CN100591681C - 8-氰基-1-环丙基-7-(1s,6s-2,8-二氮杂二环[4.3.0]壬烷-8-基)-6-氟-1,4-二氢-4-氧-3-喹啉羧酸的新晶型 - Google Patents
8-氰基-1-环丙基-7-(1s,6s-2,8-二氮杂二环[4.3.0]壬烷-8-基)-6-氟-1,4-二氢-4-氧-3-喹啉羧酸的新晶型 Download PDFInfo
- Publication number
- CN100591681C CN100591681C CN200580010668A CN200580010668A CN100591681C CN 100591681 C CN100591681 C CN 100591681C CN 200580010668 A CN200580010668 A CN 200580010668A CN 200580010668 A CN200580010668 A CN 200580010668A CN 100591681 C CN100591681 C CN 100591681C
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- Prior art keywords
- pradofloxacin
- trihydrate
- water
- cyclopropyl
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
试验 | 产率 | 水量 | 条件 |
B.1 | 91% | 25ml | 85℃ |
B.2 | 93% | 50ml | 85℃ |
B.3 | 92% | 100ml | 85℃ |
试验 | 酸 | 量(mmol) | 产率% | 评论 |
C.1 | 硫酸 | 6 | 93.5 | 在酸性pH下沉淀 |
C.2 | 乙酸 | 6 | 92 | |
C.3 | 甲酸 | 6 | 81.7 | |
C.4 | 硫酸 | 3 | 94.2 | 在酸性pH下沉淀 |
C.5 | 乙酸 | 6 | 89.8 | 在60℃沉淀,并热处理2小时 |
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004015981.5 | 2004-04-01 | ||
DE102004015981A DE102004015981A1 (de) | 2004-04-01 | 2004-04-01 | Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1938304A CN1938304A (zh) | 2007-03-28 |
CN100591681C true CN100591681C (zh) | 2010-02-24 |
Family
ID=34962324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200580010668A Active CN100591681C (zh) | 2004-04-01 | 2005-03-19 | 8-氰基-1-环丙基-7-(1s,6s-2,8-二氮杂二环[4.3.0]壬烷-8-基)-6-氟-1,4-二氢-4-氧-3-喹啉羧酸的新晶型 |
Country Status (32)
Country | Link |
---|---|
US (1) | US7977484B2 (zh) |
EP (1) | EP1737859B1 (zh) |
JP (1) | JP5190259B2 (zh) |
KR (1) | KR101217678B1 (zh) |
CN (1) | CN100591681C (zh) |
AR (2) | AR048099A1 (zh) |
AT (1) | ATE450536T1 (zh) |
AU (1) | AU2005231918B2 (zh) |
BR (1) | BRPI0509529B8 (zh) |
CA (1) | CA2561635C (zh) |
CY (2) | CY1109762T1 (zh) |
DE (3) | DE102004015981A1 (zh) |
DK (1) | DK1737859T3 (zh) |
ES (1) | ES2335899T3 (zh) |
GT (1) | GT200500043A (zh) |
HK (1) | HK1104537A1 (zh) |
HR (1) | HRP20100097T1 (zh) |
IL (1) | IL178353A (zh) |
MY (1) | MY140998A (zh) |
NO (1) | NO337279B1 (zh) |
NZ (1) | NZ550226A (zh) |
PE (1) | PE20060170A1 (zh) |
PL (1) | PL1737859T3 (zh) |
PT (1) | PT1737859E (zh) |
RU (1) | RU2383543C2 (zh) |
SI (1) | SI1737859T1 (zh) |
SV (1) | SV2006002070A (zh) |
TW (1) | TWI350755B (zh) |
UA (1) | UA84329C2 (zh) |
UY (1) | UY28828A1 (zh) |
WO (1) | WO2005097789A1 (zh) |
ZA (1) | ZA200608072B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006010642A1 (de) * | 2006-03-08 | 2007-09-27 | Bayer Healthcare Aktiengesellschaft | Arzneimittelformulierungen, enthaltend Fluorchinolone |
DE102006010643A1 (de) | 2006-03-08 | 2007-09-13 | Bayer Healthcare Aktiengesellschaft | Arzneimittel enthaltend Fluorchinolone |
DE102007026550A1 (de) | 2007-06-08 | 2008-12-11 | Bayer Healthcare Ag | Extrudate mit verbesserter Geschmacksmaskierung |
KR102504435B1 (ko) | 2017-02-13 | 2023-02-27 | 바이엘 애니멀 헬스 게엠베하 | 프라도플록사신을 함유하는 액체 조성물 |
CN115710267A (zh) * | 2022-11-30 | 2023-02-24 | 天津大学 | 一种普拉沙星水合物晶体及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE228130T1 (de) * | 1996-02-23 | 2002-12-15 | Bayer Ag | Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0)-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3- hinolincarbonsäuren und ihre derivate |
DE19854357A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
DE19854355A1 (de) | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
DE19854356A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
DE19908449A1 (de) | 1999-02-26 | 2000-08-31 | Bayer Ag | Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure |
DE19908448A1 (de) | 1999-02-26 | 2000-08-31 | Bayer Ag | Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
-
2004
- 2004-04-01 DE DE102004015981A patent/DE102004015981A1/de not_active Withdrawn
-
2005
- 2005-03-10 GT GT200500043A patent/GT200500043A/es unknown
- 2005-03-15 AR ARP050101004A patent/AR048099A1/es not_active Application Discontinuation
- 2005-03-19 US US11/547,420 patent/US7977484B2/en active Active
- 2005-03-19 ES ES05716236T patent/ES2335899T3/es active Active
- 2005-03-19 AT AT05716236T patent/ATE450536T1/de active
- 2005-03-19 NZ NZ550226A patent/NZ550226A/en unknown
- 2005-03-19 PL PL05716236T patent/PL1737859T3/pl unknown
- 2005-03-19 EP EP05716236A patent/EP1737859B1/de active Active
- 2005-03-19 PT PT05716236T patent/PT1737859E/pt unknown
- 2005-03-19 SI SI200530913T patent/SI1737859T1/sl unknown
- 2005-03-19 DK DK05716236.4T patent/DK1737859T3/da active
- 2005-03-19 DE DE502005008620T patent/DE502005008620D1/de active Active
- 2005-03-19 WO PCT/EP2005/002953 patent/WO2005097789A1/de active Application Filing
- 2005-03-19 CA CA2561635A patent/CA2561635C/en active Active
- 2005-03-19 RU RU2006138362/04A patent/RU2383543C2/ru active
- 2005-03-19 AU AU2005231918A patent/AU2005231918B2/en active Active
- 2005-03-19 UA UAA200611491A patent/UA84329C2/ru unknown
- 2005-03-19 JP JP2007505435A patent/JP5190259B2/ja active Active
- 2005-03-19 CN CN200580010668A patent/CN100591681C/zh active Active
- 2005-03-19 BR BRPI0509529A patent/BRPI0509529B8/pt active IP Right Grant
- 2005-03-30 UY UY28828A patent/UY28828A1/es not_active Application Discontinuation
- 2005-03-30 MY MYPI20051428A patent/MY140998A/en unknown
- 2005-03-31 TW TW094110161A patent/TWI350755B/zh active
- 2005-03-31 PE PE2005000369A patent/PE20060170A1/es not_active Application Discontinuation
- 2005-04-01 SV SV2005002070A patent/SV2006002070A/es unknown
-
2006
- 2006-09-28 ZA ZA2006/08072A patent/ZA200608072B/en unknown
- 2006-09-28 IL IL178353A patent/IL178353A/en active IP Right Grant
- 2006-10-26 KR KR1020067022260A patent/KR101217678B1/ko active IP Right Grant
- 2006-10-31 NO NO20064988A patent/NO337279B1/no unknown
-
2007
- 2007-09-05 HK HK07109664.9A patent/HK1104537A1/xx unknown
-
2010
- 2010-01-29 CY CY20101100090T patent/CY1109762T1/el unknown
- 2010-02-24 HR HR20100097T patent/HRP20100097T1/hr unknown
-
2011
- 2011-10-11 CY CY2011018C patent/CY2011018I1/el unknown
- 2011-10-11 DE DE201112100055 patent/DE122011100055I1/de active Pending
-
2016
- 2016-06-28 AR ARP160101954A patent/AR105177A2/es not_active Application Discontinuation
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Owner name: BAYER INTELLECTUAL PROPERTY GMBH Free format text: FORMER OWNER: BAYER ANIMAL HEALTH GMBH Effective date: 20130124 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20130124 Address after: German Monheim Patentee after: Bayer Pharma Aktiengesellschaft Address before: Germany Leverkusen Patentee before: Bayer Animal Health GmbH |