CL2019001882A1 - Estrategia optimizada para modificaciones de omisión de exón utilizando crispr/cas9 con secuencias de guía triple. - Google Patents

Estrategia optimizada para modificaciones de omisión de exón utilizando crispr/cas9 con secuencias de guía triple.

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Publication number
CL2019001882A1
CL2019001882A1 CL2019001882A CL2019001882A CL2019001882A1 CL 2019001882 A1 CL2019001882 A1 CL 2019001882A1 CL 2019001882 A CL2019001882 A CL 2019001882A CL 2019001882 A CL2019001882 A CL 2019001882A CL 2019001882 A1 CL2019001882 A1 CL 2019001882A1
Authority
CL
Chile
Prior art keywords
cas9
crispr
modifications
exon skipping
guide sequences
Prior art date
Application number
CL2019001882A
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English (en)
Spanish (es)
Inventor
Leonela Amoasil
Eric Olson
Original Assignee
Univ Texas
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Application filed by Univ Texas filed Critical Univ Texas
Publication of CL2019001882A1 publication Critical patent/CL2019001882A1/es

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CL2019001882A 2017-01-05 2019-07-05 Estrategia optimizada para modificaciones de omisión de exón utilizando crispr/cas9 con secuencias de guía triple. CL2019001882A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762442606P 2017-01-05 2017-01-05
US201762544449P 2017-08-11 2017-08-11
US201762596298P 2017-12-08 2017-12-08

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CL2019001882A1 true CL2019001882A1 (es) 2019-10-04

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CL2019001882A CL2019001882A1 (es) 2017-01-05 2019-07-05 Estrategia optimizada para modificaciones de omisión de exón utilizando crispr/cas9 con secuencias de guía triple.

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Country Link
US (1) US20190338311A1 (OSRAM)
EP (1) EP3565897B1 (OSRAM)
JP (1) JP2020503869A (OSRAM)
KR (1) KR102606174B1 (OSRAM)
CN (1) CN110506115A (OSRAM)
AU (1) AU2018205521A1 (OSRAM)
BR (1) BR112019013962A2 (OSRAM)
CA (1) CA3048635A1 (OSRAM)
CL (1) CL2019001882A1 (OSRAM)
CO (1) CO2019008181A2 (OSRAM)
CR (1) CR20190326A (OSRAM)
DK (1) DK3565897T3 (OSRAM)
DO (1) DOP2019000179A (OSRAM)
EC (1) ECSP19056408A (OSRAM)
IL (1) IL267786A (OSRAM)
JO (1) JOP20190166A1 (OSRAM)
MA (1) MA47239A (OSRAM)
MX (1) MX2019008064A (OSRAM)
PE (1) PE20191357A1 (OSRAM)
PH (1) PH12019501561A1 (OSRAM)
SG (1) SG11201906147VA (OSRAM)
WO (1) WO2018129296A1 (OSRAM)

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EP3952884A4 (en) * 2019-04-12 2023-03-22 Duke University Crispr/cas-based base editing composition for restoring dystrophin function
EP3952925A4 (en) * 2019-04-12 2024-01-24 The Regents of the University of California COMPOSITIONS AND METHODS FOR MODIFYING DYSTROPHIN GENES
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CN116096394A (zh) * 2020-02-13 2023-05-09 特纳亚治疗股份有限公司 用于治疗心脏病的基因疗法载体
CN111172191B (zh) * 2020-02-21 2020-12-22 浙江大学 一种高效基因敲除载体及其应用
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WO2023159103A1 (en) * 2022-02-17 2023-08-24 The Board Of Regents Of The University Of Texas System CRISPR/SpCas9 VARIANT AND METHODS FOR ENHANCED CORRECTON OF DUCHENNE MUSCULAR DYSTROPHY MUTATIONS
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