LT3197868T - N-akrilaril-5-oksiaril-oktahidro-ciklopenta[c]pirolas, neigiami alosteriniai nr2b moduliatoriai - Google Patents

N-akrilaril-5-oksiaril-oktahidro-ciklopenta[c]pirolas, neigiami alosteriniai nr2b moduliatoriai

Info

Publication number
LT3197868T
LT3197868T LTEP15844057.8T LT15844057T LT3197868T LT 3197868 T LT3197868 T LT 3197868T LT 15844057 T LT15844057 T LT 15844057T LT 3197868 T LT3197868 T LT 3197868T
Authority
LT
Lithuania
Prior art keywords
alostteric
acrylaryl
oxyaryl
nr2b
octahydro
Prior art date
Application number
LTEP15844057.8T
Other languages
English (en)
Lithuanian (lt)
Inventor
David R. Anderson
Robert A. Volkmann
Frank S. Menniti
Original Assignee
Cadent Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55581945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3197868(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cadent Therapeutics, Inc. filed Critical Cadent Therapeutics, Inc.
Publication of LT3197868T publication Critical patent/LT3197868T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEP15844057.8T 2014-09-26 2015-09-23 N-akrilaril-5-oksiaril-oktahidro-ciklopenta[c]pirolas, neigiami alosteriniai nr2b moduliatoriai LT3197868T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462056284P 2014-09-26 2014-09-26
PCT/US2015/051694 WO2016049165A1 (en) 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Publications (1)

Publication Number Publication Date
LT3197868T true LT3197868T (lt) 2020-09-10

Family

ID=55581945

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15844057.8T LT3197868T (lt) 2014-09-26 2015-09-23 N-akrilaril-5-oksiaril-oktahidro-ciklopenta[c]pirolas, neigiami alosteriniai nr2b moduliatoriai

Country Status (40)

Country Link
US (4) US10239835B2 (enExample)
EP (4) EP3197868B1 (enExample)
JP (5) JP6473227B2 (enExample)
KR (1) KR102479356B1 (enExample)
CN (1) CN106795111B (enExample)
AP (1) AP2017009832A0 (enExample)
AR (1) AR103199A1 (enExample)
AU (1) AU2015320721B2 (enExample)
BR (1) BR112017006093B1 (enExample)
CA (1) CA2962569C (enExample)
CL (1) CL2017000474A1 (enExample)
CO (1) CO2017002494A2 (enExample)
CR (1) CR20170114A (enExample)
CU (1) CU24482B1 (enExample)
CY (1) CY1123533T1 (enExample)
DK (1) DK3197868T3 (enExample)
EA (1) EA034937B1 (enExample)
EC (1) ECSP17025302A (enExample)
ES (3) ES2791327T3 (enExample)
GT (1) GT201700062A (enExample)
HR (1) HRP20200959T1 (enExample)
HU (1) HUE049698T2 (enExample)
IL (1) IL250909B (enExample)
JO (1) JO3579B1 (enExample)
LT (1) LT3197868T (enExample)
MX (1) MX374657B (enExample)
MY (1) MY182342A (enExample)
NZ (1) NZ729569A (enExample)
PE (1) PE20170893A1 (enExample)
PH (1) PH12017500513A1 (enExample)
PL (1) PL3197868T3 (enExample)
PT (1) PT3197868T (enExample)
RS (1) RS60497B1 (enExample)
SG (1) SG11201702023QA (enExample)
SI (1) SI3197868T1 (enExample)
TN (1) TN2017000076A1 (enExample)
TW (1) TWI687407B (enExample)
UY (1) UY36326A (enExample)
WO (1) WO2016049165A1 (enExample)
ZA (1) ZA201701061B (enExample)

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JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
ES3064093T3 (en) 2017-10-20 2026-04-22 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
AU2018360581A1 (en) 2017-10-31 2020-06-11 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
US11414406B2 (en) 2018-02-02 2022-08-16 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
US12054500B2 (en) 2018-03-05 2024-08-06 Arcus Biosciences, Inc. Arginase inhibitors
TW202112378A (zh) * 2019-06-04 2021-04-01 德商百靈佳殷格翰國際股份有限公司 嘌呤衍生物及其作為藥物之用途
CN113906033B (zh) 2019-06-04 2024-04-02 勃林格殷格翰国际有限公司 咪唑并吡嗪衍生物及其作为药剂的用途
CN111481543A (zh) * 2020-05-21 2020-08-04 苏州健雄职业技术学院 Nr2b负变构调节剂联合gaba受体调节剂在制备治疗阿尔兹海默症的药物中的用途
CN116744922A (zh) * 2020-12-04 2023-09-12 诺华股份有限公司 Nr2b-nmda受体nam在治疗抑郁症中的剂量方案
WO2022118264A1 (en) 2020-12-04 2022-06-09 Novartis Ag Dosage regimen for a nr2b-nmda receptor nam for the treatment of depression
JP2021058765A (ja) * 2021-01-19 2021-04-15 株式会社藤商事 遊技機
US20240199576A1 (en) * 2021-03-26 2024-06-20 Novartis Ag Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b
BR112023018766A2 (pt) * 2021-03-26 2023-10-24 Novartis Ag Moduladores alostéricos negativos de ciclopental[c]pirrol de nr2b
EP4531851A1 (en) 2022-06-02 2025-04-09 Novartis AG Subcutaneous administration of onfasprodil and dosing methods for use in the treatment of depression disorders
JP2026504068A (ja) 2023-01-12 2026-02-03 ノバルティス アーゲー 改変ケトレダクターゼポリペプチド
WO2025120013A1 (en) 2023-12-06 2025-06-12 Novartis Ag Compositions and methods for treating depression disorders

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JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول

Also Published As

Publication number Publication date
AR103199A1 (es) 2017-04-26
EP4282412A2 (en) 2023-11-29
KR20170063599A (ko) 2017-06-08
BR112017006093A2 (pt) 2017-12-19
JP6473227B2 (ja) 2019-02-20
US10239835B2 (en) 2019-03-26
JP6772307B2 (ja) 2020-10-21
ES2911004T3 (es) 2022-05-17
CU20170037A7 (es) 2017-08-08
JP2017528502A (ja) 2017-09-28
EP3197868A1 (en) 2017-08-02
EA034937B1 (ru) 2020-04-08
US12145909B2 (en) 2024-11-19
EP3197868B1 (en) 2020-04-15
JO3579B1 (ar) 2020-07-05
AU2015320721A1 (en) 2017-03-30
US20180111902A1 (en) 2018-04-26
SI3197868T1 (sl) 2020-10-30
PL3197868T3 (pl) 2020-11-02
CN106795111B (zh) 2020-04-07
UY36326A (es) 2016-04-29
JP2023052515A (ja) 2023-04-11
MX2017003940A (es) 2018-03-01
US20200369610A1 (en) 2020-11-26
TW201625528A (zh) 2016-07-16
TWI687407B (zh) 2020-03-11
US20190152912A1 (en) 2019-05-23
MX374657B (es) 2025-03-06
WO2016049165A1 (en) 2016-03-31
RS60497B1 (sr) 2020-08-31
CA2962569A1 (en) 2016-03-31
PH12017500513A1 (en) 2017-08-07
AU2015320721B2 (en) 2020-01-30
US20220274925A1 (en) 2022-09-01
CN106795111A (zh) 2017-05-31
GT201700062A (es) 2019-09-30
BR112017006093B1 (pt) 2023-03-21
PE20170893A1 (es) 2017-07-12
HUE049698T2 (hu) 2020-10-28
CL2017000474A1 (es) 2017-08-18
CR20170114A (es) 2017-08-21
DK3197868T3 (da) 2020-06-22
ECSP17025302A (es) 2018-11-30
US10781174B2 (en) 2020-09-22
CO2017002494A2 (es) 2017-08-31
SG11201702023QA (en) 2017-04-27
CU24482B1 (es) 2020-03-04
EP3197868A4 (en) 2018-04-25
PT3197868T (pt) 2020-05-21
ES2956546T3 (es) 2023-12-22
ZA201701061B (en) 2019-07-31
IL250909B (en) 2019-06-30
JP2025060835A (ja) 2025-04-10
EP3683207A1 (en) 2020-07-22
KR102479356B1 (ko) 2022-12-19
IL250909A0 (en) 2017-04-30
JP7216060B2 (ja) 2023-01-31
EA201790713A1 (ru) 2017-07-31
JP2019077713A (ja) 2019-05-23
EP3683207B1 (en) 2021-12-29
TN2017000076A1 (en) 2018-07-04
NZ729569A (en) 2019-06-28
EP4282412A3 (en) 2024-01-17
MY182342A (en) 2021-01-20
AP2017009832A0 (en) 2017-03-31
JP2021006554A (ja) 2021-01-21
EP3974420B1 (en) 2023-08-16
EP3974420A1 (en) 2022-03-30
CY1123533T1 (el) 2022-03-24
CA2962569C (en) 2023-09-19
JP7612722B2 (ja) 2025-01-14
HRP20200959T1 (hr) 2020-10-02
ES2791327T3 (es) 2020-11-03

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