DE69824277D1 - Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten - Google Patents

Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten

Info

Publication number
DE69824277D1
DE69824277D1 DE69824277T DE69824277T DE69824277D1 DE 69824277 D1 DE69824277 D1 DE 69824277D1 DE 69824277 T DE69824277 T DE 69824277T DE 69824277 T DE69824277 T DE 69824277T DE 69824277 D1 DE69824277 D1 DE 69824277D1
Authority
DE
Germany
Prior art keywords
derivatives
epoxymorphine
compositions containing
medical compositions
stable medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824277T
Other languages
English (en)
Other versions
DE69824277T2 (de
Inventor
Nobuyuki Hanamura
Yasuhide Horiuchi
Ryoji Yoshii
Takao Aoki
Michio Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69824277D1 publication Critical patent/DE69824277D1/de
Publication of DE69824277T2 publication Critical patent/DE69824277T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69824277T 1997-07-11 1998-07-10 Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten Expired - Lifetime DE69824277T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18695097 1997-07-11
JP18695097 1997-07-11
PCT/JP1998/003096 WO1999002158A1 (fr) 1997-07-11 1998-07-10 Compositions medicinales stables, contenant des derives de 4,5-epoxymorphinane

Publications (2)

Publication Number Publication Date
DE69824277D1 true DE69824277D1 (de) 2004-07-08
DE69824277T2 DE69824277T2 (de) 2004-09-23

Family

ID=16197570

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824277T Expired - Lifetime DE69824277T2 (de) 1997-07-11 1998-07-10 Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten

Country Status (15)

Country Link
US (1) US6372755B2 (de)
EP (1) EP0948965B1 (de)
JP (3) JP3617055B2 (de)
KR (1) KR100514963B1 (de)
CN (1) CN100379419C (de)
AT (1) ATE268178T1 (de)
AU (1) AU740404B2 (de)
CA (1) CA2265767C (de)
DE (1) DE69824277T2 (de)
DK (1) DK0948965T3 (de)
ES (1) ES2217563T3 (de)
NO (1) NO318831B1 (de)
PT (1) PT948965E (de)
TW (1) TWI285644B (de)
WO (1) WO1999002158A1 (de)

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AUPQ899400A0 (en) * 2000-07-26 2000-08-17 Csl Limited A method of stabilisation and compositions for use therein
TWI282275B (en) * 2000-08-17 2007-06-11 Control Ox Oy Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections
JP4880813B2 (ja) * 2000-10-26 2012-02-22 第一三共株式会社 外用消炎鎮痛剤組成物
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
DE10161110A1 (de) * 2001-12-12 2003-06-26 Ursapharm Arzneimittel Gmbh Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung
DE10161149B4 (de) * 2001-12-12 2007-03-08 Ursapharm Arzneimittel Gmbh & Co. Kg Verwendung von Heparin-haltigem Ophthalmikum
ZA200409537B (en) 2003-01-31 2006-10-25 Yamanouchi Pharma Co Ltd Stable solid medicinal composition for oral administration
CN1956733B (zh) * 2004-04-07 2012-10-10 白藜芦醇合伙人有限责任公司 营养补充剂及其加工方法
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
US7544671B2 (en) * 2004-05-07 2009-06-09 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
WO2006024138A1 (en) * 2004-08-30 2006-03-09 Taro Pharmaceutical Industries Ltd. A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol
WO2006067605A1 (en) * 2004-12-23 2006-06-29 Ranbaxy Laboratories Limited Stable pharmaceutical compositions of tiagabine and processes for their preparation
CN101150955B (zh) * 2005-01-27 2013-04-17 埃里莫斯医药品有限公司 递送包括ndga化合物的儿茶酚丁烷的口服制剂
MX2007009033A (es) * 2005-01-27 2008-01-16 Erimos Pharmaceuticals Llc Formulaciones orales para lsuministro de butanos catecolicos incluyendo compuestos ndga.
TWI286941B (en) * 2005-07-27 2007-09-21 Anagen Therapeutics Inc Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof
AU2008244936B2 (en) 2007-04-26 2013-02-21 Toray Industries, Inc. Stable solid preparation comprising 4,5-epoxymorphinan derivative
JP5343845B2 (ja) * 2007-05-21 2013-11-13 東レ株式会社 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法
CN101658489B (zh) * 2008-08-27 2011-11-23 海南四环心脑血管药物研究院有限公司 一种盐酸纳美芬注射液及其制备方法
KR101682963B1 (ko) * 2008-10-24 2016-12-06 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 정제
TWI455733B (zh) 2009-03-30 2014-10-11 Toray Industries 口腔內崩壞性被覆錠劑
KR20120028344A (ko) * 2009-06-04 2012-03-22 에이엘케이 에이쥐 적어도 하나의 아드레날린성 화합물을 포함하는 안정화된 조성물
KR102114568B1 (ko) 2010-10-21 2020-05-22 알티유 파머수티컬즈, 엘엘시 즉시 사용가능한 케토로락 제제
JP5750278B2 (ja) * 2011-02-28 2015-07-15 東洋カプセル株式会社 カンデサルタンシレキセチルのカプセル充填用組成物
US20130115253A1 (en) * 2011-11-07 2013-05-09 Mahendra R. Patel Sustained Release Suspension Preparation For Dextromethorphan
WO2013074948A1 (en) 2011-11-16 2013-05-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
JP6247118B2 (ja) * 2014-03-05 2017-12-13 東海カプセル株式会社 カプセル充填組成物
CA2980096C (en) * 2015-03-19 2019-12-17 Daiichi Sankyo Company, Limited Solid preparations of [(1r,5s,6s)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate stabilized by containing a specific antioxidant, and methodsfor preparing the same
EP3513788B1 (de) 2015-03-19 2020-07-29 Daiichi Sankyo Company, Limited Feststoffpräparat mit farbstoff
JP5918894B1 (ja) * 2015-05-21 2016-05-18 富士カプセル株式会社 ナルフラフィン塩酸塩含有カプセル製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
CN109562109A (zh) * 2016-07-29 2019-04-02 东丽株式会社 光稳定性提高的固体制剂
JP6131379B1 (ja) * 2016-12-28 2017-05-17 森下仁丹株式会社 4,5−エポキシモルヒナン誘導体含有製剤
ES2902123T3 (es) 2017-03-31 2022-03-25 Toray Industries Composición medicinal en tabletas que comprende nalfurafina
EP3761982A4 (de) 2018-03-08 2021-12-15 Victoria Link Ltd Behandlung von demyelinisierungskrankheiten
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
US11214577B2 (en) 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders
JPWO2021100728A1 (de) * 2019-11-20 2021-05-27
JP2024522192A (ja) 2021-06-14 2024-06-11 スコーピオン セラピューティクス インコーポレイテッド がんを処置するために使用され得る尿素誘導体

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JP2765694B2 (ja) 1988-01-29 1998-06-18 日清バーディシェ株式会社 酸化感受性化合物の安定な組成物
GB8820327D0 (en) 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
NZ246687A (en) * 1992-01-23 1996-12-20 Toray Industries Morphinan derivative and pharmaceutical compositions thereof
ES2146654T3 (es) * 1993-07-23 2000-08-16 Toray Industries Derivado de morfinano y uso medico.
US5948389A (en) * 1995-06-07 1999-09-07 El Khoury & Stein, Ltd. Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
DE29719704U1 (de) 1997-02-14 1998-01-22 Gödecke AG, 10587 Berlin Stabile Zubereitungen von Naloxonhydrochlorid

Also Published As

Publication number Publication date
US20010004637A1 (en) 2001-06-21
AU8128298A (en) 1999-02-08
DK0948965T3 (da) 2004-07-05
JP2005247866A (ja) 2005-09-15
CN100379419C (zh) 2008-04-09
AU740404B2 (en) 2001-11-01
KR20000068528A (ko) 2000-11-25
EP0948965A1 (de) 1999-10-13
NO991152L (no) 1999-05-10
CA2265767A1 (en) 1999-01-21
NO318831B1 (no) 2005-05-09
US6372755B2 (en) 2002-04-16
TWI285644B (en) 2007-08-21
CA2265767C (en) 2007-12-04
JP2005002123A (ja) 2005-01-06
CN1237106A (zh) 1999-12-01
EP0948965A4 (de) 2002-10-16
PT948965E (pt) 2004-08-31
KR100514963B1 (ko) 2005-09-15
JP4311369B2 (ja) 2009-08-12
ES2217563T3 (es) 2004-11-01
JP3617055B2 (ja) 2005-02-02
ATE268178T1 (de) 2004-06-15
JP3743449B2 (ja) 2006-02-08
EP0948965B1 (de) 2004-06-02
DE69824277T2 (de) 2004-09-23
WO1999002158A1 (fr) 1999-01-21
NO991152D0 (no) 1999-03-10

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