO2007021234A1/en not_active Ceased
- 2006-08-18 TW TW095130337A patent/TWI376381B/zh active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI721200B (zh) * | 2016-07-28 | 2021-03-11 | 日商史鐵勒製藥股份有限公司 | 含硼化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009504732A (ja) | 2009-02-05 |
| CN101268085A (zh) | 2008-09-17 |
| RU2008110472A (ru) | 2009-09-27 |
| JP5053277B2 (ja) | 2012-10-17 |
| EP1915381B1 (en) | 2013-04-10 |
| US20090227539A1 (en) | 2009-09-10 |
| EP1915381A1 (en) | 2008-04-30 |
| EP1915381A4 (en) | 2011-02-09 |
| SE0501903L (sv) | 2006-11-07 |
| CN101268085B (zh) | 2012-06-20 |
| RU2423368C2 (ru) | 2011-07-10 |
| US8183247B2 (en) | 2012-05-22 |
| WO2007021234A1 (en) | 2007-02-22 |
| TW200740833A (en) | 2007-11-01 |
| SE528407C2 (sv) | 2006-11-07 |
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