CL2011000420A1 - Ester ter-butilico del acido [6-(5-etoximetoxi-benzofuran-2-il)-2-nitro-piridin-3-il]-metil-carbamico; proceso de preparacion; ester ter-butilico del acido [5-(5-etoximetoxi-benzofuran-2-il)-6-nitro-piridin-2-il]-metilcarbamico; y su uso como precursor para preparar un compuesto marcado. - Google Patents
Ester ter-butilico del acido [6-(5-etoximetoxi-benzofuran-2-il)-2-nitro-piridin-3-il]-metil-carbamico; proceso de preparacion; ester ter-butilico del acido [5-(5-etoximetoxi-benzofuran-2-il)-6-nitro-piridin-2-il]-metilcarbamico; y su uso como precursor para preparar un compuesto marcado.Info
- Publication number
- CL2011000420A1 CL2011000420A1 CL2011000420A CL2011000420A CL2011000420A1 CL 2011000420 A1 CL2011000420 A1 CL 2011000420A1 CL 2011000420 A CL2011000420 A CL 2011000420A CL 2011000420 A CL2011000420 A CL 2011000420A CL 2011000420 A1 CL2011000420 A1 CL 2011000420A1
- Authority
- CL
- Chile
- Prior art keywords
- ethoxymethoxy
- benzofuran
- pyridin
- nitro
- butyl ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Ester terbutílico del ácido [6-(5-etoximetoxi-benzofuran-2-il)-2-nitro-piridin-3-il]-metil-carbamico, y su forma cristalina; proceso de preparación; ester terbutílico del ácido [5-(5-etoximetoxi-benzofuran-2-il)-6-nitro-piridin-2-il]-metil-carbamico, y su forma cristalina; y su uso como precursor para preparar un compuesto marcado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9285108P | 2008-08-29 | 2008-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011000420A1 true CL2011000420A1 (es) | 2011-07-15 |
Family
ID=41721733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011000420A CL2011000420A1 (es) | 2008-08-29 | 2011-02-25 | Ester ter-butilico del acido [6-(5-etoximetoxi-benzofuran-2-il)-2-nitro-piridin-3-il]-metil-carbamico; proceso de preparacion; ester ter-butilico del acido [5-(5-etoximetoxi-benzofuran-2-il)-6-nitro-piridin-2-il]-metilcarbamico; y su uso como precursor para preparar un compuesto marcado. |
Country Status (22)
Country | Link |
---|---|
US (3) | US8193363B2 (es) |
EP (1) | EP2328891B1 (es) |
JP (1) | JP5613669B2 (es) |
KR (1) | KR101648848B1 (es) |
CN (3) | CN102197036B (es) |
AR (2) | AR073230A1 (es) |
AU (1) | AU2009286176B2 (es) |
BR (1) | BRPI0917147B8 (es) |
CA (1) | CA2735497C (es) |
CL (1) | CL2011000420A1 (es) |
CO (1) | CO6341628A2 (es) |
EA (1) | EA019093B1 (es) |
EC (1) | ECSP11010850A (es) |
ES (1) | ES2627769T3 (es) |
IL (1) | IL211188A0 (es) |
MX (1) | MX2011001918A (es) |
NZ (1) | NZ591446A (es) |
PE (1) | PE20110393A1 (es) |
TW (1) | TW201014848A (es) |
UY (1) | UY32076A (es) |
WO (1) | WO2010024769A1 (es) |
ZA (1) | ZA201102284B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
JP5825608B2 (ja) * | 2010-08-06 | 2015-12-02 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
US10098859B2 (en) | 2012-09-05 | 2018-10-16 | Amri Ssci, Llc | Cocrystals of p-coumaric acid |
CN107412788B (zh) | 2012-12-21 | 2021-06-18 | 国立研究开发法人量子科学技术研究开发机构 | 用于对脑内所蓄积的Tau蛋白质进行成像的新的化合物 |
WO2016029146A1 (en) * | 2014-08-22 | 2016-02-25 | University Of Washington | Specific inhibitors of methionyl-trna synthetase |
JP2018534334A (ja) * | 2015-11-20 | 2018-11-22 | ナビディア・バイオファーマシューティカルズ,インコーポレーテッド | 2−ヘテロアリール置換ベンゾフラン類のための製剤 |
CN114728071A (zh) | 2019-11-13 | 2022-07-08 | 新旭生技股份有限公司 | 用于降解tau蛋白聚集体的化合物及其用途 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1041525A (en) | 1964-11-11 | 1966-09-07 | Belge Produits Chimiques Sa | Benzofuran derivatives and processes for preparing the same |
JPH09507071A (ja) | 1993-12-21 | 1997-07-15 | イーライ・リリー・アンド・カンパニー | アミロイド原性ペプチドに関連した状態を治療又は予防する方法 |
CZ20021663A3 (cs) * | 1999-10-15 | 2002-09-11 | F. Hoffmann-La Roche Ag | Nové deriváty benzodiazepinu |
FR2800069A1 (fr) * | 1999-10-22 | 2001-04-27 | Centre Nat Rech Scient | 3-amino-2,2-di-c-alkyl-1,4-butyrolactones et 1,4- thiobutyrolactones n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et leur procede de preparation |
WO2002055496A1 (en) | 2001-01-15 | 2002-07-18 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
JP4307001B2 (ja) | 2001-03-14 | 2009-08-05 | キヤノン株式会社 | 金属配位化合物、電界発光素子及び表示装置 |
GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
US7498349B2 (en) | 2002-08-02 | 2009-03-03 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
WO2004100998A2 (en) * | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
EP1644365A2 (en) | 2003-07-02 | 2006-04-12 | Biofocus Discovery Ltd | Pyrazine and pyridine derivatives as rho kinase inhibitors |
ZA200701232B (en) * | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
CN101142194B (zh) * | 2005-03-14 | 2012-10-10 | 顶点制药有限责任公司 | 吲哚衍生物,组合物及用作β-分泌酶抑制剂的方法 |
AU2006264966B2 (en) | 2005-07-04 | 2013-02-21 | High Point Pharmaceuticals, Llc | Histamine H3 receptor antagonists |
WO2007047204A1 (en) * | 2005-10-11 | 2007-04-26 | University Of Pittsburgh | Isotopically-labeled benzofuran compounds as imagingagents foramyloidogenic proteins |
TW201018678A (en) * | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
AU2007330190A1 (en) * | 2006-12-05 | 2008-06-12 | Nagasaki University | Aurone derivative-containing composition for diagnosis |
JP4328820B2 (ja) | 2007-01-10 | 2009-09-09 | 田辺三菱製薬株式会社 | 医薬組成物 |
TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
-
2009
- 2009-08-20 US US12/544,556 patent/US8193363B2/en active Active
- 2009-08-27 UY UY0001032076A patent/UY32076A/es not_active Application Discontinuation
- 2009-08-27 TW TW098128873A patent/TW201014848A/zh unknown
- 2009-08-28 KR KR1020117004579A patent/KR101648848B1/ko active IP Right Grant
- 2009-08-28 BR BRPI0917147A patent/BRPI0917147B8/pt active IP Right Grant
- 2009-08-28 CN CN200980142788.7A patent/CN102197036B/zh active Active
- 2009-08-28 EP EP09810319.5A patent/EP2328891B1/en active Active
- 2009-08-28 AR ARP090103323A patent/AR073230A1/es active IP Right Grant
- 2009-08-28 JP JP2011524942A patent/JP5613669B2/ja active Active
- 2009-08-28 WO PCT/SE2009/050972 patent/WO2010024769A1/en active Application Filing
- 2009-08-28 CA CA2735497A patent/CA2735497C/en active Active
- 2009-08-28 CN CN201410655681.5A patent/CN104447710A/zh active Pending
- 2009-08-28 NZ NZ591446A patent/NZ591446A/xx not_active IP Right Cessation
- 2009-08-28 MX MX2011001918A patent/MX2011001918A/es active IP Right Grant
- 2009-08-28 EA EA201100267A patent/EA019093B1/ru not_active IP Right Cessation
- 2009-08-28 PE PE2011000219A patent/PE20110393A1/es not_active Application Discontinuation
- 2009-08-28 CN CN201410653507.7A patent/CN104478862B/zh active Active
- 2009-08-28 AU AU2009286176A patent/AU2009286176B2/en active Active
- 2009-08-28 ES ES09810319.5T patent/ES2627769T3/es active Active
-
2011
- 2011-02-10 IL IL211188A patent/IL211188A0/en unknown
- 2011-02-21 CO CO11020875A patent/CO6341628A2/es not_active Application Discontinuation
- 2011-02-25 CL CL2011000420A patent/CL2011000420A1/es unknown
- 2011-02-28 EC EC2011010850A patent/ECSP11010850A/es unknown
- 2011-03-28 ZA ZA2011/02284A patent/ZA201102284B/en unknown
-
2012
- 2012-06-04 US US13/487,349 patent/US8653274B2/en active Active
-
2014
- 2014-01-07 US US14/149,563 patent/US9309267B2/en active Active
-
2018
- 2018-11-12 AR ARP180103297A patent/AR114029A2/es unknown
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