CH659136A5 - Immunoreaktives liposom. - Google Patents
Immunoreaktives liposom. Download PDFInfo
- Publication number
- CH659136A5 CH659136A5 CH6401/81A CH640181A CH659136A5 CH 659136 A5 CH659136 A5 CH 659136A5 CH 6401/81 A CH6401/81 A CH 6401/81A CH 640181 A CH640181 A CH 640181A CH 659136 A5 CH659136 A5 CH 659136A5
- Authority
- CH
- Switzerland
- Prior art keywords
- enzyme
- antigen
- antibody
- liposome
- noise ratio
- Prior art date
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11786480A | 1980-02-04 | 1980-02-04 | |
| US06/222,815 US4342826A (en) | 1980-02-04 | 1981-01-12 | Immunoassay products and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH659136A5 true CH659136A5 (de) | 1986-12-31 |
Family
ID=26815728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH6401/81A CH659136A5 (de) | 1980-02-04 | 1981-01-13 | Immunoreaktives liposom. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4342826A (show.php) |
| AU (1) | AU551950B2 (show.php) |
| CA (1) | CA1175740A (show.php) |
| CH (1) | CH659136A5 (show.php) |
| DE (1) | DE3103826C2 (show.php) |
| DK (1) | DK436781A (show.php) |
| FR (1) | FR2485038A1 (show.php) |
| GB (1) | GB2069133B (show.php) |
| SE (1) | SE8105827L (show.php) |
| WO (1) | WO1981002344A1 (show.php) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4372745A (en) * | 1979-12-19 | 1983-02-08 | Electro-Nucleonics, Inc. | Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer |
| FR2486657A1 (fr) * | 1980-07-09 | 1982-01-15 | Pasteur Institut | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
| US4483921A (en) * | 1981-01-12 | 1984-11-20 | Collaborative Research, Inc. | Immunoassay with antigen or antibody labeled liposomes sequestering enzyme |
| US4659655A (en) * | 1981-11-25 | 1987-04-21 | Bio-Response, Inc. | Method for isolating product-producing cells |
| DE3374837D1 (en) * | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| AU1510183A (en) * | 1982-03-26 | 1983-10-24 | Liposome Company, Inc., The | Lupus assay method and compositions |
| CA1201382A (en) * | 1982-03-26 | 1986-03-04 | Andrew S. Janoff | Lupus assay method and composition |
| US4480041A (en) * | 1982-07-09 | 1984-10-30 | Collaborative Research, Inc. | Use of phosphotriester intermediates for preparation of functionalized liposomes |
| EP0103139B1 (en) * | 1982-08-11 | 1990-01-03 | Kabushiki Kaisha Toshiba | Reagent composition for immunoassay and immunoassay using the same |
| US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4517303A (en) * | 1982-10-20 | 1985-05-14 | E. I. Du Pont De Nemours And Company | Specific binding assays utilizing analyte-cytolysin conjugates |
| JPS5984162A (ja) * | 1982-11-05 | 1984-05-15 | Toshiba Corp | 免疫分析法 |
| SE8206744D0 (sv) * | 1982-11-26 | 1982-11-26 | Fluidcarbon International Ab | Preparat for kontrollerad avgivning av substanser |
| US4456691A (en) * | 1983-02-28 | 1984-06-26 | Suad Stark | Antigen for PCB, antibody raised by same, and method of making same |
| US4668638A (en) * | 1983-03-24 | 1987-05-26 | The Liposome Company, Inc. | Liposome composition for lupus assay |
| US5186941A (en) * | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
| JPH06105256B2 (ja) * | 1983-06-14 | 1994-12-21 | 株式会社東芝 | 免疫分析方法 |
| US4605630A (en) * | 1983-07-27 | 1986-08-12 | Cooper Lipotech Inc. | Large-liposome agglutination reagent and method |
| US4713324A (en) * | 1983-09-01 | 1987-12-15 | Technicon Instruments Corporation | Inverted latency specific binding assay |
| US4692433A (en) * | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
| JPH06100601B2 (ja) * | 1983-11-30 | 1994-12-12 | 株式会社東芝 | 免疫分析用試薬及びそれを用いた分析方法 |
| US4745074A (en) * | 1984-02-23 | 1988-05-17 | Cooper-Lipotech Partnership | Blood-fluid composition for cell lysis system |
| US4731324A (en) * | 1984-05-21 | 1988-03-15 | Cooper-Lipotech, Inc. | Viral lysis assay |
| US4957735A (en) * | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US4708933A (en) * | 1984-06-12 | 1987-11-24 | Leaf Huang | Immunoliposome assay-methods and products |
| US4707441A (en) * | 1984-08-06 | 1987-11-17 | Technicon Instruments Corp. | Binding assays in automated apparatus with liposome compatible surfactants |
| US4656129A (en) * | 1984-08-16 | 1987-04-07 | Becton Dickinson And Company | Assay for a ligand by use of supported binder and sac lysing agent |
| US4666830A (en) * | 1984-08-23 | 1987-05-19 | Wagner Daniel B | Assay employing sacs and sac lysing agent |
| US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| US4897269A (en) * | 1984-09-24 | 1990-01-30 | Mezei Associates Limited | Administration of drugs with multiphase liposomal delivery system |
| US4839276A (en) * | 1984-12-05 | 1989-06-13 | Technicon Instruments Corporation | Interference - resistant liposome specific binding assay |
| US4619795A (en) * | 1984-12-24 | 1986-10-28 | Technicon Instruments Corp. | Method for preparing lipid vesicles |
| DE3583015D1 (de) * | 1984-12-28 | 1991-07-04 | Technicon Instr | Phospholipidkonjugate und deren herstellung. |
| US5053497A (en) * | 1984-12-28 | 1991-10-01 | Technion Instruments Corporation | Phospholipid conjugates and their preparation |
| JPS61176855A (ja) * | 1985-02-01 | 1986-08-08 | Hitachi Ltd | 免疫分析用試薬および免疫分析方法 |
| US4622294A (en) * | 1985-02-08 | 1986-11-11 | Kung Viola T | Liposome immunoassay reagent and method |
| US4704355A (en) * | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| JPH076984B2 (ja) * | 1985-05-31 | 1995-01-30 | 株式会社日立製作所 | 複数項目分析方法 |
| US4693970A (en) * | 1985-06-21 | 1987-09-15 | Becton, Dickinson And Company | Immunoassay using complement |
| US4752572A (en) * | 1985-08-30 | 1988-06-21 | Eastman Kodak Company | Lipid vesicles containing labeled species and their analytical uses |
| US5622713A (en) * | 1985-09-17 | 1997-04-22 | The Regents Of The University Of California | Method of detoxifying animal suffering from overdose |
| US5068198A (en) * | 1986-03-26 | 1991-11-26 | Syntex (U.S.A.) Inc. | Liquid single reagent for assays involving confining gels |
| CA1308020C (en) * | 1986-03-26 | 1992-09-29 | Ian Gibbons | Liquid single reagent for assays |
| EP0268773B1 (en) * | 1986-09-24 | 1992-04-15 | Wako Pure Chemical Industries, Ltd. | Novel method for determination of antistreptolysin o and a kit used therefor |
| US4902466A (en) * | 1986-12-11 | 1990-02-20 | Ciba Corning Diagnostics Corp. | Process for making lipid films suitable for liposomes |
| JPH0799374B2 (ja) * | 1987-02-06 | 1995-10-25 | 株式会社日立製作所 | 免疫分析用試薬およびこれを用いる免疫分析方法 |
| US4912208A (en) * | 1987-06-29 | 1990-03-27 | Abbott Laboratories | Fluorophores for encapsulation into liposomes |
| US4970074A (en) * | 1987-06-29 | 1990-11-13 | Abbott Laboratories | Fluorophores for encapsulation into liposomes |
| US4978625A (en) * | 1987-10-19 | 1990-12-18 | Becton, Dickinson And Company | Fluorescence immunoassay using water insoluble dyes |
| US4873035A (en) * | 1987-11-25 | 1989-10-10 | Abbott Laboratories | Preparation of sized populations of liposomes |
| US5017501A (en) * | 1987-11-25 | 1991-05-21 | Abbott Laboratories | Preparation of uniformly sized liposomes encapsulating an aqueous liquid |
| US5389523A (en) * | 1988-05-31 | 1995-02-14 | The United States Of Americas, As Represented By The Secretary Of Commerce | Liposome immunoanalysis by flow injection assay |
| US4937078A (en) * | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| MY104234A (en) * | 1988-11-17 | 1994-02-28 | Becton Dickinson Co | Immunoassay on a preblocked solid surface |
| US5443955A (en) * | 1989-01-27 | 1995-08-22 | Australian Membrane And Biotechnology Research Institute | Receptor membranes and ionophore gating |
| US5874316A (en) * | 1989-01-27 | 1999-02-23 | Australian Membrane Biotechnology Research Institute | Receptor membranes and ionophore gating |
| ATE135820T1 (de) * | 1989-02-06 | 1996-04-15 | Wako Pure Chem Ind Ltd | Immunoassay-verfahren und flüssigreagenzien dafür |
| US5015483A (en) * | 1989-02-09 | 1991-05-14 | Nabisco Brands, Inc. | Liposome composition for the stabilization of oxidizable substances |
| US5139803A (en) * | 1989-02-09 | 1992-08-18 | Nabisco, Inc. | Method and liposome composition for the stabilization of oxidizable substances |
| US5085864A (en) * | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US6001335A (en) * | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5776429A (en) * | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US6146657A (en) * | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US20020150539A1 (en) | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| CA2087397A1 (en) * | 1992-01-22 | 1993-07-23 | Kazuhisa Kubotsu | Immunoassay and reagents used therefor |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US5830430A (en) * | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
| US5997898A (en) * | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US6033645A (en) * | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| US6139819A (en) * | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US6071535A (en) * | 1996-01-31 | 2000-06-06 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| US6183774B1 (en) | 1996-01-31 | 2001-02-06 | Collaborative Laboratories, Inc. | Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts |
| US5874105A (en) * | 1996-01-31 | 1999-02-23 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| JP2001507207A (ja) | 1996-05-01 | 2001-06-05 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 化合物を細胞に送達する方法 |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| DK1323434T3 (da) * | 1996-09-11 | 2007-11-12 | Bristol Myers Squibb Medical I | Fremgangsmåde til diagnostisk billeddannelse af nyreregioner under anvendelse af et kontrastmiddel og en vasodilator |
| US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| US5935572A (en) * | 1997-01-10 | 1999-08-10 | Collaborative Laboratories, Inc. | Composition containing protease separate from glycosidase for removing nits in treating lice infestation |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6143276A (en) * | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| GB9721901D0 (en) * | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
| US6123923A (en) * | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| GB9801120D0 (en) * | 1998-01-21 | 1998-03-18 | Secr Defence | Detection system |
| DE19954843C2 (de) * | 1999-11-09 | 2003-11-20 | Novosom Ag | Verfahren zur Verkapselung von Proteinen oder Peptiden in Liposomen, mit dem Verfahren hergestellte Liposomen und deren Verwendung |
| WO2003102541A2 (en) | 2002-05-31 | 2003-12-11 | Cornell Research Foundation, Inc. | Universal biosensor and methods of use |
| US8029985B2 (en) * | 2004-09-01 | 2011-10-04 | Vybion, Inc. | Amplified bioassay |
| RU2557936C2 (ru) * | 2012-12-25 | 2015-07-27 | Общество с ограниченной ответственностью "РЭД" | Способ повышения диагностической эффективности иммунохроматографических систем определения патогенов |
| WO2016137236A1 (ko) * | 2015-02-25 | 2016-09-01 | 재단법인 바이오나노헬스가드연구단 | 리포좀 또는 리포좀-폴리머 하이브리드를 이용한 바이러스 검출방법 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US20220091110A1 (en) * | 2020-09-22 | 2022-03-24 | United States Of America, As Represented By The Secretary Of The Navy | Chemically Amplified Detection |
| EP4268800A1 (en) | 2022-04-28 | 2023-11-01 | Prescience Biotechnology Inc. | Liposome comprising rapamycin or a derivative thereof and use thereof in therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
| CH594444A5 (show.php) * | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
| US3850578A (en) * | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| FR2221731B1 (show.php) * | 1973-03-12 | 1978-11-10 | Univ Leland Stanford Junior | |
| US3887698A (en) * | 1973-03-12 | 1975-06-03 | Univ Leland Stanford Junior | Sacs with epitopic sites on walls enclosing stable free radicals |
| US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| US4235792A (en) * | 1977-04-14 | 1980-11-25 | The Governing Council Of The University Of Toronto | Immunological materials |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4193983A (en) * | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
| US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4342739A (en) * | 1979-01-09 | 1982-08-03 | Fuji Photo Film Co., Ltd. | Novel material for immunological assay of biochemical components and a process for the determination of said components |
| ATE6698T1 (de) * | 1979-01-18 | 1984-03-15 | Unilever Nv | Verfahren zum nachweis und zur bestimmung spezifisch bindender proteinsubstanzen und mit diesen substanzen bindbarer materialien, testzusammensetzung und reagenziensatz dafuer. |
-
1981
- 1981-01-12 US US06/222,815 patent/US4342826A/en not_active Expired - Lifetime
- 1981-01-13 CH CH6401/81A patent/CH659136A5/de not_active IP Right Cessation
- 1981-01-13 WO PCT/US1981/000040 patent/WO1981002344A1/en not_active Ceased
- 1981-01-13 AU AU67859/81A patent/AU551950B2/en not_active Ceased
- 1981-01-30 CA CA000369832A patent/CA1175740A/en not_active Expired
- 1981-01-30 FR FR8101894A patent/FR2485038A1/fr active Granted
- 1981-02-03 GB GB8103282A patent/GB2069133B/en not_active Expired
- 1981-02-04 DE DE3103826A patent/DE3103826C2/de not_active Expired - Fee Related
- 1981-10-02 DK DK436781A patent/DK436781A/da not_active Application Discontinuation
- 1981-10-02 SE SE8105827A patent/SE8105827L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2069133B (en) | 1984-01-18 |
| FR2485038B1 (show.php) | 1985-03-15 |
| WO1981002344A1 (en) | 1981-08-20 |
| GB2069133A (en) | 1981-08-19 |
| DE3103826A1 (de) | 1981-12-03 |
| FR2485038A1 (fr) | 1981-12-24 |
| DK436781A (da) | 1981-10-02 |
| SE8105827L (sv) | 1981-10-02 |
| CA1175740A (en) | 1984-10-09 |
| AU6785981A (en) | 1981-08-31 |
| US4342826A (en) | 1982-08-03 |
| DE3103826C2 (de) | 1995-03-16 |
| AU551950B2 (en) | 1986-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |