CH668960A5 - Milieu, dispositif et procede pour separation cellulaire. - Google Patents
Milieu, dispositif et procede pour separation cellulaire. Download PDFInfo
- Publication number
- CH668960A5 CH668960A5 CH1439/86A CH143986A CH668960A5 CH 668960 A5 CH668960 A5 CH 668960A5 CH 1439/86 A CH1439/86 A CH 1439/86A CH 143986 A CH143986 A CH 143986A CH 668960 A5 CH668960 A5 CH 668960A5
- Authority
- CH
- Switzerland
- Prior art keywords
- cells
- column
- cell
- sintered
- separation
- Prior art date
Links
- 238000000926 separation method Methods 0.000 title claims description 56
- 238000000034 method Methods 0.000 title claims description 29
- 230000001413 cellular effect Effects 0.000 title 1
- 229910052586 apatite Inorganic materials 0.000 claims description 37
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 37
- KIZFHUJKFSNWKO-UHFFFAOYSA-M calcium monohydroxide Chemical compound [Ca]O KIZFHUJKFSNWKO-UHFFFAOYSA-M 0.000 claims description 29
- 239000002245 particle Substances 0.000 claims description 18
- 239000006285 cell suspension Substances 0.000 claims description 13
- 238000001179 sorption measurement Methods 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000006185 dispersion Substances 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 238000003320 cell separation method Methods 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 73
- 239000002609 medium Substances 0.000 description 18
- 210000001616 monocyte Anatomy 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 10
- 238000011084 recovery Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 239000004677 Nylon Substances 0.000 description 5
- 239000012980 RPMI-1640 medium Substances 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000011491 glass wool Substances 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 230000001900 immune effect Effects 0.000 description 5
- 229920001778 nylon Polymers 0.000 description 5
- 229920002307 Dextran Polymers 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000010079 rubber tapping Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 206010016807 Fluid retention Diseases 0.000 description 2
- 101100342977 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) leu-1 gene Proteins 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000002153 concerted effect Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- PGRNEGLBSNLPNP-UHFFFAOYSA-N 1,6-dichloro-3-methylhex-1-ene Chemical compound ClC=CC(C)CCCCl PGRNEGLBSNLPNP-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical class FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Chemical class 0.000 description 1
- 229920001287 Chondroitin sulfate Chemical class 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 108010077077 Osteonectin Proteins 0.000 description 1
- 102100037599 SPARC Human genes 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60077222A JPS61235752A (ja) | 1985-04-11 | 1985-04-11 | 細胞分離材、分離器および分離方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH668960A5 true CH668960A5 (fr) | 1989-02-15 |
Family
ID=13627821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1439/86A CH668960A5 (fr) | 1985-04-11 | 1986-04-11 | Milieu, dispositif et procede pour separation cellulaire. |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US4761366A (enExample) |
| JP (1) | JPS61235752A (enExample) |
| CH (1) | CH668960A5 (enExample) |
| GB (1) | GB2175602B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4865733A (en) * | 1986-03-22 | 1989-09-12 | Toa Nenryo Kogyo K.K. | Cell separator device |
| JP2657403B2 (ja) * | 1988-09-13 | 1997-09-24 | 旭光学工業株式会社 | 細胞の観察・培養器具 |
| US5055307A (en) * | 1988-12-29 | 1991-10-08 | Asahi Kagaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
| DE4042579C2 (de) * | 1989-02-28 | 2000-11-30 | Asahi Optical Co Ltd | Trennmittel zum Abtrennen von Zellen oder Viren |
| SE9000650L (sv) * | 1989-02-28 | 1990-08-29 | Asahi Optical Co Ltd | Separation av celler eller virus |
| DE69033632T2 (de) * | 1989-04-21 | 2001-05-03 | Asahi Kogaku Kogyo K.K., Tokio/Tokyo | Filterschicht |
| US5158756A (en) * | 1989-06-24 | 1992-10-27 | Asahi Kogaku Kogyo Kabushiki Kaisha | Porous particles of calcium phosphate compound and production process thereof |
| US5240856A (en) * | 1991-10-23 | 1993-08-31 | Cellpro Incorporated | Apparatus for cell separation |
| US5672481A (en) * | 1991-10-23 | 1997-09-30 | Cellpro, Incorporated | Apparatus and method for particle separation in a closed field |
| US7001371B1 (en) * | 1993-07-02 | 2006-02-21 | Med Usa | Porous drug delivery system |
| JP3600676B2 (ja) * | 1996-01-29 | 2004-12-15 | ペンタックス株式会社 | 生体内可溶性複合体粒子 |
| US6071527A (en) * | 1996-04-10 | 2000-06-06 | Asahi Kogaku Kogyo Kabushiki Kaisha | Deodorant microphone cover and method of producing the same |
| JP2001500753A (ja) | 1996-08-26 | 2001-01-23 | ヘマシュア，インク． | 腫瘍細胞に汚染された幹細胞産物から腫瘍細胞を除去する方法 |
| US5910584A (en) * | 1996-09-05 | 1999-06-08 | Asahi Kogaku Kogyo Kabushiki Kaisha | Method for isolating plasmid DNA |
| US5843731A (en) * | 1996-09-05 | 1998-12-01 | Asahi Kogaku Kogyo Kabushiki Kaisha | Method for purifying plasmid DNA on calcium phosphate compound |
| WO1998032840A1 (en) * | 1997-01-24 | 1998-07-30 | Asahi Medical Co., Ltd. | Method for separating cells |
| FR2836923B1 (fr) * | 2002-02-25 | 2007-06-15 | Pentax Corp | Support pour culture de cellules et procede pour cultiver des cellules. |
| JP5476558B2 (ja) * | 2006-08-02 | 2014-04-23 | 公益財団法人ヒューマンサイエンス振興財団 | 水試料中の原虫のろ過回収方法および水道水又は水道原水の水質の管理方法 |
| US8633016B2 (en) * | 2008-09-30 | 2014-01-21 | Covidien Lp | Microbial detection assembly |
| AU2013229008B2 (en) | 2012-03-06 | 2018-11-08 | Cellect Biotherapeutics Ltd | Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof |
| JP6444615B2 (ja) * | 2014-05-20 | 2018-12-26 | 株式会社ビケンバイオミクス | 分離容器およびウイルスの濃縮・精製方法 |
| EP3556839A1 (en) * | 2018-04-19 | 2019-10-23 | Aglaris Ltd | Cell separation chamber and cell separation system and method |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3737516A (en) * | 1971-03-05 | 1973-06-05 | Du Pont | Calcium-deficient hydroxylapatite for use in column chromatography |
| JPS6050743B2 (ja) * | 1976-06-02 | 1985-11-09 | 旭光学工業株式会社 | アパタイト焼結体及びその製造方法 |
| US4097935A (en) * | 1976-07-21 | 1978-07-04 | Sterling Drug Inc. | Hydroxylapatite ceramic |
| JPS53144194A (en) * | 1977-05-20 | 1978-12-15 | Kureha Chemical Ind Co Ltd | Compound implanted material and making method thereof |
| JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
| DE3022914A1 (de) * | 1980-06-19 | 1981-12-24 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zurgewinnung eines anaphylatoxin und cocytotaxin enthaltenden leukotaxinpraeparates sowie von anaphylatoxin und cocytotaxin in molekular einheitlicher form |
| US4503157A (en) * | 1982-09-25 | 1985-03-05 | Ina Seito Co., Ltd. | Sintered apatite bodies and composites thereof |
| US4654314A (en) * | 1983-07-09 | 1987-03-31 | Sumitomo Cement Co., Ltd. | Porous ceramic material and processes for preparing same |
| JPS60186455A (ja) * | 1984-03-06 | 1985-09-21 | 株式会社ニコン | アパタイトコンポジツトセラミクス |
| JPS60198458A (ja) * | 1984-03-22 | 1985-10-07 | Koken:Kk | クロマトグラフイ用カラム |
| US4757017A (en) * | 1984-09-14 | 1988-07-12 | Mcw Research Foundation, Inc. | In vitro cell culture system |
| US4629464A (en) * | 1984-09-25 | 1986-12-16 | Tdk Corporation | Porous hydroxyapatite material for artificial bone substitute |
| US4693986A (en) * | 1985-06-25 | 1987-09-15 | Orthomatrix, Inc. | Ceramic process and products |
| JPH0624964B2 (ja) * | 1985-09-23 | 1994-04-06 | 東燃株式会社 | リン酸カルシウム系ヒドロキシアパタイト及びその製造方法 |
| US4861733A (en) * | 1987-02-13 | 1989-08-29 | Interpore International | Calcium phosphate bone substitute materials |
-
1985
- 1985-04-11 JP JP60077222A patent/JPS61235752A/ja active Granted
-
1986
- 1986-04-10 GB GB8608736A patent/GB2175602B/en not_active Expired
- 1986-04-10 US US06/850,186 patent/US4761366A/en not_active Expired - Lifetime
- 1986-04-11 CH CH1439/86A patent/CH668960A5/fr not_active IP Right Cessation
-
1988
- 1988-01-14 US US07/145,667 patent/US5098842A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2175602B (en) | 1989-06-21 |
| US4761366A (en) | 1988-08-02 |
| GB8608736D0 (en) | 1986-05-14 |
| GB2175602A (en) | 1986-12-03 |
| JPH0513269B2 (enExample) | 1993-02-22 |
| JPS61235752A (ja) | 1986-10-21 |
| US5098842A (en) | 1992-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |