UA88795C2 - Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений - Google Patents
Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушенийInfo
- Publication number
- UA88795C2 UA88795C2 UAA200707953A UAA200707953A UA88795C2 UA 88795 C2 UA88795 C2 UA 88795C2 UA A200707953 A UAA200707953 A UA A200707953A UA A200707953 A UAA200707953 A UA A200707953A UA 88795 C2 UA88795 C2 UA 88795C2
- Authority
- UA
- Ukraine
- Prior art keywords
- allergic
- treatment
- pharmaceutically acceptable
- reperfusion injury
- inflammatory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Изобретение касается новых ингибиторов фосфодиэстеразы 4 типа (PDE-4) формулы (1) EMBED ISISServer , (1) а также их аналогов, таутомеров, энантиомеров, диастереомеров, региоизомеров, стереоизомеров, полиморфных модификаций, фармацевтически приемлемых солей, которые отвечают N-оксидам и фармацевтически приемлемым сольватам указанных веществ, а также фармацевтических композиций, содержащих указанные соединения, которые применяются для лечения аллергических и воспалительных состояний, включающих астму, хронический бронхит, атопический дерматит, крапивницу, аллергический ринит, аллергический конъюнктивит, весенний конъюнктивит, эозинофильную гранулему, псориаз, ревматоидный артрит, септический шок, язвенный колит, болезнь Крона, реперфузионное поражение миокарда и реперфузионное поражение мозга, хронический гломерулонефрит, эндотоксический шок и респираторный дистресс-синдром у взрослых.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1352MU2004 | 2004-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA88795C2 true UA88795C2 (ru) | 2009-11-25 |
Family
ID=38658137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200707953A UA88795C2 (ru) | 2004-12-17 | 2005-12-15 | Гетероциклические соединения, которые применяются для лечения воспалителных и аллергических нарушений |
Country Status (9)
Country | Link |
---|---|
US (1) | US7943634B2 (ru) |
CN (1) | CN101124229B (ru) |
DK (1) | DK1831227T3 (ru) |
ES (1) | ES2417491T3 (ru) |
NO (1) | NO20073436L (ru) |
PT (1) | PT1831227E (ru) |
SI (1) | SI1831227T1 (ru) |
UA (1) | UA88795C2 (ru) |
ZA (1) | ZA200706097B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1620429E (pt) * | 2003-04-11 | 2009-04-28 | Glenmark Pharmaceuticals Sa | Novos compostos heterocíclicos úteis para o tratamento de perturbações inflamatórias e alérgicas: processo para a sua preparação e composições farmacêuticas que os contêm |
WO2008142542A2 (en) * | 2007-05-22 | 2008-11-27 | Glenmark Pharmaceuticals, S.A. | Processes for preparing benzofuro [3, 2-c] pyridine- 9-carbaldehyde derivatives as novel intermediates for the synthesis of pde iv inhibitors |
CN103864779B (zh) * | 2012-12-07 | 2016-06-22 | 天津科技大学 | 一种1-(苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用 |
CN103864781A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新型1,9-二取代四氢咔啉类衍生物的制备及其抗肿瘤药物中的应用 |
CN104961742B (zh) * | 2015-03-17 | 2017-04-12 | 丁新生 | 具有防治阿尔茨海默病作用的化合物及其应用 |
CN106883270B (zh) | 2015-11-26 | 2019-03-26 | 财团法人工业技术研究院 | 有机金属化合物、包含其的有机发光装置 |
CN113754675B (zh) * | 2020-06-04 | 2022-09-02 | 首都医科大学 | 二甲基二氧六环-四氢-β-咔啉-3-羧酸的合成,生物活性和应用 |
CN116514824A (zh) * | 2022-01-29 | 2023-08-01 | 上海科技大学 | 三并环类化合物、其制备方法和用途 |
Family Cites Families (40)
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GB1041861A (en) | 1962-03-14 | 1966-09-07 | Organon Labor Ltd | Pyrrolidone derivatives and pharmaceutical preparations containing them |
NL7008628A (ru) | 1969-06-25 | 1970-12-29 | ||
US3759948A (en) * | 1969-06-25 | 1973-09-18 | Merck & Co Inc | Non-steroid anti-inflammatory compounds |
NL7016899A (ru) | 1969-12-03 | 1971-06-07 | ||
US3846553A (en) * | 1969-12-03 | 1974-11-05 | Merck & Co Inc | 3-substituted-2-pyridones in the treatment of pain, fever or inflammation |
US4222944A (en) * | 1978-07-31 | 1980-09-16 | Hoffmann-La Roche Inc. | Halo-3-dibenzofuran alkanonitriles |
JPS62158253A (ja) | 1985-12-28 | 1987-07-14 | Kirin Brewery Co Ltd | 4−アミノピリジンアミド誘導体 |
JPH0812430B2 (ja) | 1986-07-07 | 1996-02-07 | キヤノン株式会社 | 電子写真感光体 |
EP0257956B2 (en) * | 1986-08-19 | 2000-11-22 | Genentech, Inc. | Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion |
US5202344A (en) | 1990-12-11 | 1993-04-13 | G. D. Searle & Co. | N-substituted lactams useful as cholecystokinin antagonists |
IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
US5602173A (en) | 1992-04-02 | 1997-02-11 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
NZ254881A (en) | 1992-07-28 | 1996-09-25 | Rhone Poulenc Rorer Ltd | Diether, dithioether or diether thioether derivatives of 1,2-dihydroxybenzenes substituted in position-4 by an (hetero)aryl-containing group; |
MX9306311A (es) | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
US5814651A (en) * | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
KR100331255B1 (ko) | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
WO1995009837A1 (en) | 1993-10-01 | 1995-04-13 | Smithkline Beecham Corporation | Cyano compounds |
GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
GB9404706D0 (en) | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
CN1166169A (zh) | 1994-07-27 | 1997-11-26 | 三共株式会社 | 用作毒蕈碱性受体别构效应物的杂环化合物 |
EE03997B1 (et) * | 1995-04-14 | 2003-04-15 | Glaxo Wellcome Inc. | Albuterooli doseeriv inhalaator |
US6514996B2 (en) * | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
DE19616573C2 (de) * | 1996-04-25 | 1999-03-04 | Pari Gmbh | Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase |
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JP3530004B2 (ja) * | 1998-02-06 | 2004-05-24 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
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US6110962A (en) * | 1998-05-12 | 2000-08-29 | American Home Products Corporation | 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia |
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US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
CA2401870A1 (en) | 2000-03-17 | 2001-09-27 | Bristol-Myers Squibb Pharma Company | Cyclic .beta.-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-.alpha. |
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WO2002060867A2 (en) | 2001-01-29 | 2002-08-08 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
AU2002306687A1 (en) | 2001-03-13 | 2002-09-24 | Glenmark Pharmaceuticals Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them |
WO2004016596A1 (en) | 2002-08-19 | 2004-02-26 | Glenmark Pharmaceuticals Limited | Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders |
AU2003263393A1 (en) | 2002-09-04 | 2004-03-29 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
CN100532374C (zh) * | 2002-10-23 | 2009-08-26 | 格兰马克药品有限公司 | 可用于治疗炎性和变应性病症的新的三环化合物:它们的制备方法以及包含它们的药物组合物 |
WO2004069831A1 (en) * | 2003-02-10 | 2004-08-19 | Glenmark Pharmaceuticals Ltd. | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation |
PT1620429E (pt) * | 2003-04-11 | 2009-04-28 | Glenmark Pharmaceuticals Sa | Novos compostos heterocíclicos úteis para o tratamento de perturbações inflamatórias e alérgicas: processo para a sua preparação e composições farmacêuticas que os contêm |
-
2005
- 2005-12-15 ES ES05826587T patent/ES2417491T3/es active Active
- 2005-12-15 UA UAA200707953A patent/UA88795C2/ru unknown
- 2005-12-15 SI SI200531753T patent/SI1831227T1/sl unknown
- 2005-12-15 CN CN2005800483152A patent/CN101124229B/zh not_active Expired - Fee Related
- 2005-12-15 US US11/721,912 patent/US7943634B2/en active Active
- 2005-12-15 PT PT58265877T patent/PT1831227E/pt unknown
- 2005-12-15 DK DK05826587.7T patent/DK1831227T3/da active
-
2007
- 2007-07-03 NO NO20073436A patent/NO20073436L/no not_active Application Discontinuation
- 2007-07-13 ZA ZA200706097A patent/ZA200706097B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US7943634B2 (en) | 2011-05-17 |
US20090306082A1 (en) | 2009-12-10 |
SI1831227T1 (sl) | 2013-09-30 |
CN101124229B (zh) | 2012-07-18 |
ZA200706097B (en) | 2008-07-30 |
PT1831227E (pt) | 2013-08-23 |
ES2417491T3 (es) | 2013-08-08 |
NO20073436L (no) | 2007-09-05 |
CN101124229A (zh) | 2008-02-13 |
DK1831227T3 (da) | 2013-08-19 |
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