CL2016002317A1 - Compuestos derivados de (4,5,7,8-tetrahidro o 7,8-dihidro)-pirazolo-[1,5-d][1,4]-diazepina, 5,6,8,9-tetrahidroimidazo-[1,2-d][1,4]-diazepina sustituidos, inhibidores de la autotaxina (atx); composiciones farmacológicas; útiles para el tratamiento de estados patológicos renales, hepáticos, del sistema nervioso central, enfermedades fibróticas y rechazo agudo y crónicos de trasplante de órganos. - Google Patents
Compuestos derivados de (4,5,7,8-tetrahidro o 7,8-dihidro)-pirazolo-[1,5-d][1,4]-diazepina, 5,6,8,9-tetrahidroimidazo-[1,2-d][1,4]-diazepina sustituidos, inhibidores de la autotaxina (atx); composiciones farmacológicas; útiles para el tratamiento de estados patológicos renales, hepáticos, del sistema nervioso central, enfermedades fibróticas y rechazo agudo y crónicos de trasplante de órganos.Info
- Publication number
- CL2016002317A1 CL2016002317A1 CL2016002317A CL2016002317A CL2016002317A1 CL 2016002317 A1 CL2016002317 A1 CL 2016002317A1 CL 2016002317 A CL2016002317 A CL 2016002317A CL 2016002317 A CL2016002317 A CL 2016002317A CL 2016002317 A1 CL2016002317 A1 CL 2016002317A1
- Authority
- CL
- Chile
- Prior art keywords
- diazepine
- hepatic
- renal
- treatment
- nervous system
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002440 hepatic effect Effects 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- POXWDTQUDZUOGP-UHFFFAOYSA-N 1h-1,4-diazepine Chemical group N1C=CC=NC=C1 POXWDTQUDZUOGP-UHFFFAOYSA-N 0.000 title 1
- SURHWLZWEACCGO-UHFFFAOYSA-N 6,7,8,9-tetrahydro-5h-imidazo[1,2-d][1,4]diazepine Chemical group C1CNCCC2=NC=CN21 SURHWLZWEACCGO-UHFFFAOYSA-N 0.000 title 1
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title 1
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title 1
- 206010052779 Transplant rejections Diseases 0.000 title 1
- 230000001154 acute effect Effects 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003176 fibrotic effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000000056 organ Anatomy 0.000 title 1
- 239000008196 pharmacological composition Substances 0.000 title 1
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161756 | 2014-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016002317A1 true CL2016002317A1 (es) | 2017-03-17 |
Family
ID=50389847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016002317A CL2016002317A1 (es) | 2014-03-26 | 2016-09-14 | Compuestos derivados de (4,5,7,8-tetrahidro o 7,8-dihidro)-pirazolo-[1,5-d][1,4]-diazepina, 5,6,8,9-tetrahidroimidazo-[1,2-d][1,4]-diazepina sustituidos, inhibidores de la autotaxina (atx); composiciones farmacológicas; útiles para el tratamiento de estados patológicos renales, hepáticos, del sistema nervioso central, enfermedades fibróticas y rechazo agudo y crónicos de trasplante de órganos. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10669285B2 (enExample) |
| EP (1) | EP3122751B1 (enExample) |
| JP (1) | JP6554481B2 (enExample) |
| KR (1) | KR20160128428A (enExample) |
| CN (1) | CN106029667B (enExample) |
| AR (1) | AR099823A1 (enExample) |
| AU (1) | AU2015238541B2 (enExample) |
| CA (1) | CA2935612A1 (enExample) |
| CL (1) | CL2016002317A1 (enExample) |
| CR (1) | CR20160418A (enExample) |
| EA (1) | EA032357B1 (enExample) |
| IL (1) | IL246501B (enExample) |
| MX (1) | MX373236B (enExample) |
| PE (1) | PE20161223A1 (enExample) |
| PH (1) | PH12016501633B1 (enExample) |
| SG (1) | SG11201607845RA (enExample) |
| TW (1) | TWI678370B (enExample) |
| UA (1) | UA119347C2 (enExample) |
| WO (1) | WO2015144609A1 (enExample) |
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| PT2861566T (pt) | 2012-06-13 | 2017-02-08 | Hoffmann La Roche | Novos diazaspirocicloalcanos e azaspirocicloalcanos |
| AU2013322838B2 (en) | 2012-09-25 | 2018-02-01 | F. Hoffmann-La Roche Ag | New bicyclic derivatives |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| AU2014356583B2 (en) | 2013-11-26 | 2019-02-28 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl |
| KR102408261B1 (ko) | 2014-02-03 | 2022-06-10 | 비타이 파마슈티컬즈, 엘엘씨 | Ror-감마의 디하이드로피롤로피리딘 저해제 |
| WO2015144609A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
| KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
| CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
| CR20180072A (es) | 2015-09-24 | 2018-02-26 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de atx |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| EP3868750A1 (en) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| AR110282A1 (es) * | 2016-12-02 | 2019-03-13 | Hoffmann La Roche | Compuestos de amida bicíclica y uso de éstos en el tratamiento de enfermedades mediadas por rip1 |
| CN110382484B (zh) * | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| SG11201908560SA (en) * | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| AR112274A1 (es) | 2017-07-14 | 2019-10-09 | Hoffmann La Roche | Compuestos bicíclicos de cetona y sus métodos de uso |
| CN111225914B (zh) | 2017-07-24 | 2022-10-11 | 生命医药有限责任公司 | RORγ的抑制剂 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| MX2020003451A (es) | 2017-10-31 | 2020-08-03 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de uso de los mismos. |
| TW202043229A (zh) | 2019-01-11 | 2020-12-01 | 瑞士商赫孚孟拉羅股份公司 | 雙環酮化合物及其使用方法 |
| AU2022356017B2 (en) * | 2021-10-01 | 2024-05-30 | Nextgen Bioscience Co., Ltd. | Novel piperidine derivative and pharmaceutical composition for inhibiting autotaxin comprising same |
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-
2015
- 2015-03-23 WO PCT/EP2015/056041 patent/WO2015144609A1/en not_active Ceased
- 2015-03-23 CN CN201580008228.8A patent/CN106029667B/zh not_active Expired - Fee Related
- 2015-03-23 UA UAA201610688A patent/UA119347C2/uk unknown
- 2015-03-23 EA EA201691794A patent/EA032357B1/ru not_active IP Right Cessation
- 2015-03-23 CR CR20160418A patent/CR20160418A/es unknown
- 2015-03-23 SG SG11201607845RA patent/SG11201607845RA/en unknown
- 2015-03-23 AU AU2015238541A patent/AU2015238541B2/en not_active Ceased
- 2015-03-23 CA CA2935612A patent/CA2935612A1/en not_active Abandoned
- 2015-03-23 JP JP2016558222A patent/JP6554481B2/ja not_active Expired - Fee Related
- 2015-03-23 PE PE2016001541A patent/PE20161223A1/es active IP Right Grant
- 2015-03-23 MX MX2016010675A patent/MX373236B/es active IP Right Grant
- 2015-03-23 KR KR1020167029704A patent/KR20160128428A/ko not_active Ceased
- 2015-03-23 EP EP15711207.9A patent/EP3122751B1/en active Active
- 2015-03-25 TW TW104109652A patent/TWI678370B/zh not_active IP Right Cessation
- 2015-03-25 AR ARP150100864A patent/AR099823A1/es unknown
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2016
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- 2016-08-16 PH PH12016501633A patent/PH12016501633B1/en unknown
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- 2016-09-21 US US15/272,085 patent/US10669285B2/en active Active
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2020
- 2020-03-02 US US16/806,302 patent/US20200199155A1/en not_active Abandoned
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| US20200199155A1 (en) | 2020-06-25 |
| CR20160418A (es) | 2016-11-07 |
| EP3122751B1 (en) | 2019-10-30 |
| IL246501B (en) | 2020-01-30 |
| PH12016501633A1 (en) | 2017-02-06 |
| AU2015238541A1 (en) | 2016-07-14 |
| CA2935612A1 (en) | 2015-10-01 |
| AU2015238541B2 (en) | 2019-09-19 |
| EA201691794A1 (ru) | 2017-01-30 |
| EA032357B1 (ru) | 2019-05-31 |
| PH12016501633B1 (en) | 2017-02-06 |
| UA119347C2 (uk) | 2019-06-10 |
| JP6554481B2 (ja) | 2019-07-31 |
| SG11201607845RA (en) | 2016-10-28 |
| TW201625646A (zh) | 2016-07-16 |
| AR099823A1 (es) | 2016-08-24 |
| US10669285B2 (en) | 2020-06-02 |
| MX2016010675A (es) | 2016-11-10 |
| IL246501A0 (en) | 2016-08-31 |
| KR20160128428A (ko) | 2016-11-07 |
| CN106029667A (zh) | 2016-10-12 |
| PE20161223A1 (es) | 2016-11-12 |
| CN106029667B (zh) | 2019-08-23 |
| EP3122751A1 (en) | 2017-02-01 |
| TWI678370B (zh) | 2019-12-01 |
| MX373236B (es) | 2020-05-08 |
| WO2015144609A1 (en) | 2015-10-01 |
| JP2017510576A (ja) | 2017-04-13 |
| US20170008913A1 (en) | 2017-01-12 |
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