CN101151037A - 作为抗菌剂的β-环糊精衍生物 - Google Patents

作为抗菌剂的β-环糊精衍生物 Download PDF

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Publication number
CN101151037A
CN101151037A CNA2006800101557A CN200680010155A CN101151037A CN 101151037 A CN101151037 A CN 101151037A CN A2006800101557 A CNA2006800101557 A CN A2006800101557A CN 200680010155 A CN200680010155 A CN 200680010155A CN 101151037 A CN101151037 A CN 101151037A
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CN
China
Prior art keywords
aryl
alkyl
aralkyl
lower alkyl
aminoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800101557A
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English (en)
Chinese (zh)
Inventor
诺里丹·法米
弗兰克·W·施米特曼
悉尼·赫克特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pinnacle Pharmaceuticals Inc
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Pinnacle Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Pinnacle Pharmaceuticals Inc filed Critical Pinnacle Pharmaceuticals Inc
Publication of CN101151037A publication Critical patent/CN101151037A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2006800101557A 2005-01-28 2006-01-27 作为抗菌剂的β-环糊精衍生物 Pending CN101151037A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64784105P 2005-01-28 2005-01-28
US60/647,841 2005-01-28

Publications (1)

Publication Number Publication Date
CN101151037A true CN101151037A (zh) 2008-03-26

Family

ID=36777776

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800101557A Pending CN101151037A (zh) 2005-01-28 2006-01-27 作为抗菌剂的β-环糊精衍生物

Country Status (12)

Country Link
US (2) US7737132B2 (https=)
EP (1) EP1846006A4 (https=)
JP (1) JP2008528761A (https=)
KR (1) KR20070101347A (https=)
CN (1) CN101151037A (https=)
AU (1) AU2006211173A1 (https=)
CA (1) CA2596026A1 (https=)
IL (1) IL184844A0 (https=)
MX (1) MX2007010129A (https=)
RU (1) RU2007133709A (https=)
WO (1) WO2006083678A2 (https=)
ZA (1) ZA200706191B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104870464A (zh) * 2012-07-24 2015-08-26 国家科研中心 多聚甘露糖苷及其制备方法和它们作为药物的用途
CN112516003A (zh) * 2020-12-18 2021-03-19 上海杜可生物科技有限公司 环糊精用于抑制口腔细菌生长的组合物的用途
CN116284506A (zh) * 2023-03-22 2023-06-23 江南大学 一种γ-环糊精-香叶醇衍生物及其制备方法与应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1735326A4 (en) * 2004-01-29 2011-04-20 Pinnacle Pharmaceuticals BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST LETHAL ANTHRAX TOXIN
WO2006075580A1 (ja) * 2005-01-13 2006-07-20 National University Corporation Nagoya Institute Of Technology 菌体膜傷害性・抗菌性物質とその利用方法
CN101151037A (zh) * 2005-01-28 2008-03-26 平纳克尔医药股份有限公司 作为抗菌剂的β-环糊精衍生物
CA2662142A1 (en) * 2006-08-30 2008-09-04 Pace University Antimicrobial compositions
WO2009058327A1 (en) * 2007-10-30 2009-05-07 Pinnacle Pharmaceuticals, Inc. Cyclodextrin derivatives as potentiators for antibiotics
JP5364923B2 (ja) * 2009-01-28 2013-12-11 学校法人福岡大学 多機能性シクロデキストリン誘導体、その包接化合物およびそれらの製造方法。
WO2012151445A1 (en) * 2011-05-03 2012-11-08 Innovative Biologics, Inc. DERIVATIVES OF α-, β- AND γ-CYCLODEXTRIN AND THEIR USE AS ANTI-INFECTIVES
GB201114459D0 (en) 2011-08-22 2011-10-05 Isis Innovation Anti-bacterial compounds
JP6249208B2 (ja) * 2012-10-31 2017-12-20 国立大学法人 名古屋工業大学 糖誘導体及びそれを用いた抗菌剤
CN103497275B (zh) * 2013-08-09 2015-12-23 华北电力大学（保定） 一种抗菌、抗病毒胍盐星形聚合物及其制备方法和应用
JP6624422B2 (ja) * 2014-07-25 2019-12-25 国立大学法人 名古屋工業大学 糖誘導体またはその塩、それらを用いた抗菌剤または抗菌活性増強剤、およびこれらを合成する試薬、試薬を用いたこれらの製造方法
CN106734046A (zh) * 2015-11-20 2017-05-31 南京科技职业学院 一种焦化污泥无害化处理方法
EP3514182A4 (en) 2016-09-13 2020-06-24 Nagoya Institute of Technology Sugar derivative or salt thereof, and antibacterial agent or antibacterial activity enhancer using same
WO2018127819A1 (en) 2017-01-03 2018-07-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
JP7403152B2 (ja) 2017-03-28 2023-12-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景
KR101967326B1 (ko) * 2017-10-30 2019-08-13 한남대학교 산학협력단 양이온성 사이클로덱스트린 유도체 및 이를 이용한 약물전달 시스템
EP3710514B1 (en) 2017-11-15 2023-06-07 The University of North Carolina at Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
CA3091458A1 (en) * 2018-03-06 2019-09-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
CN113383019B (zh) 2018-12-28 2023-11-17 北卡罗来纳大学教堂山分校 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法
TWI774079B (zh) * 2020-10-05 2022-08-11 逢興生物科技股份有限公司 環糊精用於製造抑制口腔細菌生長的組合物的用途
US11856953B2 (en) 2021-03-11 2024-01-02 Nano And Advanced Materials Institute Limited Launderable bactericidal and virucidal fabric finish

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US576017A (en) * 1897-01-26 Game-counter
JPS5211348B2 (https=) 1972-12-23 1977-03-30
JPS5311000B2 (https=) 1974-04-18 1978-04-18
DE2425663A1 (de) 1974-05-28 1975-12-04 Tanabe Seiyaku Co Cyclodextrinderivate sowie verfahren zu ihrer herstellung
JPS51142088A (en) 1975-05-29 1976-12-07 Tanabe Seiyaku Co Ltd Aminocyclodextrin derivatives and their prepapation.
JPS52138580A (en) * 1976-05-14 1977-11-18 Tanabe Seiyaku Co Ltd Cyclodextrin derivatives
JPS5349089A (en) 1976-10-15 1978-05-04 Tanabe Seiyaku Co Ltd Cyclic polysaccaride compounds and their preparatin
US4247535A (en) * 1979-11-05 1981-01-27 American Cyanamid Company Modified cyclodextrin sulfate salts as complement inhibitors
US4258180A (en) * 1979-11-05 1981-03-24 American Cyanamid Company C6-Modified cyclodextrin sulfate salts as complement inhibitors
JPS63117003A (ja) * 1986-10-31 1988-05-21 Agency Of Ind Science & Technol シクロデキストリン誘導体
JPS63144329A (ja) * 1986-12-09 1988-06-16 Agency Of Ind Science & Technol 色素とシクロデキストリン誘導体の包接体の有機超薄膜とその製造方法
DE3744742C2 (https=) * 1986-10-31 1993-03-11 Director-General Of Agency Of Industrial Science And Technology, Tokio/Tokyo, Jp
JPH0375634A (ja) 1989-08-17 1991-03-29 Agency Of Ind Science & Technol 光学記憶媒体
DK0447171T3 (da) * 1990-03-15 1994-12-12 Tanabe Seiyaku Co Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf
JPH04227602A (ja) * 1990-03-15 1992-08-17 Tanabe Seiyaku Co Ltd アミノ−β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法
JPH04136001A (ja) * 1990-09-27 1992-05-11 Tanabe Seiyaku Co Ltd β―シクロデキストリン・スルホンアミド誘導体のポリ硫酸エステル及びその製法
JPH04226502A (ja) * 1990-09-27 1992-08-17 Tanabe Seiyaku Co Ltd アシルアミノシクロデキストリン誘導体のポリ硫酸エステル及びその製法
FR2669535A1 (fr) 1990-11-26 1992-05-29 Medgenix Group Sa Utilisation a titre de medicament de macromolecules polysulfonees.
FR2681868A1 (fr) * 1991-09-30 1993-04-02 Sederma Sa Nouvelles substances amphiphiles derivees de cyclodextrines et leur utilisation dans des compositions cosmetiques.
DE4136325A1 (de) 1991-11-05 1993-05-13 Hoechst Ag Cyclodextrinderivate als adsorptionsmittel fuer gallensaeure, mit gallensaeuren beladene cyclodextrinderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel
HUT63704A (en) 1991-11-20 1993-09-28 Forte Fotokemiai Ipar Method for accelerating development of photo-materials
JPH0665307A (ja) 1992-06-17 1994-03-08 Sankyo Co Ltd シクロデキストリン誘導体
ES2053399B1 (es) 1993-01-11 1995-02-16 Univ Madrid Complutense Procedimiento para la obtencion de derivados de beta-ciclodextrina.
US5959089A (en) * 1993-07-19 1999-09-28 Hannessian; Stephen Amino-cyclodextrin syntheses
US5599912A (en) * 1993-09-10 1997-02-04 Coretech, Inc. Compounds and methods for suppressing an immune response to sulfomethoxozale containing substances
GB9325330D0 (en) * 1993-12-10 1994-02-16 Univ Toronto Fluorocyclodextrin drug delivery system
FR2714067B1 (fr) * 1993-12-22 1996-01-12 Commissariat Energie Atomique Nouveaux dérivés de cyclodextrines, utilisables en particulier pour solubiliser des composés chimiques hydrophobes tels que des médicaments, et leur procédé de préparation.
FR2713934B1 (fr) 1993-12-22 1996-01-12 Commissariat Energie Atomique Utilisation de cyclodextrines aminées pour la solubilisation aqueuse de composés hydrophobes, en particulier de molécules pharmaceutiquement actives.
DE4418842A1 (de) * 1994-05-30 1995-12-07 Hoechst Ag Verwendung ringförmiger Oligosaccharide als Ladungssteuermittel
DE4429229A1 (de) * 1994-08-18 1996-02-22 Consortium Elektrochem Ind Cyclodextrinderivate mit mindestens einem stickstoffhaltigen Heterozyklus, ihre Herstellung und Verwendung
DE19517034A1 (de) * 1995-05-10 1996-11-14 Hoechst Ag Verwendung von Einschluß-Verbindungen ringförmiger Polysaccharide als Ladungssteuermittel
DE19520989A1 (de) 1995-06-08 1996-12-12 Consortium Elektrochem Ind Cyclodextrinmodifizierte Polymere
DE19520967A1 (de) 1995-06-08 1996-12-12 Consortium Elektrochem Ind Textiles Material oder Leder, welches mit Cyclodextrinderivaten mit mindestens einem stickstoffhaltigen Heterozyklus ausgerüstet ist
FR2736056B1 (fr) * 1995-06-29 1997-08-08 Commissariat Energie Atomique Derives de cyclodextrines, leur preparation et leur utilisation pour incorporer des molecules hydrophobes dans des systemes de tensioactifs organises
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JPH1060006A (ja) 1996-08-27 1998-03-03 Kikkoman Corp 非還元末端アジド化アセチルマルトオリゴシルブロマイドの製造法
FR2767834B1 (fr) * 1997-08-29 1999-12-03 Inst Francais Du Petrole Mono et di-derives de cyclodextrines, leurs synthese et purification et leur utilisation en support
US6180356B1 (en) * 1998-03-06 2001-01-30 The Research Foundation Of State University Of Ny Membrane pore inhibiting agents for treating infection
FR2776666B1 (fr) * 1998-03-31 2002-09-06 Commissariat Energie Atomique Complexes d'inclusion dans des cyclodextrines d'isothiocyanates organiques, en particulier bacteriostatiques, bactericides et/ou fongicides ou de leurs precurseurs naturels, et leur preparation
FR2792942B1 (fr) * 1999-04-29 2001-06-08 Commissariat Energie Atomique Cyclodextrines amphiphiles, leur preparation et leur utilisation pour solubiliser des systemes organises et incorporer des molecules hydrophobes
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
CN1439023A (zh) 2000-04-28 2003-08-27 国立爱尔兰都柏林大学 两亲大环衍生物及其类似物
SG114468A1 (en) 2000-06-23 2005-09-28 Univ Singapore Separation materials for chromatography and electrophoresis applications comprising cyclodextrins cross-linked and chemically bonded to a support via urethane linkages
AU2002246302A1 (en) 2001-03-23 2002-10-08 University College Dublin Macrocyclic oligosaccharide derivatives which form manoscale assemblies
US6632748B2 (en) * 2001-03-27 2003-10-14 Samsung Electronics Co., Ltd. Composition for preparing substances having nano-pores
EP1245628B1 (en) * 2001-03-27 2008-08-27 Samsung Electronics Co., Ltd. Composition for preparing substances having nano-pores
FR2843397B1 (fr) 2002-08-06 2004-10-15 Chelator Nouveaux derives de cyclodextrines, leur procede de preparation et leurs applications
KR100533538B1 (ko) * 2002-12-03 2005-12-05 삼성전자주식회사 새로운 기공형성물질을 포함하는 다공성 층간 절연막을형성하기 위한 조성물
WO2004085487A1 (ja) 2003-03-27 2004-10-07 Yokohama Tlo Company, Ltd. 新規シクロデキストリン誘導体
FR2852959B1 (fr) 2003-03-28 2008-02-15 Centre Nat Rech Scient Nouveaux derives de cyclodextrines, leur procede de preparation et leur utilisation notamment pour solubilisation de substances pharmacologiquement actives
US20050059634A1 (en) * 2003-07-28 2005-03-17 Venton Duane L. Per-6-substituted-per-6-deoxy-cyclodextrins, and use of the same to inhibit soluble beta-amyloid-peptide derived oligomers and to treat alzheimer's and related diseases
FR2861396B1 (fr) 2003-10-24 2005-12-16 Commissariat Energie Atomique Derives amphiphiles de cyclodextrines,leur procede de preparation et leurs utilisations
EP1735326A4 (en) * 2004-01-29 2011-04-20 Pinnacle Pharmaceuticals BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST LETHAL ANTHRAX TOXIN
JP2005290066A (ja) 2004-03-31 2005-10-20 Nihon Hels Industry Corp シクロデキストリンポリマーおよびこれを利用した水の汚染度の測定方法
EP1817348B1 (en) 2004-09-10 2011-06-22 National Center for Scientific Research "Demokritos" Neapoleos & Per-6-guanidino-, -aminoalkylamino-and -guanidino-alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna and intracellular delivery
FR2878853B1 (fr) 2004-12-07 2007-03-16 Biocydex Soc Par Actions Simpl Procede d'obtention d'un complexe fluorescent, complexe obtenu et utilisation
WO2006075580A1 (ja) 2005-01-13 2006-07-20 National University Corporation Nagoya Institute Of Technology 菌体膜傷害性・抗菌性物質とその利用方法
CN101151037A (zh) * 2005-01-28 2008-03-26 平纳克尔医药股份有限公司 作为抗菌剂的β-环糊精衍生物
WO2007009265A1 (en) * 2005-07-22 2007-01-25 The Governors Of The University Of Alberta Tec Edmonton NOVEL β-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104870464A (zh) * 2012-07-24 2015-08-26 国家科研中心 多聚甘露糖苷及其制备方法和它们作为药物的用途
CN112516003A (zh) * 2020-12-18 2021-03-19 上海杜可生物科技有限公司 环糊精用于抑制口腔细菌生长的组合物的用途
CN116284506A (zh) * 2023-03-22 2023-06-23 江南大学 一种γ-环糊精-香叶醇衍生物及其制备方法与应用
CN116284506B (zh) * 2023-03-22 2023-12-08 江南大学 一种γ-环糊精-香叶醇衍生物及其制备方法与应用

Also Published As

Publication number Publication date
WO2006083678A2 (en) 2006-08-10
WO2006083678A3 (en) 2006-12-14
KR20070101347A (ko) 2007-10-16
RU2007133709A (ru) 2009-03-20
US20060199785A1 (en) 2006-09-07
US7737132B2 (en) 2010-06-15
IL184844A0 (en) 2008-06-05
EP1846006A2 (en) 2007-10-24
ZA200706191B (en) 2010-05-26
MX2007010129A (es) 2007-11-16
AU2006211173A1 (en) 2006-08-10
JP2008528761A (ja) 2008-07-31
EP1846006A4 (en) 2011-04-20
US20110071108A1 (en) 2011-03-24
CA2596026A1 (en) 2006-08-10

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