CL2008003465A1 - Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion. - Google Patents
Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion.Info
- Publication number
- CL2008003465A1 CL2008003465A1 CL2008003465A CL2008003465A CL2008003465A1 CL 2008003465 A1 CL2008003465 A1 CL 2008003465A1 CL 2008003465 A CL2008003465 A CL 2008003465A CL 2008003465 A CL2008003465 A CL 2008003465A CL 2008003465 A1 CL2008003465 A1 CL 2008003465A1
- Authority
- CL
- Chile
- Prior art keywords
- cognitive
- sleep
- cycloalkyloxy
- histamine
- dementia
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000001149 cognitive effect Effects 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 206010012289 Dementia Diseases 0.000 title abstract 2
- 102000004384 Histamine H3 receptors Human genes 0.000 title abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 title abstract 2
- 208000010877 cognitive disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000020016 psychiatric disease Diseases 0.000 title abstract 2
- 208000019116 sleep disease Diseases 0.000 title 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title 1
- 230000007278 cognition impairment Effects 0.000 title 1
- 125000000000 cycloalkoxy group Chemical group 0.000 title 1
- 206010022437 insomnia Diseases 0.000 title 1
- 208000022925 sleep disturbance Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98924607P | 2007-11-20 | 2007-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008003465A1 true CL2008003465A1 (es) | 2009-03-06 |
Family
ID=40297867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008003465A CL2008003465A1 (es) | 2007-11-20 | 2008-11-20 | Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8883776B2 (enExample) |
| EP (1) | EP2222664B1 (enExample) |
| JP (1) | JP5498390B2 (enExample) |
| KR (1) | KR101546712B1 (enExample) |
| CN (2) | CN105712977B (enExample) |
| AR (2) | AR069387A1 (enExample) |
| AU (1) | AU2008326561B2 (enExample) |
| BR (1) | BRPI0820481A2 (enExample) |
| CA (1) | CA2706328C (enExample) |
| CL (1) | CL2008003465A1 (enExample) |
| CO (1) | CO6210700A2 (enExample) |
| CR (1) | CR11529A (enExample) |
| EA (1) | EA018582B1 (enExample) |
| EC (1) | ECSP10010190A (enExample) |
| MX (1) | MX2010005488A (enExample) |
| MY (1) | MY158253A (enExample) |
| NI (1) | NI201000086A (enExample) |
| NZ (1) | NZ584998A (enExample) |
| TW (1) | TWI491604B (enExample) |
| UA (1) | UA103468C2 (enExample) |
| WO (1) | WO2009067401A1 (enExample) |
| ZA (1) | ZA201004334B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
| US20090170869A1 (en) * | 2007-09-06 | 2009-07-02 | Desmond John Best | Piperazine derivative having affinity for the histamine h3 receptor |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| CA2721303C (en) * | 2008-05-08 | 2016-06-28 | Evotec Ag | Azetidines and cyclobutanes as histamine h3 receptor antagonists |
| AU2010226711B2 (en) * | 2009-03-18 | 2015-06-18 | Janssen Pharmaceutica Nv | Process for the preparation of histamine H3 receptor modulators |
| MX2012003394A (es) * | 2009-09-21 | 2012-08-15 | Univ Vanderbilt | Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5. |
| SI2729130T1 (en) | 2011-07-07 | 2018-03-30 | Janssen Sciences Ireland Uc | Combined formulations of darunavir |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE817911C (de) | 1947-12-16 | 1951-10-22 | Chem Fab Tempelhof Preuss & Te | Verfahren zur Darstellung von in 6-Stellung basisch substituierten Pyridin-3-carbonsaeureamiden |
| BE726551A (enExample) | 1968-01-22 | 1969-06-16 | ||
| ES436109A1 (es) | 1974-04-04 | 1977-01-01 | Christiaens Sa A | Procedimiento para la preparacion de nuevos derivados de pi-ridina. |
| EP0089765A3 (en) | 1982-03-17 | 1984-05-23 | Smith Kline & French Laboratories Limited | Pyridine derivatives |
| GB8311443D0 (en) | 1983-04-27 | 1983-06-02 | Smith Kline French Lab | Chemical compounds |
| GB8320505D0 (en) | 1983-07-29 | 1983-09-01 | Smith Kline French Lab | Chemical compounds |
| GB8332091D0 (en) | 1983-12-01 | 1984-01-11 | Smith Kline French Lab | Chemical compounds |
| JPS61149119A (ja) | 1984-12-22 | 1986-07-07 | 旭光学工業株式会社 | 検眼用試験枠 |
| US4792547A (en) | 1985-12-26 | 1988-12-20 | Hokuriku Pharmaceutical Co., Ltd. | Pyrazine-2-carboxamide derivatives useful in treating allergic disease |
| JPH0637595B2 (ja) | 1986-08-06 | 1994-05-18 | 日本ペイント株式会社 | 陰極電着塗料組成物 |
| GB9025828D0 (en) | 1990-11-28 | 1991-01-09 | Shell Int Research | Herbicidal carboxamide derivatives |
| JP3354271B2 (ja) | 1993-02-25 | 2002-12-09 | 三共株式会社 | ピリジルオキシアミド誘導体 |
| DE69628705T2 (de) | 1995-08-24 | 2004-05-13 | Basf Ag | Isoxazole- und Isothiazole-5-carboxamid Derivate, deren Herstellung und deren Verwendung als Herbizide |
| US6339045B1 (en) | 1995-12-28 | 2002-01-15 | Kureha Kagaku Kogyo Kabushiki Kaisha | N-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides |
| TNSN97092A1 (ar) | 1996-09-18 | 1999-12-31 | Agouron Pharma | مثبطات انزيم بروتيني فلزي وتركيبات صيدلانية تحتوي على تلك المثبتطات واستخدامها الصيدلاني وطرق ومركبات وسيطة مفيدة لتحضير التركيبات المذكورة. |
| MXPA01008606A (es) | 1999-02-26 | 2003-05-05 | Merck & Co Inc | Compuestos de sulfonamida novedosos y uso de los mismos. |
| CN1242995C (zh) | 1999-05-21 | 2006-02-22 | 比奥维特罗姆股份公司 | 化合物,它们的用途和制备方法 |
| US6399607B1 (en) | 1999-07-02 | 2002-06-04 | Research Foundation-State University Of New York | Aminomethylene amide analogs of pyrazinamide with intracellular antimycobacterial activity against pyrazinamide-resistant mycobacteria combined with a rifamycin |
| DE10023492A1 (de) | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| JP2002322163A (ja) | 2001-04-20 | 2002-11-08 | Sumitomo Pharmaceut Co Ltd | ピペラジン誘導体 |
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| ATE417038T1 (de) | 2001-06-15 | 2008-12-15 | Astellas Pharma Inc | Phenylpyridincarbonyl piperazinderivate |
| US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
| ATE449090T1 (de) | 2001-07-02 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
| MXPA04004178A (es) | 2001-11-01 | 2004-09-06 | Janssen Pharmaceutica Nv | Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta. |
| CN1582277A (zh) | 2001-11-01 | 2005-02-16 | 詹森药业有限公司 | 用作糖原合酶激酶3β抑制剂的酰胺衍生物 |
| AU2003203148A1 (en) | 2002-02-05 | 2003-09-02 | High Point Pharmaceuticals, Llc | Novel aryl- and heteroarylpiperazines |
| GB0206219D0 (en) | 2002-03-15 | 2002-05-01 | Ferring Bv | Non-Peptide GnRH antagonists |
| WO2003082205A2 (en) | 2002-03-27 | 2003-10-09 | Smithkline Beecham Corporation | Compounds and methods |
| US20040014744A1 (en) | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| GB0209715D0 (en) | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| EP1388535A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| GB0224084D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| EP1554260A1 (en) * | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivatives as h3 receptor ligands |
| DE60330269D1 (de) | 2002-10-23 | 2010-01-07 | Janssen Pharmaceutica Nv | Piperazinyl- und diazapanylbenzamide und-benzothioamide |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| CA2529790A1 (en) | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| CA2532236C (en) | 2003-07-29 | 2011-08-23 | Novo Nordisk A/S | Pyridazinyl- piperazines and their use as histamine h3 receptor ligands |
| WO2005023247A1 (en) | 2003-09-03 | 2005-03-17 | Smithkline Beecham Corporation | Compounds and methods |
| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
| CN1972914A (zh) | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| US7429659B2 (en) | 2004-03-31 | 2008-09-30 | Janssen Pharmaceutica N.V. | Furan compounds as histamine H3 modulators |
| GB0514812D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| PL1948607T3 (pl) | 2005-09-16 | 2010-09-30 | Janssen Pharmaceutica Nv | Cyklopropyloaminy jako modulatory receptora histaminowego H3 |
| EP1976848A2 (en) | 2005-12-21 | 2008-10-08 | Schering Corporation | Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists |
| JP2009521451A (ja) | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | ヒスタミンｈ３アンタゴニストとして有用な置換アニリン誘導体 |
| JP2009530274A (ja) | 2006-03-15 | 2009-08-27 | ワイス | ヒスタミン−３アンタゴニストとしてのｎ−置換−アザシクリルアミン化合物 |
| KR101372941B1 (ko) | 2006-05-30 | 2014-03-14 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ３ 수용체 조절제로서의 치환된 피리딜 아미드 화합물 |
| US20080045507A1 (en) | 2006-06-29 | 2008-02-21 | Allison Brett D | Substituted benzamide modulators of the histamine h3 receptor |
| US20090131417A1 (en) * | 2007-11-20 | 2009-05-21 | Letavic Michael A | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
-
2008
- 2008-11-17 BR BRPI0820481-0A patent/BRPI0820481A2/pt not_active IP Right Cessation
- 2008-11-17 MX MX2010005488A patent/MX2010005488A/es active IP Right Grant
- 2008-11-17 US US12/272,268 patent/US8883776B2/en not_active Expired - Fee Related
- 2008-11-17 EA EA201070637A patent/EA018582B1/ru unknown
- 2008-11-17 CA CA2706328A patent/CA2706328C/en not_active Expired - Fee Related
- 2008-11-17 UA UAA201007603A patent/UA103468C2/ru unknown
- 2008-11-17 AU AU2008326561A patent/AU2008326561B2/en not_active Ceased
- 2008-11-17 MY MYPI2010002288A patent/MY158253A/en unknown
- 2008-11-17 CN CN201610094782.9A patent/CN105712977B/zh not_active Expired - Fee Related
- 2008-11-17 KR KR1020107013252A patent/KR101546712B1/ko not_active Expired - Fee Related
- 2008-11-17 CN CN200880117055A patent/CN101868454A/zh active Pending
- 2008-11-17 WO PCT/US2008/083764 patent/WO2009067401A1/en not_active Ceased
- 2008-11-17 NZ NZ584998A patent/NZ584998A/xx not_active IP Right Cessation
- 2008-11-17 EP EP08852442.6A patent/EP2222664B1/en not_active Not-in-force
- 2008-11-17 JP JP2010535014A patent/JP5498390B2/ja not_active Expired - Fee Related
- 2008-11-19 TW TW097144606A patent/TWI491604B/zh not_active IP Right Cessation
- 2008-11-20 CL CL2008003465A patent/CL2008003465A1/es unknown
- 2008-11-20 AR ARP080105055A patent/AR069387A1/es not_active Application Discontinuation
-
2010
- 2010-05-18 NI NI201000086A patent/NI201000086A/es unknown
- 2010-05-19 EC EC2010010190A patent/ECSP10010190A/es unknown
- 2010-05-20 CO CO10060285A patent/CO6210700A2/es active IP Right Grant
- 2010-06-18 ZA ZA2010/04334A patent/ZA201004334B/en unknown
- 2010-06-21 CR CR11529A patent/CR11529A/es not_active Application Discontinuation
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2018
- 2018-02-14 AR ARP180100346A patent/AR110977A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR069387A1 (es) | 2010-01-20 |
| CO6210700A2 (es) | 2010-10-20 |
| EP2222664A1 (en) | 2010-09-01 |
| ZA201004334B (en) | 2011-10-26 |
| WO2009067401A1 (en) | 2009-05-28 |
| NI201000086A (es) | 2011-03-17 |
| US8883776B2 (en) | 2014-11-11 |
| EA201070637A1 (ru) | 2010-12-30 |
| JP5498390B2 (ja) | 2014-05-21 |
| NZ584998A (en) | 2012-08-31 |
| MY158253A (en) | 2016-09-30 |
| CN105712977B (zh) | 2021-06-29 |
| JP2011503233A (ja) | 2011-01-27 |
| AU2008326561B2 (en) | 2013-12-05 |
| CR11529A (es) | 2012-10-25 |
| CA2706328A1 (en) | 2009-05-28 |
| CN105712977A (zh) | 2016-06-29 |
| EP2222664B1 (en) | 2014-10-29 |
| CN101868454A (zh) | 2010-10-20 |
| ECSP10010190A (es) | 2010-06-29 |
| MX2010005488A (es) | 2010-06-01 |
| BRPI0820481A2 (pt) | 2015-06-16 |
| CA2706328C (en) | 2016-04-19 |
| US20090131415A1 (en) | 2009-05-21 |
| TW200936579A (en) | 2009-09-01 |
| UA103468C2 (ru) | 2013-10-25 |
| TWI491604B (zh) | 2015-07-11 |
| AU2008326561A1 (en) | 2009-05-28 |
| KR101546712B1 (ko) | 2015-08-24 |
| AR110977A2 (es) | 2019-05-22 |
| EA018582B1 (ru) | 2013-09-30 |
| KR20100098636A (ko) | 2010-09-08 |
| HK1147994A1 (en) | 2011-08-26 |
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