DE69918854D1 - Verbesserter chemischer prozess und eine pharmazeutische zubereitung - Google Patents
Verbesserter chemischer prozess und eine pharmazeutische zubereitungInfo
- Publication number
- DE69918854D1 DE69918854D1 DE69918854T DE69918854T DE69918854D1 DE 69918854 D1 DE69918854 D1 DE 69918854D1 DE 69918854 T DE69918854 T DE 69918854T DE 69918854 T DE69918854 T DE 69918854T DE 69918854 D1 DE69918854 D1 DE 69918854D1
- Authority
- DE
- Germany
- Prior art keywords
- manufacturing
- substituted sulphinyl
- compound
- formula
- adjusted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001311 chemical methods and process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 159000000011 group IA salts Chemical class 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000012512 bulk drug substance Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical class [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940126409 proton pump inhibitor Drugs 0.000 abstract 1
- 239000000612 proton pump inhibitor Substances 0.000 abstract 1
- -1 sulphinyl compound Chemical class 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9803952 | 1998-11-18 | ||
| SE9803952A SE9803952D0 (sv) | 1998-11-18 | 1998-11-18 | Pharmaceutical formulation |
| SE9803953A SE9803953D0 (sv) | 1998-11-18 | 1998-11-18 | Improved chemical process |
| SE9803953 | 1998-11-18 | ||
| PCT/SE1999/002093 WO2000028975A2 (en) | 1998-11-18 | 1999-11-15 | Improved chemical process and pharmaceutical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918854D1 true DE69918854D1 (de) | 2004-08-26 |
| DE69918854T2 DE69918854T2 (de) | 2005-07-21 |
Family
ID=26663439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918854T Expired - Lifetime DE69918854T2 (de) | 1998-11-18 | 1999-11-15 | Verbesserter chemischer prozess und eine pharmazeutische zubereitung |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6403616B1 (de) |
| EP (1) | EP1131316B1 (de) |
| JP (1) | JP4610086B2 (de) |
| KR (1) | KR100619200B1 (de) |
| CN (1) | CN100503598C (de) |
| AT (1) | ATE271556T1 (de) |
| AU (1) | AU770633B2 (de) |
| BR (1) | BR9915421A (de) |
| CA (1) | CA2347981C (de) |
| DE (1) | DE69918854T2 (de) |
| DK (1) | DK1131316T3 (de) |
| ES (1) | ES2222754T3 (de) |
| HK (1) | HK1038920B (de) |
| IL (2) | IL142629A0 (de) |
| NO (1) | NO321275B1 (de) |
| NZ (1) | NZ511169A (de) |
| PT (1) | PT1131316E (de) |
| WO (1) | WO2000028975A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| WO2005082888A1 (en) * | 2004-03-01 | 2005-09-09 | Milen Merkez Ilac Endustrisi A.S. | Process for the preparation of magnesium salt of omeprazole |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
| US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
| US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
| WO2007138606A2 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| US20090280173A1 (en) * | 2008-05-09 | 2009-11-12 | Ishwar Chauhan | Multilayer Omeprazole Tablets |
| EP2708124B1 (de) | 2011-11-10 | 2018-03-21 | Rotam Agrochem International Co., Ltd | Herbizidzusammensetzung und Verwendungsverfahren dafür |
| EP3288556A4 (de) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Oral zerfallende zusammensetzungen |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| DK0519144T3 (da) | 1991-06-21 | 1998-03-23 | Ilsan Ilac Ve Hammaddeleri San | Ny galenisk proces for omeprazol indeholdende pellets |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
| SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
| TNSN95062A1 (fr) * | 1994-05-27 | 1996-02-06 | Astra Ab | Nouveaux derives dialkoxy-pyridinyle-benzimidazole |
| SE9402431D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| US5945124A (en) | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| AUPN846496A0 (en) * | 1996-03-05 | 1996-03-28 | Research Laboratories Of Australia Pty Ltd | Electronic printing for display technology |
| SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| EP0898712B1 (de) * | 1996-05-17 | 2003-08-06 | Formfactor, Inc. | Einbrennen und testen eines halbleiterwafers |
| CN1128997C (zh) * | 2001-01-04 | 2003-11-26 | 中国科学院南京土壤研究所 | 一种吸力平板的制作方法 |
-
1999
- 1999-11-15 WO PCT/SE1999/002093 patent/WO2000028975A2/en active IP Right Grant
- 1999-11-15 CA CA2347981A patent/CA2347981C/en not_active Expired - Fee Related
- 1999-11-15 DK DK99962610T patent/DK1131316T3/da active
- 1999-11-15 KR KR1020017006233A patent/KR100619200B1/ko not_active IP Right Cessation
- 1999-11-15 DE DE69918854T patent/DE69918854T2/de not_active Expired - Lifetime
- 1999-11-15 EP EP99962610A patent/EP1131316B1/de not_active Expired - Lifetime
- 1999-11-15 US US09/485,897 patent/US6403616B1/en not_active Expired - Lifetime
- 1999-11-15 AU AU19017/00A patent/AU770633B2/en not_active Ceased
- 1999-11-15 JP JP2000582023A patent/JP4610086B2/ja not_active Expired - Fee Related
- 1999-11-15 PT PT99962610T patent/PT1131316E/pt unknown
- 1999-11-15 CN CNB998133280A patent/CN100503598C/zh not_active Expired - Fee Related
- 1999-11-15 NZ NZ511169A patent/NZ511169A/xx not_active IP Right Cessation
- 1999-11-15 IL IL14262999A patent/IL142629A0/xx active IP Right Grant
- 1999-11-15 BR BR9915421-8A patent/BR9915421A/pt active Search and Examination
- 1999-11-15 ES ES99962610T patent/ES2222754T3/es not_active Expired - Lifetime
- 1999-11-15 AT AT99962610T patent/ATE271556T1/de active
-
2001
- 2001-04-16 IL IL142629A patent/IL142629A/en not_active IP Right Cessation
- 2001-05-16 NO NO20012427A patent/NO321275B1/no not_active IP Right Cessation
-
2002
- 2002-01-21 HK HK02100464.5A patent/HK1038920B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1038920B (zh) | 2005-03-11 |
| IL142629A0 (en) | 2002-03-10 |
| DE69918854T2 (de) | 2005-07-21 |
| ES2222754T3 (es) | 2005-02-01 |
| KR20010089474A (ko) | 2001-10-06 |
| DK1131316T3 (da) | 2004-09-27 |
| JP2002529497A (ja) | 2002-09-10 |
| AU1901700A (en) | 2000-06-05 |
| CN100503598C (zh) | 2009-06-24 |
| HK1038920A1 (en) | 2002-04-04 |
| IL142629A (en) | 2007-12-03 |
| NO20012427D0 (no) | 2001-05-16 |
| KR100619200B1 (ko) | 2006-09-05 |
| NO321275B1 (no) | 2006-04-10 |
| EP1131316B1 (de) | 2004-07-21 |
| WO2000028975A3 (en) | 2000-08-10 |
| US6403616B1 (en) | 2002-06-11 |
| PT1131316E (pt) | 2004-10-29 |
| JP4610086B2 (ja) | 2011-01-12 |
| EP1131316A2 (de) | 2001-09-12 |
| ATE271556T1 (de) | 2004-08-15 |
| CA2347981C (en) | 2010-05-04 |
| CA2347981A1 (en) | 2000-05-25 |
| CN1326455A (zh) | 2001-12-12 |
| BR9915421A (pt) | 2001-08-07 |
| NZ511169A (en) | 2003-06-30 |
| NO20012427L (no) | 2001-07-09 |
| AU770633B2 (en) | 2004-02-26 |
| WO2000028975A2 (en) | 2000-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |