CN100544730C - 异甘草酸镁外用制剂及其制备方法和应用 - Google Patents
异甘草酸镁外用制剂及其制备方法和应用 Download PDFInfo
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- CN100544730C CN100544730C CNB2005101061107A CN200510106110A CN100544730C CN 100544730 C CN100544730 C CN 100544730C CN B2005101061107 A CNB2005101061107 A CN B2005101061107A CN 200510106110 A CN200510106110 A CN 200510106110A CN 100544730 C CN100544730 C CN 100544730C
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- magnesium isoglycyrrhetate
- transdermal patch
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- magnesium
- isoglycyrrhetate
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- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
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- 229920001285 xanthan gum Polymers 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别 | 有颗粒层鳞片比例(个/100个) | 变化率(%) |
正常对照组 | 6.70±1.06 | |
软膏组 | 10.10±2.81** | 50.75 |
乳膏组 | 10.50±3.57** | 56.72 |
透皮贴剂组 | 10.30±2.36** | 53.73 |
组别 | 阴道上皮细胞有丝分裂指数 | 变化率(%) |
模型对照组 | 13.30±1.64 | |
软膏组 | 10.00±1.83** | -24.81 |
乳膏组 | 9.90±1.79** | -25.56 |
组别 | 耳廓肿胀度μm | 耳廓肿胀抑制率(%) |
模型对照组 | 155.20±25.33 | |
软膏组 | 107.90±18.51 | 30.48 |
乳膏组 | 103.00±21.50** | 33.63 |
透皮贴剂组 | 105.30±20.36** | 32.15 |
组别 | 耳廓肿胀度μm | 耳廓肿胀抑制率(%) |
正常对照组 | 155.70±24.60** | |
模型对照组 | 231.10±34.54 | |
软膏组 | 181.60±28.06** | 21.42 |
乳膏组 | 182.70±25.44** | 20.94 |
透皮贴剂组 | 181.10±18.49** | 21.64 |
组别 | 炎性细胞数(个/mm<sup>2</sup>) | 抑制率(%) |
模型对照组 | 94.83±10.28 | |
软膏组 | 54.00±9.12** | 43.06 |
乳膏组 | 55.50±8.26** | 41.48 |
透皮贴剂组 | 55.83±6.24** | 41.12 |
Claims (7)
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CN101396368B (zh) * | 2007-09-29 | 2010-12-01 | 江苏正大天晴药业股份有限公司 | 异甘草酸或其盐在制备治疗过敏性鼻炎药物中的应用 |
CN101947200B (zh) * | 2010-07-30 | 2013-04-03 | 东南大学 | 一种乳化型软膏 |
CN101947322B (zh) * | 2010-09-03 | 2012-07-04 | 南方医科大学 | 一种凝胶贴剂的基质及其制备方法和应用 |
CN103536700B (zh) * | 2013-11-12 | 2015-04-22 | 扬州大学 | 一种治疗带状疱疹的中药醇质体凝胶贴剂及其制备方法 |
CN106309353A (zh) * | 2015-06-19 | 2017-01-11 | 江苏吉贝尔药业股份有限公司 | 一种治疗银屑病的软膏剂及其制备方法 |
CN105687125A (zh) * | 2016-01-29 | 2016-06-22 | 王绿江 | 一种用于治疗皮肤病的硅凝胶 |
CN106177693A (zh) * | 2016-09-27 | 2016-12-07 | 泰山医学院 | 一种用于治疗湿疹的中药及其复方溶液 |
CN108324724A (zh) * | 2018-04-10 | 2018-07-27 | 苏州芝宇生物科技有限公司 | 一种克立硼罗可溶性膜制剂的制法及其应用 |
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