ES2092822T3 - Procedimiento para la preparacion de derivados del acido bis(aminometil)fosfinico. - Google Patents

Procedimiento para la preparacion de derivados del acido bis(aminometil)fosfinico.

Info

Publication number
ES2092822T3
ES2092822T3 ES93908906T ES93908906T ES2092822T3 ES 2092822 T3 ES2092822 T3 ES 2092822T3 ES 93908906 T ES93908906 T ES 93908906T ES 93908906 T ES93908906 T ES 93908906T ES 2092822 T3 ES2092822 T3 ES 2092822T3
Authority
ES
Spain
Prior art keywords
alpha
bis
pct
preparation
phosphinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93908906T
Other languages
English (en)
Inventor
Anuschirwan Peyman
Karl-Heinz Budt
Jorg Spanig
Jian-Qi Li
Bernd Stowasser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2092822T3 publication Critical patent/ES2092822T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA ELABORACION DE DERIVADOS ALFA O ALFA, ALFA''L) ACIDO FOSFINICO DE LA FORMULA (I) Y SUS ACIDOS O SALES BASICAS, DONDE R1, R2 Y R3 ESTAN DEFINIDOS COMO EN LA DESCRIPCION, CARACTERIZADOS PORQUE UN BIS(AMINOMETIL) ESTER DE ACIDO FOSFINICO SE TRANSFORMA EN LA CORRESPONDIENTE BISIMINA, QUE DESPUES DE LA TRANSFORMACION CON UNA BASE SE ALQUILIZA EN ALFA, O EN ALFA'' POSICION A TRAVES DE R2 Y R3 Y DESPUES DEL TRATAMIENTO ACIDO CORRESPONDIENTE SE TRANSFORMA EN UN COMPUESTO DE LA FORMULA (I).
ES93908906T 1992-04-06 1993-04-05 Procedimiento para la preparacion de derivados del acido bis(aminometil)fosfinico. Expired - Lifetime ES2092822T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4211536A DE4211536A1 (de) 1992-04-06 1992-04-06 Verfahren zur Herstellung von Derivaten der Bis(aminomethyl)phosphinsäure

Publications (1)

Publication Number Publication Date
ES2092822T3 true ES2092822T3 (es) 1996-12-01

Family

ID=6456222

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93908906T Expired - Lifetime ES2092822T3 (es) 1992-04-06 1993-04-05 Procedimiento para la preparacion de derivados del acido bis(aminometil)fosfinico.

Country Status (9)

Country Link
US (1) US5510504A (es)
EP (1) EP0635021B1 (es)
JP (1) JP3358811B2 (es)
AT (1) ATE143965T1 (es)
DE (2) DE4211536A1 (es)
DK (1) DK0635021T3 (es)
ES (1) ES2092822T3 (es)
TW (1) TW227003B (es)
WO (1) WO1993020086A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4310815A1 (de) * 1993-04-02 1994-10-06 Hoechst Ag Neue Bis(aminomethyl)phosphinsäure-Derviate und Verfahren zur Herstellung von Bis(aminomethyl)phosphinsäure-Derivaten
AR091858A1 (es) * 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH627477A5 (de) * 1977-02-10 1982-01-15 Ciba Geigy Ag Verfahren zur herstellung einer neuen phosphinsaeure und ihrer salze.
DE3824961A1 (de) * 1988-07-22 1990-01-25 Basf Ag Verfahren zur herstellung von bis(aminomethyl)-phosphinsaeure oder deren sauren oder basischen salzen

Also Published As

Publication number Publication date
DK0635021T3 (da) 1997-03-17
TW227003B (es) 1994-07-21
DE59304137D1 (de) 1996-11-14
US5510504A (en) 1996-04-23
WO1993020086A1 (de) 1993-10-14
EP0635021A1 (de) 1995-01-25
ATE143965T1 (de) 1996-10-15
JPH07505622A (ja) 1995-06-22
JP3358811B2 (ja) 2002-12-24
EP0635021B1 (de) 1996-10-09
DE4211536A1 (de) 1993-10-07

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