CN101083986A - 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 - Google Patents
双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 Download PDFInfo
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- CN101083986A CN101083986A CNA2005800396667A CN200580039666A CN101083986A CN 101083986 A CN101083986 A CN 101083986A CN A2005800396667 A CNA2005800396667 A CN A2005800396667A CN 200580039666 A CN200580039666 A CN 200580039666A CN 101083986 A CN101083986 A CN 101083986A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- C07—ORGANIC CHEMISTRY
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61164604P | 2004-09-20 | 2004-09-20 | |
| US60/611,646 | 2004-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101083986A true CN101083986A (zh) | 2007-12-05 |
Family
ID=35623357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800396667A Pending CN101083986A (zh) | 2004-09-20 | 2005-09-20 | 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7547698B2 (enExample) |
| EP (1) | EP1804792A1 (enExample) |
| JP (2) | JP5080256B2 (enExample) |
| CN (1) | CN101083986A (enExample) |
| AR (1) | AR051294A1 (enExample) |
| AU (1) | AU2005286790A1 (enExample) |
| BR (1) | BRPI0515477A (enExample) |
| CA (1) | CA2580781A1 (enExample) |
| MX (1) | MX2007003329A (enExample) |
| TW (1) | TW200626148A (enExample) |
| WO (1) | WO2006034312A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020993A (zh) * | 2009-09-16 | 2011-04-20 | Jsr株式会社 | 液晶取向剂、液晶取向膜、液晶显示元件、聚酰胺酸以及化合物 |
| CN115667273A (zh) * | 2020-05-22 | 2023-01-31 | 范德堡大学 | 毒蕈碱型乙酰胆碱受体m5的竞争性和非竞争性抑制剂 |
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| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| JP4958785B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体およびステアロイル−CoAデサチュラーゼインヒビターとしてのそれらの使用 |
| WO2006034441A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| TW200626155A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| ES2359840T5 (es) * | 2004-09-20 | 2015-03-25 | Xenon Pharmaceuticals Inc. | Derivados de piridina para inhibición de estearoil-CoA-desaturasa humana |
| BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
| CA2580855A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CA2585172C (en) | 2004-10-29 | 2014-08-12 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
| WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US20090099200A1 (en) * | 2005-06-09 | 2009-04-16 | Chun Sing Li | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2007051095A1 (en) | 2005-10-25 | 2007-05-03 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| AU2006326815A1 (en) | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase |
| AU2007256708B2 (en) | 2006-06-05 | 2011-12-15 | Novartis Ag | Organic compounds |
| JP2010501567A (ja) | 2006-08-24 | 2010-01-21 | ノバルティス アクチエンゲゼルシャフト | 代謝系、心血管系および他の障害の処置のためのステアロイル−CoA不飽和化酵素(SCD)阻害剤としての2−(ピラジン−2−イル)−チアゾールおよび2−(1H−ピラゾール−3−イル)チアゾール誘導体ならびに関連化合物 |
| WO2008044767A1 (en) * | 2006-10-13 | 2008-04-17 | Takeda Pharmaceutical Company Limited | Aromatic amine derivative and use thereof |
| TW200826936A (en) | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| AR064965A1 (es) | 2007-01-26 | 2009-05-06 | Merck Frosst Canada Inc | Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa |
| US8575167B2 (en) | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
| US20100152208A1 (en) * | 2007-05-23 | 2010-06-17 | Merck Frosst Canada Ltd. | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US7842696B2 (en) | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
| KR20100056462A (ko) * | 2007-07-13 | 2010-05-27 | 글락소스미스클라인 엘엘씨 | 항바이러스 화합물, 조성물 및 용도 |
| WO2009012573A1 (en) * | 2007-07-20 | 2009-01-29 | Merck Frosst Canada Ltd. | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
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| AU2010215035B2 (en) | 2009-02-17 | 2014-06-12 | Merck Canada Inc. | Novel spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase |
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| WO2011030312A1 (en) | 2009-09-10 | 2011-03-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES |
| BR112012028445A2 (pt) | 2010-05-06 | 2016-07-19 | Bristol Myers Squibb Co | compostos de heteroarila bicíclica como moduladores de gpr119 |
| KR20130087002A (ko) | 2010-06-04 | 2013-08-05 | 알바니 몰레큘라 리써치, 인크. | 글리신 수송체-1 저해제, 그의 제조 방법 및 그의 용도 |
| US8993626B2 (en) | 2010-06-25 | 2015-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treatment using sterculic acid |
| BR112014008590A2 (pt) | 2011-10-15 | 2017-10-24 | Genentech Inc | métodos de uso de antagonistas de scd1 |
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| JP6293127B2 (ja) | 2012-05-22 | 2018-03-14 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | 未分化細胞の選択的阻害剤 |
| BR112015007312A2 (pt) * | 2012-12-03 | 2017-08-08 | Hoffmann La Roche | composto, composição farmacêutica, utilização de um composto, método para o tratamento de câncer e invenção |
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| US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| HUE044040T2 (hu) | 2014-08-06 | 2019-09-30 | Pfizer | Imidazopiridazin vegyületek |
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-
2005
- 2005-09-20 AU AU2005286790A patent/AU2005286790A1/en not_active Abandoned
- 2005-09-20 CN CNA2005800396667A patent/CN101083986A/zh active Pending
- 2005-09-20 MX MX2007003329A patent/MX2007003329A/es unknown
- 2005-09-20 US US11/575,643 patent/US7547698B2/en not_active Expired - Fee Related
- 2005-09-20 WO PCT/US2005/033738 patent/WO2006034312A1/en not_active Ceased
- 2005-09-20 EP EP05808906A patent/EP1804792A1/en not_active Withdrawn
- 2005-09-20 TW TW094132549A patent/TW200626148A/zh unknown
- 2005-09-20 BR BRPI0515477-4A patent/BRPI0515477A/pt not_active IP Right Cessation
- 2005-09-20 AR ARP050103902A patent/AR051294A1/es unknown
- 2005-09-20 JP JP2007532629A patent/JP5080256B2/ja not_active Expired - Fee Related
- 2005-09-20 CA CA002580781A patent/CA2580781A1/en not_active Abandoned
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2009
- 2009-05-06 US US12/436,665 patent/US20110009414A9/en not_active Abandoned
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2012
- 2012-06-13 JP JP2012133967A patent/JP2012193188A/ja not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020993A (zh) * | 2009-09-16 | 2011-04-20 | Jsr株式会社 | 液晶取向剂、液晶取向膜、液晶显示元件、聚酰胺酸以及化合物 |
| CN102020993B (zh) * | 2009-09-16 | 2014-10-29 | Jsr株式会社 | 液晶取向剂、液晶取向膜、液晶显示元件、聚酰胺酸以及化合物 |
| CN115667273A (zh) * | 2020-05-22 | 2023-01-31 | 范德堡大学 | 毒蕈碱型乙酰胆碱受体m5的竞争性和非竞争性抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012193188A (ja) | 2012-10-11 |
| JP5080256B2 (ja) | 2012-11-21 |
| CA2580781A1 (en) | 2006-03-30 |
| US20110009414A9 (en) | 2011-01-13 |
| US7547698B2 (en) | 2009-06-16 |
| AR051294A1 (es) | 2007-01-03 |
| US20070219211A1 (en) | 2007-09-20 |
| MX2007003329A (es) | 2007-06-05 |
| JP2008513498A (ja) | 2008-05-01 |
| BRPI0515477A (pt) | 2008-07-22 |
| WO2006034312A1 (en) | 2006-03-30 |
| EP1804792A1 (en) | 2007-07-11 |
| AU2005286790A1 (en) | 2006-03-30 |
| US20090291957A1 (en) | 2009-11-26 |
| TW200626148A (en) | 2006-08-01 |
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