CL2012000585A1 - Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante. - Google Patents
Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante.Info
- Publication number
- CL2012000585A1 CL2012000585A1 CL2012000585A CL2012000585A CL2012000585A1 CL 2012000585 A1 CL2012000585 A1 CL 2012000585A1 CL 2012000585 A CL2012000585 A CL 2012000585A CL 2012000585 A CL2012000585 A CL 2012000585A CL 2012000585 A1 CL2012000585 A1 CL 2012000585A1
- Authority
- CL
- Chile
- Prior art keywords
- aluminum
- tlr7
- immunogenic composition
- composition
- antigen
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
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- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
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- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN INMUNOGENICA QUE COMPRENDE (I) UN COMPUESTO DE FÓRMULA (I), Ó UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, (II) UN ANTIGENO, Y (III) UN ADYUVANTE QUE CONTIENE ALUMINIO: EN DONDE EL ADYUVANTE QUE CONTIENE ALUMINIO ES SELECCIONADO DE HIDRÓXIDO DE ALUMINIO, OXIHIDROXIDO DE ALUMINIO, Y HIDROXIFOSFATO DE ALUMINIO: Y EN DONDE EL COMPUESTO DE FÓRMULA (I) ES UN AGONISTA DE TLR7; UN MÉTODO PARA MEJORAR SU EFECTIVIDAD, Y SU USO PARA AUMENTAR LA RESPUESTA INMUNE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23915609P | 2009-09-02 | 2009-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012000585A1 true CL2012000585A1 (es) | 2012-09-14 |
Family
ID=43415378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012000585A CL2012000585A1 (es) | 2009-09-02 | 2012-03-02 | Composición inmunogénica que comprende un compuesto agonista de un receptor tipo toll 7 (tlr7) o una sal de este, un antígeno, y un adyuvante que contiene aluminio; método para mejorar la efectividad de una composición inmunogénica que comprende adicionar dicha composición que contiene un agonista de tlr7; y su uso como inmunoestimulante. |
Country Status (15)
Country | Link |
---|---|
US (1) | US9950062B2 (es) |
EP (1) | EP2459216B1 (es) |
JP (1) | JP5988492B2 (es) |
CN (1) | CN102844047B (es) |
AU (1) | AU2010290896B2 (es) |
BR (1) | BR112012004806B8 (es) |
CA (1) | CA2772916C (es) |
CL (1) | CL2012000585A1 (es) |
DK (1) | DK2459216T3 (es) |
EA (1) | EA026401B1 (es) |
ES (1) | ES2443952T3 (es) |
MX (1) | MX2012002723A (es) |
NZ (1) | NZ598654A (es) |
SG (1) | SG178954A1 (es) |
WO (1) | WO2011027222A2 (es) |
Cited By (1)
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US11324821B2 (en) | 2017-10-16 | 2022-05-10 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
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SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
RS54489B1 (en) | 2010-07-06 | 2016-06-30 | Glaxosmithkline Biologicals Sa | LIPOSOMS WITH LIPIDS THAT HAVE IMPROVED PKA VALUE FOR RNA RELEASE |
EP2590670B1 (en) | 2010-07-06 | 2017-08-23 | GlaxoSmithKline Biologicals SA | Methods of raising an immune response by delivery of rna |
PL3970742T3 (pl) | 2010-08-31 | 2022-09-19 | Glaxosmithkline Biologicals S.A. | Pegylowane liposomy do dostarczania rna kodującego immunogen |
US20120177681A1 (en) * | 2010-09-01 | 2012-07-12 | Manmohan Singh | Formulation of immunopotentiators |
US20140030292A1 (en) | 2010-10-11 | 2014-01-30 | Novartis Ag | Antigen delivery platforms |
EP2652511B8 (en) | 2010-12-14 | 2017-06-28 | GlaxoSmithKline Biologicals SA | Flow cytometry analysis of materials adsorbed to metal salts |
SG191830A1 (en) | 2011-01-10 | 2013-08-30 | Cleveland Biolabs Inc | Use of toll-like receptor agonist for treating cancer |
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US20150030630A1 (en) | 2012-03-07 | 2015-01-29 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
RU2014140521A (ru) * | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
EP2892553A1 (en) | 2012-09-06 | 2015-07-15 | Novartis AG | Combination vaccines with serogroup b meningococcus and d/t/p |
CA2888721A1 (en) | 2012-10-25 | 2014-05-01 | Glaxosmithkline Biologicals Sa | Nicotinamide as adjuvant |
-
2010
- 2010-09-01 SG SG2012014833A patent/SG178954A1/en unknown
- 2010-09-01 NZ NZ598654A patent/NZ598654A/en not_active IP Right Cessation
- 2010-09-01 ES ES10766332.0T patent/ES2443952T3/es active Active
- 2010-09-01 WO PCT/IB2010/002386 patent/WO2011027222A2/en active Application Filing
- 2010-09-01 EA EA201270356A patent/EA026401B1/ru not_active IP Right Cessation
- 2010-09-01 MX MX2012002723A patent/MX2012002723A/es active IP Right Grant
- 2010-09-01 AU AU2010290896A patent/AU2010290896B2/en active Active
- 2010-09-01 CA CA2772916A patent/CA2772916C/en active Active
- 2010-09-01 EP EP10766332.0A patent/EP2459216B1/en active Active
- 2010-09-01 BR BR112012004806A patent/BR112012004806B8/pt active IP Right Grant
- 2010-09-01 DK DK10766332.0T patent/DK2459216T3/da active
- 2010-09-01 JP JP2012527403A patent/JP5988492B2/ja active Active
- 2010-09-01 US US13/394,036 patent/US9950062B2/en active Active
- 2010-09-01 CN CN201080049574.8A patent/CN102844047B/zh active Active
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2012
- 2012-03-02 CL CL2012000585A patent/CL2012000585A1/es unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11324821B2 (en) | 2017-10-16 | 2022-05-10 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
Also Published As
Publication number | Publication date |
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EP2459216B1 (en) | 2013-10-30 |
MX2012002723A (es) | 2012-04-11 |
CN102844047A (zh) | 2012-12-26 |
DK2459216T3 (da) | 2013-12-09 |
EA026401B1 (ru) | 2017-04-28 |
BR112012004806B8 (pt) | 2022-10-04 |
CA2772916C (en) | 2019-01-15 |
JP2013503845A (ja) | 2013-02-04 |
BR112012004806A2 (pt) | 2016-11-29 |
JP5988492B2 (ja) | 2016-09-07 |
ES2443952T3 (es) | 2014-02-21 |
CA2772916A1 (en) | 2011-03-10 |
EA201270356A1 (ru) | 2012-09-28 |
US20120237546A1 (en) | 2012-09-20 |
AU2010290896A1 (en) | 2012-04-05 |
NZ598654A (en) | 2014-05-30 |
US9950062B2 (en) | 2018-04-24 |
CN102844047B (zh) | 2017-04-05 |
WO2011027222A2 (en) | 2011-03-10 |
WO2011027222A3 (en) | 2011-05-05 |
BR112012004806B1 (pt) | 2020-12-29 |
EP2459216A2 (en) | 2012-06-06 |
AU2010290896B2 (en) | 2014-07-03 |
SG178954A1 (en) | 2012-04-27 |
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