JPS6451402A - Beta-cyclodextrin chemically modified with amino acid and its preparation - Google Patents
Beta-cyclodextrin chemically modified with amino acid and its preparationInfo
- Publication number
- JPS6451402A JPS6451402A JP20835287A JP20835287A JPS6451402A JP S6451402 A JPS6451402 A JP S6451402A JP 20835287 A JP20835287 A JP 20835287A JP 20835287 A JP20835287 A JP 20835287A JP S6451402 A JPS6451402 A JP S6451402A
- Authority
- JP
- Japan
- Prior art keywords
- beta
- cyclodextrin
- amino acid
- give
- aminated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE:To prepare the title dextrin which selectively adsorbs compd. having a functional group and an anionic group, by reacting a beta-cyclodextrin in which C on a specified position has been converted into an amino group and an N- protected chiral amino acid. CONSTITUTION:A 6-monotosylated beta-cyclodextrin obtd. by reacting beta- cyclodextrin (beta-CD) with tosyl chloride in an alkaline soln. is reacted with sodium azide in hot water to give a beta-CD azide. The beta-CD azide is reduced with triphenylphosphine in a solvent to give an aminated beta-CD in which C on position 6 has been converted into an amino group. The aminated beta-CD is dissolved in DMF at -10-0 deg.C, and a condensing agent (e.g., dicyclohexylcarbodiimide) is added thereto to react the amino group of the aminated beta-CD with an N-protected chiral amino acid (e.g., N-formylamino acid) to give a product. The product is reacted with a 10-30vol.% aq. soln. of hydrazine at 80-100 deg.C for 1-30hr.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20835287A JPS6451402A (en) | 1987-08-24 | 1987-08-24 | Beta-cyclodextrin chemically modified with amino acid and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20835287A JPS6451402A (en) | 1987-08-24 | 1987-08-24 | Beta-cyclodextrin chemically modified with amino acid and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6451402A true JPS6451402A (en) | 1989-02-27 |
Family
ID=16554861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20835287A Pending JPS6451402A (en) | 1987-08-24 | 1987-08-24 | Beta-cyclodextrin chemically modified with amino acid and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6451402A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2053399A1 (en) * | 1993-01-11 | 1994-07-16 | Univ Madrid Complutense | Procedure for obtaining beta-cyclodextrin derivatives |
EP0624599A2 (en) * | 1993-05-13 | 1994-11-17 | L'oreal | Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications |
WO1996019502A1 (en) * | 1994-12-20 | 1996-06-27 | Kimberly-Clark Worldwide, Inc. | Improved mutable composition |
-
1987
- 1987-08-24 JP JP20835287A patent/JPS6451402A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2053399A1 (en) * | 1993-01-11 | 1994-07-16 | Univ Madrid Complutense | Procedure for obtaining beta-cyclodextrin derivatives |
EP0624599A2 (en) * | 1993-05-13 | 1994-11-17 | L'oreal | Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications |
FR2705350A1 (en) * | 1993-05-13 | 1994-11-25 | Oreal | Novel mono- (6-amino-6-deoxy) cyclodextrin derivatives substituted in the 6-position by an alpha-amino acid residue, process for their preparation and their uses. |
EP0624599A3 (en) * | 1993-05-13 | 1994-12-21 | L'oreal | Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications |
US5631244A (en) * | 1993-05-13 | 1997-05-20 | L'oreal | mono(6-amino-6-deoxy)cyclodextrin derivatives substituted in the 6-position by an α-amino acid residue, process for their preparation and their uses |
WO1996019502A1 (en) * | 1994-12-20 | 1996-06-27 | Kimberly-Clark Worldwide, Inc. | Improved mutable composition |
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