KR20070101347A - 항균제로서의 β시클로덱스트린 유도체 - Google Patents
항균제로서의 β시클로덱스트린 유도체 Download PDFInfo
- Publication number
- KR20070101347A KR20070101347A KR1020077019399A KR20077019399A KR20070101347A KR 20070101347 A KR20070101347 A KR 20070101347A KR 1020077019399 A KR1020077019399 A KR 1020077019399A KR 20077019399 A KR20077019399 A KR 20077019399A KR 20070101347 A KR20070101347 A KR 20070101347A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- lower alkyl
- aryl
- aralkyl
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 30
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 90
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 44
- 150000001875 compounds Chemical class 0.000 claims description 41
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 33
- 229910052757 nitrogen Inorganic materials 0.000 claims description 25
- 229910052717 sulfur Inorganic materials 0.000 claims description 24
- 241000894006 Bacteria Species 0.000 claims description 23
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
- 125000004432 carbon atom Chemical group C* 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 19
- 241000124008 Mammalia Species 0.000 claims description 16
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 208000035143 Bacterial infection Diseases 0.000 claims description 11
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 11
- 230000003115 biocidal effect Effects 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 abstract description 27
- 244000052616 bacterial pathogen Species 0.000 abstract description 7
- 125000002353 D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract description 3
- 125000004122 cyclic group Chemical group 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 7
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 6
- 229960003085 meticillin Drugs 0.000 description 6
- 125000003277 amino group Chemical group 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000194031 Enterococcus faecium Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000193410 Bacillus atrophaeus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64784105P | 2005-01-28 | 2005-01-28 | |
| US60/647,841 | 2005-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070101347A true KR20070101347A (ko) | 2007-10-16 |
Family
ID=36777776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077019399A Withdrawn KR20070101347A (ko) | 2005-01-28 | 2006-01-27 | 항균제로서의 β시클로덱스트린 유도체 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7737132B2 (https=) |
| EP (1) | EP1846006A4 (https=) |
| JP (1) | JP2008528761A (https=) |
| KR (1) | KR20070101347A (https=) |
| CN (1) | CN101151037A (https=) |
| AU (1) | AU2006211173A1 (https=) |
| CA (1) | CA2596026A1 (https=) |
| IL (1) | IL184844A0 (https=) |
| MX (1) | MX2007010129A (https=) |
| RU (1) | RU2007133709A (https=) |
| WO (1) | WO2006083678A2 (https=) |
| ZA (1) | ZA200706191B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1735326A4 (en) * | 2004-01-29 | 2011-04-20 | Pinnacle Pharmaceuticals | BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST LETHAL ANTHRAX TOXIN |
| WO2006075580A1 (ja) * | 2005-01-13 | 2006-07-20 | National University Corporation Nagoya Institute Of Technology | 菌体膜傷害性・抗菌性物質とその利用方法 |
| CN101151037A (zh) * | 2005-01-28 | 2008-03-26 | 平纳克尔医药股份有限公司 | 作为抗菌剂的β-环糊精衍生物 |
| CA2662142A1 (en) * | 2006-08-30 | 2008-09-04 | Pace University | Antimicrobial compositions |
| WO2009058327A1 (en) * | 2007-10-30 | 2009-05-07 | Pinnacle Pharmaceuticals, Inc. | Cyclodextrin derivatives as potentiators for antibiotics |
| JP5364923B2 (ja) * | 2009-01-28 | 2013-12-11 | 学校法人福岡大学 | 多機能性シクロデキストリン誘導体、その包接化合物およびそれらの製造方法。 |
| WO2012151445A1 (en) * | 2011-05-03 | 2012-11-08 | Innovative Biologics, Inc. | DERIVATIVES OF α-, β- AND γ-CYCLODEXTRIN AND THEIR USE AS ANTI-INFECTIVES |
| GB201114459D0 (en) | 2011-08-22 | 2011-10-05 | Isis Innovation | Anti-bacterial compounds |
| EP2690105A1 (en) * | 2012-07-24 | 2014-01-29 | Centre National De La Recherche Scientifique | Mannose derivatives, a process for preparing the same and their uses as a drug |
| JP6249208B2 (ja) * | 2012-10-31 | 2017-12-20 | 国立大学法人 名古屋工業大学 | 糖誘導体及びそれを用いた抗菌剤 |
| CN103497275B (zh) * | 2013-08-09 | 2015-12-23 | 华北电力大学（保定） | 一种抗菌、抗病毒胍盐星形聚合物及其制备方法和应用 |
| JP6624422B2 (ja) * | 2014-07-25 | 2019-12-25 | 国立大学法人 名古屋工業大学 | 糖誘導体またはその塩、それらを用いた抗菌剤または抗菌活性増強剤、およびこれらを合成する試薬、試薬を用いたこれらの製造方法 |
| CN106734046A (zh) * | 2015-11-20 | 2017-05-31 | 南京科技职业学院 | 一种焦化污泥无害化处理方法 |
| EP3514182A4 (en) | 2016-09-13 | 2020-06-24 | Nagoya Institute of Technology | Sugar derivative or salt thereof, and antibacterial agent or antibacterial activity enhancer using same |
| WO2018127819A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
| JP7403152B2 (ja) | 2017-03-28 | 2023-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
| KR101967326B1 (ko) * | 2017-10-30 | 2019-08-13 | 한남대학교 산학협력단 | 양이온성 사이클로덱스트린 유도체 및 이를 이용한 약물전달 시스템 |
| EP3710514B1 (en) | 2017-11-15 | 2023-06-07 | The University of North Carolina at Chapel Hill | Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto |
| CA3091458A1 (en) * | 2018-03-06 | 2019-09-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
| CN113383019B (zh) | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
| TWI774079B (zh) * | 2020-10-05 | 2022-08-11 | 逢興生物科技股份有限公司 | 環糊精用於製造抑制口腔細菌生長的組合物的用途 |
| CN112516003A (zh) * | 2020-12-18 | 2021-03-19 | 上海杜可生物科技有限公司 | 环糊精用于抑制口腔细菌生长的组合物的用途 |
| US11856953B2 (en) | 2021-03-11 | 2024-01-02 | Nano And Advanced Materials Institute Limited | Launderable bactericidal and virucidal fabric finish |
| CN116284506B (zh) * | 2023-03-22 | 2023-12-08 | 江南大学 | 一种γ-环糊精-香叶醇衍生物及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US576017A (en) * | 1897-01-26 | Game-counter | ||
| JPS5211348B2 (https=) | 1972-12-23 | 1977-03-30 | ||
| JPS5311000B2 (https=) | 1974-04-18 | 1978-04-18 | ||
| DE2425663A1 (de) | 1974-05-28 | 1975-12-04 | Tanabe Seiyaku Co | Cyclodextrinderivate sowie verfahren zu ihrer herstellung |
| JPS51142088A (en) | 1975-05-29 | 1976-12-07 | Tanabe Seiyaku Co Ltd | Aminocyclodextrin derivatives and their prepapation. |
| JPS52138580A (en) * | 1976-05-14 | 1977-11-18 | Tanabe Seiyaku Co Ltd | Cyclodextrin derivatives |
| JPS5349089A (en) | 1976-10-15 | 1978-05-04 | Tanabe Seiyaku Co Ltd | Cyclic polysaccaride compounds and their preparatin |
| US4247535A (en) * | 1979-11-05 | 1981-01-27 | American Cyanamid Company | Modified cyclodextrin sulfate salts as complement inhibitors |
| US4258180A (en) * | 1979-11-05 | 1981-03-24 | American Cyanamid Company | C6-Modified cyclodextrin sulfate salts as complement inhibitors |
| JPS63117003A (ja) * | 1986-10-31 | 1988-05-21 | Agency Of Ind Science & Technol | シクロデキストリン誘導体 |
| JPS63144329A (ja) * | 1986-12-09 | 1988-06-16 | Agency Of Ind Science & Technol | 色素とシクロデキストリン誘導体の包接体の有機超薄膜とその製造方法 |
| DE3744742C2 (https=) * | 1986-10-31 | 1993-03-11 | Director-General Of Agency Of Industrial Science And Technology, Tokio/Tokyo, Jp | |
| JPH0375634A (ja) | 1989-08-17 | 1991-03-29 | Agency Of Ind Science & Technol | 光学記憶媒体 |
| DK0447171T3 (da) * | 1990-03-15 | 1994-12-12 | Tanabe Seiyaku Co | Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf |
| JPH04227602A (ja) * | 1990-03-15 | 1992-08-17 | Tanabe Seiyaku Co Ltd | アミノ−β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法 |
| JPH04136001A (ja) * | 1990-09-27 | 1992-05-11 | Tanabe Seiyaku Co Ltd | β―シクロデキストリン・スルホンアミド誘導体のポリ硫酸エステル及びその製法 |
| JPH04226502A (ja) * | 1990-09-27 | 1992-08-17 | Tanabe Seiyaku Co Ltd | アシルアミノシクロデキストリン誘導体のポリ硫酸エステル及びその製法 |
| FR2669535A1 (fr) | 1990-11-26 | 1992-05-29 | Medgenix Group Sa | Utilisation a titre de medicament de macromolecules polysulfonees. |
| FR2681868A1 (fr) * | 1991-09-30 | 1993-04-02 | Sederma Sa | Nouvelles substances amphiphiles derivees de cyclodextrines et leur utilisation dans des compositions cosmetiques. |
| DE4136325A1 (de) | 1991-11-05 | 1993-05-13 | Hoechst Ag | Cyclodextrinderivate als adsorptionsmittel fuer gallensaeure, mit gallensaeuren beladene cyclodextrinderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
| HUT63704A (en) | 1991-11-20 | 1993-09-28 | Forte Fotokemiai Ipar | Method for accelerating development of photo-materials |
| JPH0665307A (ja) | 1992-06-17 | 1994-03-08 | Sankyo Co Ltd | シクロデキストリン誘導体 |
| ES2053399B1 (es) | 1993-01-11 | 1995-02-16 | Univ Madrid Complutense | Procedimiento para la obtencion de derivados de beta-ciclodextrina. |
| US5959089A (en) * | 1993-07-19 | 1999-09-28 | Hannessian; Stephen | Amino-cyclodextrin syntheses |
| US5599912A (en) * | 1993-09-10 | 1997-02-04 | Coretech, Inc. | Compounds and methods for suppressing an immune response to sulfomethoxozale containing substances |
| GB9325330D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Toronto | Fluorocyclodextrin drug delivery system |
| FR2714067B1 (fr) * | 1993-12-22 | 1996-01-12 | Commissariat Energie Atomique | Nouveaux dérivés de cyclodextrines, utilisables en particulier pour solubiliser des composés chimiques hydrophobes tels que des médicaments, et leur procédé de préparation. |
| FR2713934B1 (fr) | 1993-12-22 | 1996-01-12 | Commissariat Energie Atomique | Utilisation de cyclodextrines aminées pour la solubilisation aqueuse de composés hydrophobes, en particulier de molécules pharmaceutiquement actives. |
| DE4418842A1 (de) * | 1994-05-30 | 1995-12-07 | Hoechst Ag | Verwendung ringförmiger Oligosaccharide als Ladungssteuermittel |
| DE4429229A1 (de) * | 1994-08-18 | 1996-02-22 | Consortium Elektrochem Ind | Cyclodextrinderivate mit mindestens einem stickstoffhaltigen Heterozyklus, ihre Herstellung und Verwendung |
| DE19517034A1 (de) * | 1995-05-10 | 1996-11-14 | Hoechst Ag | Verwendung von Einschluß-Verbindungen ringförmiger Polysaccharide als Ladungssteuermittel |
| DE19520989A1 (de) | 1995-06-08 | 1996-12-12 | Consortium Elektrochem Ind | Cyclodextrinmodifizierte Polymere |
| DE19520967A1 (de) | 1995-06-08 | 1996-12-12 | Consortium Elektrochem Ind | Textiles Material oder Leder, welches mit Cyclodextrinderivaten mit mindestens einem stickstoffhaltigen Heterozyklus ausgerüstet ist |
| FR2736056B1 (fr) * | 1995-06-29 | 1997-08-08 | Commissariat Energie Atomique | Derives de cyclodextrines, leur preparation et leur utilisation pour incorporer des molecules hydrophobes dans des systemes de tensioactifs organises |
| US5834446A (en) * | 1996-06-21 | 1998-11-10 | Queen's University At Kingston | Nerve process growth modulators |
| JPH1060006A (ja) | 1996-08-27 | 1998-03-03 | Kikkoman Corp | 非還元末端アジド化アセチルマルトオリゴシルブロマイドの製造法 |
| FR2767834B1 (fr) * | 1997-08-29 | 1999-12-03 | Inst Francais Du Petrole | Mono et di-derives de cyclodextrines, leurs synthese et purification et leur utilisation en support |
| US6180356B1 (en) * | 1998-03-06 | 2001-01-30 | The Research Foundation Of State University Of Ny | Membrane pore inhibiting agents for treating infection |
| FR2776666B1 (fr) * | 1998-03-31 | 2002-09-06 | Commissariat Energie Atomique | Complexes d'inclusion dans des cyclodextrines d'isothiocyanates organiques, en particulier bacteriostatiques, bactericides et/ou fongicides ou de leurs precurseurs naturels, et leur preparation |
| FR2792942B1 (fr) * | 1999-04-29 | 2001-06-08 | Commissariat Energie Atomique | Cyclodextrines amphiphiles, leur preparation et leur utilisation pour solubiliser des systemes organises et incorporer des molecules hydrophobes |
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| CN1439023A (zh) | 2000-04-28 | 2003-08-27 | 国立爱尔兰都柏林大学 | 两亲大环衍生物及其类似物 |
| SG114468A1 (en) | 2000-06-23 | 2005-09-28 | Univ Singapore | Separation materials for chromatography and electrophoresis applications comprising cyclodextrins cross-linked and chemically bonded to a support via urethane linkages |
| AU2002246302A1 (en) | 2001-03-23 | 2002-10-08 | University College Dublin | Macrocyclic oligosaccharide derivatives which form manoscale assemblies |
| US6632748B2 (en) * | 2001-03-27 | 2003-10-14 | Samsung Electronics Co., Ltd. | Composition for preparing substances having nano-pores |
| EP1245628B1 (en) * | 2001-03-27 | 2008-08-27 | Samsung Electronics Co., Ltd. | Composition for preparing substances having nano-pores |
| FR2843397B1 (fr) | 2002-08-06 | 2004-10-15 | Chelator | Nouveaux derives de cyclodextrines, leur procede de preparation et leurs applications |
| KR100533538B1 (ko) * | 2002-12-03 | 2005-12-05 | 삼성전자주식회사 | 새로운 기공형성물질을 포함하는 다공성 층간 절연막을형성하기 위한 조성물 |
| WO2004085487A1 (ja) | 2003-03-27 | 2004-10-07 | Yokohama Tlo Company, Ltd. | 新規シクロデキストリン誘導体 |
| FR2852959B1 (fr) | 2003-03-28 | 2008-02-15 | Centre Nat Rech Scient | Nouveaux derives de cyclodextrines, leur procede de preparation et leur utilisation notamment pour solubilisation de substances pharmacologiquement actives |
| US20050059634A1 (en) * | 2003-07-28 | 2005-03-17 | Venton Duane L. | Per-6-substituted-per-6-deoxy-cyclodextrins, and use of the same to inhibit soluble beta-amyloid-peptide derived oligomers and to treat alzheimer's and related diseases |
| FR2861396B1 (fr) | 2003-10-24 | 2005-12-16 | Commissariat Energie Atomique | Derives amphiphiles de cyclodextrines,leur procede de preparation et leurs utilisations |
| EP1735326A4 (en) * | 2004-01-29 | 2011-04-20 | Pinnacle Pharmaceuticals | BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST LETHAL ANTHRAX TOXIN |
| JP2005290066A (ja) | 2004-03-31 | 2005-10-20 | Nihon Hels Industry Corp | シクロデキストリンポリマーおよびこれを利用した水の汚染度の測定方法 |
| EP1817348B1 (en) | 2004-09-10 | 2011-06-22 | National Center for Scientific Research "Demokritos" Neapoleos & | Per-6-guanidino-, -aminoalkylamino-and -guanidino-alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna and intracellular delivery |
| FR2878853B1 (fr) | 2004-12-07 | 2007-03-16 | Biocydex Soc Par Actions Simpl | Procede d'obtention d'un complexe fluorescent, complexe obtenu et utilisation |
| WO2006075580A1 (ja) | 2005-01-13 | 2006-07-20 | National University Corporation Nagoya Institute Of Technology | 菌体膜傷害性・抗菌性物質とその利用方法 |
| CN101151037A (zh) * | 2005-01-28 | 2008-03-26 | 平纳克尔医药股份有限公司 | 作为抗菌剂的β-环糊精衍生物 |
| WO2007009265A1 (en) * | 2005-07-22 | 2007-01-25 | The Governors Of The University Of Alberta Tec Edmonton | NOVEL β-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS |
-
2006
- 2006-01-27 CN CNA2006800101557A patent/CN101151037A/zh active Pending
- 2006-01-27 US US11/342,339 patent/US7737132B2/en not_active Expired - Fee Related
- 2006-01-27 MX MX2007010129A patent/MX2007010129A/es unknown
- 2006-01-27 RU RU2007133709/04A patent/RU2007133709A/ru not_active Application Discontinuation
- 2006-01-27 CA CA002596026A patent/CA2596026A1/en not_active Abandoned
- 2006-01-27 JP JP2007553231A patent/JP2008528761A/ja active Pending
- 2006-01-27 KR KR1020077019399A patent/KR20070101347A/ko not_active Withdrawn
- 2006-01-27 AU AU2006211173A patent/AU2006211173A1/en not_active Abandoned
- 2006-01-27 EP EP06733927A patent/EP1846006A4/en not_active Withdrawn
- 2006-01-27 WO PCT/US2006/002801 patent/WO2006083678A2/en not_active Ceased
-
2007
- 2007-07-26 ZA ZA200706191A patent/ZA200706191B/xx unknown
- 2007-07-26 IL IL184844A patent/IL184844A0/en unknown
-
2010
- 2010-05-03 US US12/772,740 patent/US20110071108A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006083678A2 (en) | 2006-08-10 |
| WO2006083678A3 (en) | 2006-12-14 |
| RU2007133709A (ru) | 2009-03-20 |
| US20060199785A1 (en) | 2006-09-07 |
| US7737132B2 (en) | 2010-06-15 |
| IL184844A0 (en) | 2008-06-05 |
| EP1846006A2 (en) | 2007-10-24 |
| ZA200706191B (en) | 2010-05-26 |
| MX2007010129A (es) | 2007-11-16 |
| AU2006211173A1 (en) | 2006-08-10 |
| JP2008528761A (ja) | 2008-07-31 |
| EP1846006A4 (en) | 2011-04-20 |
| US20110071108A1 (en) | 2011-03-24 |
| CA2596026A1 (en) | 2006-08-10 |
| CN101151037A (zh) | 2008-03-26 |
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