DE69824277D1 - Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten - Google Patents

Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten

Info

Publication number
DE69824277D1
DE69824277D1 DE69824277T DE69824277T DE69824277D1 DE 69824277 D1 DE69824277 D1 DE 69824277D1 DE 69824277 T DE69824277 T DE 69824277T DE 69824277 T DE69824277 T DE 69824277T DE 69824277 D1 DE69824277 D1 DE 69824277D1
Authority
DE
Germany
Prior art keywords
derivatives
epoxymorphine
compositions containing
medical compositions
stable medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824277T
Other languages
English (en)
Other versions
DE69824277T2 (de
Inventor
Nobuyuki Hanamura
Yasuhide Horiuchi
Ryoji Yoshii
Takao Aoki
Michio Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69824277D1 publication Critical patent/DE69824277D1/de
Publication of DE69824277T2 publication Critical patent/DE69824277T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
DE69824277T 1997-07-11 1998-07-10 Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten Expired - Lifetime DE69824277T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18695097 1997-07-11
JP18695097 1997-07-11
PCT/JP1998/003096 WO1999002158A1 (fr) 1997-07-11 1998-07-10 Compositions medicinales stables, contenant des derives de 4,5-epoxymorphinane

Publications (2)

Publication Number Publication Date
DE69824277D1 true DE69824277D1 (de) 2004-07-08
DE69824277T2 DE69824277T2 (de) 2004-09-23

Family

ID=16197570

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824277T Expired - Lifetime DE69824277T2 (de) 1997-07-11 1998-07-10 Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten

Country Status (15)

Country Link
US (1) US6372755B2 (de)
EP (1) EP0948965B1 (de)
JP (3) JP3617055B2 (de)
KR (1) KR100514963B1 (de)
CN (1) CN100379419C (de)
AT (1) ATE268178T1 (de)
AU (1) AU740404B2 (de)
CA (1) CA2265767C (de)
DE (1) DE69824277T2 (de)
DK (1) DK0948965T3 (de)
ES (1) ES2217563T3 (de)
NO (1) NO318831B1 (de)
PT (1) PT948965E (de)
TW (1) TWI285644B (de)
WO (1) WO1999002158A1 (de)

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AUPQ899400A0 (en) * 2000-07-26 2000-08-17 Csl Limited A method of stabilisation and compositions for use therein
SG90259A1 (en) * 2000-08-17 2002-07-23 Control Ox Oy Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections
JP4880813B2 (ja) * 2000-10-26 2012-02-22 第一三共株式会社 外用消炎鎮痛剤組成物
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
DE10161110A1 (de) * 2001-12-12 2003-06-26 Ursapharm Arzneimittel Gmbh Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung
DE10161149B4 (de) * 2001-12-12 2007-03-08 Ursapharm Arzneimittel Gmbh & Co. Kg Verwendung von Heparin-haltigem Ophthalmikum
ZA200409537B (en) 2003-01-31 2006-10-25 Yamanouchi Pharma Co Ltd Stable solid medicinal composition for oral administration
CN1956733B (zh) * 2004-04-07 2012-10-10 白藜芦醇合伙人有限责任公司 营养补充剂及其加工方法
CA2565944C (en) * 2004-05-07 2011-07-19 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
WO2006024138A1 (en) * 2004-08-30 2006-03-09 Taro Pharmaceutical Industries Ltd. A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol
WO2006067605A1 (en) * 2004-12-23 2006-06-29 Ranbaxy Laboratories Limited Stable pharmaceutical compositions of tiagabine and processes for their preparation
EP1845787B1 (de) * 2005-01-27 2015-04-15 Erimos Pharmaceuticals LLC Formulierungen für die injektion von cathecholbutanen, darunter ndga-verbindungen, bei tieren
CN101150956B (zh) * 2005-01-27 2013-04-17 埃里莫斯医药品有限公司 用于注射入动物的包括ndga化合物的儿茶酚丁烷配方
TWI286941B (en) * 2005-07-27 2007-09-21 Anagen Therapeutics Inc Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof
AU2008244936B2 (en) 2007-04-26 2013-02-21 Toray Industries, Inc. Stable solid preparation comprising 4,5-epoxymorphinan derivative
EP2168579B1 (de) * 2007-05-21 2017-10-11 Toray Industries, Inc. Orale zubereitung mit einer spezifischen orgnanischen säure und verfahren zur verbesserung der auflösungseigenschaft und chemischen stabilität der oralen zubereitung
CN101658489B (zh) * 2008-08-27 2011-11-23 海南四环心脑血管药物研究院有限公司 一种盐酸纳美芬注射液及其制备方法
KR101682963B1 (ko) * 2008-10-24 2016-12-06 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 정제
TWI455733B (zh) 2009-03-30 2014-10-11 Toray Industries 口腔內崩壞性被覆錠劑
SI2437782T1 (sl) 2009-06-04 2013-12-31 Alk Ag Stabiliziran sestavek, ki obsega vsaj eno adrenergično spojino
WO2012054831A2 (en) 2010-10-21 2012-04-26 Rtu Pharmaceuticals, Llc Ready to use ketorolac formulations
JP5750278B2 (ja) * 2011-02-28 2015-07-15 東洋カプセル株式会社 カンデサルタンシレキセチルのカプセル充填用組成物
US20130115253A1 (en) * 2011-11-07 2013-05-09 Mahendra R. Patel Sustained Release Suspension Preparation For Dextromethorphan
US8916528B2 (en) 2011-11-16 2014-12-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
JP6064252B2 (ja) * 2012-01-19 2017-01-25 三笠製薬株式会社 そう痒症改善経皮吸収貼付剤
JP6247118B2 (ja) * 2014-03-05 2017-12-13 東海カプセル株式会社 カプセル充填組成物
EP3437639A1 (de) 2015-03-19 2019-02-06 Daiichi Sankyo Company, Limited Feststoffpräparat mit farbstoff
US10561628B2 (en) * 2015-03-19 2020-02-18 Daiichi Sankyo Company, Limited Solid preparation including antioxidant
JP5918895B1 (ja) * 2015-05-21 2016-05-18 富士カプセル株式会社 ナルフラフィン塩酸塩含有カプセル製剤
TW201707703A (zh) * 2015-06-04 2017-03-01 Tokai Capsule Co Ltd 軟膠囊劑
US11185509B2 (en) 2016-07-29 2021-11-30 Toray Industries, Inc. Solid preparation having improved light stability
JP6131379B1 (ja) * 2016-12-28 2017-05-17 森下仁丹株式会社 ４，５−エポキシモルヒナン誘導体含有製剤
BR112019016802A2 (pt) * 2017-03-31 2020-04-07 Toray Industries composição farmacêutica em comprimidos, e, comprimido
EP3761982A4 (de) 2018-03-08 2021-12-15 Victoria Link Ltd Behandlung von demyelinisierungskrankheiten
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
WO2020205735A1 (en) 2019-03-29 2020-10-08 Humanwell Pharmaceutical US Novel morphinans useful for treating medical disorders
JPWO2021100728A1 (de) * 2019-11-20 2021-05-27
IL309232A (en) 2021-06-14 2024-02-01 Scorpion Therapeutics Inc History of urea which can be used to treat cancer

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JP2765694B2 (ja) 1988-01-29 1998-06-18 日清バーディシェ株式会社 酸化感受性化合物の安定な組成物
GB8820327D0 (en) 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
ES2121988T3 (es) 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
JP3843456B2 (ja) * 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
US5948389A (en) * 1995-06-07 1999-09-07 El Khoury & Stein, Ltd. Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
DE29719704U1 (de) 1997-02-14 1998-01-22 Gödecke AG, 10587 Berlin Stabile Zubereitungen von Naloxonhydrochlorid

Also Published As

Publication number Publication date
KR100514963B1 (ko) 2005-09-15
NO991152L (no) 1999-05-10
EP0948965A4 (de) 2002-10-16
DE69824277T2 (de) 2004-09-23
CA2265767A1 (en) 1999-01-21
JP3617055B2 (ja) 2005-02-02
NO318831B1 (no) 2005-05-09
CA2265767C (en) 2007-12-04
DK0948965T3 (da) 2004-07-05
EP0948965B1 (de) 2004-06-02
JP2005247866A (ja) 2005-09-15
US6372755B2 (en) 2002-04-16
EP0948965A1 (de) 1999-10-13
NO991152D0 (no) 1999-03-10
JP3743449B2 (ja) 2006-02-08
TWI285644B (en) 2007-08-21
AU8128298A (en) 1999-02-08
JP4311369B2 (ja) 2009-08-12
ES2217563T3 (es) 2004-11-01
AU740404B2 (en) 2001-11-01
ATE268178T1 (de) 2004-06-15
PT948965E (pt) 2004-08-31
KR20000068528A (ko) 2000-11-25
US20010004637A1 (en) 2001-06-21
JP2005002123A (ja) 2005-01-06
WO1999002158A1 (fr) 1999-01-21
CN100379419C (zh) 2008-04-09
CN1237106A (zh) 1999-12-01

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