CL2017000474A1 - N-alquilaril-5 oxyaryl-octahydri-cyclopenta [c] pyrrole modeladores allosteriscos negativos de nr2b - Google Patents

N-alquilaril-5 oxyaryl-octahydri-cyclopenta [c] pyrrole modeladores allosteriscos negativos de nr2b

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Publication number
CL2017000474A1
CL2017000474A1 CL2017000474A CL2017000474A CL2017000474A1 CL 2017000474 A1 CL2017000474 A1 CL 2017000474A1 CL 2017000474 A CL2017000474 A CL 2017000474A CL 2017000474 A CL2017000474 A CL 2017000474A CL 2017000474 A1 CL2017000474 A1 CL 2017000474A1
Authority
CL
Chile
Prior art keywords
nr2b
rentail
octahydri
allosteriscal
modelers
Prior art date
Application number
CL2017000474A
Other languages
English (en)
Spanish (es)
Inventor
R Anderson David
A Volkmann Robert
S Menniti Frank
Original Assignee
Luc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55581945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000474(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Luc Therapeutics Inc filed Critical Luc Therapeutics Inc
Publication of CL2017000474A1 publication Critical patent/CL2017000474A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CL2017000474A 2014-09-26 2017-02-28 N-alquilaril-5 oxyaryl-octahydri-cyclopenta [c] pyrrole modeladores allosteriscos negativos de nr2b CL2017000474A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462056284P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
CL2017000474A1 true CL2017000474A1 (es) 2017-08-18

Family

ID=55581945

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000474A CL2017000474A1 (es) 2014-09-26 2017-02-28 N-alquilaril-5 oxyaryl-octahydri-cyclopenta [c] pyrrole modeladores allosteriscos negativos de nr2b

Country Status (40)

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US (4) US10239835B2 (enExample)
EP (4) EP3683207B1 (enExample)
JP (5) JP6473227B2 (enExample)
KR (1) KR102479356B1 (enExample)
CN (1) CN106795111B (enExample)
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CA (1) CA2962569C (enExample)
CL (1) CL2017000474A1 (enExample)
CO (1) CO2017002494A2 (enExample)
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UY (1) UY36326A (enExample)
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WO2020245136A1 (en) * 2019-06-04 2020-12-10 Boehringer Ingelheim International Gmbh Purine derivatives, as nr2b negative modulators and the use thereof as medicament, in particular for treating depressive disorders
CN111481543A (zh) * 2020-05-21 2020-08-04 苏州健雄职业技术学院 Nr2b负变构调节剂联合gaba受体调节剂在制备治疗阿尔兹海默症的药物中的用途
CN116744922A (zh) * 2020-12-04 2023-09-12 诺华股份有限公司 Nr2b-nmda受体nam在治疗抑郁症中的剂量方案
KR20230116865A (ko) 2020-12-04 2023-08-04 노파르티스 아게 우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법
JP2021058765A (ja) * 2021-01-19 2021-04-15 株式会社藤商事 遊技機
WO2022204336A1 (en) * 2021-03-26 2022-09-29 Novartis Ag Novel cyclopental[c]pyrrol negative allosteric modulators of nr2b
EP4313042A4 (en) * 2021-03-26 2025-01-15 Novartis AG NEW CYCLOPENTA[C PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B
KR20250019704A (ko) 2022-06-02 2025-02-10 노파르티스 아게 우울증 장애의 치료에 사용하기 위한 온파스프로딜의 피하 투여 및 투약 방법
CN120981566A (zh) 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽
TW202539663A (zh) 2023-12-06 2025-10-16 瑞士商諾華公司 用於治療抑鬱障礙之組成物和方法

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JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول

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CA2962569C (en) 2023-09-19
US12145909B2 (en) 2024-11-19
EA034937B1 (ru) 2020-04-08
JP6473227B2 (ja) 2019-02-20
CY1123533T1 (el) 2022-03-24
KR102479356B1 (ko) 2022-12-19
TW201625528A (zh) 2016-07-16
TWI687407B (zh) 2020-03-11
JP2019077713A (ja) 2019-05-23
BR112017006093A2 (pt) 2017-12-19
WO2016049165A1 (en) 2016-03-31
HRP20200959T1 (hr) 2020-10-02
SG11201702023QA (en) 2017-04-27
AU2015320721B2 (en) 2020-01-30
EP3197868A1 (en) 2017-08-02
US20190152912A1 (en) 2019-05-23
CN106795111B (zh) 2020-04-07
MX374657B (es) 2025-03-06
CO2017002494A2 (es) 2017-08-31
ZA201701061B (en) 2019-07-31
JP2025060835A (ja) 2025-04-10
EP3974420B1 (en) 2023-08-16
UY36326A (es) 2016-04-29
AU2015320721A1 (en) 2017-03-30
PT3197868T (pt) 2020-05-21
EP4282412A3 (en) 2024-01-17
EP4282412A2 (en) 2023-11-29
ES2911004T3 (es) 2022-05-17
US20220274925A1 (en) 2022-09-01
JP2023052515A (ja) 2023-04-11
US10239835B2 (en) 2019-03-26
CU20170037A7 (es) 2017-08-08
KR20170063599A (ko) 2017-06-08
AR103199A1 (es) 2017-04-26
ECSP17025302A (es) 2018-11-30
EP3683207A1 (en) 2020-07-22
US20180111902A1 (en) 2018-04-26
TN2017000076A1 (en) 2018-07-04
JP7612722B2 (ja) 2025-01-14
RS60497B1 (sr) 2020-08-31
MY182342A (en) 2021-01-20
CR20170114A (es) 2017-08-21
US10781174B2 (en) 2020-09-22
ES2956546T3 (es) 2023-12-22
AP2017009832A0 (en) 2017-03-31
MX2017003940A (es) 2018-03-01
CA2962569A1 (en) 2016-03-31
BR112017006093B1 (pt) 2023-03-21
JP2017528502A (ja) 2017-09-28
SI3197868T1 (sl) 2020-10-30
NZ729569A (en) 2019-06-28
EA201790713A1 (ru) 2017-07-31
DK3197868T3 (da) 2020-06-22
EP3197868A4 (en) 2018-04-25
CU24482B1 (es) 2020-03-04
JP7216060B2 (ja) 2023-01-31
LT3197868T (lt) 2020-09-10
GT201700062A (es) 2019-09-30
EP3683207B1 (en) 2021-12-29
HUE049698T2 (hu) 2020-10-28
IL250909A0 (en) 2017-04-30
JP6772307B2 (ja) 2020-10-21
PH12017500513A1 (en) 2017-08-07
US20200369610A1 (en) 2020-11-26
EP3974420A1 (en) 2022-03-30
CN106795111A (zh) 2017-05-31
EP3197868B1 (en) 2020-04-15
ES2791327T3 (es) 2020-11-03
JP2021006554A (ja) 2021-01-21
JO3579B1 (ar) 2020-07-05
PE20170893A1 (es) 2017-07-12
IL250909B (en) 2019-06-30
PL3197868T3 (pl) 2020-11-02

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