CL2004000526A1 - Compuestos derivados de dibenzofurano, carbazoles, inhibidores de fosfodiesterasa tipo 4; procedimiento de preparacion; y su uso en el tratamiento de trastornos y condiciones inflamatorias, del sistema nervioso central y diabetes insulino resistente. - Google Patents
Compuestos derivados de dibenzofurano, carbazoles, inhibidores de fosfodiesterasa tipo 4; procedimiento de preparacion; y su uso en el tratamiento de trastornos y condiciones inflamatorias, del sistema nervioso central y diabetes insulino resistente.Info
- Publication number
- CL2004000526A1 CL2004000526A1 CL200400526A CL2004000526A CL2004000526A1 CL 2004000526 A1 CL2004000526 A1 CL 2004000526A1 CL 200400526 A CL200400526 A CL 200400526A CL 2004000526 A CL2004000526 A CL 2004000526A CL 2004000526 A1 CL2004000526 A1 CL 2004000526A1
- Authority
- CL
- Chile
- Prior art keywords
- phosphodesterase
- carbazols
- dibenzofurane
- inhibitors
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN363MU2003 | 2003-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000526A1 true CL2004000526A1 (es) | 2005-03-18 |
Family
ID=36947516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400526A CL2004000526A1 (es) | 2003-04-11 | 2004-03-15 | Compuestos derivados de dibenzofurano, carbazoles, inhibidores de fosfodiesterasa tipo 4; procedimiento de preparacion; y su uso en el tratamiento de trastornos y condiciones inflamatorias, del sistema nervioso central y diabetes insulino resistente. |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US7223789B2 (es) |
| EP (1) | EP1620429B1 (es) |
| JP (1) | JP2006522789A (es) |
| KR (1) | KR20060017494A (es) |
| CN (1) | CN1829711B (es) |
| AP (1) | AP2008A (es) |
| AR (1) | AR043199A1 (es) |
| AT (1) | ATE427308T1 (es) |
| AU (1) | AU2004228453B2 (es) |
| BR (1) | BRPI0409747A (es) |
| CA (1) | CA2522023A1 (es) |
| CL (1) | CL2004000526A1 (es) |
| CO (1) | CO5700824A2 (es) |
| DE (1) | DE602004020332D1 (es) |
| DK (1) | DK1620429T3 (es) |
| EA (1) | EA010634B1 (es) |
| ES (1) | ES2320888T3 (es) |
| GE (1) | GEP20084526B (es) |
| HR (1) | HRP20050944A2 (es) |
| IS (1) | IS8123A (es) |
| MA (1) | MA27801A1 (es) |
| MX (1) | MXPA05010948A (es) |
| MY (1) | MY136516A (es) |
| NO (1) | NO20055316L (es) |
| NZ (1) | NZ542882A (es) |
| OA (1) | OA13154A (es) |
| PL (1) | PL378813A1 (es) |
| PT (1) | PT1620429E (es) |
| SI (1) | SI1620429T1 (es) |
| TN (1) | TNSN05252A1 (es) |
| TW (1) | TW200508212A (es) |
| UA (1) | UA79558C2 (es) |
| WO (1) | WO2004089940A1 (es) |
| ZA (1) | ZA200508240B (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2503015A1 (en) * | 2002-10-23 | 2004-05-06 | Glenmark Pharmaceuticals Ltd. | Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| AP2008A (en) * | 2003-04-11 | 2009-06-29 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them |
| EP1799632A2 (en) | 2004-10-13 | 2007-06-27 | Glenmark Pharmaceuticals S.A. | Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide |
| WO2006051390A1 (en) * | 2004-11-10 | 2006-05-18 | Glenmark Pharmaceuticals S.A. | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders, pharmaceutical compositions containing them, and methods of preparing them |
| UA88795C2 (ru) * | 2004-12-17 | 2009-11-25 | Гленмарк Фармасьютікалс С.А. | Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений |
| NZ555809A (en) * | 2004-12-17 | 2010-07-30 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| ES2443342T3 (es) | 2006-07-05 | 2014-02-19 | Takeda Gmbh | Combinación de inhibidor de la HMG-CoA reductasa rosuvastatina con un inhibidor de la fosfodiesterasa 4, tal como roflumilast, roflumilast-N-óxido para el tratamiento de enfermedades pulmonares inflamatorias |
| WO2008005955A2 (en) | 2006-07-06 | 2008-01-10 | Forest Laboratories Holdings Limited | Synthesis of heterocyclic compounds |
| JPWO2008026687A1 (ja) * | 2006-09-01 | 2010-01-21 | 杏林製薬株式会社 | ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ（ｐｄｅ）阻害剤 |
| JPWO2008029829A1 (ja) * | 2006-09-06 | 2010-01-21 | 杏林製薬株式会社 | ピラゾロピリジン誘導体及びそれらを有効成分とするホスホジエステラーゼ（ｐｄｅ）阻害剤 |
| SG174810A1 (en) * | 2006-09-11 | 2011-10-28 | Matrix Lab Ltd | Dibenzofuran derivatives as inhibitors of pde-4 and pde-10 |
| MX2009004289A (es) * | 2006-10-27 | 2009-05-05 | Wyeth Corp | Compuestos triciclicos como inhibidores de metaloproteinasas matriciales. |
| WO2008065522A2 (en) * | 2006-11-29 | 2008-06-05 | Glenmark Pharmaceuticals S.A. | Process for the synthesis of 4-difluoromethoxy-8-nitro-1-formyl dibenzo[b,d] furan-an intermediate for pde iv inhibitors |
| AR064307A1 (es) * | 2006-12-13 | 2009-03-25 | Gilead Sciences Inc | Monofosfatos utiles para el tratamiento de la inflamacion pulmonar y broncoconstriccion, formulaciones aerosolicas que los contienen, y metodo de preparacion. |
| MX2009008463A (es) * | 2007-02-09 | 2010-01-27 | Forest Lab Holdings Ltd | Formulaciones biodisponibles de compuestos heterociclicos. |
| WO2008142542A2 (en) * | 2007-05-22 | 2008-11-27 | Glenmark Pharmaceuticals, S.A. | Processes for preparing benzofuro [3, 2-c] pyridine- 9-carbaldehyde derivatives as novel intermediates for the synthesis of pde iv inhibitors |
| WO2008157205A2 (en) * | 2007-06-15 | 2008-12-24 | Duke University | Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp |
| EP2070913A1 (en) * | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
| WO2009147476A1 (en) * | 2008-06-02 | 2009-12-10 | Matrix Laboratories Ltd. | Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation |
| TWI474282B (zh) * | 2008-10-03 | 2015-02-21 | Himax Tech Ltd | 深度相關的影像加強 |
| JP5487214B2 (ja) | 2008-12-19 | 2014-05-07 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物 |
| WO2011132051A2 (en) * | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceuticals S.A. | Tricycle compounds as phosphodiesterase-10 inhibitors |
| BR112013014890B1 (pt) * | 2010-12-15 | 2023-10-24 | Contravir Pharmaceuticals, Inc | Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos |
| WO2014133020A1 (ja) * | 2013-02-28 | 2014-09-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
| CN104177612A (zh) * | 2013-05-28 | 2014-12-03 | 韩文毅 | 一种新的非线性聚合物及其制备和用途 |
| CN104211947A (zh) * | 2013-05-31 | 2014-12-17 | 韩文毅 | 一种非线性聚合物及其制备和用途 |
| CN104211950A (zh) * | 2013-06-04 | 2014-12-17 | 韩文毅 | 一种非线性聚合物及其制备与用途 |
| CN104211949A (zh) * | 2013-06-04 | 2014-12-17 | 韩文毅 | 一种非线性聚合物及其制备与用途 |
| MA52119A (fr) | 2015-10-19 | 2018-08-29 | Ncyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| EP3377488B1 (en) | 2015-11-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MD3394033T2 (ro) | 2015-12-22 | 2021-04-30 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| RU2616617C1 (ru) * | 2016-04-12 | 2017-04-18 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | 5-(9-этил-9Н-карбазол-3-ил)-4-[5-(9-этил-9Н-карбазол-3-ил)-тиофен-2-ил]-пиримидин |
| AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| MA45116A (fr) | 2016-05-26 | 2021-06-02 | Incyte Corp | Composés hétérocycliques comme immunomodulateurs |
| JP7000357B2 (ja) | 2016-06-20 | 2022-01-19 | インサイト・コーポレイション | 免疫調節剤としての複素環化合物 |
| WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| JP7101678B2 (ja) | 2016-12-22 | 2022-07-15 | インサイト・コーポレイション | 免疫調節剤としての複素環式化合物 |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| AU2019245288C1 (en) | 2018-03-30 | 2024-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| PE20211918A1 (es) | 2018-05-11 | 2021-09-28 | Incyte Corp | Derivados de tetrahidro-imidazo[4,5-c]piridin como inmunomoduladores de pd-l1 |
| CN109651232A (zh) * | 2018-12-12 | 2019-04-19 | 河北华清光电材料有限公司 | 制备4-溴咔唑及其衍生物的方法 |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| EP4037773A1 (en) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| WO2021096849A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| AR124001A1 (es) | 2020-11-06 | 2023-02-01 | Incyte Corp | Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| CN114163417B (zh) * | 2021-12-06 | 2023-08-04 | 郑州海阔光电材料有限公司 | 一种3-溴硫芴的合成方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1041861A (en) | 1962-03-14 | 1966-09-07 | Organon Labor Ltd | Pyrrolidone derivatives and pharmaceutical preparations containing them |
| NL7008628A (es) * | 1969-06-25 | 1970-12-29 | ||
| US3759948A (en) | 1969-06-25 | 1973-09-18 | Merck & Co Inc | Non-steroid anti-inflammatory compounds |
| US3846553A (en) | 1969-12-03 | 1974-11-05 | Merck & Co Inc | 3-substituted-2-pyridones in the treatment of pain, fever or inflammation |
| NL7016899A (es) | 1969-12-03 | 1971-06-07 | ||
| US4222944A (en) * | 1978-07-31 | 1980-09-16 | Hoffmann-La Roche Inc. | Halo-3-dibenzofuran alkanonitriles |
| JPS62158253A (ja) | 1985-12-28 | 1987-07-14 | Kirin Brewery Co Ltd | ４−アミノピリジンアミド誘導体 |
| JPH0812430B2 (ja) | 1986-07-07 | 1996-02-07 | キヤノン株式会社 | 電子写真感光体 |
| US5202344A (en) | 1990-12-11 | 1993-04-13 | G. D. Searle & Co. | N-substituted lactams useful as cholecystokinin antagonists |
| IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| AU3738293A (en) | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| EP0652868B1 (en) | 1992-07-28 | 2004-11-10 | Aventis Pharma Limited | INHIBITORS OF c-AMP PHOSPHODIESTERASE |
| MX9306311A (es) * | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
| US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| US5712298A (en) | 1993-07-02 | 1998-01-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
| WO1995009837A1 (en) | 1993-10-01 | 1995-04-13 | Smithkline Beecham Corporation | Cyano compounds |
| GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| GB9404706D0 (en) | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
| CN1166169A (zh) | 1994-07-27 | 1997-11-26 | 三共株式会社 | 用作毒蕈碱性受体别构效应物的杂环化合物 |
| JP2000517341A (ja) * | 1996-09-04 | 2000-12-26 | ワーナー―ランバート・コンパニー | マトリックスメタロプロテイナーゼ阻害剤およびそれらの治療的使用 |
| EP1064298B1 (en) | 1998-03-19 | 2008-10-08 | Vertex Pharmaceuticals Incorporated | Inhibitors of caspases |
| US6110962A (en) | 1998-05-12 | 2000-08-29 | American Home Products Corporation | 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia |
| JP2002514638A (ja) | 1998-05-12 | 2002-05-21 | アメリカン・ホーム・プロダクツ・コーポレイション | インスリン抵抗性および高血糖症の治療に有用な１１−アリール−ベンゾ［ｂ］ナフト［２，３−ｄ］フラン類および１１−アリール−ベンゾ［ｂ］ナフト［２，３−ｄ］チオフェン類 |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| NZ521248A (en) | 2000-03-17 | 2004-04-30 | Bristol Myers Squibb Pharma Co | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| AU2001239550A1 (en) | 2000-03-23 | 2001-10-03 | Takeda Chemical Industries Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
| EP1844766B1 (en) * | 2000-12-18 | 2012-04-18 | Institute of Medicinal Molecular Design, Inc. | Inhibitors against the production and release of inflammatory cytokines |
| AU2002228316A1 (en) * | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| WO2002072567A2 (en) | 2001-03-13 | 2002-09-19 | Glenmark Pharmaceuticals Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| TW200302726A (en) * | 2002-01-31 | 2003-08-16 | Ono Pharmaceutical Co | Nitrogen-containing bicyclic compound and medicament containing same as active ingredient |
| WO2004016596A1 (en) | 2002-08-19 | 2004-02-26 | Glenmark Pharmaceuticals Limited | Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders |
| AU2003263393A1 (en) | 2002-09-04 | 2004-03-29 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| CA2503015A1 (en) * | 2002-10-23 | 2004-05-06 | Glenmark Pharmaceuticals Ltd. | Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| AP2008A (en) * | 2003-04-11 | 2009-06-29 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them |
| UA88795C2 (ru) * | 2004-12-17 | 2009-11-25 | Гленмарк Фармасьютікалс С.А. | Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений |
-
2004
- 2004-02-11 AP AP2005003424A patent/AP2008A/xx active
- 2004-02-11 PT PT04710093T patent/PT1620429E/pt unknown
- 2004-02-11 ES ES04710093T patent/ES2320888T3/es not_active Expired - Lifetime
- 2004-02-11 KR KR1020057019359A patent/KR20060017494A/ko not_active Application Discontinuation
- 2004-02-11 NZ NZ542882A patent/NZ542882A/en unknown
- 2004-02-11 WO PCT/IB2004/000355 patent/WO2004089940A1/en active Application Filing
- 2004-02-11 AT AT04710093T patent/ATE427308T1/de not_active IP Right Cessation
- 2004-02-11 GE GEAP20049048A patent/GEP20084526B/en unknown
- 2004-02-11 DK DK04710093T patent/DK1620429T3/da active
- 2004-02-11 EP EP04710093A patent/EP1620429B1/en not_active Expired - Lifetime
- 2004-02-11 SI SI200431133T patent/SI1620429T1/sl unknown
- 2004-02-11 CN CN2004800160486A patent/CN1829711B/zh not_active Expired - Fee Related
- 2004-02-11 BR BRPI0409747-5A patent/BRPI0409747A/pt not_active IP Right Cessation
- 2004-02-11 JP JP2006506259A patent/JP2006522789A/ja active Pending
- 2004-02-11 MX MXPA05010948A patent/MXPA05010948A/es active IP Right Grant
- 2004-02-11 CA CA002522023A patent/CA2522023A1/en not_active Abandoned
- 2004-02-11 AU AU2004228453A patent/AU2004228453B2/en not_active Expired - Fee Related
- 2004-02-11 OA OA1200500280A patent/OA13154A/en unknown
- 2004-02-11 PL PL378813A patent/PL378813A1/pl not_active Application Discontinuation
- 2004-02-11 EA EA200501617A patent/EA010634B1/ru not_active IP Right Cessation
- 2004-02-11 DE DE602004020332T patent/DE602004020332D1/de not_active Expired - Lifetime
- 2004-02-17 AR ARP040100483A patent/AR043199A1/es unknown
- 2004-02-24 TW TW093104603A patent/TW200508212A/zh unknown
- 2004-03-09 MY MYPI20040813A patent/MY136516A/en unknown
- 2004-03-15 CL CL200400526A patent/CL2004000526A1/es unknown
- 2004-04-09 US US10/821,642 patent/US7223789B2/en active Active
- 2004-11-02 UA UAA200510680A patent/UA79558C2/uk unknown
-
2005
- 2005-10-06 TN TNP2005000252A patent/TNSN05252A1/en unknown
- 2005-10-12 ZA ZA200508240A patent/ZA200508240B/en unknown
- 2005-11-04 HR HR20050944A patent/HRP20050944A2/xx not_active Application Discontinuation
- 2005-11-09 MA MA28593A patent/MA27801A1/fr unknown
- 2005-11-10 NO NO20055316A patent/NO20055316L/no not_active Application Discontinuation
- 2005-11-10 IS IS8123A patent/IS8123A/is unknown
- 2005-11-11 CO CO05115151A patent/CO5700824A2/es not_active Application Discontinuation
-
2006
- 2006-09-28 US US11/536,448 patent/US7393846B2/en not_active Expired - Fee Related
- 2006-09-28 US US11/536,434 patent/US7384962B2/en not_active Expired - Fee Related
-
2008
- 2008-06-02 US US12/131,286 patent/US20090182143A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2004000526A1 (es) | Compuestos derivados de dibenzofurano, carbazoles, inhibidores de fosfodiesterasa tipo 4; procedimiento de preparacion; y su uso en el tratamiento de trastornos y condiciones inflamatorias, del sistema nervioso central y diabetes insulino resistente. | |
| CL2004001069A1 (es) | Compuestos derivados de 1-benzoil-isoquinolinas sustituidos; procedimiento de preparacion, composicion farmaceutica; y uso para el tratamiento o profilaxis de diabetes tipo ii. | |
| LTC1830843I2 (lt) | Indolidono dariniai, skirti fibrozinių ligų gydymui arba prevencijai | |
| TW200612926A (en) | Compounds and compositions as ppar modulators | |
| DK1656372T3 (da) | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme | |
| IS2722B (is) | 1, 2, 3, 4- Tetrasetin indól til meðhöndlunar á öndunarfærasjúkdómum | |
| HK1092467A1 (en) | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- | |
| CL2007002261A1 (es) | Compuestos derivados de imidazo[1,2-b]piridazina, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento o prevencion del cancer. | |
| NO20070247L (no) | Amino-5,5-difenylimidazolonderivater for inhibisjon av beta-sekretase | |
| EA200970302A1 (ru) | Тиофенпиразолопиримидиновые соединения | |
| NO20055098D0 (no) | Anvendelse av 10-hydroksy-10,11-dihydrokarbamazepinderivater for behandling av affektive forstyrrelser | |
| HN2005035605A (es) | Analogos de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos, proliferativos e inflamatorios | |
| CL2004000234A1 (es) | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid | |
| WO2006124863A3 (en) | Pyrrolopyridine derivatives as protein kinase inhibitors | |
| WO2006047516A3 (en) | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity | |
| UY29796A1 (es) | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor | |
| MX2007009356A (es) | Compuestos y composiciones como moduladores de ppar. | |
| NO20053211D0 (no) | Forbindelser for behandling av metabolske forstyrrelser. | |
| CL2007002757A1 (es) | Compuestos derivados de 1,2,4-triazina sustituida; composicion farmaceutica; y uso en el tratamiento o prevencion del reflujo gastroesofagico y ansiedad. | |
| CL2007002920A1 (es) | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. | |
| WO2007056366A3 (en) | Compounds and compositions as ppar modulators | |
| WO2004074243A3 (en) | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands | |
| ATE409188T1 (de) | Naphthyridinverbindungen | |
| EA200601074A1 (ru) | Применение производных пептидов для лечения болей, связанных с заболеванием центральной нервной системы (центральной невропатической боли) | |
| NO20055563L (no) | Midler for behandlingen av lavere abdominale lidelser |