CN100503598C - 改进的化学方法和药物制剂 - Google Patents

改进的化学方法和药物制剂 Download PDF

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Publication number
CN100503598C
CN100503598C CNB998133280A CN99813328A CN100503598C CN 100503598 C CN100503598 C CN 100503598C CN B998133280 A CNB998133280 A CN B998133280A CN 99813328 A CN99813328 A CN 99813328A CN 100503598 C CN100503598 C CN 100503598C
Authority
CN
China
Prior art keywords
omeprazole
prepared
magnesium
salt
substituted sulfinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998133280A
Other languages
English (en)
Chinese (zh)
Other versions
CN1326455A (zh
Inventor
M·艾利松
A·古斯塔夫松
L·约瑟夫松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26663439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100503598(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9803953A external-priority patent/SE9803953D0/xx
Priority claimed from SE9803952A external-priority patent/SE9803952D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1326455A publication Critical patent/CN1326455A/zh
Application granted granted Critical
Publication of CN100503598C publication Critical patent/CN100503598C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CNB998133280A 1998-11-18 1999-11-15 改进的化学方法和药物制剂 Expired - Fee Related CN100503598C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9803953A SE9803953D0 (sv) 1998-11-18 1998-11-18 Improved chemical process
SE9803952A SE9803952D0 (sv) 1998-11-18 1998-11-18 Pharmaceutical formulation
SE98039530 1998-11-18
SE98039522 1998-11-18

Publications (2)

Publication Number Publication Date
CN1326455A CN1326455A (zh) 2001-12-12
CN100503598C true CN100503598C (zh) 2009-06-24

Family

ID=26663439

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998133280A Expired - Fee Related CN100503598C (zh) 1998-11-18 1999-11-15 改进的化学方法和药物制剂

Country Status (18)

Country Link
US (1) US6403616B1 (https=)
EP (1) EP1131316B1 (https=)
JP (1) JP4610086B2 (https=)
KR (1) KR100619200B1 (https=)
CN (1) CN100503598C (https=)
AT (1) ATE271556T1 (https=)
AU (1) AU770633B2 (https=)
BR (1) BR9915421A (https=)
CA (1) CA2347981C (https=)
DE (1) DE69918854T2 (https=)
DK (1) DK1131316T3 (https=)
ES (1) ES2222754T3 (https=)
HK (1) HK1038920B (https=)
IL (2) IL142629A0 (https=)
NO (1) NO321275B1 (https=)
NZ (1) NZ511169A (https=)
PT (1) PT1131316E (https=)
WO (1) WO2000028975A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2005082888A1 (en) * 2004-03-01 2005-09-09 Milen Merkez Ilac Endustrisi A.S. Process for the preparation of magnesium salt of omeprazole
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060141054A1 (en) 2004-10-25 2006-06-29 Thomas Piccariello Metal coordinated compositions
US7799937B2 (en) 2004-10-25 2010-09-21 Synthonics, Inc. Metal coordinated compositions
AU2007266574A1 (en) * 2006-06-01 2007-12-06 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
US20090280173A1 (en) * 2008-05-09 2009-11-12 Ishwar Chauhan Multilayer Omeprazole Tablets
EP3372080A3 (en) 2011-11-10 2018-10-17 Rotam Agrochem International Co., Ltd Herbicidal composition and method of using the same
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686230A (en) * 1984-10-31 1987-08-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Picoline derivative useful as gastric acid secretion inhibitors
CN1126993C (zh) * 1996-03-05 2003-11-05 澳大利亚研究实验室持股有限公司 显示技术的电子印刷
CN1128997C (zh) * 2001-01-04 2003-11-26 中国科学院南京土壤研究所 一种吸力平板的制作方法
CN1134667C (zh) * 1996-05-17 2004-01-14 福姆法克特公司 微电子弹性接触元件

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE69127275T2 (de) * 1991-06-21 1998-03-12 Ilsan Ilac Ve Hammaddeleri San Neues galenisches Verfahren für Omeprazol enthaltende Pellets
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9302395D0 (sv) 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
TNSN95062A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux derives dialkoxy-pyridinyle-benzimidazole
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
US5945124A (en) * 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686230A (en) * 1984-10-31 1987-08-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Picoline derivative useful as gastric acid secretion inhibitors
CN1126993C (zh) * 1996-03-05 2003-11-05 澳大利亚研究实验室持股有限公司 显示技术的电子印刷
CN1134667C (zh) * 1996-05-17 2004-01-14 福姆法克特公司 微电子弹性接触元件
CN1128997C (zh) * 2001-01-04 2003-11-26 中国科学院南京土壤研究所 一种吸力平板的制作方法

Also Published As

Publication number Publication date
NO321275B1 (no) 2006-04-10
BR9915421A (pt) 2001-08-07
JP2002529497A (ja) 2002-09-10
NZ511169A (en) 2003-06-30
KR20010089474A (ko) 2001-10-06
EP1131316B1 (en) 2004-07-21
HK1038920B (en) 2005-03-11
AU770633B2 (en) 2004-02-26
CA2347981C (en) 2010-05-04
PT1131316E (pt) 2004-10-29
ATE271556T1 (de) 2004-08-15
IL142629A0 (en) 2002-03-10
JP4610086B2 (ja) 2011-01-12
NO20012427D0 (no) 2001-05-16
NO20012427L (no) 2001-07-09
DE69918854D1 (de) 2004-08-26
IL142629A (en) 2007-12-03
US6403616B1 (en) 2002-06-11
WO2000028975A2 (en) 2000-05-25
WO2000028975A3 (en) 2000-08-10
CA2347981A1 (en) 2000-05-25
KR100619200B1 (ko) 2006-09-05
CN1326455A (zh) 2001-12-12
HK1038920A1 (en) 2002-04-04
DE69918854T2 (de) 2005-07-21
AU1901700A (en) 2000-06-05
EP1131316A2 (en) 2001-09-12
ES2222754T3 (es) 2005-02-01
DK1131316T3 (da) 2004-09-27

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ASTRAZENECA AB

Free format text: FORMER NAME: ASTRA ZENECA AKTIEBOLAG

CP01 Change in the name or title of a patent holder

Address after: Swedish Sodertalje

Patentee after: Astrazeneca (Sweden) AB

Address before: Swedish Sodertalje

Patentee before: Astra Zeneca Aktiebolag

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090624

Termination date: 20161115