CL2023003162A1 - Formulación de medios de contraste y proceso para prepararlos - Google Patents

Formulación de medios de contraste y proceso para prepararlos

Info

Publication number
CL2023003162A1
CL2023003162A1 CL2023003162A CL2023003162A CL2023003162A1 CL 2023003162 A1 CL2023003162 A1 CL 2023003162A1 CL 2023003162 A CL2023003162 A CL 2023003162A CL 2023003162 A CL2023003162 A CL 2023003162A CL 2023003162 A1 CL2023003162 A1 CL 2023003162A1
Authority
CL
Chile
Prior art keywords
formulation
prepare
contrast media
pharmaceutical formulation
liquid pharmaceutical
Prior art date
Application number
CL2023003162A
Other languages
English (en)
Inventor
Thomas Brumby
Thomas Frenzel
Jessica Lohrke
Gregor Jost
Stephan Holzschuh
Wolfgang Ebert
Wolfgang Halfbrodt
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of CL2023003162A1 publication Critical patent/CL2023003162A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La presente divulgación se refiere a una formulación farmacéutica líquida que comprende un tetra–quelato derivado de DO3A de la fórmula (I), en la que M es un ion de un metal paramagnético, preferentemente un ion Gd3+, y R1 , R2 , R3 , R4 y R5 son como se define en las reivindicaciones, en un solvente farmacéutico aceptable. La presente divulgación también se refiere a un método de preparación de dicha formulación farmacéutica líquida y a un método de obtención de imágenes que comprende dicha formulación farmacéutica líquida.
CL2023003162A 2018-11-23 2023-10-23 Formulación de medios de contraste y proceso para prepararlos CL2023003162A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18208090 2018-11-23
CL2021001331A CL2021001331A1 (es) 2018-11-23 2021-05-20 Formulación de medios de contraste y proceso para prepararlos

Publications (1)

Publication Number Publication Date
CL2023003162A1 true CL2023003162A1 (es) 2024-04-01

Family

ID=64456867

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2021001331A CL2021001331A1 (es) 2018-11-23 2021-05-20 Formulación de medios de contraste y proceso para prepararlos
CL2023003162A CL2023003162A1 (es) 2018-11-23 2023-10-23 Formulación de medios de contraste y proceso para prepararlos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2021001331A CL2021001331A1 (es) 2018-11-23 2021-05-20 Formulación de medios de contraste y proceso para prepararlos

Country Status (16)

Country Link
US (1) US11944690B2 (es)
EP (1) EP3883613A1 (es)
JP (1) JP2022508185A (es)
KR (1) KR20210095168A (es)
CN (1) CN113164628A (es)
AU (1) AU2019382881A1 (es)
BR (1) BR112021007707A2 (es)
CA (1) CA3120665A1 (es)
CL (2) CL2021001331A1 (es)
CO (1) CO2021006034A2 (es)
IL (1) IL283281A (es)
JO (1) JOP20210114A1 (es)
MX (1) MX2021006024A (es)
PE (1) PE20211471A1 (es)
SG (1) SG11202104657RA (es)
WO (1) WO2020104602A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4335461A1 (en) * 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
EP4360660A1 (en) * 2022-10-24 2024-05-01 Bayer AG Process for the preparation of a gadolinium contrast agent

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