CN100379419C - 含有4,5-环氧吗啡喃衍生物的稳定的药物组合物 - Google Patents

含有4,5-环氧吗啡喃衍生物的稳定的药物组合物 Download PDF

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Publication number
CN100379419C
CN100379419C CNB98801274XA CN98801274A CN100379419C CN 100379419 C CN100379419 C CN 100379419C CN B98801274X A CNB98801274X A CN B98801274XA CN 98801274 A CN98801274 A CN 98801274A CN 100379419 C CN100379419 C CN 100379419C
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CN
China
Prior art keywords
group
carbon atoms
group containing
atom
hydrogen atom
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Expired - Lifetime
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CNB98801274XA
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English (en)
Chinese (zh)
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CN1237106A (zh
Inventor
花村伸幸
堀内保秀
吉井良二
青木孝夫
原三千雄
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Toray Industries Inc
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Toray Industries Inc
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Publication of CN1237106A publication Critical patent/CN1237106A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CNB98801274XA 1997-07-11 1998-07-10 含有4,5-环氧吗啡喃衍生物的稳定的药物组合物 Expired - Lifetime CN100379419C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP186950/97 1997-07-11
JP18695097 1997-07-11

Publications (2)

Publication Number Publication Date
CN1237106A CN1237106A (zh) 1999-12-01
CN100379419C true CN100379419C (zh) 2008-04-09

Family

ID=16197570

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB98801274XA Expired - Lifetime CN100379419C (zh) 1997-07-11 1998-07-10 含有4,5-环氧吗啡喃衍生物的稳定的药物组合物

Country Status (15)

Country Link
US (1) US6372755B2 (enExample)
EP (1) EP0948965B1 (enExample)
JP (3) JP3617055B2 (enExample)
KR (1) KR100514963B1 (enExample)
CN (1) CN100379419C (enExample)
AT (1) ATE268178T1 (enExample)
AU (1) AU740404B2 (enExample)
CA (1) CA2265767C (enExample)
DE (1) DE69824277T2 (enExample)
DK (1) DK0948965T3 (enExample)
ES (1) ES2217563T3 (enExample)
NO (1) NO318831B1 (enExample)
PT (1) PT948965E (enExample)
TW (1) TWI285644B (enExample)
WO (1) WO1999002158A1 (enExample)

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JP4880813B2 (ja) * 2000-10-26 2012-02-22 第一三共株式会社 外用消炎鎮痛剤組成物
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
DE10161110A1 (de) * 2001-12-12 2003-06-26 Ursapharm Arzneimittel Gmbh Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung
DE10161149B4 (de) * 2001-12-12 2007-03-08 Ursapharm Arzneimittel Gmbh & Co. Kg Verwendung von Heparin-haltigem Ophthalmikum
ZA200409537B (en) 2003-01-31 2006-10-25 Yamanouchi Pharma Co Ltd Stable solid medicinal composition for oral administration
GB0308734D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules
JP4963670B2 (ja) * 2004-04-07 2012-06-27 レスベラトロル パートナーズ， エルエルシー 栄養補助サプリメントおよびそれを処理する方法
AU2005244059A1 (en) * 2004-05-07 2005-11-24 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
WO2006024138A1 (en) * 2004-08-30 2006-03-09 Taro Pharmaceutical Industries Ltd. A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol
WO2006067605A1 (en) * 2004-12-23 2006-06-29 Ranbaxy Laboratories Limited Stable pharmaceutical compositions of tiagabine and processes for their preparation
EP1845787B1 (en) * 2005-01-27 2015-04-15 Erimos Pharmaceuticals LLC Formulations for injection of catecholic butanes, including ndga compounds, into animals
CN101150955B (zh) * 2005-01-27 2013-04-17 埃里莫斯医药品有限公司 递送包括ndga化合物的儿茶酚丁烷的口服制剂
TWI286941B (en) * 2005-07-27 2007-09-21 Anagen Therapeutics Inc Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof
CA2685131C (en) * 2007-04-26 2015-05-19 Toray Industries, Inc. Stable solid preparation containing 4,5-epoxymorphinan derivative
WO2008143240A1 (ja) * 2007-05-21 2008-11-27 Toray Industries, Inc. 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法
CN101658489B (zh) * 2008-08-27 2011-11-23 海南四环心脑血管药物研究院有限公司 一种盐酸纳美芬注射液及其制备方法
DK2356989T3 (en) * 2008-10-24 2018-05-07 Toray Industries Stable tablet containing 4,5-epoxymorphinane derivative
TWI455733B (zh) 2009-03-30 2014-10-11 Toray Industries 口腔內崩壞性被覆錠劑
WO2010139752A2 (en) * 2009-06-04 2010-12-09 Alk Ag Stabilised composition comprising at least one adrenergic compound
HUE045889T2 (hu) 2010-10-21 2020-01-28 Rtu Pharmaceuticals Llc Használatkész ketorolak készítmények
JP5750278B2 (ja) * 2011-02-28 2015-07-15 東洋カプセル株式会社 カンデサルタンシレキセチルのカプセル充填用組成物
WO2013070656A1 (en) * 2011-11-07 2013-05-16 Navinta Llc Sustained release suspension preparation for dextromethorphan
WO2013074948A1 (en) 2011-11-16 2013-05-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
JP6247118B2 (ja) * 2014-03-05 2017-12-13 東海カプセル株式会社 カプセル充填組成物
US10561628B2 (en) * 2015-03-19 2020-02-18 Daiichi Sankyo Company, Limited Solid preparation including antioxidant
BR112017019920B1 (pt) 2015-03-19 2023-11-07 Daiichi Sankyo Company, Limited Preparação sólida farmacêutica, e, método para estabilização de uma preparação sólida farmacêutica
JP5918895B1 (ja) * 2015-05-21 2016-05-18 富士カプセル株式会社 ナルフラフィン塩酸塩含有カプセル製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
CN109562109A (zh) * 2016-07-29 2019-04-02 东丽株式会社 光稳定性提高的固体制剂
JP6131379B1 (ja) * 2016-12-28 2017-05-17 森下仁丹株式会社 ４，５−エポキシモルヒナン誘導体含有製剤
EP3603643B1 (en) * 2017-03-31 2021-09-15 Toray Industries, Inc. Tableted medicinal composition comprising nalfurafine
CA3091752A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases
JP7312751B2 (ja) 2018-07-30 2023-07-21 第一三共株式会社 安定化剤を含有する医薬品の固形製剤
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WO1993015081A1 (en) * 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use

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GB8820327D0 (en) 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
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US5948389A (en) * 1995-06-07 1999-09-07 El Khoury & Stein, Ltd. Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
DE29719704U1 (de) 1997-02-14 1998-01-22 Gödecke AG, 10587 Berlin Stabile Zubereitungen von Naloxonhydrochlorid

Patent Citations (1)

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WO1993015081A1 (en) * 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use

Also Published As

Publication number Publication date
TWI285644B (en) 2007-08-21
US6372755B2 (en) 2002-04-16
DE69824277T2 (de) 2004-09-23
DE69824277D1 (de) 2004-07-08
NO991152L (no) 1999-05-10
KR20000068528A (ko) 2000-11-25
KR100514963B1 (ko) 2005-09-15
AU740404B2 (en) 2001-11-01
ATE268178T1 (de) 2004-06-15
EP0948965A4 (en) 2002-10-16
ES2217563T3 (es) 2004-11-01
PT948965E (pt) 2004-08-31
US20010004637A1 (en) 2001-06-21
EP0948965A1 (en) 1999-10-13
WO1999002158A1 (fr) 1999-01-21
DK0948965T3 (da) 2004-07-05
NO991152D0 (no) 1999-03-10
CA2265767A1 (en) 1999-01-21
JP2005002123A (ja) 2005-01-06
JP3617055B2 (ja) 2005-02-02
CN1237106A (zh) 1999-12-01
EP0948965B1 (en) 2004-06-02
JP3743449B2 (ja) 2006-02-08
AU8128298A (en) 1999-02-08
JP4311369B2 (ja) 2009-08-12
NO318831B1 (no) 2005-05-09
CA2265767C (en) 2007-12-04
JP2005247866A (ja) 2005-09-15

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