PT948965E - Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinano - Google Patents
Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinanoInfo
- Publication number
- PT948965E PT948965E PT98931040T PT98931040T PT948965E PT 948965 E PT948965 E PT 948965E PT 98931040 T PT98931040 T PT 98931040T PT 98931040 T PT98931040 T PT 98931040T PT 948965 E PT948965 E PT 948965E
- Authority
- PT
- Portugal
- Prior art keywords
- stabilizable
- medicinal compositions
- compositions containing
- epoxymorphinan derivative
- epoxymorphinan
- Prior art date
Links
- QONGLMDHKNFCDX-KBHMWOLSSA-N (4r,4ar,12bs)-1,2,3,4,4a,5,6,7,7a,13-decahydro-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical class O1C2CCC[C@H]3[C@]4([H])NCC[C@]23C2=C1C=CC=C2C4 QONGLMDHKNFCDX-KBHMWOLSSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18695097 | 1997-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT948965E true PT948965E (pt) | 2004-08-31 |
Family
ID=16197570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98931040T PT948965E (pt) | 1997-07-11 | 1998-07-10 | Composicoes medicinais estaveis contendo um derivado de 4,5-epoximorfinano |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6372755B2 (enExample) |
| EP (1) | EP0948965B1 (enExample) |
| JP (3) | JP3617055B2 (enExample) |
| KR (1) | KR100514963B1 (enExample) |
| CN (1) | CN100379419C (enExample) |
| AT (1) | ATE268178T1 (enExample) |
| AU (1) | AU740404B2 (enExample) |
| CA (1) | CA2265767C (enExample) |
| DE (1) | DE69824277T2 (enExample) |
| DK (1) | DK0948965T3 (enExample) |
| ES (1) | ES2217563T3 (enExample) |
| NO (1) | NO318831B1 (enExample) |
| PT (1) | PT948965E (enExample) |
| TW (1) | TWI285644B (enExample) |
| WO (1) | WO1999002158A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899400A0 (en) * | 2000-07-26 | 2000-08-17 | Csl Limited | A method of stabilisation and compositions for use therein |
| TWI282275B (en) * | 2000-08-17 | 2007-06-11 | Control Ox Oy | Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections |
| JP4880813B2 (ja) * | 2000-10-26 | 2012-02-22 | 第一三共株式会社 | 外用消炎鎮痛剤組成物 |
| US20140271788A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| DE10161110A1 (de) * | 2001-12-12 | 2003-06-26 | Ursapharm Arzneimittel Gmbh | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
| DE10161149B4 (de) * | 2001-12-12 | 2007-03-08 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Heparin-haltigem Ophthalmikum |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| GB0308734D0 (en) * | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
| JP4963670B2 (ja) * | 2004-04-07 | 2012-06-27 | レスベラトロル パートナーズ， エルエルシー | 栄養補助サプリメントおよびそれを処理する方法 |
| AU2005244059A1 (en) * | 2004-05-07 | 2005-11-24 | S.K. Pharmaceuticals, Inc. | Stabilized hyaluronan preparations and related methods |
| US8288362B2 (en) | 2004-05-07 | 2012-10-16 | S.K. Pharmaceuticals, Inc. | Stabilized glycosaminoglycan preparations and related methods |
| WO2006024138A1 (en) * | 2004-08-30 | 2006-03-09 | Taro Pharmaceutical Industries Ltd. | A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
| WO2006067605A1 (en) * | 2004-12-23 | 2006-06-29 | Ranbaxy Laboratories Limited | Stable pharmaceutical compositions of tiagabine and processes for their preparation |
| EP1845787B1 (en) * | 2005-01-27 | 2015-04-15 | Erimos Pharmaceuticals LLC | Formulations for injection of catecholic butanes, including ndga compounds, into animals |
| CN101150955B (zh) * | 2005-01-27 | 2013-04-17 | 埃里莫斯医药品有限公司 | 递送包括ndga化合物的儿茶酚丁烷的口服制剂 |
| TWI286941B (en) * | 2005-07-27 | 2007-09-21 | Anagen Therapeutics Inc | Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof |
| CA2685131C (en) * | 2007-04-26 | 2015-05-19 | Toray Industries, Inc. | Stable solid preparation containing 4,5-epoxymorphinan derivative |
| WO2008143240A1 (ja) * | 2007-05-21 | 2008-11-27 | Toray Industries, Inc. | 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法 |
| CN101658489B (zh) * | 2008-08-27 | 2011-11-23 | 海南四环心脑血管药物研究院有限公司 | 一种盐酸纳美芬注射液及其制备方法 |
| DK2356989T3 (en) * | 2008-10-24 | 2018-05-07 | Toray Industries | Stable tablet containing 4,5-epoxymorphinane derivative |
| TWI455733B (zh) | 2009-03-30 | 2014-10-11 | Toray Industries | 口腔內崩壞性被覆錠劑 |
| WO2010139752A2 (en) * | 2009-06-04 | 2010-12-09 | Alk Ag | Stabilised composition comprising at least one adrenergic compound |
| HUE045889T2 (hu) | 2010-10-21 | 2020-01-28 | Rtu Pharmaceuticals Llc | Használatkész ketorolak készítmények |
| JP5750278B2 (ja) * | 2011-02-28 | 2015-07-15 | 東洋カプセル株式会社 | カンデサルタンシレキセチルのカプセル充填用組成物 |
| WO2013070656A1 (en) * | 2011-11-07 | 2013-05-16 | Navinta Llc | Sustained release suspension preparation for dextromethorphan |
| WO2013074948A1 (en) | 2011-11-16 | 2013-05-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| JP6064252B2 (ja) * | 2012-01-19 | 2017-01-25 | 三笠製薬株式会社 | そう痒症改善経皮吸収貼付剤 |
| JP6247118B2 (ja) * | 2014-03-05 | 2017-12-13 | 東海カプセル株式会社 | カプセル充填組成物 |
| US10561628B2 (en) * | 2015-03-19 | 2020-02-18 | Daiichi Sankyo Company, Limited | Solid preparation including antioxidant |
| BR112017019920B1 (pt) | 2015-03-19 | 2023-11-07 | Daiichi Sankyo Company, Limited | Preparação sólida farmacêutica, e, método para estabilização de uma preparação sólida farmacêutica |
| JP5918895B1 (ja) * | 2015-05-21 | 2016-05-18 | 富士カプセル株式会社 | ナルフラフィン塩酸塩含有カプセル製剤 |
| TW201707703A (zh) * | 2015-06-04 | 2017-03-01 | Tokai Capsule Co Ltd | 軟膠囊劑 |
| CN109562109A (zh) * | 2016-07-29 | 2019-04-02 | 东丽株式会社 | 光稳定性提高的固体制剂 |
| JP6131379B1 (ja) * | 2016-12-28 | 2017-05-17 | 森下仁丹株式会社 | ４，５−エポキシモルヒナン誘導体含有製剤 |
| EP3603643B1 (en) * | 2017-03-31 | 2021-09-15 | Toray Industries, Inc. | Tableted medicinal composition comprising nalfurafine |
| CA3091752A1 (en) | 2018-03-08 | 2019-09-12 | Victoria Link Ltd | Treatment of demyelinating diseases |
| JP7312751B2 (ja) | 2018-07-30 | 2023-07-21 | 第一三共株式会社 | 安定化剤を含有する医薬品の固形製剤 |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
| WO2020205735A1 (en) | 2019-03-29 | 2020-10-08 | Humanwell Pharmaceutical US | Novel morphinans useful for treating medical disorders |
| WO2021100728A1 (ja) * | 2019-11-20 | 2021-05-27 | 塩野義製薬株式会社 | ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有固形製剤 |
| MX2023014819A (es) | 2021-06-14 | 2024-03-21 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2765694B2 (ja) * | 1988-01-29 | 1998-06-18 | 日清バーディシェ株式会社 | 酸化感受性化合物の安定な組成物 |
| GB8820327D0 (en) | 1988-08-26 | 1988-09-28 | May & Baker Ltd | New compositions of matter |
| JP2525552B2 (ja) * | 1992-01-23 | 1996-08-21 | 東レ株式会社 | モルヒナン誘導体および医薬用途 |
| NZ268969A (en) * | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| US5948389A (en) * | 1995-06-07 | 1999-09-07 | El Khoury & Stein, Ltd. | Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
| DE29719704U1 (de) | 1997-02-14 | 1998-01-22 | Gödecke AG, 10587 Berlin | Stabile Zubereitungen von Naloxonhydrochlorid |
-
1998
- 1998-07-10 CA CA002265767A patent/CA2265767C/en not_active Expired - Lifetime
- 1998-07-10 WO PCT/JP1998/003096 patent/WO1999002158A1/ja not_active Ceased
- 1998-07-10 PT PT98931040T patent/PT948965E/pt unknown
- 1998-07-10 KR KR10-1999-7001987A patent/KR100514963B1/ko not_active Expired - Lifetime
- 1998-07-10 AU AU81282/98A patent/AU740404B2/en not_active Expired
- 1998-07-10 DE DE69824277T patent/DE69824277T2/de not_active Expired - Lifetime
- 1998-07-10 TW TW087111243A patent/TWI285644B/zh not_active IP Right Cessation
- 1998-07-10 ES ES98931040T patent/ES2217563T3/es not_active Expired - Lifetime
- 1998-07-10 AT AT98931040T patent/ATE268178T1/de active
- 1998-07-10 DK DK98931040T patent/DK0948965T3/da active
- 1998-07-10 US US09/254,650 patent/US6372755B2/en not_active Expired - Lifetime
- 1998-07-10 JP JP50845399A patent/JP3617055B2/ja not_active Expired - Lifetime
- 1998-07-10 EP EP98931040A patent/EP0948965B1/en not_active Expired - Lifetime
- 1998-07-10 CN CNB98801274XA patent/CN100379419C/zh not_active Expired - Lifetime
-
1999
- 1999-03-10 NO NO19991152A patent/NO318831B1/no not_active IP Right Cessation
-
2004
- 2004-07-16 JP JP2004210133A patent/JP3743449B2/ja not_active Expired - Lifetime
-
2005
- 2005-04-22 JP JP2005124736A patent/JP4311369B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| TWI285644B (en) | 2007-08-21 |
| US6372755B2 (en) | 2002-04-16 |
| DE69824277T2 (de) | 2004-09-23 |
| DE69824277D1 (de) | 2004-07-08 |
| NO991152L (no) | 1999-05-10 |
| KR20000068528A (ko) | 2000-11-25 |
| KR100514963B1 (ko) | 2005-09-15 |
| AU740404B2 (en) | 2001-11-01 |
| ATE268178T1 (de) | 2004-06-15 |
| EP0948965A4 (en) | 2002-10-16 |
| ES2217563T3 (es) | 2004-11-01 |
| US20010004637A1 (en) | 2001-06-21 |
| CN100379419C (zh) | 2008-04-09 |
| EP0948965A1 (en) | 1999-10-13 |
| WO1999002158A1 (fr) | 1999-01-21 |
| DK0948965T3 (da) | 2004-07-05 |
| NO991152D0 (no) | 1999-03-10 |
| CA2265767A1 (en) | 1999-01-21 |
| JP2005002123A (ja) | 2005-01-06 |
| JP3617055B2 (ja) | 2005-02-02 |
| CN1237106A (zh) | 1999-12-01 |
| EP0948965B1 (en) | 2004-06-02 |
| JP3743449B2 (ja) | 2006-02-08 |
| AU8128298A (en) | 1999-02-08 |
| JP4311369B2 (ja) | 2009-08-12 |
| NO318831B1 (no) | 2005-05-09 |
| CA2265767C (en) | 2007-12-04 |
| JP2005247866A (ja) | 2005-09-15 |
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