PE20110393A1 - Nuevos compuestos adecuados como precursores de compuestos que son utiles para obtener imagenes de depositos amiloides - Google Patents

Nuevos compuestos adecuados como precursores de compuestos que son utiles para obtener imagenes de depositos amiloides

Info

Publication number
PE20110393A1
PE20110393A1 PE2011000219A PE2011000219A PE20110393A1 PE 20110393 A1 PE20110393 A1 PE 20110393A1 PE 2011000219 A PE2011000219 A PE 2011000219A PE 2011000219 A PE2011000219 A PE 2011000219A PE 20110393 A1 PE20110393 A1 PE 20110393A1
Authority
PE
Peru
Prior art keywords
compound
amyloid deposits
obtain images
useful
benzofuran
Prior art date
Application number
PE2011000219A
Other languages
English (en)
Inventor
Seth Bjork
Vernd Delisser
Peter Johnstrom
Nils Anders Nilsson
Katinka Ruda
Per Magnus Schou
Brit-Marie Swahn
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20110393A1 publication Critical patent/PE20110393A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

REFERIDA AL COMPUESTO ESTER TERC-BUTILICO DEL ACIDO [6-(5-ETOXIMETOXI-BENZOFURAN-2-IL)-2-NITRO-PIRIDIN-3-IL]-METIL-CARBAMICO O UNA DE SUS SALES. LA FORMA CRISTALINA DE DICHO COMPUESTO QUE PRESENTA PICOS DE DIFRACCION DE 11,27, 12,00, 13,51, 15,53, 16,82, 17,91 23,72 (2 TETHA). TAMBIEN ESTA REFERIDO A UN COMPUESTO MARCADO TAL COMO 2-(6-[18F]-FLUORO-5-METILAMINO-PIRIDIN-2-IL)-BENZOFURAN-5-OL QUE TIENE COMO COMPUESTO INTERMEDIARIO AL COMPUESTO AL ESTER TERC-BUTILICO DEL ACIDO [6-(5-ETOXIMETOXI-BENZOFURAN-2-IL)-2-NITRO-PIRIDIN-3-IL]-METIL-CARBAMICO. DICHOS COMPUESTOS SON PRECURSORES DE COMPUESTOS UTILES PARA OBTENER IMAGENES DE DEPOSITOS AMILOIDES EN ENFERMEDADES TALES COMO LA ENFERMEDAD DE ALZHEIMER
PE2011000219A 2008-08-29 2009-08-28 Nuevos compuestos adecuados como precursores de compuestos que son utiles para obtener imagenes de depositos amiloides PE20110393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9285108P 2008-08-29 2008-08-29

Publications (1)

Publication Number Publication Date
PE20110393A1 true PE20110393A1 (es) 2011-07-15

Family

ID=41721733

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000219A PE20110393A1 (es) 2008-08-29 2009-08-28 Nuevos compuestos adecuados como precursores de compuestos que son utiles para obtener imagenes de depositos amiloides

Country Status (22)

Country Link
US (3) US8193363B2 (es)
EP (1) EP2328891B1 (es)
JP (1) JP5613669B2 (es)
KR (1) KR101648848B1 (es)
CN (3) CN104447710A (es)
AR (2) AR073230A1 (es)
AU (1) AU2009286176B2 (es)
BR (1) BRPI0917147B8 (es)
CA (1) CA2735497C (es)
CL (1) CL2011000420A1 (es)
CO (1) CO6341628A2 (es)
EA (1) EA019093B1 (es)
EC (1) ECSP11010850A (es)
ES (1) ES2627769T3 (es)
IL (1) IL211188A0 (es)
MX (1) MX2011001918A (es)
NZ (1) NZ591446A (es)
PE (1) PE20110393A1 (es)
TW (1) TW201014848A (es)
UY (1) UY32076A (es)
WO (1) WO2010024769A1 (es)
ZA (1) ZA201102284B (es)

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US8193363B2 (en) 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
JP5825608B2 (ja) * 2010-08-06 2015-12-02 国立大学法人京都大学 ピリジルベンゾフラン誘導体
US10098859B2 (en) 2012-09-05 2018-10-16 Amri Ssci, Llc Cocrystals of p-coumaric acid
CN107412788B (zh) 2012-12-21 2021-06-18 国立研究开发法人量子科学技术研究开发机构 用于对脑内所蓄积的Tau蛋白质进行成像的新的化合物
US10913736B2 (en) 2014-08-22 2021-02-09 University Of Washington Specific inhibitors of methionyl-tRNA synthetase
JP2018534334A (ja) * 2015-11-20 2018-11-22 ナビディア・バイオファーマシューティカルズ，インコーポレーテッド ２−ヘテロアリール置換ベンゾフラン類のための製剤
TWI759962B (zh) 2019-11-13 2022-04-01 香港商新旭生技股份有限公司 用於降解tau蛋白聚集體的化合物及其用途

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Also Published As

Publication number Publication date
KR101648848B1 (ko) 2016-08-17
NZ591446A (en) 2012-08-31
ES2627769T3 (es) 2017-07-31
MX2011001918A (es) 2011-03-24
EP2328891A4 (en) 2012-07-04
US20100056796A1 (en) 2010-03-04
AU2009286176B2 (en) 2012-04-26
ZA201102284B (en) 2012-09-26
CN104447710A (zh) 2015-03-25
US8653274B2 (en) 2014-02-18
US9309267B2 (en) 2016-04-12
WO2010024769A1 (en) 2010-03-04
EA019093B1 (ru) 2014-01-30
JP5613669B2 (ja) 2014-10-29
US8193363B2 (en) 2012-06-05
BRPI0917147A2 (pt) 2015-11-17
AR114029A2 (es) 2020-07-15
JP2012501324A (ja) 2012-01-19
TW201014848A (en) 2010-04-16
CA2735497A1 (en) 2010-03-04
EA201100267A1 (ru) 2011-10-31
AR073230A1 (es) 2010-10-20
US20140296534A1 (en) 2014-10-02
EP2328891A1 (en) 2011-06-08
US20120264943A1 (en) 2012-10-18
ECSP11010850A (es) 2011-03-31
AU2009286176A1 (en) 2010-03-04
IL211188A0 (en) 2011-04-28
CN104478862B (zh) 2017-05-24
KR20110045023A (ko) 2011-05-03
UY32076A (es) 2010-03-26
CL2011000420A1 (es) 2011-07-15
CO6341628A2 (es) 2011-11-21
CN102197036B (zh) 2014-12-10
CN102197036A (zh) 2011-09-21
BRPI0917147B1 (pt) 2020-09-15
CA2735497C (en) 2016-07-19
BRPI0917147B8 (pt) 2021-05-25
EP2328891B1 (en) 2017-04-05
CN104478862A (zh) 2015-04-01

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