UA88795C2 - Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений - Google Patents

Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений

Info

Publication number
UA88795C2
UA88795C2 UAA200707953A UAA200707953A UA88795C2 UA 88795 C2 UA88795 C2 UA 88795C2 UA A200707953 A UAA200707953 A UA A200707953A UA A200707953 A UAA200707953 A UA A200707953A UA 88795 C2 UA88795 C2 UA 88795C2
Authority
UA
Ukraine
Prior art keywords
allergic
treatment
pharmaceutically acceptable
reperfusion injury
inflammatory
Prior art date
Application number
UAA200707953A
Other languages
English (en)
Ukrainian (uk)
Inventor
Лаксмікант Атмарам Гхарат
Баласубраманіан Гопалан
Нііліма Кхаіраткар-Йоші
Original Assignee
Гленмарк Фармасьютікалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гленмарк Фармасьютікалс С.А. filed Critical Гленмарк Фармасьютікалс С.А.
Publication of UA88795C2 publication Critical patent/UA88795C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретение касается новых ингибиторов фосфодиэстеразы 4 типа (PDE-4) формулы (1) EMBED ISISServer , (1) а также их аналогов, таутомеров, энантиомеров, диастереомеров, региоизомеров, стереоизомеров, полиморфных модификаций, фармацевтически приемлемых солей, которые отвечают N-оксидам и фармацевтически приемлемым сольватам указанных веществ, а также фармацевтических композиций, содержащих указанные соединения, которые применяются для лечения аллергических и воспалительных состояний, включающих астму, хронический бронхит, атопический дерматит, крапивницу, аллергический ринит, аллергический конъюнктивит, весенний конъюнктивит, эозинофильную гранулему, псориаз, ревматоидный артрит, септический шок, язвенный колит, болезнь Крона, реперфузионное поражение миокарда и реперфузионное поражение мозга, хронический гломерулонефрит, эндотоксический шок и респираторный дистресс-синдром у взрослых.
UAA200707953A 2004-12-17 2005-12-15 Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений UA88795C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1352MU2004 2004-12-17

Publications (1)

Publication Number Publication Date
UA88795C2 true UA88795C2 (ru) 2009-11-25

Family

ID=38658137

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200707953A UA88795C2 (ru) 2004-12-17 2005-12-15 Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений

Country Status (9)

Country Link
US (1) US7943634B2 (ru)
CN (1) CN101124229B (ru)
DK (1) DK1831227T3 (ru)
ES (1) ES2417491T3 (ru)
NO (1) NO20073436L (ru)
PT (1) PT1831227E (ru)
SI (1) SI1831227T1 (ru)
UA (1) UA88795C2 (ru)
ZA (1) ZA200706097B (ru)

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DK1620429T3 (da) * 2003-04-11 2009-05-18 Glenmark Pharmaceuticals Sa Nye heterocykliske forbindelser anvendelige til behandling af inflammatoriske og allergiske sygdomme, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger indeholdende disse
US8524905B2 (en) * 2007-05-22 2013-09-03 Glenmark Pharmaceuticals S.A. Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
CN103864779B (zh) * 2012-12-07 2016-06-22 天津科技大学 一种1-(苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用
CN103864781A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新型1，9-二取代四氢咔啉类衍生物的制备及其抗肿瘤药物中的应用
CN104961742B (zh) * 2015-03-17 2017-04-12 丁新生 具有防治阿尔茨海默病作用的化合物及其应用
CN106883270B (zh) 2015-11-26 2019-03-26 财团法人工业技术研究院 有机金属化合物、包含其的有机发光装置
CN113754675B (zh) * 2020-06-04 2022-09-02 首都医科大学 二甲基二氧六环-四氢-β-咔啉-3-羧酸的合成,生物活性和应用
WO2023143393A1 (zh) * 2022-01-29 2023-08-03 上海科技大学 三并环类化合物、其制备方法和用途

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Also Published As

Publication number Publication date
US20090306082A1 (en) 2009-12-10
CN101124229A (zh) 2008-02-13
CN101124229B (zh) 2012-07-18
ES2417491T3 (es) 2013-08-08
ZA200706097B (en) 2008-07-30
NO20073436L (no) 2007-09-05
PT1831227E (pt) 2013-08-23
US7943634B2 (en) 2011-05-17
SI1831227T1 (sl) 2013-09-30
DK1831227T3 (da) 2013-08-19

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