CN100506815C - 选择性结合整联蛋白的哌啶化合物 - Google Patents

Info

Publication number

CN100506815C

CN100506815C CNB038240904A CN03824090A CN100506815C CN 100506815 C CN100506815 C CN 100506815C CN B038240904 A CNB038240904 A CN B038240904A CN 03824090 A CN03824090 A CN 03824090A CN 100506815 C CN100506815 C CN 100506815C

Authority

CN

China

Prior art keywords

base

alkyl

compound

structural formula

tetrahydrochysene

Prior art date

2002-08-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 108010044426 integrins Proteins 0.000 title claims abstract description 88
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• 239000001257 hydrogen Substances 0.000 claims description 79
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• -1 2-benzofuryl Chemical group 0.000 claims description 61
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 51
• 150000003839 salts Chemical class 0.000 claims description 49
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 45
• 239000003795 chemical substances by application Substances 0.000 claims description 44
• 229910052736 halogen Inorganic materials 0.000 claims description 27
• 150000002367 halogens Chemical class 0.000 claims description 27
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 27
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• 125000004043 oxo group Chemical group O=* 0.000 claims description 18
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 15
• 125000004076 pyridyl group Chemical group 0.000 claims description 15
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 14
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• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 8
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• KUZSBKJSGSKPJH-VXGBXAGGSA-N 5-[(9R)-6-[(3R)-3-methylmorpholin-4-yl]-11-oxa-1,3,5-triazatricyclo[7.4.0.02,7]trideca-2,4,6-trien-4-yl]pyrazin-2-amine Chemical compound C[C@@H]1COCCN1c1nc(nc2N3CCOC[C@H]3Cc12)-c1cnc(N)cn1 KUZSBKJSGSKPJH-VXGBXAGGSA-N 0.000 description 12
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