CH647518A5 - Verfahren zur herstellung von buspiron. - Google Patents

Verfahren zur herstellung von buspiron. Download PDF

Info

Publication number
CH647518A5
CH647518A5 CH7842/81A CH784281A CH647518A5 CH 647518 A5 CH647518 A5 CH 647518A5 CH 7842/81 A CH7842/81 A CH 7842/81A CH 784281 A CH784281 A CH 784281A CH 647518 A5 CH647518 A5 CH 647518A5
Authority
CH
Switzerland
Prior art keywords
dione
labeled
butyl
formula
azaspiro
Prior art date
Application number
CH7842/81A
Other languages
German (de)
English (en)
Inventor
Robert R Covington
Davis L Jun Temple
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH647518A5 publication Critical patent/CH647518A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
CH7842/81A 1980-12-11 1981-12-08 Verfahren zur herstellung von buspiron. CH647518A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21521480A 1980-12-11 1980-12-11

Publications (1)

Publication Number Publication Date
CH647518A5 true CH647518A5 (de) 1985-01-31

Family

ID=22802113

Family Applications (1)

Application Number Title Priority Date Filing Date
CH7842/81A CH647518A5 (de) 1980-12-11 1981-12-08 Verfahren zur herstellung von buspiron.

Country Status (18)

Country Link
JP (1) JPS57122082A (el)
AT (1) AT380686B (el)
AU (1) AU528067B2 (el)
BE (1) BE891446A (el)
CA (1) CA1172255A (el)
CH (1) CH647518A5 (el)
DE (1) DE3149011A1 (el)
DK (1) DK154560C (el)
FI (1) FI73993C (el)
FR (1) FR2496105B1 (el)
GB (1) GB2089341B (el)
GR (1) GR76331B (el)
IE (1) IE51948B1 (el)
IT (1) IT1172073B (el)
LU (1) LU83833A1 (el)
NL (1) NL8105529A (el)
SE (1) SE444438B (el)
YU (1) YU42432B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2341925A1 (de) * 1973-08-20 1975-03-06 Thomae Gmbh Dr K Neue pyrimidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DK548081A (da) 1982-06-12
IE51948B1 (en) 1987-04-29
AT380686B (de) 1986-06-25
DK154560B (da) 1988-11-28
JPH0113476B2 (el) 1989-03-06
FR2496105B1 (fr) 1985-12-13
FR2496105A1 (fr) 1982-06-18
SE444438B (sv) 1986-04-14
DE3149011C2 (el) 1988-08-25
DE3149011A1 (de) 1982-07-15
LU83833A1 (fr) 1982-07-07
DK154560C (da) 1989-04-17
GB2089341A (en) 1982-06-23
NL8105529A (nl) 1982-07-01
ATA529581A (de) 1985-11-15
SE8107446L (sv) 1982-06-12
YU243681A (en) 1984-02-29
FI813937L (fi) 1982-06-12
IE812897L (en) 1982-06-11
IT1172073B (it) 1987-06-18
CA1172255A (en) 1984-08-07
IT8149718A0 (it) 1981-11-16
GR76331B (el) 1984-08-04
JPS57122082A (en) 1982-07-29
GB2089341B (en) 1984-09-19
FI73993C (fi) 1987-12-10
AU528067B2 (en) 1983-04-14
YU42432B (en) 1988-08-31
FI73993B (fi) 1987-08-31
AU7604181A (en) 1982-07-15
BE891446A (fr) 1982-06-11

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PL Patent ceased