ES2053399B1 - Procedimiento para la obtencion de derivados de beta-ciclodextrina. - Google Patents

Procedimiento para la obtencion de derivados de beta-ciclodextrina.

Info

Publication number
ES2053399B1
ES2053399B1 ES9300028A ES9300028A ES2053399B1 ES 2053399 B1 ES2053399 B1 ES 2053399B1 ES 9300028 A ES9300028 A ES 9300028A ES 9300028 A ES9300028 A ES 9300028A ES 2053399 B1 ES2053399 B1 ES 2053399B1
Authority
ES
Spain
Prior art keywords
procedure
beta
cyclodextrin
amino acid
basic amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9300028A
Other languages
English (en)
Other versions
ES2053399A1 (es
Inventor
Robles Domingo Triguero
Pertierra Amando Garrido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Complutense de Madrid
Original Assignee
Universidad Complutense de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Complutense de Madrid filed Critical Universidad Complutense de Madrid
Priority to ES9300028A priority Critical patent/ES2053399B1/es
Publication of ES2053399A1 publication Critical patent/ES2053399A1/es
Application granted granted Critical
Publication of ES2053399B1 publication Critical patent/ES2053399B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS CATIONIZADOS DE BETA-CICLODEXTRINA POR UNION COVALENTE DE RESIDUOS DE AMINOACIDOS BASICOS Y SU APLICACION COMO VECTORES DE FARMACOS AL CEREBRO. PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BETA-CICLODEXTRINA DE FORMULA GENERAL (I), DONDE R PUEDE SER H O UN GRUPO ALQUILO DE 1 A 4 ATOMOS DE CARBONO; Y AA+ ES EL RESTO DE UN AMINOACIDO BASICO.EL PROCEDIMIENTO COMPRENDE LA REACCION ENTRE UN AMINODERIVADO DE BETA-CICLODEXTRINA DE FORMULA GENERAL (VI) O (VII) CON UN AMINOACIDO BASICO PROTEGIDO EN SUS GRUPOS AMINO O GUANIDO LATERALES, EN UN DISOLVENTE APROTICO, EN ATMOSFERA INERTE Y EN PRESENCIA DE DICICLOHEXILCARBODIIMIDA Y 1-HIDROXIBENZOTRIAZOL. LOS PRODUCTOS DE FORMULA (I) PUEDEN SER UTILIZADOS PARA EL MICROENCAPSULAMIENTO MOLECULAR DE FARMACOS QUE VEN RESTRINGIDO SU TRANSPORTE CEREBRAL POR LA PRESENCIA DE LA BARRERA HEMATOENCEFALICA.
ES9300028A 1993-01-11 1993-01-11 Procedimiento para la obtencion de derivados de beta-ciclodextrina. Expired - Fee Related ES2053399B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9300028A ES2053399B1 (es) 1993-01-11 1993-01-11 Procedimiento para la obtencion de derivados de beta-ciclodextrina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9300028A ES2053399B1 (es) 1993-01-11 1993-01-11 Procedimiento para la obtencion de derivados de beta-ciclodextrina.

Publications (2)

Publication Number Publication Date
ES2053399A1 ES2053399A1 (es) 1994-07-16
ES2053399B1 true ES2053399B1 (es) 1995-02-16

Family

ID=8280415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9300028A Expired - Fee Related ES2053399B1 (es) 1993-01-11 1993-01-11 Procedimiento para la obtencion de derivados de beta-ciclodextrina.

Country Status (1)

Country Link
ES (1) ES2053399B1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861396B1 (fr) 2003-10-24 2005-12-16 Commissariat Energie Atomique Derives amphiphiles de cyclodextrines,leur procede de preparation et leurs utilisations
US7851457B2 (en) 2004-01-29 2010-12-14 Innovative Biologics, Inc. β-Cyclodextrin derivatives
EP1846006A4 (en) 2005-01-28 2011-04-20 Pinnacle Pharmaceuticals Inc BETA-CYCLODEXTRIN DERIVATIVES AS ANTIBACTERIAL AGENTS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0672163B2 (ja) * 1986-05-22 1994-09-14 日本食品化工株式会社 アミノ化シクロデキストリンポリマ−の製造法
JPS6451402A (en) * 1987-08-24 1989-02-27 Tosoh Corp Beta-cyclodextrin chemically modified with amino acid and its preparation
US5173481A (en) * 1989-04-03 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Preparation of specifically substituted cyclodextrins
IL100856A (en) * 1991-02-15 1998-03-10 Janssen Pharmaceutica Nv History of carboxyl (alkyloxyalkyl of cyclodextrins, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
ES2053399A1 (es) 1994-07-16

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Effective date: 20141120