CN101031572B - (r/s)利福霉素衍生物,它们的制备和药物组合物 - Google Patents
(r/s)利福霉素衍生物,它们的制备和药物组合物 Download PDFInfo
- Publication number
- CN101031572B CN101031572B CN2005800308596A CN200580030859A CN101031572B CN 101031572 B CN101031572 B CN 101031572B CN 2005800308596 A CN2005800308596 A CN 2005800308596A CN 200580030859 A CN200580030859 A CN 200580030859A CN 101031572 B CN101031572 B CN 101031572B
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- CN
- China
- Prior art keywords
- cyclopropyl
- methyl
- compound
- base
- tetramethyleneimine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Abstract
Description
Claims (7)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59019004P | 2004-07-22 | 2004-07-22 | |
US60/590,190 | 2004-07-22 | ||
PCT/US2005/025924 WO2006012443A1 (en) | 2004-07-22 | 2005-07-21 | (r/s) rifamycin derivatives, their preparation and pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101031572A CN101031572A (zh) | 2007-09-05 |
CN101031572B true CN101031572B (zh) | 2010-12-08 |
Family
ID=35355764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005800316554A Pending CN101065385A (zh) | 2004-07-22 | 2005-07-21 | 治疗微生物感染的利福霉素衍生物 |
CN2005800308596A Active CN101031572B (zh) | 2004-07-22 | 2005-07-21 | (r/s)利福霉素衍生物,它们的制备和药物组合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005800316554A Pending CN101065385A (zh) | 2004-07-22 | 2005-07-21 | 治疗微生物感染的利福霉素衍生物 |
Country Status (11)
Country | Link |
---|---|
US (2) | US7226931B2 (zh) |
EP (2) | EP1768987B1 (zh) |
JP (2) | JP5236944B2 (zh) |
CN (2) | CN101065385A (zh) |
AT (1) | ATE427311T1 (zh) |
AU (1) | AU2005267054B2 (zh) |
CA (2) | CA2574307A1 (zh) |
DE (1) | DE602005013671D1 (zh) |
HK (1) | HK1102808A1 (zh) |
NZ (1) | NZ565002A (zh) |
WO (2) | WO2006012470A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107840854A (zh) * | 2012-08-13 | 2018-03-27 | 阿迪帕姆单人股份公司 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
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US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
CA2533292C (en) * | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
WO2005009364A2 (en) * | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
CA2533178C (en) * | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
WO2005016311A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
AU2004264356B2 (en) * | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
JP5686494B2 (ja) * | 2003-08-29 | 2015-03-18 | シオノギ インコーポレイテッド | 抗生物質製剤、その使用法及び作成方法 |
EP1663169A4 (en) * | 2003-09-15 | 2010-11-24 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, ITS USE AND FORMULATION |
WO2005056526A1 (ja) * | 2003-12-12 | 2005-06-23 | Daiichi Pharmaceutical Co., Ltd. | 光学活性なシクロプロピルアミン誘導体の製造中間体およびその製造法 |
JP2008505124A (ja) * | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
GB0505909D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
WO2007096703A2 (en) | 2005-08-11 | 2007-08-30 | Targanta Therapeutics Inc. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
US7892826B2 (en) | 2005-08-15 | 2011-02-22 | Janssen Pharmaceutica N.V. | Human cell clones having an endogeneous urotensin II receptor |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US8299052B2 (en) * | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
TWI454262B (zh) * | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
WO2009064792A1 (en) * | 2007-11-16 | 2009-05-22 | Cumbre Pharmaceuticals Inc. | Quinolone carboxylic acid-substituted rifamycin derivatives |
CN102015725B (zh) | 2008-02-25 | 2014-10-22 | 萨利克斯药品有限公司 | 利福昔明的多种形式及其用途 |
US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
CA2716863A1 (en) * | 2008-03-05 | 2009-09-11 | Targacept, Inc. | Sub-type selective amides of diazabicycloalkanes |
US8278313B2 (en) * | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
EP2324041A4 (en) | 2008-08-13 | 2012-06-13 | Targanta Therapeutics Corp | PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS |
CN101875658B (zh) * | 2009-04-28 | 2013-01-09 | 上海药明康德新药开发有限公司 | 3-羰基-2,8-二氮杂螺[4.5] 癸烷-8-羧酸叔丁酯的制备方法 |
CN102781942B (zh) | 2009-10-23 | 2015-09-23 | 詹森药业有限公司 | 用作食欲肽受体调节剂的二取代八氢吡咯并[3,4-c]吡咯 |
NZ604035A (en) | 2010-06-04 | 2015-02-27 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
MX2015003108A (es) * | 2012-09-12 | 2015-09-10 | Salix Pharmaceuticals Inc | Metodos de administracion de rifaximina sin producir resistencia a los antibioticos. |
CN103709177B (zh) * | 2013-12-20 | 2016-02-24 | 武汉工程大学 | 利福霉素类沃尼妙林杂合抗生素及其制备方法 |
CN104628745B (zh) * | 2015-03-06 | 2017-03-08 | 丹诺医药(苏州)有限公司 | 一种利福霉素‑喹嗪酮双靶标分子的富马酸盐及其制备方法 |
CN104710439B (zh) * | 2015-03-06 | 2017-11-07 | 丹诺医药(苏州)有限公司 | 一种利福霉素‑喹嗪酮双靶标分子的晶型i及其制备方法 |
CN108883110B (zh) | 2016-03-10 | 2022-05-27 | 詹森药业有限公司 | 使用食欲素-2受体拮抗剂治疗抑郁症的方法 |
CN105879009A (zh) * | 2016-04-18 | 2016-08-24 | 丹诺医药(苏州)有限公司 | 一种用于治疗革兰氏阴性菌感染的抗菌药物组合物 |
AU2017279027A1 (en) * | 2016-06-08 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
CN106902116B (zh) * | 2017-02-28 | 2021-03-23 | 丹诺医药(苏州)有限公司 | 一种利福霉素-喹嗪酮双靶标分子的应用 |
CN106822125A (zh) * | 2017-02-28 | 2017-06-13 | 丹诺医药(苏州)有限公司 | 一种利福霉素‑喹嗪酮双靶标分子的新用途 |
CN109251258B (zh) * | 2017-07-13 | 2021-06-01 | 中国石油天然气股份有限公司 | 宽分布聚丙烯催化组分、组分制备方法及其催化剂 |
JP7166331B2 (ja) * | 2017-08-01 | 2022-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中間体化合物及び方法 |
CN108310393A (zh) * | 2018-02-12 | 2018-07-24 | 丹诺医药(苏州)有限公司 | 一种利福霉素-喹嗪酮偶联分子的应用 |
CN109464673A (zh) * | 2019-01-08 | 2019-03-15 | 丹诺医药(苏州)有限公司 | 利福霉素-喹嗪酮偶联分子及其盐的应用和制剂 |
CN109529045B (zh) * | 2019-01-08 | 2021-05-18 | 丹诺医药(苏州)有限公司 | 利福霉素-喹嗪酮偶联分子及其药学上可接受的盐的应用 |
CN109942474B (zh) * | 2019-03-04 | 2020-09-18 | 华中科技大学 | 一种邻叠氮-肼类化合物及其制备方法 |
CN115501230B (zh) * | 2022-08-05 | 2023-11-21 | 丹诺医药(苏州)有限公司 | 利福霉素-喹嗪酮偶联分子软膏剂及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1036576A (zh) * | 1988-03-18 | 1989-10-25 | 钟渊化学工业株式会社 | 取代的苯并恶嗪利福霉素及其制备方法以及含该利福霉素的抗菌剂 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100325562B1 (ko) * | 1993-05-24 | 2002-07-22 | 그루포 레페티트 에스. 피. 에이. | 리파마이신의36-유도체및항미생물제로서의그의용도 |
JP2005510534A (ja) | 2001-11-21 | 2005-04-21 | アクティブバイオティクス インコーポレイティッド | 標的化治療薬およびその使用 |
US7238694B2 (en) * | 2004-01-13 | 2007-07-03 | Cumbre Pharmaceuticals, Inc. | Rifamycin imino derivatives effective against drug-resistant microbes |
WO2005070940A2 (en) * | 2004-01-13 | 2005-08-04 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives effective against drug-resistant microbes |
-
2005
- 2005-07-21 WO PCT/US2005/025969 patent/WO2006012470A1/en active Application Filing
- 2005-07-21 AT AT05791212T patent/ATE427311T1/de not_active IP Right Cessation
- 2005-07-21 JP JP2007522780A patent/JP5236944B2/ja active Active
- 2005-07-21 US US11/186,425 patent/US7226931B2/en active Active
- 2005-07-21 NZ NZ565002A patent/NZ565002A/en active Application Filing
- 2005-07-21 WO PCT/US2005/025924 patent/WO2006012443A1/en active Application Filing
- 2005-07-21 CN CNA2005800316554A patent/CN101065385A/zh active Pending
- 2005-07-21 CA CA002574307A patent/CA2574307A1/en not_active Abandoned
- 2005-07-21 CA CA2574301A patent/CA2574301C/en active Active
- 2005-07-21 JP JP2007522765A patent/JP5153329B2/ja active Active
- 2005-07-21 AU AU2005267054A patent/AU2005267054B2/en active Active
- 2005-07-21 US US11/186,187 patent/US7229996B2/en active Active
- 2005-07-21 EP EP05791212A patent/EP1768987B1/en active Active
- 2005-07-21 EP EP05773711A patent/EP1781670A1/en not_active Withdrawn
- 2005-07-21 CN CN2005800308596A patent/CN101031572B/zh active Active
- 2005-07-21 DE DE602005013671T patent/DE602005013671D1/de active Active
-
2007
- 2007-10-04 HK HK07110800.2A patent/HK1102808A1/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1036576A (zh) * | 1988-03-18 | 1989-10-25 | 钟渊化学工业株式会社 | 取代的苯并恶嗪利福霉素及其制备方法以及含该利福霉素的抗菌剂 |
Non-Patent Citations (2)
Title |
---|
Qun Li et al.The 2-pyridone antibacterial agents:bacterialtopoisomeraseinhibitors.Medicinal research reviews20 4.2000,20(4),231-293. |
Qun Li et al.The 2-pyridone antibacterial agents:bacterialtopoisomeraseinhibitors.Medicinal research reviews20 4.2000,20(4),231-293. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107840854A (zh) * | 2012-08-13 | 2018-03-27 | 阿迪帕姆单人股份公司 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
Also Published As
Publication number | Publication date |
---|---|
HK1102808A1 (en) | 2007-12-07 |
DE602005013671D1 (de) | 2009-05-14 |
US20060019985A1 (en) | 2006-01-26 |
US7229996B2 (en) | 2007-06-12 |
AU2005267054B2 (en) | 2011-06-23 |
CN101031572A (zh) | 2007-09-05 |
JP5236944B2 (ja) | 2013-07-17 |
US20060019986A1 (en) | 2006-01-26 |
CA2574301C (en) | 2013-09-10 |
CA2574301A1 (en) | 2006-02-02 |
NZ565002A (en) | 2009-08-28 |
EP1781670A1 (en) | 2007-05-09 |
US7226931B2 (en) | 2007-06-05 |
JP2008507549A (ja) | 2008-03-13 |
EP1768987A1 (en) | 2007-04-04 |
EP1768987B1 (en) | 2009-04-01 |
CA2574307A1 (en) | 2006-02-02 |
CN101065385A (zh) | 2007-10-31 |
WO2006012443A1 (en) | 2006-02-02 |
JP2008507548A (ja) | 2008-03-13 |
JP5153329B2 (ja) | 2013-02-27 |
WO2006012470A1 (en) | 2006-02-02 |
AU2005267054A1 (en) | 2006-02-02 |
ATE427311T1 (de) | 2009-04-15 |
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Owner name: CAMBRI IP VENTURE LIMITED PARTNERSHIP CO.,LTD. Free format text: FORMER OWNER: CAMBRI PHARMACEUTICAL CO.,LTD. Effective date: 20090717 |
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Effective date of registration: 20090717 Address after: Texas in the United States Applicant after: Cumbre Pharmaceuticals Inc. Address before: Texas in the United States Applicant before: Cumbre Pharmaceuticals Inc. |
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Owner name: DANNUO PHARMACEUTICAL (SUZHOU) CO., LTD. Free format text: FORMER OWNER: KANBULI IP VENTURE CAPITAL LIMITED PARTNERSHIP Effective date: 20140522 |
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Effective date of registration: 20140522 Address after: Xinghu street Suzhou Industrial Park, 215123 No. 218 in Jiangsu Province Patentee after: Dunlop medical (Suzhou) Co. Ltd. Address before: texas Patentee before: Cumbre Pharmaceuticals Inc. |