CN101052393A - 氮杂双环己烷的新型多晶型物 - Google Patents

氮杂双环己烷的新型多晶型物 Download PDF

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Publication number
CN101052393A
CN101052393A CNA2005800279269A CN200580027926A CN101052393A CN 101052393 A CN101052393 A CN 101052393A CN A2005800279269 A CNA2005800279269 A CN A2005800279269A CN 200580027926 A CN200580027926 A CN 200580027926A CN 101052393 A CN101052393 A CN 101052393A
Authority
CN
China
Prior art keywords
polymorph form
polymorph
addition salts
azabicyclo
hexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800279269A
Other languages
English (en)
Chinese (zh)
Inventor
埃里克·J·哈根
凯文·哈洛伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOV Pharmaceutical Inc
Original Assignee
DOV Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOV Pharmaceutical Inc filed Critical DOV Pharmaceutical Inc
Publication of CN101052393A publication Critical patent/CN101052393A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CNA2005800279269A 2004-08-18 2005-08-17 氮杂双环己烷的新型多晶型物 Pending CN101052393A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
US10/920,748 2004-08-18

Publications (1)

Publication Number Publication Date
CN101052393A true CN101052393A (zh) 2007-10-10

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800279269A Pending CN101052393A (zh) 2004-08-18 2005-08-17 氮杂双环己烷的新型多晶型物

Country Status (14)

Country Link
EP (1) EP1786417A4 (de)
JP (1) JP2008510715A (de)
KR (3) KR20130004370A (de)
CN (1) CN101052393A (de)
AU (1) AU2005277351A1 (de)
BR (1) BRPI0515193A (de)
CA (1) CA2619817A1 (de)
IL (1) IL181185A (de)
MX (1) MX2007001827A (de)
NO (1) NO20071372L (de)
NZ (1) NZ589033A (de)
RU (1) RU2007109817A (de)
WO (1) WO2006023659A2 (de)
ZA (1) ZA200701570B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
KR20170005888A (ko) 2005-07-27 2017-01-16 뉴로반스, 인크. 신규 1-아릴-3-아자바이사이클로［3.1.0］헥산：제조 방법 및 신경 정신 질환 치료를 위한 용도
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
KR20140053822A (ko) * 2010-12-03 2014-05-08 유티믹스 바이오사이언스 인코포레이티드 (+)-1-(3,4-디클로로페닐)-3-아자비시클로[3.1.0]헥산의 제조방법 및 모노아민 신경전달물질에 의해 영향을 받는 병태를 치료하기 위한 용도
WO2014182279A1 (en) * 2013-05-07 2014-11-13 Euthymics Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
KR101567003B1 (ko) 2013-12-27 2015-11-06 경희대학교 산학협력단 골편 고정장치 및 골편 절단을 위한 드릴 어셈블리
CN107921021A (zh) 2015-06-17 2018-04-17 大塚制药美国公司 结晶化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
NO20071372L (no) 2007-05-18
EP1786417A4 (de) 2009-05-20
WO2006023659A3 (en) 2006-12-07
IL181185A0 (en) 2007-07-04
RU2007109817A (ru) 2008-09-27
BRPI0515193A (pt) 2008-07-08
WO2006023659A2 (en) 2006-03-02
NZ589033A (en) 2012-06-29
MX2007001827A (es) 2007-04-23
AU2005277351A1 (en) 2006-03-02
EP1786417A2 (de) 2007-05-23
JP2008510715A (ja) 2008-04-10
CA2619817A1 (en) 2006-03-02
IL181185A (en) 2012-10-31
KR20130108489A (ko) 2013-10-02
ZA200701570B (en) 2008-08-27
KR20130004370A (ko) 2013-01-09
KR20070054208A (ko) 2007-05-28

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