UY37686A - Sistemas de entrega de liberación sostenida que comprenden enlazadores no rastreables - Google Patents
Sistemas de entrega de liberación sostenida que comprenden enlazadores no rastreablesInfo
- Publication number
- UY37686A UY37686A UY0001037686A UY37686A UY37686A UY 37686 A UY37686 A UY 37686A UY 0001037686 A UY0001037686 A UY 0001037686A UY 37686 A UY37686 A UY 37686A UY 37686 A UY37686 A UY 37686A
- Authority
- UY
- Uruguay
- Prior art keywords
- delivery systems
- drug delivery
- sustained release
- trackable
- linkers
- Prior art date
Links
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
En este documento se describen sistemas de entrega del fármaco para administrar agentes biológicamente activos que comprenden aminas primarias o secundarias, o un átomo de nitrógeno del anillo de un anillo de azaheteroarilo, sales farmacéuticamente aceptables de los mismos, reactivos de administración de fármacos relacionados con los mismos, composiciones farmacéuticas que comprenden los sistemas de entrega del fármaco y el uso de los sistemas de entrega del fármaco como agentes terapéuticos de liberación sostenida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762487888P | 2017-04-20 | 2017-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37686A true UY37686A (es) | 2018-11-30 |
Family
ID=62116508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037686A UY37686A (es) | 2017-04-20 | 2018-04-19 | Sistemas de entrega de liberación sostenida que comprenden enlazadores no rastreables |
Country Status (26)
Country | Link |
---|---|
US (3) | US10751417B2 (es) |
EP (1) | EP3612233A1 (es) |
JP (1) | JP7323453B2 (es) |
KR (1) | KR20190137888A (es) |
CN (1) | CN110603060A (es) |
AR (1) | AR111481A1 (es) |
AU (1) | AU2018255933B2 (es) |
BR (1) | BR112019021810A2 (es) |
CA (1) | CA3057590A1 (es) |
CL (1) | CL2019002969A1 (es) |
CO (1) | CO2019011577A2 (es) |
CR (1) | CR20190479A (es) |
CU (1) | CU20190082A7 (es) |
DO (1) | DOP2019000268A (es) |
EA (2) | EA201992484A1 (es) |
EC (1) | ECSP19075134A (es) |
IL (1) | IL269991B2 (es) |
JO (1) | JOP20190245A1 (es) |
MA (1) | MA50260A (es) |
MX (1) | MX2019012447A (es) |
PE (2) | PE20191837A1 (es) |
PH (1) | PH12019502325A1 (es) |
SG (1) | SG11201908740VA (es) |
TW (1) | TW201842935A (es) |
UY (1) | UY37686A (es) |
WO (1) | WO2018193408A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018001447A (es) | 2015-08-03 | 2019-02-21 | Harvard College | Bloqueadores de canal de ion cargado y metodos para su uso. |
JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
JOP20190245A1 (ar) * | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
TW202027794A (zh) * | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣3多肽之持續遞送 |
JP2022527731A (ja) | 2019-03-11 | 2022-06-06 | ノシオン セラピューティクス,インコーポレイテッド | エステル置換イオンチャンネル遮断薬および使用方法 |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CA3129111A1 (en) | 2019-03-11 | 2020-09-17 | Bridget M. Cole | Charged ion channel blockers and methods for use |
CN113811305A (zh) | 2019-03-11 | 2021-12-17 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
WO2020254617A1 (en) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Anti-ctla4 compounds with localized pk properties |
WO2020254607A1 (en) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Anti-ctla4 compounds with localized pd properties |
CA3143279A1 (en) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Anti-ctla4 conjugates |
US11795320B2 (en) * | 2019-09-20 | 2023-10-24 | Bausch + Lomb Ireland Limited | Grafted polymer and use thereof |
US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
IL292505A (en) | 2019-11-06 | 2022-06-01 | Nocion Therapeutics Inc | Charged ion channel blockers and methods of use |
CN111110829A (zh) * | 2019-12-24 | 2020-05-08 | 浙江大学 | 一种纳米防御素凝胶支架及其制备方法和应用 |
US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
CN111285736A (zh) * | 2020-04-09 | 2020-06-16 | 郑州先利达化工有限公司 | 含亚磷酸钾、矿源黄腐酸钾、聚谷氨酸的药肥组合物 |
CN114129780B (zh) * | 2020-09-03 | 2022-06-28 | 天津大学 | 一种光控释放一氧化氮的复合水凝胶的制备及应用 |
WO2023034299A1 (en) * | 2021-08-31 | 2023-03-09 | The Research Foundation For The State University Of New York | Shear-thinning hydrogels and uses thereof |
US20240075001A1 (en) * | 2022-05-24 | 2024-03-07 | Darren Rubin | Methods to reduce hemorrhage and mortality on the battlefield and applications for trauma patients |
CN115074402B (zh) * | 2022-07-20 | 2022-11-18 | 点滴(南京)生物科技有限公司 | 一种采用酶法合成的γ-聚谷氨酸钠交联水凝胶及其合成方法 |
CN115947956B (zh) * | 2022-10-09 | 2024-03-19 | 西北农林科技大学 | 一种基于细菌纤维素纳米晶的皮克林纳米乳液及应用 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3737523A1 (de) | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
WO1995031223A1 (fr) | 1994-05-13 | 1995-11-23 | Kuraray Co., Ltd. | Gel polymere a usage medical |
WO1998009987A1 (en) | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
WO2000021572A2 (en) | 1998-10-09 | 2000-04-20 | The University Of Michigan | Hydrogels and water soluble polymeric carriers for drug delivery |
US7169777B2 (en) | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
AU2004274468B2 (en) | 2003-09-18 | 2009-07-23 | Vertex Pharmaceuticals, Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
BRPI0507875B8 (pt) | 2004-03-23 | 2021-05-25 | Complex Biosystems Gmbh | pró-fármaco de cascata polimérico |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
WO2007003054A1 (en) | 2005-07-06 | 2007-01-11 | Shoichet Molly S | Method of biomolecule immobilization on polymers using click-type chemistry |
US20070060658A1 (en) | 2005-08-31 | 2007-03-15 | Diaz David D | Stabilization of organogels and hydrogels by azide-alkyne [3+2] cycloaddition |
US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
JO2968B1 (en) | 2006-06-09 | 2016-03-15 | نوفارتيس ايه جي | Polypeptides are a stable insulin-like growth factor |
ITMI20061726A1 (it) | 2006-09-11 | 2008-03-12 | Fidia Farmaceutici | Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry |
CN101600428A (zh) | 2007-02-09 | 2009-12-09 | Irm责任有限公司 | 作为通道活化蛋白酶抑制剂的化合物和组合物 |
WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
BRPI0810082A2 (pt) | 2007-03-29 | 2014-10-21 | Novartis Ag | 3-imidazolil-indóis para o tratamento de doenças proliferativas |
WO2008148839A2 (en) | 2007-06-08 | 2008-12-11 | Ascendis Pharma As | Long-acting polymeric prodrugs of exendin |
CN102124424A (zh) | 2008-01-31 | 2011-07-13 | 安普赛德股份有限公司 | 数据输入装置、数据输入方法和数据输入程序及记录有该程序的记录介质 |
ES2733355T3 (es) | 2008-02-01 | 2019-11-28 | Ascendis Pharma As | Profármaco que comprende un enlazador autoescindible |
KR101671886B1 (ko) | 2008-06-25 | 2016-11-04 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Vegf를 억제하는 안정하고 가용성인 항체 |
WO2010053861A2 (en) | 2008-11-07 | 2010-05-14 | H. Lundbeck A/S | Biologically active amides |
JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
US8133979B2 (en) | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
CA2753179A1 (en) | 2009-02-21 | 2010-08-26 | Sofradim Production | Crosslinked fibers and method of making same by extrusion |
WO2010099818A1 (en) | 2009-03-03 | 2010-09-10 | Ao Technology Ag | Thermoreversible polysaccharide hydrogel |
WO2010102663A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Piperazine derivatives for use in therapy |
IN2012DN00352A (es) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
WO2011000945A2 (en) | 2009-07-03 | 2011-01-06 | Nensius Research A/S | Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns |
EP3782649A1 (en) | 2009-07-31 | 2021-02-24 | Ascendis Pharma A/S | Biodegradable polyethylene glycol based water-insoluble hydrogels |
MX2012001399A (es) | 2009-07-31 | 2012-03-21 | Sanofi Aventis Deutschland | Profarmacos que comprenden un conjugado de insulina-conector. |
UA108475C2 (uk) | 2009-07-31 | 2015-05-12 | Санофі-Авентіс Дойчланд Гмбх | Композиція інсуліну тривалої дії |
EP2459227B1 (en) | 2009-07-31 | 2021-03-17 | Ascendis Pharma A/S | Prodrugs containing an aromatic amine connected by an amide bond to a carrier |
US20120191039A1 (en) | 2009-07-31 | 2012-07-26 | Ascendis Pharma A/S | Carrier linked pramipexole prodrugs |
WO2011012723A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Injectable sustained release compositions comprising a pramipexole prodrug |
US8758780B2 (en) | 2009-10-06 | 2014-06-24 | Ascendis Pharma As | Subcutaneous paliperidone composition |
WO2011042450A1 (en) | 2009-10-06 | 2011-04-14 | Ascendis Pharma As | Carrier linked paliperidone prodrugs |
AU2010311421B2 (en) | 2009-10-29 | 2014-11-20 | Ascendis Pharma A/S | Sterilization of biodegradable hydrogels |
EP2525831B1 (en) | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
US9062094B2 (en) | 2010-01-22 | 2015-06-23 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
US20130030359A1 (en) | 2010-01-22 | 2013-01-31 | Ascendis Pharma A/S | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
CN103153927B (zh) | 2010-04-27 | 2017-02-15 | 西纳福克斯股份有限公司 | 稠合的环辛炔化合物及其在无金属点击反应中的应用 |
US8946405B2 (en) | 2010-05-05 | 2015-02-03 | Prolynx Llc | Controlled release from solid supports |
EP2598483B1 (en) | 2010-07-29 | 2020-07-29 | Rigel Pharmaceuticals, Inc. | Ampk-activating heterocyclic compounds and methods for using the same |
WO2012116250A1 (en) | 2011-02-25 | 2012-08-30 | University Of Massachusetts Medical School | Monomers and polymers for functional polycarbonates and poly (ester-carbonates) and peg-co-polycarbonate hydrogels |
CZ304072B6 (cs) | 2011-04-26 | 2013-09-25 | Contipro Biotech S.R.O. | Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití |
US20140256831A1 (en) | 2011-05-31 | 2014-09-11 | The University Of Tokyo | Hydrogel and method for producing same |
US9428478B2 (en) | 2011-06-13 | 2016-08-30 | Emory University | Piperazine derivatives, compositions, and uses related thereto |
JP2014522878A (ja) | 2011-08-12 | 2014-09-08 | アセンディス ファーマ エー/エス | プロスタサイクリンの徐放組成物 |
SG11201400444VA (en) | 2011-09-07 | 2014-04-28 | Prolynx Llc | Hydrogels with biodegradable crosslinking |
EP2753607B1 (en) | 2011-09-09 | 2016-04-13 | Berry And Associates, Inc. | Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides |
KR20140103099A (ko) | 2011-10-12 | 2014-08-25 | 아센디스 파마 옵탈몰로지 디비젼 에이/에스 | 안구 병태의 예방 및 치료 |
JP2013116858A (ja) | 2011-12-01 | 2013-06-13 | Dainippon Sumitomo Pharma Co Ltd | Bdnf様低分子化合物を含有する治療薬 |
CA2857548A1 (en) | 2011-12-01 | 2013-06-06 | Angiochem Inc. | Targeted enzyme compounds and uses thereof |
RU2014126484A (ru) | 2011-12-01 | 2016-02-10 | Ангиочем Инк. | Нацеленные соединения лизосомальных ферментов |
US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
SG11201501920PA (en) | 2012-10-11 | 2015-04-29 | Ascendis Pharma As | Diagnosis, prevention and treatment of diseases of the joint |
JP2015533132A (ja) * | 2012-10-11 | 2015-11-19 | アセンディス ファーマ オフサルモロジー ディヴィジョン エー/エス | 眼状態を処置するためのvegf中和プロドラッグ |
MY178680A (en) | 2012-10-11 | 2020-10-20 | Ascendis Pharma As | Hydrogel prodrugs |
US20150267196A1 (en) | 2012-10-12 | 2015-09-24 | Case Western Reserve University | Biodegradable hydrogel for polynucleotide delivery |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
WO2014116717A1 (en) | 2013-01-22 | 2014-07-31 | Prolynx Llc | Sealants having controlled degradation |
KR102447350B1 (ko) * | 2013-02-08 | 2022-09-23 | 노파르티스 아게 | 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위 |
US9789203B2 (en) | 2013-03-15 | 2017-10-17 | Novartis Ag | cKIT antibody drug conjugates |
CA2907830C (en) | 2013-04-22 | 2022-03-29 | Ascendis Pharma A/S | Hydrogel-linked prodrugs releasing tagged drugs |
JP6311008B2 (ja) | 2013-04-22 | 2018-04-11 | アセンディス ファーマ エー/エス | 修飾されたヒドロゲル |
WO2014181287A1 (en) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Heterocyclyl compounds and uses thereof |
CN104292454B (zh) * | 2013-07-17 | 2017-12-01 | 北京键凯科技股份有限公司 | 聚乙二醇‑环辛炔衍生物 |
JP6505691B2 (ja) | 2013-07-25 | 2019-04-24 | ノバルティス アーゲー | 心不全治療用の環状アペリン誘導体 |
JP6501775B2 (ja) | 2013-07-25 | 2019-04-17 | ノバルティス アーゲー | 心不全治療用の環状ポリペプチド |
JP6505692B2 (ja) | 2013-07-25 | 2019-04-24 | ノバルティス アーゲー | 心不全治療のためのジスルフィド環状ポリペプチド |
JP2016172783A (ja) | 2013-08-08 | 2016-09-29 | 生化学工業株式会社 | 組織膨隆材 |
AU2014333953C1 (en) | 2013-10-08 | 2020-06-25 | Ascendis Pharma A/S | Hydrogel-linked IL-1ra prodrug |
US10086049B2 (en) | 2013-10-22 | 2018-10-02 | Prolynx Llc | Conjugates of somatostatin analogues |
CA2929201A1 (en) | 2013-11-11 | 2015-05-14 | Ascendis Pharma Relaxin Division A/S | Relaxin prodrugs |
WO2015130878A1 (en) | 2014-02-26 | 2015-09-03 | University Of Massachusetts Medical School | Degradable hydrogel with predictable tuning of properties, and compositions and methods thereof |
AU2015299055C1 (en) | 2014-08-06 | 2021-05-06 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
WO2016025752A1 (en) | 2014-08-14 | 2016-02-18 | Prolynx Llc | Reagents for thiol conjugation and conjugates formed therefrom |
TWI705827B (zh) | 2014-11-07 | 2020-10-01 | 瑞士商諾華公司 | 治療眼部疾病之方法 |
JP2018502868A (ja) | 2015-01-09 | 2018-02-01 | アセンディス ファーマ グロース ディスオーダーズ エー/エス | Cnpプロドラッグ |
WO2016161372A1 (en) * | 2015-04-01 | 2016-10-06 | President And Fellows Of Harvard College | Immunoconjugates for programming or reprogramming of cells |
EP3303365A4 (en) | 2015-05-29 | 2019-04-24 | Ascendis Pharma Inc. | PRODRUGS WITH A PYROGLUTAMATE LINKER |
JP2018534320A (ja) | 2015-11-20 | 2018-11-22 | クリスタル・デリバリー・ビー・ブイ | 能動的標的指向性を有するナノ粒子 |
WO2017161174A1 (en) | 2016-03-16 | 2017-09-21 | Prolynx Llc | Extended release conjugates of exenatide analogs |
WO2018011266A1 (en) | 2016-07-13 | 2018-01-18 | Ascendis Pharma A/S | Conjugation method for carrier-linked prodrugs |
JOP20190245A1 (ar) * | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
-
2017
- 2017-06-16 JO JOP/2019/0245A patent/JOP20190245A1/ar unknown
-
2018
- 2018-04-19 EA EA201992484A patent/EA201992484A1/ru unknown
- 2018-04-19 AR ARP180101000A patent/AR111481A1/es unknown
- 2018-04-19 BR BR112019021810-6A patent/BR112019021810A2/pt active Search and Examination
- 2018-04-19 WO PCT/IB2018/052740 patent/WO2018193408A1/en unknown
- 2018-04-19 CU CU2019000082A patent/CU20190082A7/es unknown
- 2018-04-19 AU AU2018255933A patent/AU2018255933B2/en active Active
- 2018-04-19 PE PE2019002069A patent/PE20191837A1/es unknown
- 2018-04-19 US US15/957,474 patent/US10751417B2/en active Active
- 2018-04-19 EA EA202192099A patent/EA202192099A3/ru unknown
- 2018-04-19 SG SG11201908740V patent/SG11201908740VA/en unknown
- 2018-04-19 EP EP18722730.1A patent/EP3612233A1/en active Pending
- 2018-04-19 UY UY0001037686A patent/UY37686A/es not_active Application Discontinuation
- 2018-04-19 CA CA3057590A patent/CA3057590A1/en active Pending
- 2018-04-19 TW TW107113326A patent/TW201842935A/zh unknown
- 2018-04-19 PE PE2021000630A patent/PE20211281A1/es unknown
- 2018-04-19 JP JP2019556685A patent/JP7323453B2/ja active Active
- 2018-04-19 MX MX2019012447A patent/MX2019012447A/es unknown
- 2018-04-19 CR CR20190479A patent/CR20190479A/es unknown
- 2018-04-19 MA MA050260A patent/MA50260A/fr unknown
- 2018-04-19 KR KR1020197033766A patent/KR20190137888A/ko not_active Application Discontinuation
- 2018-04-19 CN CN201880026014.7A patent/CN110603060A/zh active Pending
-
2019
- 2019-10-11 PH PH12019502325A patent/PH12019502325A1/en unknown
- 2019-10-15 IL IL269991A patent/IL269991B2/en unknown
- 2019-10-17 CL CL2019002969A patent/CL2019002969A1/es unknown
- 2019-10-18 DO DO2019000268A patent/DOP2019000268A/es unknown
- 2019-10-18 EC ECSENADI201975134A patent/ECSP19075134A/es unknown
- 2019-10-18 CO CO2019011577A patent/CO2019011577A2/es unknown
-
2020
- 2020-06-15 US US16/901,601 patent/US20200376129A1/en not_active Abandoned
-
2022
- 2022-11-11 US US18/054,767 patent/US20230201353A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY37686A (es) | Sistemas de entrega de liberación sostenida que comprenden enlazadores no rastreables | |
CO2021004012A2 (es) | Administración sostenida de polipéptidos similares a la angiopoyetina 3 | |
ECSP22047876A (es) | Derivados de pirazolilo ?tiles como agentes anticancer?genos | |
CY1123571T1 (el) | Βουπροπιονη για τη ρυθμιση των φαρμακευτικων επιπεδων δεξτρομεθορφανης στο πλασμα | |
CR20160518A (es) | Compuestos para tratar atrofia muscular espinal | |
GT201600269A (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
UY36003A (es) | Derivados de amida, procesos de preparación y composiciones, útiles en afecciones asociadas con el receptor sub-tipo 1 de orexina. | |
CO2020004977A2 (es) | Compuestos bicíclicos para su uso como inhibidores de la ripi quinasa | |
CL2019001991A1 (es) | Moduladores del receptor de estrógeno. | |
DOP2019000070A (es) | Compuestos de azaindazol para usar en lesiones de tendones y/o ligamentos | |
CR20180184A (es) | Compuestos heteroarilo y su uso como fármacos terapéuticos | |
ECSP16086247A (es) | (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
CU20160166A7 (es) | Compuestos derivados de n-(1,5-dimetil-3-oxo-2,3-dihidro-1h-pirazol-4-il)-4-metil-5-isoxazol-3-carboxamida activos como inhibidores selectivos de smurf-1 | |
ECSP21071644A (es) | Compuestos macrocíclicos como agonistas de sting | |
ECSP16086232A (es) | (r) -pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
UY37412A (es) | Compuestos de indazol para uso en lesiones de tendones y/o ligamentos | |
CL2018002010A1 (es) | Derivados de indano y su uso en terapias. | |
CL2018003338A1 (es) | Formulaciones inyectables fisiológicamente balanceadas de fosnetupitant. | |
CL2019002899A1 (es) | Formulaciones con mayor estabilidad y biodisponibilidad para administración de (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas en 4. | |
UY36958A (es) | Compuestos para administración intracelular |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20231103 |