DE69427675T2 - Heterozyklische Verbindungen, ihre Herstellung und Verwendung - Google Patents
Heterozyklische Verbindungen, ihre Herstellung und VerwendungInfo
- Publication number
- DE69427675T2 DE69427675T2 DE69427675T DE69427675T DE69427675T2 DE 69427675 T2 DE69427675 T2 DE 69427675T2 DE 69427675 T DE69427675 T DE 69427675T DE 69427675 T DE69427675 T DE 69427675T DE 69427675 T2 DE69427675 T2 DE 69427675T2
- Authority
- DE
- Germany
- Prior art keywords
- stands
- optionally substituted
- ring
- hydrogen atom
- hydrocarbon residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28117893 | 1993-11-10 | ||
| JP33748893 | 1993-12-28 | ||
| JP3363794 | 1994-03-03 | ||
| JP13855194 | 1994-06-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69427675D1 DE69427675D1 (de) | 2001-08-16 |
| DE69427675T2 true DE69427675T2 (de) | 2002-05-16 |
Family
ID=27459814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69427675T Expired - Fee Related DE69427675T2 (de) | 1993-11-10 | 1994-11-08 | Heterozyklische Verbindungen, ihre Herstellung und Verwendung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5585385A (de) |
| EP (1) | EP0652218B1 (de) |
| KR (1) | KR950014108A (de) |
| CN (1) | CN1052004C (de) |
| AT (1) | ATE203024T1 (de) |
| AU (1) | AU678295B2 (de) |
| BR (1) | BR9404403A (de) |
| CA (1) | CA2135440A1 (de) |
| DE (1) | DE69427675T2 (de) |
| FI (1) | FI945281A (de) |
| HU (1) | HUT68810A (de) |
| IL (1) | IL111590A0 (de) |
| NO (1) | NO301764B1 (de) |
| NZ (1) | NZ264887A (de) |
| RU (1) | RU2135471C1 (de) |
| TW (1) | TW263498B (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2194937T3 (es) * | 1995-03-24 | 2003-12-01 | Takeda Chemical Industries Ltd | Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina. |
| US5770590A (en) * | 1995-03-24 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Cyclic compounds, their prudiction and use |
| FR2732221B1 (fr) * | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| GB9524104D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| AU740447B2 (en) * | 1997-09-23 | 2001-11-01 | Merck & Co., Inc. | Thrombin inhibitors |
| US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
| US6727258B2 (en) * | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
| US5939432A (en) * | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| WO2000012503A1 (fr) * | 1998-08-26 | 2000-03-09 | Tanabe Seiyaku Co., Ltd. | Derives de naphthyridine et leur procede de preparation |
| AU6228499A (en) * | 1998-10-22 | 2000-05-08 | Akzo Nobel N.V. | Tetrahydropyridopyridine derivatives and intermediates for producing the same |
| US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2374654A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Thrombin inhibitors |
| US20040152727A1 (en) * | 2001-05-18 | 2004-08-05 | Hay Douglas William Pierre | Novel use |
| AU2002354104A1 (en) | 2001-12-10 | 2003-06-23 | Kyorin Pharmaceutical Co., Ltd. | Fused bicyclic pyridine derivatives as tachykinin receptor antagonists |
| EP1473295B1 (de) * | 2002-01-18 | 2009-04-01 | Kyorin Pharmaceutical Co., Ltd. | Kondensierte bicyclische pyrimidinderivate |
| US7402595B2 (en) * | 2002-02-13 | 2008-07-22 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
| CA2478310A1 (en) | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors |
| US7026309B2 (en) | 2002-03-26 | 2006-04-11 | Kyorin Pharmaceutical Co., Ltd. | Fused bicyclic pyridine derivative as tachykinin receptor antagonist |
| EP1569925A1 (de) | 2002-12-13 | 2005-09-07 | Neurogen Corporation | 2-substituierte chinazolin-4-ylamin analoge verbindungen als capsaicin receptor modulatoren |
| EP1667977A4 (de) * | 2003-09-23 | 2009-09-09 | Merck & Co Inc | Isochinolinon-kaliumkanalinhibitoren |
| EP1667973B1 (de) | 2003-09-23 | 2013-12-04 | Merck Sharp & Dohme Corp. | Chinolin-kaliumkanalinhibitoren |
| WO2005068427A1 (ja) * | 2004-01-14 | 2005-07-28 | Takeda Pharmaceutical Company Limited | カルボキサミド誘導体およびその用途 |
| KR100781704B1 (ko) * | 2005-04-20 | 2007-12-03 | 에스케이케미칼주식회사 | 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물 |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| ES2786298T3 (es) * | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Inhibidores de benzimidazol del canal de sodio |
| CN102358730A (zh) * | 2011-08-24 | 2012-02-22 | 济南赛文医药技术有限公司 | 一种小分子mek蛋白激酶抑制剂 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| WO2014078257A1 (en) * | 2012-11-14 | 2014-05-22 | Glaxosmithkline Llc | Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors |
| JP2016525503A (ja) | 2013-06-28 | 2016-08-25 | アッヴィ・インコーポレイテッド | ブロモドメイン阻害剤 |
| ES2824552T3 (es) | 2015-03-04 | 2021-05-12 | Vanda Pharmaceuticals Inc | Método de tratamiento con tradipitant |
| EP3133065A1 (de) | 2015-08-21 | 2017-02-22 | Merck Patent GmbH | Verbindungen für optisch aktive vorrichtungen |
| EP3693369A3 (de) | 2016-04-15 | 2020-09-09 | AbbVie Inc. | Bromdomäneninhibitoren |
| EP3363793A1 (de) | 2017-02-15 | 2018-08-22 | Merck Patent GmbH | Hydrophobe verbindungen zur herstellung von optisch aktiven vorrichtungen |
| EP3363786A1 (de) | 2017-02-15 | 2018-08-22 | Merck Patent GmbH | Verbindungen für optisch aktive vorrichtungen |
| CA3073998A1 (en) | 2017-09-13 | 2019-03-21 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| WO2021233800A1 (en) | 2020-05-20 | 2021-11-25 | Merck Patent Gmbh | Azacoumarin and azathiocoumarin derivatives for use in optically active devices |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| EP4175719A1 (de) | 2020-07-02 | 2023-05-10 | Incyte Corporation | Tricyclische harnstoffverbindungen als jak2-v617f-hemmer |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| TW205037B (de) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| DE69106499T2 (de) * | 1990-02-10 | 1995-06-29 | Takeda Chemical Industries Ltd | Chromenderivate, deren herstellung und verwendung. |
| US5143919A (en) * | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
| DE69110828T2 (de) * | 1990-10-16 | 1995-11-30 | Takeda Chemical Industries Ltd | Heterozyklische Aminderivate, deren Herstellung und deren Verwendung. |
| TW241258B (de) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| DE4215588A1 (de) * | 1992-05-12 | 1993-11-18 | Bayer Ag | Biphenylmethyl-substituierte Pyridone |
| DE4215587A1 (de) * | 1992-05-12 | 1993-11-18 | Bayer Ag | Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone |
| DE69315920T2 (de) * | 1992-09-04 | 1998-06-10 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
| JPH06298757A (ja) * | 1993-04-15 | 1994-10-25 | Kissei Pharmaceut Co Ltd | ピペリジノ−３，４−ジヒドロカルボスチリル誘導体 |
-
1994
- 1994-11-05 TW TW083110229A patent/TW263498B/zh active
- 1994-11-08 NO NO944252A patent/NO301764B1/no not_active IP Right Cessation
- 1994-11-08 AT AT94117576T patent/ATE203024T1/de not_active IP Right Cessation
- 1994-11-08 EP EP94117576A patent/EP0652218B1/de not_active Expired - Lifetime
- 1994-11-08 DE DE69427675T patent/DE69427675T2/de not_active Expired - Fee Related
- 1994-11-09 NZ NZ264887A patent/NZ264887A/en unknown
- 1994-11-09 CA CA002135440A patent/CA2135440A1/en not_active Abandoned
- 1994-11-09 AU AU77738/94A patent/AU678295B2/en not_active Ceased
- 1994-11-09 FI FI945281A patent/FI945281A/fi unknown
- 1994-11-09 RU RU94040174A patent/RU2135471C1/ru active
- 1994-11-09 BR BR9404403A patent/BR9404403A/pt not_active Application Discontinuation
- 1994-11-10 US US08/338,762 patent/US5585385A/en not_active Expired - Fee Related
- 1994-11-10 CN CN94113866A patent/CN1052004C/zh not_active Expired - Fee Related
- 1994-11-10 IL IL11159094A patent/IL111590A0/xx unknown
- 1994-11-10 KR KR1019940029451A patent/KR950014108A/ko not_active IP Right Cessation
- 1994-11-10 HU HU9403230A patent/HUT68810A/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1052004C (zh) | 2000-05-03 |
| FI945281A (fi) | 1995-05-11 |
| IL111590A0 (en) | 1995-01-24 |
| BR9404403A (pt) | 1995-07-18 |
| CN1107476A (zh) | 1995-08-30 |
| NO944252L (no) | 1995-05-11 |
| ATE203024T1 (de) | 2001-07-15 |
| NO944252D0 (no) | 1994-11-08 |
| FI945281A0 (fi) | 1994-11-09 |
| HUT68810A (en) | 1995-05-19 |
| TW263498B (de) | 1995-11-21 |
| RU2135471C1 (ru) | 1999-08-27 |
| US5585385A (en) | 1996-12-17 |
| HU9403230D0 (en) | 1995-01-30 |
| EP0652218B1 (de) | 2001-07-11 |
| EP0652218A1 (de) | 1995-05-10 |
| AU7773894A (en) | 1995-05-18 |
| KR950014108A (ko) | 1995-06-15 |
| DE69427675D1 (de) | 2001-08-16 |
| CA2135440A1 (en) | 1995-05-11 |
| NO301764B1 (no) | 1997-12-08 |
| NZ264887A (en) | 1996-12-20 |
| AU678295B2 (en) | 1997-05-22 |
| RU94040174A (ru) | 1996-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |
|
| 8339 | Ceased/non-payment of the annual fee |