CN100567322C - 抑制生长分化因子活性的多肽及表达该多肽的细胞 - Google Patents

抑制生长分化因子活性的多肽及表达该多肽的细胞 Download PDF

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Publication number
CN100567322C
CN100567322C CNB008053782A CN00805378A CN100567322C CN 100567322 C CN100567322 C CN 100567322C CN B008053782 A CNB008053782 A CN B008053782A CN 00805378 A CN00805378 A CN 00805378A CN 100567322 C CN100567322 C CN 100567322C
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gdf
polypeptide
cells
activity
protein
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CN1355881A (zh
Inventor
S·托普兹斯
J·F·赖特
T·拉托维茨基
L·-F·梁
小J·L·布拉迪
D·辛哈
L·雅斯文-科尔克里
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MetaMorphix Inc
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MetaMorphix Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A—HUMAN NECESSITIES
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    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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CNB008053782A 1999-01-21 2000-01-21 抑制生长分化因子活性的多肽及表达该多肽的细胞 Expired - Fee Related CN100567322C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11663999P 1999-01-21 1999-01-21
US60/116,639 1999-01-21
US13836399P 1999-06-10 1999-06-10
US60/138,363 1999-06-10

Publications (2)

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CN1355881A CN1355881A (zh) 2002-06-26
CN100567322C true CN100567322C (zh) 2009-12-09

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EP (1) EP1147413B1 (enExample)
JP (1) JP2003517580A (enExample)
CN (1) CN100567322C (enExample)
AT (1) ATE322681T1 (enExample)
AU (2) AU772694B2 (enExample)
BR (1) BR0008188A (enExample)
CA (1) CA2359242C (enExample)
DE (1) DE60027135T2 (enExample)
HK (1) HK1041521B (enExample)
MX (1) MXPA01007366A (enExample)
NZ (1) NZ513642A (enExample)
WO (1) WO2000043781A2 (enExample)

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