JPS6451402A - Beta-cyclodextrin chemically modified with amino acid and its preparation - Google Patents

Beta-cyclodextrin chemically modified with amino acid and its preparation

Info

Publication number
JPS6451402A
JPS6451402A JP20835287A JP20835287A JPS6451402A JP S6451402 A JPS6451402 A JP S6451402A JP 20835287 A JP20835287 A JP 20835287A JP 20835287 A JP20835287 A JP 20835287A JP S6451402 A JPS6451402 A JP S6451402A
Authority
JP
Japan
Prior art keywords
beta
cyclodextrin
amino acid
give
aminated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20835287A
Other languages
Japanese (ja)
Inventor
Soichi Nakada
Keiko Takahashi
Kenjiro Hattori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tosoh Corp
Original Assignee
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosoh Corp filed Critical Tosoh Corp
Priority to JP20835287A priority Critical patent/JPS6451402A/en
Publication of JPS6451402A publication Critical patent/JPS6451402A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To prepare the title dextrin which selectively adsorbs compd. having a functional group and an anionic group, by reacting a beta-cyclodextrin in which C on a specified position has been converted into an amino group and an N- protected chiral amino acid. CONSTITUTION:A 6-monotosylated beta-cyclodextrin obtd. by reacting beta- cyclodextrin (beta-CD) with tosyl chloride in an alkaline soln. is reacted with sodium azide in hot water to give a beta-CD azide. The beta-CD azide is reduced with triphenylphosphine in a solvent to give an aminated beta-CD in which C on position 6 has been converted into an amino group. The aminated beta-CD is dissolved in DMF at -10-0 deg.C, and a condensing agent (e.g., dicyclohexylcarbodiimide) is added thereto to react the amino group of the aminated beta-CD with an N-protected chiral amino acid (e.g., N-formylamino acid) to give a product. The product is reacted with a 10-30vol.% aq. soln. of hydrazine at 80-100 deg.C for 1-30hr.
JP20835287A 1987-08-24 1987-08-24 Beta-cyclodextrin chemically modified with amino acid and its preparation Pending JPS6451402A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20835287A JPS6451402A (en) 1987-08-24 1987-08-24 Beta-cyclodextrin chemically modified with amino acid and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20835287A JPS6451402A (en) 1987-08-24 1987-08-24 Beta-cyclodextrin chemically modified with amino acid and its preparation

Publications (1)

Publication Number Publication Date
JPS6451402A true JPS6451402A (en) 1989-02-27

Family

ID=16554861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20835287A Pending JPS6451402A (en) 1987-08-24 1987-08-24 Beta-cyclodextrin chemically modified with amino acid and its preparation

Country Status (1)

Country Link
JP (1) JPS6451402A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053399A1 (en) * 1993-01-11 1994-07-16 Univ Madrid Complutense Procedure for obtaining beta-cyclodextrin derivatives
EP0624599A2 (en) * 1993-05-13 1994-11-17 L'oreal Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications
WO1996019502A1 (en) * 1994-12-20 1996-06-27 Kimberly-Clark Worldwide, Inc. Improved mutable composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053399A1 (en) * 1993-01-11 1994-07-16 Univ Madrid Complutense Procedure for obtaining beta-cyclodextrin derivatives
EP0624599A2 (en) * 1993-05-13 1994-11-17 L'oreal Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications
FR2705350A1 (en) * 1993-05-13 1994-11-25 Oreal Novel mono- (6-amino-6-deoxy) cyclodextrin derivatives substituted in the 6-position by an alpha-amino acid residue, process for their preparation and their uses.
EP0624599A3 (en) * 1993-05-13 1994-12-21 L'oreal Derivatives of mono (6-amino-desoxy)cyclodextrin substituted in position 6 with an alpha aminoacid group, process of their preparation and applications
US5631244A (en) * 1993-05-13 1997-05-20 L'oreal mono(6-amino-6-deoxy)cyclodextrin derivatives substituted in the 6-position by an α-amino acid residue, process for their preparation and their uses
WO1996019502A1 (en) * 1994-12-20 1996-06-27 Kimberly-Clark Worldwide, Inc. Improved mutable composition

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