CN101048386A - 嘧啶衍生物 - Google Patents

嘧啶衍生物 Download PDF

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Publication number
CN101048386A
CN101048386A CNA2005800368883A CN200580036888A CN101048386A CN 101048386 A CN101048386 A CN 101048386A CN A2005800368883 A CNA2005800368883 A CN A2005800368883A CN 200580036888 A CN200580036888 A CN 200580036888A CN 101048386 A CN101048386 A CN 101048386A
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CN
China
Prior art keywords
methoxy
ylamino
methyl
phenylamino
pyrimidin
Prior art date
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Pending
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CNA2005800368883A
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English (en)
Chinese (zh)
Inventor
P·因巴赫
河原英二
小西一豪
松浦直子
高广三宅
大森治
J·勒泽尔
手纳直规
梅村一郎
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Novartis AG
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Novartis AG
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Publication of CN101048386A publication Critical patent/CN101048386A/zh
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
CNA2005800368883A 2004-08-27 2005-08-26 嘧啶衍生物 Pending CN101048386A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0419161.5 2004-08-27
GBGB0419161.5A GB0419161D0 (en) 2004-08-27 2004-08-27 Organic compounds

Publications (1)

Publication Number Publication Date
CN101048386A true CN101048386A (zh) 2007-10-03

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ID=33104746

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800368883A Pending CN101048386A (zh) 2004-08-27 2005-08-26 嘧啶衍生物

Country Status (23)

Country Link
US (1) US20090131436A1 (https=)
EP (1) EP1784392A2 (https=)
JP (1) JP2008510763A (https=)
KR (1) KR20070054223A (https=)
CN (1) CN101048386A (https=)
AR (1) AR054081A1 (https=)
AU (1) AU2005276582B2 (https=)
BR (1) BRPI0514681A (https=)
CA (1) CA2577251A1 (https=)
EC (1) ECSP077271A (https=)
GB (1) GB0419161D0 (https=)
GT (1) GT200500237A (https=)
HR (1) HRP20070076A2 (https=)
IL (1) IL181433A0 (https=)
MA (1) MA28824B1 (https=)
MX (1) MX2007002254A (https=)
NO (1) NO20071593L (https=)
PE (1) PE20060622A1 (https=)
RU (1) RU2401260C2 (https=)
TN (1) TNSN07075A1 (https=)
TW (1) TW200621729A (https=)
WO (1) WO2006021454A2 (https=)
ZA (1) ZA200701406B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102131788B (zh) * 2008-04-07 2014-03-19 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
CN106699743A (zh) * 2015-11-05 2017-05-24 湖北生物医药产业技术研究院有限公司 嘧啶类衍生物及其用途
CN106905303A (zh) * 2017-03-16 2017-06-30 北京师范大学 一类靶向fak的化合物和其标记物、及它们的制备方法和应用
CN108047204A (zh) * 2018-01-08 2018-05-18 沈阳药科大学 2,4-二芳氨基嘧啶衍生物及其制备方法和应用
CN110835320A (zh) * 2018-08-15 2020-02-25 江苏奥赛康药业有限公司 二氨基嘧啶类化合物及其应用
CN119264116A (zh) * 2024-09-27 2025-01-07 安徽中医药大学 一种cdk6/9双重抑制剂及其制备方法与用途

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TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
ES2445208T3 (es) 2002-07-29 2014-02-28 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
BRPI0413018B8 (pt) 2003-07-30 2021-05-25 Rigel Pharmaceuticals Inc composto, e, uso de um composto
US7521457B2 (en) * 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
AU2005322855B2 (en) * 2004-12-30 2012-09-20 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
GB0517329D0 (en) * 2005-08-25 2005-10-05 Merck Sharp & Dohme Stimulation of neurogenesis
US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
EP2450437B1 (en) 2006-04-14 2017-05-17 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
EP2043651A2 (en) 2006-07-05 2009-04-08 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
CN101535276B (zh) 2006-10-23 2013-08-28 赛福伦公司 作为ALK和c-MET抑制剂的2,4-二氨基嘧啶稠合双环衍生物
EP2311807B1 (en) * 2006-12-08 2015-11-11 Novartis AG Compounds and composition as protein kinase inhibitors
BRPI0720264B1 (pt) * 2006-12-08 2022-03-03 Novartis Ag Compostos e composições como inibidores de proteína cinase
CA2670645A1 (en) * 2006-12-19 2008-07-03 Genentech, Inc. Pyrimidine kinase inhibitors
AR065015A1 (es) 2007-01-26 2009-05-13 Smithkline Beecham Corp Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer
US7947698B2 (en) 2007-03-23 2011-05-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN103396409B (zh) 2007-07-05 2015-03-11 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
TWI389893B (zh) 2007-07-06 2013-03-21 Astellas Pharma Inc 二（芳胺基）芳基化合物
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WO2009127642A2 (en) * 2008-04-15 2009-10-22 Cellzome Limited Use of lrrk2 inhibitors for neurodegenerative diseases
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
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US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
TWI546290B (zh) 2008-06-27 2016-08-21 賽基艾維洛米斯研究股份有限公司 雜芳基化合物及其用途
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
JO3067B1 (ar) * 2008-10-27 2017-03-15 Glaxosmithkline Llc بيرميدينات بيرازولو امينو كمثبطات ل fak
US8278084B2 (en) 2009-02-11 2012-10-02 Northwestern University Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
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