CN101080406A - 吲唑－甲酰胺化合物 - Google Patents

吲唑－甲酰胺化合物 Download PDF

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Publication number
CN101080406A
CN101080406A CNA2005800433844A CN200580043384A CN101080406A CN 101080406 A CN101080406 A CN 101080406A CN A2005800433844 A CNA2005800433844 A CN A2005800433844A CN 200580043384 A CN200580043384 A CN 200580043384A CN 101080406 A CN101080406 A CN 101080406A
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CN
China
Prior art keywords
alkyl
compound
hydrogen
hydroxyl
propyl
Prior art date
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Pending
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CNA2005800433844A
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English (en)
Chinese (zh)
Inventor
保罗·R·法瑟雷
罗兰·根德龙
亚当·戈德布卢姆
丹尼尔·D·朗
丹尼尔·马凯斯
德里克·S·特纳
崔锡基
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Shiwan Pharmaceutical
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Shiwan Pharmaceutical
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Application filed by Shiwan Pharmaceutical filed Critical Shiwan Pharmaceutical
Publication of CN101080406A publication Critical patent/CN101080406A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Developing Agents For Electrophotography (AREA)
CNA2005800433844A 2004-12-22 2005-12-21 吲唑－甲酰胺化合物 Pending CN101080406A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63880004P 2004-12-22 2004-12-22
US60/638,800 2004-12-22

Publications (1)

Publication Number Publication Date
CN101080406A true CN101080406A (zh) 2007-11-28

Family

ID=36295339

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800433844A Pending CN101080406A (zh) 2004-12-22 2005-12-21 吲唑－甲酰胺化合物

Country Status (19)

Country Link
US (3) US7419989B2 (enExample)
EP (1) EP1831211B1 (enExample)
JP (1) JP5159317B2 (enExample)
KR (1) KR20070091665A (enExample)
CN (1) CN101080406A (enExample)
AT (1) ATE469897T1 (enExample)
AU (1) AU2005319190A1 (enExample)
BR (1) BRPI0519708A2 (enExample)
CA (1) CA2588037A1 (enExample)
DE (1) DE602005021696D1 (enExample)
ES (1) ES2347265T3 (enExample)
IL (1) IL183160A0 (enExample)
MA (1) MA29088B1 (enExample)
MX (1) MX2007007818A (enExample)
NO (1) NO20073182L (enExample)
NZ (1) NZ555180A (enExample)
RU (1) RU2404179C2 (enExample)
WO (1) WO2006069125A1 (enExample)
ZA (1) ZA200705115B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103748087A (zh) * 2011-06-07 2014-04-23 大日本住友制药株式会社 吲唑和吡咯并吡啶衍生物和其药学用途
CN105873920A (zh) * 2013-12-16 2016-08-17 苏文生命科学有限公司 作为5-ht4受体激动剂的吲唑化合物
CN106604921A (zh) * 2014-08-16 2017-04-26 苏文生命科学有限公司 用于大规模生产1‑异丙基‑3‑{5‑[1‑(3‑甲氧基丙基)哌啶‑4‑基]‑[1,3,4]噁二唑‑2‑基}‑1h‑吲唑草酸盐的方法
WO2021046789A1 (zh) * 2019-09-12 2021-03-18 广东东阳光药业有限公司 吲唑-甲酰胺衍生物及其用途

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DK3684767T3 (da) 2017-09-22 2024-07-15 Jubilant Epipad LLC Heterocykliske forbindelser som pad-inhibitorer
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
CN111386265A (zh) 2017-11-06 2020-07-07 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
SMT202400203T1 (it) 2017-11-24 2024-07-09 Jubilant Episcribe Llc Composti eterociclici come inibitori di prmt5
CA3093527A1 (en) 2018-03-13 2019-09-19 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
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Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN103748087A (zh) * 2011-06-07 2014-04-23 大日本住友制药株式会社 吲唑和吡咯并吡啶衍生物和其药学用途
CN105873920A (zh) * 2013-12-16 2016-08-17 苏文生命科学有限公司 作为5-ht4受体激动剂的吲唑化合物
CN105873920B (zh) * 2013-12-16 2018-06-08 苏文生命科学有限公司 作为5-ht4受体激动剂的吲唑化合物
CN106604921A (zh) * 2014-08-16 2017-04-26 苏文生命科学有限公司 用于大规模生产1‑异丙基‑3‑{5‑[1‑(3‑甲氧基丙基)哌啶‑4‑基]‑[1,3,4]噁二唑‑2‑基}‑1h‑吲唑草酸盐的方法
CN106604921B (zh) * 2014-08-16 2019-04-02 苏文生命科学有限公司 大规模生产1-异丙基-3-{5-[1-(3-甲氧基丙基)哌啶-4-基]-[1，3，4]噁二唑-2-基}-1h-吲唑草酸盐的方法
WO2021046789A1 (zh) * 2019-09-12 2021-03-18 广东东阳光药业有限公司 吲唑-甲酰胺衍生物及其用途
CN112805282A (zh) * 2019-09-12 2021-05-14 广东东阳光药业有限公司 吲唑-甲酰胺衍生物及其用途

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