CL2019002969A1 - Sistemas de administración de liberación sostenida que comprenden ligantes que no dejan huellas. - Google Patents

Sistemas de administración de liberación sostenida que comprenden ligantes que no dejan huellas.

Info

Publication number
CL2019002969A1
CL2019002969A1 CL2019002969A CL2019002969A CL2019002969A1 CL 2019002969 A1 CL2019002969 A1 CL 2019002969A1 CL 2019002969 A CL2019002969 A CL 2019002969A CL 2019002969 A CL2019002969 A CL 2019002969A CL 2019002969 A1 CL2019002969 A1 CL 2019002969A1
Authority
CL
Chile
Prior art keywords
sustained
binders
trace
delivery systems
release delivery
Prior art date
Application number
CL2019002969A
Other languages
English (en)
Inventor
Christopher M Adams
Myriam April
Tanzina Fazal
Cornelia Jutta Forster
Edward Charles Hall
Cameron Chuck-Munn Lee
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62116508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019002969(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2019002969A1 publication Critical patent/CL2019002969A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN SISTEMAS DE ADMINISTRACIÓN DE FÁRMACOS PARA ADMINISTRAR AGENTES BIOLÓGICAMENTE ACTIVOS QUE COMPRENDEN AMINAS PRIMARIAS O SECUNDARIAS, O UN ÁTOMO DE NITRÓGENO ANULAR DE UN ANILLO DE AZAHETEROARILO, SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, REACTIVOS DE ADMINISTRACIÓN DE FÁRMACOS RELACIONADOS CON LOS MISMOS, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS SISTEMAS DE ADMINISTRACIÓN DE FÁRMACOS Y EL USO DE LOS SISTEMAS DE ADMINISTRACIÓN DE FÁRMACOS COMO TERAPIAS DE LIBERACIÓN SOSTENIDA.
CL2019002969A 2017-04-20 2019-10-17 Sistemas de administración de liberación sostenida que comprenden ligantes que no dejan huellas. CL2019002969A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762487888P 2017-04-20 2017-04-20

Publications (1)

Publication Number Publication Date
CL2019002969A1 true CL2019002969A1 (es) 2020-02-07

Family

ID=62116508

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019002969A CL2019002969A1 (es) 2017-04-20 2019-10-17 Sistemas de administración de liberación sostenida que comprenden ligantes que no dejan huellas.

Country Status (26)

Country Link
US (3) US10751417B2 (es)
EP (1) EP3612233A1 (es)
JP (1) JP7323453B2 (es)
KR (1) KR20190137888A (es)
CN (1) CN110603060A (es)
AR (1) AR111481A1 (es)
AU (1) AU2018255933B2 (es)
BR (1) BR112019021810A2 (es)
CA (1) CA3057590A1 (es)
CL (1) CL2019002969A1 (es)
CO (1) CO2019011577A2 (es)
CR (1) CR20190479A (es)
CU (1) CU20190082A7 (es)
DO (1) DOP2019000268A (es)
EA (2) EA202192099A3 (es)
EC (1) ECSP19075134A (es)
IL (1) IL269991B2 (es)
JO (1) JOP20190245A1 (es)
MA (1) MA50260A (es)
MX (1) MX2019012447A (es)
PE (2) PE20191837A1 (es)
PH (1) PH12019502325A1 (es)
SG (1) SG11201908740VA (es)
TW (1) TW201842935A (es)
UY (1) UY37686A (es)
WO (1) WO2018193408A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2994545A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
JP7217700B2 (ja) 2016-09-13 2023-02-03 アラーガン、インコーポレイテッド 安定化非タンパク質クロストリジウム毒素組成物
CN110637027A (zh) 2017-02-08 2019-12-31 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
JOP20190245A1 (ar) * 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
AR116566A1 (es) * 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
JP2022525856A (ja) 2019-03-11 2022-05-20 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
KR20210145164A (ko) 2019-03-11 2021-12-01 녹시온 테라퓨틱스 인코포레이티드 에스테르 치환된 이온 채널 차단제 및 사용 방법
WO2020254607A1 (en) * 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
WO2020254617A1 (en) * 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
CA3143279A1 (en) * 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 conjugates
US11795320B2 (en) * 2019-09-20 2023-10-24 Bausch + Lomb Ireland Limited Grafted polymer and use thereof
IL292505A (en) 2019-11-06 2022-06-01 Nocion Therapeutics Inc Charged ion channel blockers and methods of use
EP4054586A4 (en) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
CN111110829A (zh) * 2019-12-24 2020-05-08 浙江大学 一种纳米防御素凝胶支架及其制备方法和应用
AU2021236130A1 (en) 2020-03-11 2022-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN111285736A (zh) * 2020-04-09 2020-06-16 郑州先利达化工有限公司 含亚磷酸钾、矿源黄腐酸钾、聚谷氨酸的药肥组合物
CN114129780B (zh) * 2020-09-03 2022-06-28 天津大学 一种光控释放一氧化氮的复合水凝胶的制备及应用
WO2023034299A1 (en) * 2021-08-31 2023-03-09 The Research Foundation For The State University Of New York Shear-thinning hydrogels and uses thereof
US20240075001A1 (en) * 2022-05-24 2024-03-07 Darren Rubin Methods to reduce hemorrhage and mortality on the battlefield and applications for trauma patients
CN115074402B (zh) * 2022-07-20 2022-11-18 点滴(南京)生物科技有限公司 一种采用酶法合成的γ-聚谷氨酸钠交联水凝胶及其合成方法
WO2024073588A1 (en) * 2022-09-28 2024-04-04 Board Of Regents, The University Of Texas System Respiratory dry powder delivery
CN115947956B (zh) * 2022-10-09 2024-03-19 西北农林科技大学 一种基于细菌纤维素纳米晶的皮克林纳米乳液及应用
CN116253809A (zh) * 2023-04-19 2023-06-13 广州润虹医药科技股份有限公司 一种去除壳聚糖中内毒素的方法

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737523A1 (de) 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1995031223A1 (fr) 1994-05-13 1995-11-23 Kuraray Co., Ltd. Gel polymere a usage medical
WO1998009987A1 (en) 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
AU743758B2 (en) 1997-04-07 2002-02-07 Genentech Inc. Anti-VEGF antibodies
JP2002527408A (ja) 1998-10-09 2002-08-27 ミシガン大学 ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー
CA2432988A1 (en) 2001-01-23 2002-08-01 Cristina Garcia-Paredes Melanocortin receptor agonists
AU2004274468B2 (en) 2003-09-18 2009-07-23 Vertex Pharmaceuticals, Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
ES2741524T3 (es) 2004-03-23 2020-02-11 Ascendis Pharma Gmbh Profármaco polimérico con un enlazador autoinmolador
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
EP1904553A4 (en) 2005-07-06 2013-04-24 Molly S Shoichet METHOD OF IMMOBILIZING BIOMOLECULE ON POLYMERS INVOLVING FAST TYPE CHEMICAL REACTIONS
US20070060658A1 (en) 2005-08-31 2007-03-15 Diaz David D Stabilization of organogels and hydrogels by azide-alkyne [3+2] cycloaddition
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
BRPI0712052A2 (pt) 2006-06-09 2012-01-10 Novartis Ag polipeptìdeos de fator de crescimento tipo insulina estabilizados
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
EA016327B1 (ru) 2007-02-09 2012-04-30 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
WO2008116107A2 (en) 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
EP2142535A2 (en) 2007-03-29 2010-01-13 Novartis Ag 3-imidazolyl-indoles for the treatment of proliferative diseases
EP2164519A2 (en) 2007-06-08 2010-03-24 Ascendis Pharma AS Long-acting polymeric prodrugs of exendin
EP2325730A1 (en) 2008-01-31 2011-05-25 Appside Co., Ltd. Data input device, data input method, data input program, and recording medium containing the program
MX2010008024A (es) 2008-02-01 2010-12-21 Ascendis Pharma As Profarmaco que comprende un enlazador que se puede separar por si mismo.
CA3020290A1 (en) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc Stable and soluble antibodies inhibiting vegf
US20110230497A1 (en) 2008-11-07 2011-09-22 H. Lundbeck A/S Biologically active amides
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US8133979B2 (en) 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
CA2753179A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same by extrusion
WO2010099818A1 (en) 2009-03-03 2010-09-10 Ao Technology Ag Thermoreversible polysaccharide hydrogel
WO2010102663A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Piperazine derivatives for use in therapy
IN2012DN00352A (es) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
WO2011000945A2 (en) 2009-07-03 2011-01-06 Nensius Research A/S Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns
EP2459225A1 (en) 2009-07-31 2012-06-06 Ascendis Pharma A/S Carrier linked pramipexole prodrugs
ES2636741T3 (es) 2009-07-31 2017-10-09 Sanofi-Aventis Deutschland Gmbh Composición de insulina de acción prolongada
NZ597960A (en) 2009-07-31 2013-07-26 Ascendis Pharma As Biodegradable polyethylene glycol based water-insoluble hydrogels
EP2459227B1 (en) 2009-07-31 2021-03-17 Ascendis Pharma A/S Prodrugs containing an aromatic amine connected by an amide bond to a carrier
MA33467B1 (fr) 2009-07-31 2012-07-03 Sanofi Aventis Deutschland Promédicaments comprenant un conjugué insuline-lieur
WO2011012723A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Injectable sustained release compositions comprising a pramipexole prodrug
WO2011042450A1 (en) 2009-10-06 2011-04-14 Ascendis Pharma As Carrier linked paliperidone prodrugs
US8758780B2 (en) 2009-10-06 2014-06-24 Ascendis Pharma As Subcutaneous paliperidone composition
EP2493514B1 (en) 2009-10-29 2018-08-22 Ascendis Pharma A/S Sterilization of biodegradable hydrogels
US20130030359A1 (en) 2010-01-22 2013-01-31 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aromatic amine-containing drugs
WO2011089214A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
DK2525830T3 (en) 2010-01-22 2016-08-15 Ascendis Pharma As DIPEPTID-BASED PRODRUG LINKERS TO ALIFATIC AMINE-CONTAINING MEDICINES
CN103153927B (zh) 2010-04-27 2017-02-15 西纳福克斯股份有限公司 稠合的环辛炔化合物及其在无金属点击反应中的应用
WO2011140392A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled drug release from solid supports
KR101764952B1 (ko) 2010-07-29 2017-08-03 리겔 파마슈티칼스, 인크. Ａｍｐｋ-활성화 헤테로시클릭 화합물 및 그의 사용 방법
US9388276B2 (en) 2011-02-25 2016-07-12 University Of Massachusetts Monomers and polymers for functional polycarbonates and poly(ester-carbonates) and PEG-co-polycarbonate hydrogels
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
US20140256831A1 (en) 2011-05-31 2014-09-11 The University Of Tokyo Hydrogel and method for producing same
WO2012173952A1 (en) 2011-06-13 2012-12-20 Emory University Piperazine derivatives, compositions, and uses related thereto
JP2014522878A (ja) 2011-08-12 2014-09-08 アセンディス ファーマ エー／エス プロスタサイクリンの徐放組成物
CN103945870B (zh) 2011-09-07 2016-10-12 普罗林科斯有限责任公司 生物可降解交联的水凝胶
US20130066063A1 (en) 2011-09-09 2013-03-14 John Cooke Hodges Bicyclo[6.1.0]non-4-yne regents for chemical modification of oligonucleotides
RU2014118642A (ru) 2011-10-12 2015-11-20 Асцендис Фарма Офтальмолоджи Дивижн А/С Предотвращение и лечение глазных нарушений
BR112014013250A2 (pt) 2011-12-01 2019-09-24 Angiochem Inc compostos com enzima alvo e usos dos mesmos
US20150037311A1 (en) 2011-12-01 2015-02-05 Angiochem Inc. Targeted lysosomal enzyme compounds
JP2013116858A (ja) 2011-12-01 2013-06-13 Dainippon Sumitomo Pharma Co Ltd Ｂｄｎｆ様低分子化合物を含有する治療薬
US20150148525A1 (en) 2012-05-18 2015-05-28 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase
SG11201501920PA (en) 2012-10-11 2015-04-29 Ascendis Pharma As Diagnosis, prevention and treatment of diseases of the joint
CN104781314B (zh) 2012-10-11 2017-11-14 阿森迪斯药物股份有限公司 水凝胶前药
AU2013328782C1 (en) 2012-10-11 2018-01-18 Ascendis Pharma Ophthalmology Division A/S VEGF neutralizing prodrugs for the treatment of ocular conditions
US20150267196A1 (en) 2012-10-12 2015-09-24 Case Western Reserve University Biodegradable hydrogel for polynucleotide delivery
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
EP2925256A4 (en) 2013-01-22 2016-08-17 Prolynx Llc SEALANTS HAVING CONTROLLED DEGRADATION
CN115925957A (zh) * 2013-02-08 2023-04-07 Irm责任有限公司 用于修饰抗体以制备免疫缀合物的特定位点
ES2701051T3 (es) 2013-03-15 2019-02-20 Novartis Ag Conjugados de anticuerpo-fármaco
AU2014257748C1 (en) 2013-04-22 2019-03-07 Ascendis Pharma A/S Modified hydrogels
WO2014173759A1 (en) 2013-04-22 2014-10-30 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing modified drugs
WO2014181287A1 (en) 2013-05-09 2014-11-13 Piramal Enterprises Limited Heterocyclyl compounds and uses thereof
CN104292454B (zh) 2013-07-17 2017-12-01 北京键凯科技股份有限公司 聚乙二醇‑环辛炔衍生物
US9683018B2 (en) 2013-07-25 2017-06-20 Novartis Ag Disulfide cyclic polypeptides for the treatment of heart failure
EP3024846A1 (en) 2013-07-25 2016-06-01 Novartis AG Cyclic apelin derivatives for the treatment of heart failure
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
JP2016172783A (ja) 2013-08-08 2016-09-29 生化学工業株式会社 組織膨隆材
AU2014333953C1 (en) 2013-10-08 2020-06-25 Ascendis Pharma A/S Hydrogel-linked IL-1ra prodrug
WO2015061503A1 (en) 2013-10-22 2015-04-30 Prolynx Llc Conjugates of somatostatin and its analogs
WO2015067791A1 (en) 2013-11-11 2015-05-14 Ascendis Pharma Relaxin Division A/S Relaxin prodrugs
US20170182220A1 (en) 2014-02-26 2017-06-29 University Of Massachusetts Degradable hydrogel with predictable tuning of properties, and compositions and methods thereof
WO2016020373A1 (en) 2014-08-06 2016-02-11 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
WO2016025752A1 (en) 2014-08-14 2016-02-18 Prolynx Llc Reagents for thiol conjugation and conjugates formed therefrom
TWI806150B (zh) 2014-11-07 2023-06-21 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
MX2017008915A (es) 2015-01-09 2018-04-26 Ascendis Pharma Growth Disorders As Profarmacos de peptido natriuretico tipo c (cnp).
WO2016161372A1 (en) * 2015-04-01 2016-10-06 President And Fellows Of Harvard College Immunoconjugates for programming or reprogramming of cells
EP3303365A4 (en) 2015-05-29 2019-04-24 Ascendis Pharma Inc. PRODRUGS WITH A PYROGLUTAMATE LINKER
BR112018010205A2 (pt) 2015-11-20 2018-11-21 Cristal Delivery B V nanopartículas com direcionamento ativo
CN109414469A (zh) 2016-03-16 2019-03-01 普罗林科斯有限责任公司 艾塞那肽类似物的缓释偶联物
US11896671B2 (en) 2016-07-13 2024-02-13 Ascendis Pharma A/S Conjugation method for carrier-linked prodrugs
JOP20190245A1 (ar) * 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط

Also Published As

Publication number Publication date
EA202192099A2 (ru) 2021-11-30
EA201992484A1 (ru) 2020-02-25
MX2019012447A (es) 2020-01-13
AU2018255933B2 (en) 2021-09-30
JP7323453B2 (ja) 2023-08-08
CN110603060A (zh) 2019-12-20
WO2018193408A1 (en) 2018-10-25
PE20211281A1 (es) 2021-07-19
EA202192099A3 (ru) 2022-02-28
AR111481A1 (es) 2019-07-17
US20180303945A1 (en) 2018-10-25
UY37686A (es) 2018-11-30
CU20190082A7 (es) 2020-10-20
US20230201353A1 (en) 2023-06-29
PH12019502325A1 (en) 2020-07-06
BR112019021810A2 (pt) 2020-05-26
EP3612233A1 (en) 2020-02-26
US10751417B2 (en) 2020-08-25
IL269991B2 (en) 2023-07-01
PE20191837A1 (es) 2019-12-30
SG11201908740VA (en) 2019-11-28
TW201842935A (zh) 2018-12-16
RU2019136872A (ru) 2021-05-21
US20200376129A1 (en) 2020-12-03
DOP2019000268A (es) 2020-02-16
CO2019011577A2 (es) 2019-10-31
RU2019136872A3 (es) 2021-08-31
KR20190137888A (ko) 2019-12-11
CA3057590A1 (en) 2018-10-25
JOP20190245A1 (ar) 2019-10-15
JP2020517623A (ja) 2020-06-18
ECSP19075134A (es) 2019-10-31
MA50260A (fr) 2020-02-26
CR20190479A (es) 2019-11-20
AU2018255933A1 (en) 2019-10-17
IL269991B1 (en) 2023-03-01
IL269991A (es) 2019-12-31

Similar Documents

Publication Publication Date Title
CL2019002969A1 (es) Sistemas de administración de liberación sostenida que comprenden ligantes que no dejan huellas.
ECSP21022120A (es) Administración sostenida de polipéptidos similares a la angiopoyetina 3
ECSP22047876A (es) Derivados de pirazolilo ?tiles como agentes anticancer?genos
CL2018002803A1 (es) Antagonistas de c5ar solubles
BR112015018087A8 (pt) composto, composição farmacêutica e uso
MX2020007625A (es) Inhibidor mtor, composicion farmaceutica y su uso.
CO2019000643A2 (es) Formulaciones gastrorretentivas orales y usos de las mismas
UY36003A (es) Derivados de amida, procesos de preparación y composiciones, útiles en afecciones asociadas con el receptor sub-tipo 1 de orexina.
BR112018005589A2 (pt) “composto, composição farmaceuticamente aceitável, e, uso de um composto”
DOP2019000070A (es) Compuestos de aza–indazol para usar en lesiones de tendones y/o ligamentos
UY37412A (es) Compuestos de indazol para uso en lesiones de tendones y/o ligamentos
CL2020001277A1 (es) Derivados de piridinona y su uso como inhibidores selectivos de alk-2.
CO2018007610A2 (es) Derivados de indano y su uso en terapias
CL2019002899A1 (es) Formulaciones con mayor estabilidad y biodisponibilidad para administración de (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas en 4.
UY36958A (es) Compuestos para administración intracelular
MX2020010259A (es) Preparacion farmaceutica.
MX2020006886A (es) Sistema para suministro de medicamento.
CO2020006552A2 (es) Composiciones farmaceuticas que comprenden safinamida
AR117298A1 (es) Aglutinante de péptido
NI202000095A (es) Métodos para modular los niveles de plasma de metabolitos de tetrabenazina utilizando bupropión
MX2019003229A (es) Formulaciones liquidas estables.