CN101010315A - 用于治疗癌症的取代的吡唑基脲衍生物 - Google Patents

用于治疗癌症的取代的吡唑基脲衍生物 Download PDF

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Publication number
CN101010315A
CN101010315A CNA2005800222909A CN200580022290A CN101010315A CN 101010315 A CN101010315 A CN 101010315A CN A2005800222909 A CNA2005800222909 A CN A2005800222909A CN 200580022290 A CN200580022290 A CN 200580022290A CN 101010315 A CN101010315 A CN 101010315A
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CN
China
Prior art keywords
phenyl
amino
butyl
tert
pyrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800222909A
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English (en)
Chinese (zh)
Inventor
温迪·李
加艾坦·拉多休尔
雅克·杜马
罗杰·史密斯
英士鸿
王甘
陈智
刘青洁
霍利亚·哈图姆·穆克达德
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Bayer Healthcare LLC
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Bayer Pharmaceuticals Corp
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Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of CN101010315A publication Critical patent/CN101010315A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800222909A 2004-04-30 2005-05-02 用于治疗癌症的取代的吡唑基脲衍生物 Pending CN101010315A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56644504P 2004-04-30 2004-04-30
US60/566,445 2004-04-30

Publications (1)

Publication Number Publication Date
CN101010315A true CN101010315A (zh) 2007-08-01

Family

ID=35064925

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800222909A Pending CN101010315A (zh) 2004-04-30 2005-05-02 用于治疗癌症的取代的吡唑基脲衍生物

Country Status (8)

Country Link
US (2) US7838524B2 (https=)
EP (3) EP2295426A1 (https=)
JP (1) JP2007535565A (https=)
CN (1) CN101010315A (https=)
AT (1) ATE517885T1 (https=)
CA (1) CA2564325A1 (https=)
MX (1) MXPA06012394A (https=)
WO (1) WO2005110994A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103211772A (zh) * 2013-03-21 2013-07-24 青岛正大海尔制药有限公司 依托泊苷冻干粉针
CN104053648A (zh) * 2011-12-30 2014-09-17 M-H·皮蒂 治疗癌症的哌嗪基衍生物
CN110167560A (zh) * 2016-08-30 2019-08-23 四相制药公司 四环素化合物和治疗方法
US11578044B2 (en) 2016-10-19 2023-02-14 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline

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US7838524B2 (en) 2010-11-23
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US20110136809A1 (en) 2011-06-09
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