CL2016001134A1 - Celula t o celula asesina natural (nk) que expresa dos receptores de antigeno quimerico (car), donde un car comprende un endodominio activador y el otro un dominio inhibitorio de proteina tirosina fosfatasa que contiene el dominio src (sh2); acido nucleico; vector; metodo de produccion; composicion; uso para preparar medicamento. - Google Patents
Celula t o celula asesina natural (nk) que expresa dos receptores de antigeno quimerico (car), donde un car comprende un endodominio activador y el otro un dominio inhibitorio de proteina tirosina fosfatasa que contiene el dominio src (sh2); acido nucleico; vector; metodo de produccion; composicion; uso para preparar medicamento.Info
- Publication number
- CL2016001134A1 CL2016001134A1 CL2016001134A CL2016001134A CL2016001134A1 CL 2016001134 A1 CL2016001134 A1 CL 2016001134A1 CL 2016001134 A CL2016001134 A CL 2016001134A CL 2016001134 A CL2016001134 A CL 2016001134A CL 2016001134 A1 CL2016001134 A1 CL 2016001134A1
- Authority
- CL
- Chile
- Prior art keywords
- car
- domain
- cell
- endodomain
- nucleic acid
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 7
- 102000036639 antigens Human genes 0.000 title abstract 7
- 108091007433 antigens Proteins 0.000 title abstract 7
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title abstract 5
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 title abstract 5
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 title abstract 5
- 230000003213 activating effect Effects 0.000 title abstract 5
- 230000002401 inhibitory effect Effects 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title abstract 5
- 210000000822 natural killer cell Anatomy 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000006306 Antigen Receptors Human genes 0.000 abstract 2
- 108010083359 Antigen Receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000006850 spacer group Chemical group 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000002463 transducing effect Effects 0.000 abstract 1
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Abstract
Se describe una célula T que coexpresa un primer receptor antigénico (CAR) y un segundo CAR en la superficie celular, y cada CAR comprende: (i) un dominio de unión a antígenos, (ii) un espaciador, (iii) un dominio transmembranal; y (iv) un endodominio, donde los dominios de unión a antígeno del primer y segundo CAR se unen a diferentes antígenos, y en donde uno del primer o segundo CAR es un CAR activador que comprende un endodominio activador, y el otro CAR es un CAR inhibitorio que comprende un endodominio inhibitorio de ligación encendida que comprende un dominio de tirosina fosfatasa de una proteína tirosina fosfatasa que contiene el dominio homologo Src (SH2); una secuencia de ácido nucleico que codifica dichos primer y segundo CAR; un kit que comprende las secuencia de ácido nucleico que codifican dichos primer y segundo CAR; un kit que comprende un primer y un segundo vector que comprenden dichas secuencias de ácido nucleico; un método para elaborar dicha célula T; una composición farmacéutica que comprende dichas células T y un vehículo, diluyente o excipiente farmacéuticamente aceptable; el uso de diha composición farmacéutica para preparar un medicamento útil para tratar y/o prevenir el cáncer; el uso de dichas células T para preparar un medicamento para tratar y/o prevenir el cáncer; una célula asesina natural (NK) que coexpresa un primer receptor antigénico (CAR) y un segundo CAR en la superficie celular, y cada CAR comprende: (i) un dominio de unión a antígenos, (ii) un espaciador, (iii) un dominio transmembranal; y (iv) un endodominio, donde los dominios de unión a antígenos del primer y segundo CAR se unen a diferentes antígenos, y en donde uno del primer o segundo CAR es un CAR activador que comprende un endodominio activador, y el otro CAR es un CAR inhibitorio que comprende un endodominio inhibitorio de ligación encendida que comprende un dominio de tirosina fosfatasa de una proteína tirosina fosfatasa que contiene el dominio homologo Src (SH2); y una composición de células que comprende las células T que expresan CAR y/o células NK que expresan CAR de acuerdo con la reivindicación 20, elaborada al transducir una muestra de sangre ex vivo con un ácido nucleico que codifica el primer y segundo CAR.
Applications Claiming Priority (2)
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GB201320573A GB201320573D0 (en) | 2013-11-21 | 2013-11-21 | T Cell |
GB201410934A GB201410934D0 (en) | 2014-06-19 | 2014-06-19 | T cell |
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CL2016001134A1 true CL2016001134A1 (es) | 2017-05-19 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CL2016001135A CL2016001135A1 (es) | 2013-11-21 | 2016-05-12 | Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio. |
CL2016001134A CL2016001134A1 (es) | 2013-11-21 | 2016-05-12 | Celula t o celula asesina natural (nk) que expresa dos receptores de antigeno quimerico (car), donde un car comprende un endodominio activador y el otro un dominio inhibitorio de proteina tirosina fosfatasa que contiene el dominio src (sh2); acido nucleico; vector; metodo de produccion; composicion; uso para preparar medicamento. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CL2016001135A CL2016001135A1 (es) | 2013-11-21 | 2016-05-12 | Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio. |
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EP (6) | EP3071222B1 (es) |
JP (4) | JP6433498B2 (es) |
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CN (2) | CN105792840B (es) |
AU (2) | AU2014351558B2 (es) |
BR (2) | BR112016011460A2 (es) |
CA (2) | CA2930215C (es) |
CL (2) | CL2016001135A1 (es) |
DK (2) | DK3071223T3 (es) |
ES (2) | ES2832586T3 (es) |
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PT (2) | PT3071223T (es) |
RU (2) | RU2717984C2 (es) |
SG (2) | SG11201603484PA (es) |
WO (3) | WO2015075470A1 (es) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
US11879016B2 (en) | 2014-03-06 | 2024-01-23 | Autolus Limited | Chimeric antigen receptor |
US11885806B2 (en) | 2014-03-05 | 2024-01-30 | Autolus Limited | Method for depleting malignant T-cells |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9724404B2 (en) | 2009-04-13 | 2017-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | HPV particles and uses thereof |
EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
PL3046583T3 (pl) | 2013-09-18 | 2019-10-31 | Aura Biosciences Inc | Koniugaty cząstek wirusopodobnych do leczenia nowotworów |
GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
CA2930215C (en) | 2013-11-21 | 2021-04-27 | Ucl Business Plc | A cell comprising more than one chimeric antigen receptor |
JP6943568B2 (ja) | 2013-12-06 | 2021-10-06 | アメリカ合衆国 | 胸腺間質性リンパ球新生因子受容体特異的キメラ抗原受容体及びそれを使用する方法 |
US10865242B2 (en) | 2014-04-10 | 2020-12-15 | Seattle Children's Hospital | Method and compositions for cellular immunotherapy |
CA2948462A1 (en) | 2014-05-15 | 2015-11-19 | National University Of Singapore | Modified natural killer cells and uses thereof |
GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
AU2015289644A1 (en) | 2014-07-15 | 2017-02-02 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
GB201415347D0 (en) * | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
US20170296623A1 (en) * | 2014-12-17 | 2017-10-19 | Cellectis | INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN |
PT3560953T (pt) * | 2014-12-24 | 2024-03-26 | Autolus Ltd | Célula |
WO2016123143A1 (en) * | 2015-01-26 | 2016-08-04 | The University Of Chicago | CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2 |
BR112017015453A2 (pt) | 2015-01-26 | 2018-01-23 | Cellectis | células imunes modificadas knockout para receptor de células t, dotadas de receptores quiméricos de antígeno, de ligação a cd123 para o tratamento de linfoma mieloide agudo recorrente/refratário ou neoplasia blástica de células dendríticas plasmacitoides |
WO2016126213A1 (en) | 2015-02-06 | 2016-08-11 | National University Of Singapore | Methods for enhancing efficacy of therapeutic immune cells |
CN114230670A (zh) * | 2015-02-27 | 2022-03-25 | 美商生物细胞基因治疗有限公司 | 靶向血液恶性肿瘤之嵌合抗原受体(car)、其组合物及使用方法 |
BR112017021500A2 (pt) | 2015-04-08 | 2018-09-25 | Novartis Ag | terapias com cd20, terapias com cd22 e terapias de combinação com uma célula que expressa (car) receptor de antígeno quimérico de cd19 |
WO2016172606A1 (en) * | 2015-04-23 | 2016-10-27 | Baylor College Of Medicine | Cd5 chimeric antigen receptor for adoptive t cell therapy |
GB201507115D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
GB201507111D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
GB201507119D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
GB201507108D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
EP3288570A4 (en) * | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
GB201507368D0 (en) * | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
PL3294764T3 (pl) * | 2015-05-15 | 2021-06-28 | City Of Hope | Kompozycje chimerycznego receptora antygenowego |
US20180161368A1 (en) * | 2015-05-29 | 2018-06-14 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
AU2016275030B2 (en) | 2015-06-10 | 2021-12-09 | Nantkwest, Inc. | Modified NK-92 cells for treating cancer |
CN107849112B (zh) | 2015-06-25 | 2022-04-01 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(car)、组合物及其使用方法 |
US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
EP3331920A4 (en) | 2015-08-07 | 2019-04-03 | Seattle Children's Hospital, dba Seattle Children's Research Institute | T CARRIER CARRIER CELLS FOR BISPECIFICATION OF SOLID TUMOR TARGETING |
GB201514874D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
GB201518817D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Cell |
CA3003728A1 (en) * | 2015-10-30 | 2017-05-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Targeted cancer therapy |
BR112018067679A2 (pt) * | 2016-03-04 | 2019-01-15 | Novartis Ag | células que expressam múltiplas moléculas do receptor de antígeno quimérico (car) e seu uso |
WO2017193059A1 (en) | 2016-05-06 | 2017-11-09 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
US10222369B2 (en) * | 2016-05-17 | 2019-03-05 | Chimera Bioengineering, Inc. | Methods for making novel antigen binding domains |
CN109562126A (zh) | 2016-06-24 | 2019-04-02 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(car)、组合物及其使用方法 |
CA3035615A1 (en) * | 2016-09-02 | 2018-03-08 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with duocars |
WO2018045811A1 (zh) * | 2016-09-09 | 2018-03-15 | 科济生物医药(上海)有限公司 | 融合蛋白及其应用 |
EP3519443A4 (en) * | 2016-09-30 | 2020-06-10 | Baylor College of Medicine | CHIMERIC ANTIGEN RECEPTOR THERAPY WITH REDUCED CYTOTOXICITY FOR VIRAL DISEASE |
EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
AU2017357649A1 (en) * | 2016-11-11 | 2019-05-23 | Autolus Limited | Chimeric antigen receptor |
SG10201912387PA (en) | 2016-11-22 | 2020-02-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
EP3551197B1 (en) | 2016-12-12 | 2023-11-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
EP3568406A4 (en) * | 2017-01-10 | 2020-10-21 | The General Hospital Corporation | T-CELLS WITH EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR |
EP3577134A1 (en) * | 2017-01-31 | 2019-12-11 | Novartis AG | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
BR112019020001A2 (pt) | 2017-03-27 | 2020-04-28 | Nat Univ Singapore | linhagens celulares estimuladoras para expansão ex vivo e ativação de células exterminadoras naturais |
CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
GB201707779D0 (en) | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
GB201707783D0 (en) * | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
AU2018270078A1 (en) * | 2017-05-15 | 2019-11-07 | Autolus Limited | A cell comprising a chimeric antigen receptor (CAR) |
JP2020530993A (ja) * | 2017-08-02 | 2020-11-05 | オートラス リミテッド | キメラ抗原受容体または改変tcrを発現し、選択的に発現されるヌクレオチド配列を含む細胞 |
SG11202000402PA (en) | 2017-08-10 | 2020-02-27 | Nat Univ Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
FI3688155T3 (fi) | 2017-09-28 | 2023-03-30 | Immpact Bio Ltd | Universaali alusta inhibitorisen kimeerisen antigeenireseptorin (icar) valmistamiseksi |
US11905528B2 (en) * | 2017-10-12 | 2024-02-20 | Icell Gene Therapeutics Inc. | Compound chimeric antigen receptor (cCAR) targeting multiple antigens, compositions and methods of use thereof |
WO2019084273A1 (en) | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | METHODS OF ANTI-CD45-BASED LYMPHODEPPLICATION AND USES THEREOF IN COMBINATION WITH ACT-BASED ANTICANCER THERAPIES |
GB201717524D0 (en) | 2017-10-25 | 2017-12-06 | Autolus Ltd | Vectors |
GB201803079D0 (en) * | 2018-02-26 | 2018-04-11 | Autolus Ltd | Cell |
CN112004829A (zh) * | 2018-03-12 | 2020-11-27 | 南克维斯特公司 | Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途 |
GB201807870D0 (en) | 2018-05-15 | 2018-06-27 | Autolus Ltd | A CD79-specific chimeric antigen receptor |
JP7335272B2 (ja) | 2018-05-15 | 2023-08-29 | オートラス リミテッド | キメラ抗原受容体 |
CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
GB201813178D0 (en) | 2018-08-13 | 2018-09-26 | Autolus Ltd | Cell |
EP3856775A2 (en) | 2018-09-27 | 2021-08-04 | Autolus Limited | Chimeric antigen receptor |
EP3632460A1 (en) * | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
EP3632461A1 (en) * | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
CN113164576A (zh) * | 2018-10-05 | 2021-07-23 | 圣安娜儿童癌症研究中心 | 嵌合抗原受体(car)组 |
US20220041687A1 (en) * | 2018-10-05 | 2022-02-10 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
GB201816522D0 (en) | 2018-10-10 | 2018-11-28 | Autolus Ltd | Methods and reagents for analysing nucleic acids from single cells |
MX2021006968A (es) | 2018-12-12 | 2021-10-13 | Kite Pharma Inc | Antígeno quimérico y receptores de las células t, y métodos de uso. |
CA3124444A1 (en) | 2019-01-23 | 2020-07-30 | Miltenyi Biotec B.V. & Co. KG | A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject |
CN113766956B (zh) | 2019-03-05 | 2024-05-07 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
GB201903237D0 (en) | 2019-03-08 | 2019-04-24 | Autolus Ltd | Method |
JP2022524042A (ja) | 2019-03-08 | 2022-04-27 | オートラス リミテッド | 操作されたキメラ抗原受容体およびcarの調節因子を含む組成物および方法 |
MX2021013225A (es) * | 2019-05-01 | 2022-01-06 | Pact Pharma Inc | Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8. |
GB201909144D0 (en) | 2019-06-25 | 2019-08-07 | Autolus Ltd | Culture medium |
GB201910185D0 (en) | 2019-07-16 | 2019-08-28 | Autolus Ltd | Method |
US20220257757A1 (en) | 2019-07-16 | 2022-08-18 | Autolus Limited | Method for preconditioning a subject who is about to receive a t-cell therapy |
CN114585371A (zh) * | 2019-08-20 | 2022-06-03 | 森迪生物科学公司 | 嵌合抑制性受体 |
WO2021044213A2 (en) * | 2019-09-05 | 2021-03-11 | Migal-galilee Research Institute Ltd. | Blocking chimeric antigen receptors for prevention of undesired activation of effector and regulatory immune cells |
BR112022006782A2 (pt) * | 2019-10-08 | 2022-09-06 | Provincial Health Services Authority | Receptores de citocina quiméricos |
EP4065157A1 (en) | 2019-11-26 | 2022-10-05 | Novartis AG | Cd19 and cd22 chimeric antigen receptors and uses thereof |
EP4073103A1 (en) * | 2019-12-11 | 2022-10-19 | A2 Biotherapeutics, Inc. | Lilrb1-based chimeric antigen receptor |
EP4100027A1 (en) | 2020-02-04 | 2022-12-14 | Miltenyi Biotec B.V. & Co. KG | Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens |
TW202144396A (zh) * | 2020-02-20 | 2021-12-01 | 美商聖堤生物科技股份有限公司 | 抑制性嵌合受體架構 |
JP2023515471A (ja) * | 2020-02-20 | 2023-04-13 | センティ バイオサイエンシズ インコーポレイテッド | 抑制性キメラ受容体構造物 |
GB202007044D0 (en) | 2020-05-13 | 2020-06-24 | Autolus Ltd | Method |
EP3915578A1 (en) | 2020-05-28 | 2021-12-01 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor with a spacer comprising c2-set ig-like domains |
GB202008957D0 (en) | 2020-06-12 | 2020-07-29 | Autolus Ltd | Culture medium |
WO2022016119A1 (en) | 2020-07-17 | 2022-01-20 | Simurx, Inc. | Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
CA3188867A1 (en) | 2020-08-20 | 2022-02-24 | Xueyin Wang | Compositions and methods for treating ceacam positive cancers |
JP2023538116A (ja) | 2020-08-20 | 2023-09-06 | エー2 バイオセラピューティクス, インコーポレイテッド | Egfr陽性がんを治療するための組成物及び方法 |
KR20230051677A (ko) | 2020-08-20 | 2023-04-18 | 에이투 바이오쎄라퓨틱스, 인크. | 메소텔린 양성 암을 치료하기 위한 조성물 및 방법 |
US20220089674A1 (en) * | 2020-09-21 | 2022-03-24 | A2 Biotherapeutics, Inc. | Engineered immune cells that modulate receptor expression |
JP2023545491A (ja) * | 2020-10-15 | 2023-10-30 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ナチュラルキラー細胞受容体の阻害のための組成物及び方法 |
EP4240404A1 (en) | 2020-11-09 | 2023-09-13 | Miltenyi Biotec B.V. & Co. KG | Methods and compositions for eliminating engineered immune cells |
JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
CN117597358A (zh) | 2021-02-16 | 2024-02-23 | A2生物治疗股份有限公司 | 用于治疗her2阳性癌症的组合物和方法 |
WO2023023602A1 (en) * | 2021-08-19 | 2023-02-23 | Boan Boston Llc | Fusion proteins for dephosphorylating proteins that regulate t cell activation through the tcr signaling pathway |
GB202112923D0 (en) | 2021-09-10 | 2021-10-27 | Ucl Business Ltd | Binding domain |
WO2023057285A1 (en) | 2021-10-06 | 2023-04-13 | Miltenyi Biotec B.V. & Co. KG | Method for targeted gene insertion into immune cells |
WO2023218381A1 (en) | 2022-05-11 | 2023-11-16 | Autolus Limited | Cd19/22 car t-cell treatment of high risk or relapsed pediatric acute lymphoblastic leukemia |
GB202209920D0 (en) | 2022-07-06 | 2022-08-17 | Autolus Ltd | Cell |
WO2024078995A1 (en) | 2022-10-15 | 2024-04-18 | Miltenyi Biotec B.V. & Co. KG | Transduction of gammadelta t cells with pseudotyped retroviral vectors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4418900A (en) | 1999-04-16 | 2000-11-02 | Celltech Therapeutics Limited | Synthetic transmembrane components |
GB9908807D0 (en) | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Synthetic signalling molecules |
WO2002077029A2 (en) * | 2000-11-07 | 2002-10-03 | City Of Hope | Cd19-specific redirected immune cells |
CA2468292A1 (en) * | 2001-11-26 | 2003-06-05 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
EP2389443B1 (en) * | 2009-01-23 | 2018-11-14 | Roger Williams Hospital | Retroviral vectors encoding multiple highly homologous non-viral polypeptides and the use of same |
US9212229B2 (en) * | 2010-09-08 | 2015-12-15 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
WO2013126726A1 (en) * | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
CA2904265C (en) | 2013-03-15 | 2023-08-08 | Victor D. FEDOROV | Compositions and methods for immunotherapy |
CA2930215C (en) | 2013-11-21 | 2021-04-27 | Ucl Business Plc | A cell comprising more than one chimeric antigen receptor |
US10865242B2 (en) * | 2014-04-10 | 2020-12-15 | Seattle Children's Hospital | Method and compositions for cellular immunotherapy |
GB201507115D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
GB201507119D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
GB201518817D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Cell |
-
2014
- 2014-11-21 CA CA2930215A patent/CA2930215C/en active Active
- 2014-11-21 RU RU2016124280A patent/RU2717984C2/ru active
- 2014-11-21 EP EP14806355.5A patent/EP3071222B1/en active Active
- 2014-11-21 SG SG11201603484PA patent/SG11201603484PA/en unknown
- 2014-11-21 JP JP2016532581A patent/JP6433498B2/ja active Active
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11885806B2 (en) | 2014-03-05 | 2024-01-30 | Autolus Limited | Method for depleting malignant T-cells |
US11885807B2 (en) | 2014-03-05 | 2024-01-30 | Autolus Limited | Method for depleting malignant T-cells |
US11879016B2 (en) | 2014-03-06 | 2024-01-23 | Autolus Limited | Chimeric antigen receptor |
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
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