CN100522135C - 含有噻托铵吸入用粉末的吸入用套盒 - Google Patents

含有噻托铵吸入用粉末的吸入用套盒 Download PDF

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Publication number
CN100522135C
CN100522135C CNB038080257A CN03808025A CN100522135C CN 100522135 C CN100522135 C CN 100522135C CN B038080257 A CNB038080257 A CN B038080257A CN 03808025 A CN03808025 A CN 03808025A CN 100522135 C CN100522135 C CN 100522135C
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CN
China
Prior art keywords
tiotropium
powder
inhaler
suction
base plate
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Expired - Lifetime
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CNB038080257A
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English (en)
Chinese (zh)
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CN1646095A (zh
Inventor
伯恩德·齐伦伯格
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Boehringer Ingelheim Pharma GmbH and Co KG
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Boehringer Ingelheim Pharma GmbH and Co KG
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Publication of CN1646095A publication Critical patent/CN1646095A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038080257A 2002-04-09 2003-04-02 含有噻托铵吸入用粉末的吸入用套盒 Expired - Lifetime CN100522135C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02007868 2002-04-09
EP02007868.9 2002-04-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2009101406488A Division CN101574552B (zh) 2002-04-09 2003-04-02 含有噻托铵吸入用粉末的吸入用套盒

Publications (2)

Publication Number Publication Date
CN1646095A CN1646095A (zh) 2005-07-27
CN100522135C true CN100522135C (zh) 2009-08-05

Family

ID=28685844

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB038080257A Expired - Lifetime CN100522135C (zh) 2002-04-09 2003-04-02 含有噻托铵吸入用粉末的吸入用套盒
CN2009101406488A Expired - Lifetime CN101574552B (zh) 2002-04-09 2003-04-02 含有噻托铵吸入用粉末的吸入用套盒

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CN2009101406488A Expired - Lifetime CN101574552B (zh) 2002-04-09 2003-04-02 含有噻托铵吸入用粉末的吸入用套盒

Country Status (30)

Country Link
EP (1) EP1496858B1 (no)
JP (1) JP2005525393A (no)
KR (1) KR101017850B1 (no)
CN (2) CN100522135C (no)
AR (1) AR039276A1 (no)
AU (1) AU2009200716B2 (no)
BR (1) BR0309117A (no)
CA (1) CA2481876C (no)
CY (1) CY1114600T1 (no)
DK (1) DK1496858T3 (no)
EA (2) EA007302B1 (no)
ES (1) ES2434834T3 (no)
HK (2) HK1079092A1 (no)
HR (1) HRP20040933B1 (no)
IL (3) IL163677A0 (no)
ME (1) MEP47108A (no)
MX (1) MXPA04009764A (no)
MY (1) MY153151A (no)
NO (1) NO20044096L (no)
NZ (1) NZ536219A (no)
PE (1) PE20030971A1 (no)
PL (1) PL207750B1 (no)
PT (1) PT1496858E (no)
RS (1) RS52624B (no)
SI (1) SI1496858T1 (no)
TW (1) TWI312688B (no)
UA (1) UA80123C2 (no)
UY (1) UY27751A1 (no)
WO (1) WO2003084502A1 (no)
ZA (1) ZA200406750B (no)

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Publication number Publication date
UA80123C2 (en) 2007-08-27
MY153151A (en) 2015-01-29
ES2434834T3 (es) 2013-12-17
KR20040108704A (ko) 2004-12-24
TWI312688B (en) 2009-08-01
EA200401304A1 (ru) 2005-06-30
EP1496858A1 (en) 2005-01-19
IL209401A0 (en) 2011-01-31
NO20044096L (no) 2004-10-20
EA007302B1 (ru) 2006-08-25
WO2003084502A1 (en) 2003-10-16
HRP20040933A2 (en) 2005-02-28
EP1496858B1 (en) 2013-08-14
HK1079092A1 (en) 2006-03-31
RS52624B (en) 2013-06-28
ZA200406750B (en) 2006-05-31
PL207750B1 (pl) 2011-01-31
DK1496858T3 (da) 2013-11-18
PE20030971A1 (es) 2003-12-31
RS88004A (en) 2006-12-15
NZ536219A (en) 2006-07-28
IL163677A0 (en) 2005-12-18
IL163677A (en) 2012-06-28
SI1496858T1 (sl) 2013-12-31
ME00307B (me) 2011-02-10
BR0309117A (pt) 2005-02-01
PT1496858E (pt) 2013-11-20
CN101574552A (zh) 2009-11-11
KR101017850B1 (ko) 2011-03-04
UY27751A1 (es) 2003-11-28
CA2481876A1 (en) 2003-10-16
TW200306863A (en) 2003-12-01
EA200600620A1 (ru) 2006-08-25
CA2481876C (en) 2011-01-18
MXPA04009764A (es) 2004-12-13
HRP20040933B1 (hr) 2014-05-23
AU2003226775A1 (en) 2003-10-20
AR039276A1 (es) 2005-02-16
JP2005525393A (ja) 2005-08-25
MEP47108A (en) 2011-02-10
CN101574552B (zh) 2011-12-07
PL371855A1 (en) 2005-06-27
AU2009200716B2 (en) 2011-06-16
CY1114600T1 (el) 2016-10-05
AU2009200716A1 (en) 2009-03-19
CN1646095A (zh) 2005-07-27
HK1136514A1 (en) 2010-07-02

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