CN100577175C - 包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法 - Google Patents

包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法 Download PDF

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Publication number
CN100577175C
CN100577175C CN02811137A CN02811137A CN100577175C CN 100577175 C CN100577175 C CN 100577175C CN 02811137 A CN02811137 A CN 02811137A CN 02811137 A CN02811137 A CN 02811137A CN 100577175 C CN100577175 C CN 100577175C
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glucose
ppar
insulin
rosiglitazone
acid
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Expired - Lifetime
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CN02811137A
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Chinese (zh)
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CN1568190A (zh
Inventor
J·C·布索拉里
X·陈
B·R·康韦
K·T·德马雷斯特
H·N·M·罗斯
R·塞维里诺
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3 Dimensional Pharmaceuticals Inc
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3 Dimensional Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A61K31/31—Mercury compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
CN02811137A 2001-04-04 2002-04-03 包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法 Expired - Lifetime CN100577175C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28142901P 2001-04-04 2001-04-04
US60/281,429 2001-04-04

Publications (2)

Publication Number Publication Date
CN1568190A CN1568190A (zh) 2005-01-19
CN100577175C true CN100577175C (zh) 2010-01-06

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CN02811137A Expired - Lifetime CN100577175C (zh) 2001-04-04 2002-04-03 包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法

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US (3) US20030045553A1 (https=)
EP (2) EP2065044A1 (https=)
JP (1) JP4590159B2 (https=)
CN (1) CN100577175C (https=)
AT (1) ATE423559T1 (https=)
CA (1) CA2442917C (https=)
DE (1) DE60231295D1 (https=)
ES (1) ES2321815T3 (https=)
MY (1) MY180762A (https=)
TW (1) TWI330084B (https=)
WO (1) WO2002080936A1 (https=)

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Publication number Priority date Publication date Assignee Title
US5424406A (en) * 1992-11-12 1995-06-13 Tanabe Seiyaku Co., Ltd. Dihydrochalcone derivatives which are hypoglycemic agents
US5731292A (en) * 1992-11-12 1998-03-24 Tanabe Seiyaku Co., Ltd. Dihydrochalcone derivatives which are hypoglycemic agents
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CN1407990A (zh) * 1999-10-12 2003-04-02 布里斯托尔-迈尔斯斯奎布公司 C－芳基葡糖苷sglt2抑制剂

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CA2442917C (en) 2011-02-01
JP4590159B2 (ja) 2010-12-01
ATE423559T1 (de) 2009-03-15
CN1568190A (zh) 2005-01-19
US20080096802A1 (en) 2008-04-24
MY180762A (en) 2020-12-08
CA2442917A1 (en) 2002-10-17
US20030199557A1 (en) 2003-10-23
JP2004529915A (ja) 2004-09-30
TWI330084B (en) 2010-09-11
EP1381361B1 (en) 2009-02-25
ES2321815T3 (es) 2009-06-12
DE60231295D1 (de) 2009-04-09
WO2002080936A1 (en) 2002-10-17
EP2065044A1 (en) 2009-06-03
US8278268B2 (en) 2012-10-02
EP1381361A1 (en) 2004-01-21
US20030045553A1 (en) 2003-03-06

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