NZ729569A - N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b - Google Patents

N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Info

Publication number
NZ729569A
NZ729569A NZ729569A NZ72956915A NZ729569A NZ 729569 A NZ729569 A NZ 729569A NZ 729569 A NZ729569 A NZ 729569A NZ 72956915 A NZ72956915 A NZ 72956915A NZ 729569 A NZ729569 A NZ 729569A
Authority
NZ
New Zealand
Prior art keywords
oxyaryl
alkylaryl
nr2b
allosteric modulators
negative allosteric
Prior art date
Application number
NZ729569A
Other languages
English (en)
Inventor
David Anderson
Robert VOLKMANN
Frank MENNITI
Original Assignee
Cadent Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55581945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ729569(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cadent Therapeutics Inc filed Critical Cadent Therapeutics Inc
Publication of NZ729569A publication Critical patent/NZ729569A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ729569A 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b NZ729569A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462056284P 2014-09-26 2014-09-26
PCT/US2015/051694 WO2016049165A1 (en) 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Publications (1)

Publication Number Publication Date
NZ729569A true NZ729569A (en) 2019-06-28

Family

ID=55581945

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ729569A NZ729569A (en) 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Country Status (40)

Country Link
US (4) US10239835B2 (enExample)
EP (4) EP4282412A3 (enExample)
JP (5) JP6473227B2 (enExample)
KR (1) KR102479356B1 (enExample)
CN (1) CN106795111B (enExample)
AP (1) AP2017009832A0 (enExample)
AR (1) AR103199A1 (enExample)
AU (1) AU2015320721B2 (enExample)
BR (1) BR112017006093B1 (enExample)
CA (1) CA2962569C (enExample)
CL (1) CL2017000474A1 (enExample)
CO (1) CO2017002494A2 (enExample)
CR (1) CR20170114A (enExample)
CU (1) CU24482B1 (enExample)
CY (1) CY1123533T1 (enExample)
DK (1) DK3197868T3 (enExample)
EA (1) EA034937B1 (enExample)
EC (1) ECSP17025302A (enExample)
ES (3) ES2791327T3 (enExample)
GT (1) GT201700062A (enExample)
HR (1) HRP20200959T1 (enExample)
HU (1) HUE049698T2 (enExample)
IL (1) IL250909B (enExample)
JO (1) JO3579B1 (enExample)
LT (1) LT3197868T (enExample)
MX (1) MX374657B (enExample)
MY (1) MY182342A (enExample)
NZ (1) NZ729569A (enExample)
PE (1) PE20170893A1 (enExample)
PH (1) PH12017500513A1 (enExample)
PL (1) PL3197868T3 (enExample)
PT (1) PT3197868T (enExample)
RS (1) RS60497B1 (enExample)
SG (1) SG11201702023QA (enExample)
SI (1) SI3197868T1 (enExample)
TN (1) TN2017000076A1 (enExample)
TW (1) TWI687407B (enExample)
UY (1) UY36326A (enExample)
WO (1) WO2016049165A1 (enExample)
ZA (1) ZA201701061B (enExample)

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WO2020245136A1 (en) * 2019-06-04 2020-12-10 Boehringer Ingelheim International Gmbh Purine derivatives, as nr2b negative modulators and the use thereof as medicament, in particular for treating depressive disorders
CN111481543A (zh) * 2020-05-21 2020-08-04 苏州健雄职业技术学院 Nr2b负变构调节剂联合gaba受体调节剂在制备治疗阿尔兹海默症的药物中的用途
CN116744922A (zh) * 2020-12-04 2023-09-12 诺华股份有限公司 Nr2b-nmda受体nam在治疗抑郁症中的剂量方案
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CA3212203A1 (en) * 2021-03-26 2022-09-29 Novartis Ag Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b
JP2024512066A (ja) * 2021-03-26 2024-03-18 ノバルティス アーゲー NR2Bの負のアロステリックモジュレーターである新規なシクロペンタ[c]ピロール
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JP6772307B2 (ja) 2020-10-21
JO3579B1 (ar) 2020-07-05
WO2016049165A1 (en) 2016-03-31
EP3197868B1 (en) 2020-04-15
IL250909A0 (en) 2017-04-30
RS60497B1 (sr) 2020-08-31
PH12017500513A1 (en) 2017-08-07
US20190152912A1 (en) 2019-05-23
US12145909B2 (en) 2024-11-19
ZA201701061B (en) 2019-07-31
EP4282412A3 (en) 2024-01-17
JP2019077713A (ja) 2019-05-23
AR103199A1 (es) 2017-04-26
ES2956546T3 (es) 2023-12-22
JP7612722B2 (ja) 2025-01-14
LT3197868T (lt) 2020-09-10
EP3683207B1 (en) 2021-12-29
SG11201702023QA (en) 2017-04-27
US10781174B2 (en) 2020-09-22
CN106795111B (zh) 2020-04-07
PE20170893A1 (es) 2017-07-12
US10239835B2 (en) 2019-03-26
HUE049698T2 (hu) 2020-10-28
EP4282412A2 (en) 2023-11-29
JP2021006554A (ja) 2021-01-21
US20180111902A1 (en) 2018-04-26
HRP20200959T1 (hr) 2020-10-02
BR112017006093A2 (pt) 2017-12-19
JP2023052515A (ja) 2023-04-11
JP7216060B2 (ja) 2023-01-31
EP3197868A1 (en) 2017-08-02
ES2911004T3 (es) 2022-05-17
JP2025060835A (ja) 2025-04-10
CL2017000474A1 (es) 2017-08-18
PL3197868T3 (pl) 2020-11-02
EP3974420A1 (en) 2022-03-30
DK3197868T3 (da) 2020-06-22
CU20170037A7 (es) 2017-08-08
JP6473227B2 (ja) 2019-02-20
CR20170114A (es) 2017-08-21
GT201700062A (es) 2019-09-30
CY1123533T1 (el) 2022-03-24
CU24482B1 (es) 2020-03-04
PT3197868T (pt) 2020-05-21
EA201790713A1 (ru) 2017-07-31
ES2791327T3 (es) 2020-11-03
BR112017006093B1 (pt) 2023-03-21
UY36326A (es) 2016-04-29
ECSP17025302A (es) 2018-11-30
AU2015320721B2 (en) 2020-01-30
US20200369610A1 (en) 2020-11-26
TW201625528A (zh) 2016-07-16
TWI687407B (zh) 2020-03-11
AU2015320721A1 (en) 2017-03-30
CN106795111A (zh) 2017-05-31
KR20170063599A (ko) 2017-06-08
JP2017528502A (ja) 2017-09-28
AP2017009832A0 (en) 2017-03-31
EP3197868A4 (en) 2018-04-25
CO2017002494A2 (es) 2017-08-31
MX374657B (es) 2025-03-06
KR102479356B1 (ko) 2022-12-19
MY182342A (en) 2021-01-20
MX2017003940A (es) 2018-03-01
EP3974420B1 (en) 2023-08-16
IL250909B (en) 2019-06-30
EA034937B1 (ru) 2020-04-08
EP3683207A1 (en) 2020-07-22
US20220274925A1 (en) 2022-09-01
TN2017000076A1 (en) 2018-07-04
CA2962569A1 (en) 2016-03-31
SI3197868T1 (sl) 2020-10-30
CA2962569C (en) 2023-09-19

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