BRPI0509529B8 - forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diaza-biciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinoli-nocarboxílico, seu uso, e medicamento - Google Patents

forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diaza-biciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinoli-nocarboxílico, seu uso, e medicamento

Info

Publication number
BRPI0509529B8
BRPI0509529B8 BRPI0509529A BRPI0509529A BRPI0509529B8 BR PI0509529 B8 BRPI0509529 B8 BR PI0509529B8 BR PI0509529 A BRPI0509529 A BR PI0509529A BR PI0509529 A BRPI0509529 A BR PI0509529A BR PI0509529 B8 BRPI0509529 B8 BR PI0509529B8
Authority
BR
Brazil
Prior art keywords
acid
nonan
dihydro
cyano
diaza
Prior art date
Application number
BRPI0509529A
Other languages
English (en)
Inventor
Grunenberg Alfons
Rast Hubert
Heep Iris
Benet-Buchholz Jordi
Hallenbach Werner
Original Assignee
Bayer Animal Health Gmbh
Bayer Ip Gmbh
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh, Bayer Ip Gmbh, Bayer Healthcare Ag filed Critical Bayer Animal Health Gmbh
Publication of BRPI0509529A publication Critical patent/BRPI0509529A/pt
Publication of BRPI0509529B1 publication Critical patent/BRPI0509529B1/pt
Publication of BRPI0509529B8 publication Critical patent/BRPI0509529B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

FORMA CRISTALINA DE ÁCIDO 8-CIANO-1-CICLO-PROPIL-7-(1 S,6S-2,8-DIAZABICICLO[4.3.0]NONAN-8-IL)-6-FLÚOR-1,4-DIHIDRO-4-OXO-3-QUINOLINOCARBOXÍLICO. A presente invenção refere-se ao trihidrato de pradofloxacina, processos para a sua fabricação, bem como agentes antibacterianos contendo o mesmo.
BRPI0509529A 2004-04-01 2005-03-19 forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diaza-biciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinoli-nocarboxílico, seu uso, e medicamento BRPI0509529B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004015981.5 2004-04-01
DE102004015981A DE102004015981A1 (de) 2004-04-01 2004-04-01 Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
PCT/EP2005/002953 WO2005097789A1 (de) 2004-04-01 2005-03-19 Neue kristalline form von 8-cyan-1-cyclopropyl-7-(1s,6s-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure

Publications (3)

Publication Number Publication Date
BRPI0509529A BRPI0509529A (pt) 2007-09-18
BRPI0509529B1 BRPI0509529B1 (pt) 2019-05-21
BRPI0509529B8 true BRPI0509529B8 (pt) 2021-05-25

Family

ID=34962324

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509529A BRPI0509529B8 (pt) 2004-04-01 2005-03-19 forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diaza-biciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinoli-nocarboxílico, seu uso, e medicamento

Country Status (32)

Country Link
US (1) US7977484B2 (pt)
EP (1) EP1737859B1 (pt)
JP (1) JP5190259B2 (pt)
KR (1) KR101217678B1 (pt)
CN (1) CN100591681C (pt)
AR (2) AR048099A1 (pt)
AT (1) ATE450536T1 (pt)
AU (1) AU2005231918B2 (pt)
BR (1) BRPI0509529B8 (pt)
CA (1) CA2561635C (pt)
CY (2) CY1109762T1 (pt)
DE (3) DE102004015981A1 (pt)
DK (1) DK1737859T3 (pt)
ES (1) ES2335899T3 (pt)
GT (1) GT200500043A (pt)
HK (1) HK1104537A1 (pt)
HR (1) HRP20100097T1 (pt)
IL (1) IL178353A (pt)
MY (1) MY140998A (pt)
NO (1) NO337279B1 (pt)
NZ (1) NZ550226A (pt)
PE (1) PE20060170A1 (pt)
PL (1) PL1737859T3 (pt)
PT (1) PT1737859E (pt)
RU (1) RU2383543C2 (pt)
SI (1) SI1737859T1 (pt)
SV (1) SV2006002070A (pt)
TW (1) TWI350755B (pt)
UA (1) UA84329C2 (pt)
UY (1) UY28828A1 (pt)
WO (1) WO2005097789A1 (pt)
ZA (1) ZA200608072B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
CA3053211A1 (en) 2017-02-13 2018-08-16 Bayer Animal Health Gmbh Liquid composition containing pradofloxacin and antioxidants
CN115710267A (zh) * 2022-11-30 2023-02-24 天津大学 一种普拉沙星水合物晶体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323213B1 (en) * 1996-02-23 2001-11-27 Bayer Aktiengesellschaft Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854357A1 (de) 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs

Also Published As

Publication number Publication date
TW200602053A (en) 2006-01-16
WO2005097789A1 (de) 2005-10-20
AU2005231918A1 (en) 2005-10-20
KR101217678B1 (ko) 2013-01-02
EP1737859B1 (de) 2009-12-02
CN1938304A (zh) 2007-03-28
KR20070014157A (ko) 2007-01-31
AU2005231918B2 (en) 2011-05-12
IL178353A (en) 2011-08-31
UA84329C2 (en) 2008-10-10
IL178353A0 (en) 2007-02-11
PE20060170A1 (es) 2006-04-13
JP5190259B2 (ja) 2013-04-24
SV2006002070A (es) 2006-03-15
EP1737859A1 (de) 2007-01-03
CA2561635C (en) 2012-10-16
NO20064988L (no) 2006-10-31
TWI350755B (en) 2011-10-21
DE502005008620D1 (de) 2010-01-14
JP2007530614A (ja) 2007-11-01
NZ550226A (en) 2009-11-27
PL1737859T3 (pl) 2010-04-30
AR048099A1 (es) 2006-03-29
SI1737859T1 (sl) 2010-03-31
BRPI0509529B1 (pt) 2019-05-21
CY1109762T1 (el) 2014-09-10
DE122011100055I1 (de) 2012-03-15
DE102004015981A1 (de) 2005-10-20
NO337279B1 (no) 2016-02-29
RU2383543C2 (ru) 2010-03-10
ZA200608072B (en) 2008-01-08
RU2006138362A (ru) 2008-05-10
CN100591681C (zh) 2010-02-24
UY28828A1 (es) 2005-11-30
ES2335899T3 (es) 2010-04-06
CA2561635A1 (en) 2005-10-20
AR105177A2 (es) 2017-09-13
CY2011018I1 (el) 2016-12-14
PT1737859E (pt) 2010-02-03
HRP20100097T1 (hr) 2010-04-30
ATE450536T1 (de) 2009-12-15
HK1104537A1 (en) 2008-01-18
US20080125458A1 (en) 2008-05-29
GT200500043A (es) 2006-02-17
US7977484B2 (en) 2011-07-12
BRPI0509529A (pt) 2007-09-18
MY140998A (en) 2010-02-12
DK1737859T3 (da) 2010-04-06

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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