ES2196184T3 - Proceso para la 6-o-alquilacion de derivados de eritromicina. - Google Patents

Proceso para la 6-o-alquilacion de derivados de eritromicina.

Info

Publication number
ES2196184T3
ES2196184T3 ES96936904T ES96936904T ES2196184T3 ES 2196184 T3 ES2196184 T3 ES 2196184T3 ES 96936904 T ES96936904 T ES 96936904T ES 96936904 T ES96936904 T ES 96936904T ES 2196184 T3 ES2196184 T3 ES 2196184T3
Authority
ES
Spain
Prior art keywords
sup
hydrogen
hydroxy
polar aprotic
rental
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96936904T
Other languages
English (en)
Inventor
Jih-Hua Liu
George A Foster Jr
Stephen H Montgomery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196184T3 publication Critical patent/ES2196184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS 6 - O - ALQUIL ERITROMICINA CON FORMULA (I), EN DONDE R 1 ES UN ALQUILO INFERIOR, R 2 Y R 3 SON, INDEPENDIENTEMENTE UNO DE OTRO, SON HIDROGENO O UN GRUPO PROTECTOR DEL HIDROXI, EXCEPTO QUE R 2 Y R 3 NO PUEDEN SER SIMULTANEAMENTE HIDROGENO; Y ES OXIGENO O UNA OXIMA ESPECIFICAMENTE SUSTITUIDA; Y Z ES HIDROGENO, HIDROXI O GRUPO DE PROTECCION DEL HIDROXI; SE OBTIENEN POR REACCION DEL COMPUESTO, EN DONDE R 1 ES HIDROGENO CON UN ALQUILANTE, EN PRESENCIA DE UNA BASE FUERTE DE METAL ALCALINO Y TAMBIEN EN PRESENCIA DE UNA BASE DEBIL DE AMINA ORGANICA, EN UN DISOLVENTE POLAR, APROTICO Y APROPIADO CON MOVIMIENTO O AGITACION, O EN UNA MEZCLA DE TALES DISOLVENTES POLARES Y APROTICOS MANTENIDA A UNA TEMPERATURA DE REACCION Y DURANTE UN PERIODO DE TIEMPO SUFICIENTE PARA EFECTUAR LA ALQUILACION.
ES96936904T 1995-11-21 1996-10-25 Proceso para la 6-o-alquilacion de derivados de eritromicina. Expired - Lifetime ES2196184T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/560,752 US5872229A (en) 1995-11-21 1995-11-21 Process for 6-O-alkylation of erythromycin derivatives

Publications (1)

Publication Number Publication Date
ES2196184T3 true ES2196184T3 (es) 2003-12-16

Family

ID=24239215

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96936904T Expired - Lifetime ES2196184T3 (es) 1995-11-21 1996-10-25 Proceso para la 6-o-alquilacion de derivados de eritromicina.

Country Status (11)

Country Link
US (2) US5872229A (es)
EP (1) EP0874862B1 (es)
JP (2) JP2000500488A (es)
AT (1) ATE236919T1 (es)
CA (1) CA2237470C (es)
DE (1) DE69627381T2 (es)
DK (1) DK0874862T3 (es)
ES (1) ES2196184T3 (es)
MX (1) MX9804047A (es)
PT (1) PT874862E (es)
WO (1) WO1997019096A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU733646B2 (en) 1996-07-29 2001-05-17 Bgp Products Operations Gmbh Preparation of crystal form II of clarithromycin
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
US5844105A (en) * 1996-07-29 1998-12-01 Abbott Laboratories Preparation of crystal form II of clarithromycin
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
AU783055B2 (en) 1999-12-16 2005-09-22 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph IV
PT1280535E (pt) 2000-01-11 2005-04-29 Teva Pharma Processos para a preparacao de polimorfos de claritromicina
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
EP1313486A1 (en) 2000-02-29 2003-05-28 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
RU2230748C2 (ru) * 2000-03-15 2004-06-20 Ханми Фарм. Ко., Лтд. Способ получения кларитромицина в виде кристаллов формы ii
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6455680B1 (en) 2000-12-21 2002-09-24 Abbott Laboratories Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
TWI246515B (en) 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005009368A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004270170B2 (en) * 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) * 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2550983C (en) * 2003-12-24 2013-09-17 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
AU2005269981A1 (en) * 2004-07-02 2006-02-09 Bonck, John A Tablet for pulsed delivery
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869444A (en) 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4336368A (en) 1981-04-20 1982-06-22 Pfizer Inc. 4 Deoxy-4-methylene oleandomycin and derivatives thereof
JPS5896095A (ja) 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS5896098A (ja) 1981-12-03 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US4526889A (en) 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60120895A (ja) * 1983-12-02 1985-06-28 Taisho Pharmaceut Co Ltd ６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
NO860901L (no) 1985-03-12 1986-09-15 Beecham Group Plc Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater.
US4670549A (en) 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4640910A (en) 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4833236A (en) 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
US4740502A (en) 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharmaceutical Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
JPH0764867B2 (ja) * 1986-09-18 1995-07-12 大正製薬株式会社 ６−ｏ−メチルエリスロマイシンａ誘導体およびその製造方法
JP2526951B2 (ja) * 1986-12-17 1996-08-21 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
JP2782793B2 (ja) * 1988-06-15 1998-08-06 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
US5302705A (en) 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives

Also Published As

Publication number Publication date
ATE236919T1 (de) 2003-04-15
DE69627381T2 (de) 2004-03-25
US5872229A (en) 1999-02-16
JP2008110976A (ja) 2008-05-15
CA2237470C (en) 2005-01-18
WO1997019096A3 (en) 1997-07-03
USRE39383E1 (en) 2006-11-07
MX9804047A (es) 1998-09-30
DE69627381D1 (de) 2003-05-15
PT874862E (pt) 2003-08-29
WO1997019096A2 (en) 1997-05-29
CA2237470A1 (en) 1997-05-29
JP2000500488A (ja) 2000-01-18
DK0874862T3 (da) 2003-07-28
EP0874862B1 (en) 2003-04-09
EP0874862A2 (en) 1998-11-04

Similar Documents

Publication Publication Date Title
ES2196184T3 (es) Proceso para la 6-o-alquilacion de derivados de eritromicina.
NZ509798A (en) Process for preparing omeprazole
MX221930B (es) Procedimiento para la obtencion de derivados de trizolintiona.
ES539668A0 (es) Procedimiento para la preparacion de nuevas 5,11-dihidro-6h-dibenzo (b,e)azepin-6-onas sustituidas
MY109628A (en) An improved proces for the preparation of substituted indoline derivatives
KR890011904A (ko) 안드로스타-1,4, -디엔-3,17-디온의 6-메틸렌 유도체 합성방법
ES2092962A1 (es) Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.
KR970074748A (ko) 3-아미노 치환된 크로토네이트의 제조방법
JPH045287A (ja) ビタミンｄ類定量用試薬およびその製法
CA2005596A1 (en) Preparation of 2-amino-4-fluoropyrimidine derivatives
Dalla Croce et al. 1, 3‐Dipolar cycloaddition of nitrones with α, β‐unsaturated sulfones
ES2152571T3 (es) Procedimiento para la preparacion de dioxoazabiciclohexanos.
GR3002989T3 (en) Process for the production of n-acylated mercapto-alpha-amino acids
MY105374A (en) A process for the preparation of 7-amino-3-methoxymeth- yl-ceph-3-em-4-carboxylic acid.
DK1109782T3 (da) Fremgangsmåde til fremstilling af N-beskyttede azetidin-2-carboxylsyrer (AzeOH'er)
JPS55149257A (en) Novel preparation of isoindoline derivative
PT1023272E (pt) Processo para a producao de alcoxitriazolinonas
TW227003B (es)
HUP0000144A2 (hu) Eljárás hidroxi-heteroaromás vegyületek aril-aminokká való átalakítására
ES8107190A1 (es) Un procedimiento para la preparacion de w-lactamas que con- tienen 5 a 14 atomos de carbono
GB2322857A (en) Nitration of aromatic compounds
EP0546875A3 (en) New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof
ES8504186A1 (es) Un procedimiento para preparar un compuesto de b-lactama monociclica (4r)-sustituida opticamente activa
Tomić et al. Die reversible Umwandlung von Thiazolidin-Tetrahydrothiazin im Thiadiazabicyclooctanon-System
ES2028790T3 (es) Procedimiento para la preparacion de compuestos de beta-lactama.