CN100356913C - 左旋(r)班布特罗及其药物用途 - Google Patents

左旋(r)班布特罗及其药物用途 Download PDF

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Publication number
CN100356913C
CN100356913C CNB028293975A CN02829397A CN100356913C CN 100356913 C CN100356913 C CN 100356913C CN B028293975 A CNB028293975 A CN B028293975A CN 02829397 A CN02829397 A CN 02829397A CN 100356913 C CN100356913 C CN 100356913C
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CN
China
Prior art keywords
bambuterol
gram
medicine
racemic
milliliters
Prior art date
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Expired - Lifetime
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CNB028293975A
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English (en)
Chinese (zh)
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CN1638756A (zh
Inventor
陈俭龙
谭文
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Individual
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Publication of CN1638756A publication Critical patent/CN1638756A/zh
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Publication of CN100356913C publication Critical patent/CN100356913C/zh
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CNB028293975A 2002-08-08 2002-08-08 左旋(r)班布特罗及其药物用途 Expired - Lifetime CN100356913C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/025225 WO2004014290A2 (en) 2002-08-08 2002-08-08 R-bambuterol, its preparation and therapeutic uses

Publications (2)

Publication Number Publication Date
CN1638756A CN1638756A (zh) 2005-07-13
CN100356913C true CN100356913C (zh) 2007-12-26

Family

ID=31713793

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028293975A Expired - Lifetime CN100356913C (zh) 2002-08-08 2002-08-08 左旋(r)班布特罗及其药物用途

Country Status (8)

Country Link
EP (2) EP2002831A1 (enExample)
JP (1) JP4979889B2 (enExample)
CN (1) CN100356913C (enExample)
AT (1) ATE406887T1 (enExample)
AU (1) AU2002332488A1 (enExample)
DE (1) DE60228764D1 (enExample)
ES (1) ES2312669T3 (enExample)
WO (1) WO2004014290A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100803291B1 (ko) 2006-09-08 2008-02-13 (주)팜스웰 밤부테롤 염산염의 개선된 제조방법
WO2010147631A1 (en) * 2009-06-16 2010-12-23 Wen Tan Use of r-bambuterol as inhaled medicament and combination therapies for treatment of respiratory disorders
CN102617404A (zh) * 2012-04-06 2012-08-01 张长利 盐酸班布特罗及其中间体的制备工艺
CN103288670B (zh) * 2013-05-16 2014-11-05 南京医科大学第一附属医院 多羟基二苯甲酮衍生物及其应用
CN104478740B (zh) * 2014-11-19 2017-01-25 上海化工研究院 一种稳定同位素标记β受体激动剂类化合物的合成方法
CN104557614B (zh) * 2014-12-15 2017-01-04 广东东阳光药业有限公司 一种胺的还原方法
CN105254512B (zh) * 2015-11-10 2017-03-22 山东达因海洋生物制药股份有限公司 一种硫酸特布他林的制备方法
CN106831452A (zh) * 2017-02-15 2017-06-13 杭州百诚医药科技股份有限公司 一种硫酸特布他林的制备方法
CN107445867A (zh) * 2017-07-13 2017-12-08 上海昕盛医药科技有限公司 一种盐酸班布特罗杂质b的合成方法
CN107445866A (zh) * 2017-07-13 2017-12-08 上海昕盛医药科技有限公司 一种盐酸班布特罗杂质d的合成方法
JP2021533190A (ja) * 2018-07-31 2021-12-02 タン ウェンTAN, Wen ＬＤＬコレステロールの細胞内クリアランスを増強しかつスタチンとの併用療法で効力を高めかつ副作用を減らすための、カルバメートβフェニルエタノールアミン類似体の新規使用法
CN109942462B (zh) * 2019-03-06 2022-01-14 宏冠生物药业有限公司 一种盐酸班布特罗的合成工艺
CN113874006A (zh) * 2019-05-07 2021-12-31 谭文 使用左旋（R）β2受体激动剂在预防和治疗肺部炎症与重构及减少其毒副作用的应用
CN115531368A (zh) * 2021-06-14 2022-12-30 谭文 R-氨基甲酸酯-β-苯乙醇胺类化合物治疗学习和记忆缺陷以及神经退行性疾病的应用
CN117586152A (zh) * 2023-11-23 2024-02-23 黑龙江乌苏里江制药有限公司 一种盐酸班布特罗的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419364A (en) * 1980-07-09 1983-12-06 Aktiebolaget Draco Bronchospasmolytic carbamate derivatives
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107196D0 (en) * 1991-04-05 1991-05-22 Sandoz Ag Improvements in or relating to organic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419364A (en) * 1980-07-09 1983-12-06 Aktiebolaget Draco Bronchospasmolytic carbamate derivatives
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels

Also Published As

Publication number Publication date
EP1542672A4 (en) 2006-06-07
JP4979889B2 (ja) 2012-07-18
ATE406887T1 (de) 2008-09-15
CN1638756A (zh) 2005-07-13
AU2002332488A1 (en) 2004-02-25
AU2002332488A8 (en) 2004-02-25
EP2002831A1 (en) 2008-12-17
JP2006503816A (ja) 2006-02-02
WO2004014290A3 (en) 2004-08-05
EP1542672B1 (en) 2008-09-03
ES2312669T3 (es) 2009-03-01
EP1542672A2 (en) 2005-06-22
WO2004014290A2 (en) 2004-02-19
DE60228764D1 (de) 2008-10-16

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