FI73993B - Foerfarande foer framstaellning av radioaktivt maerkta 8-/4-/4-(2-pyrimidyl)-1-piperazinyl/butyl/-8- azaspiro/4.5/dekan-7,9-dioner. - Google Patents

Foerfarande foer framstaellning av radioaktivt maerkta 8-/4-/4-(2-pyrimidyl)-1-piperazinyl/butyl/-8- azaspiro/4.5/dekan-7,9-dioner.

Info

Publication number
FI73993B
FI73993B FI813937A FI813937A FI73993B FI 73993 B FI73993 B FI 73993B FI 813937 A FI813937 A FI 813937A FI 813937 A FI813937 A FI 813937A FI 73993 B FI73993 B FI 73993B
Authority
FI
Finland
Prior art keywords
dioner
azaspiro
pyrimidyl
decane
piperazinyl
Prior art date
Application number
FI813937A
Other languages
English (en)
Other versions
FI813937L (fi
FI73993C (fi
Inventor
Robert R Covington
Jr Davis L Temple
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI813937L publication Critical patent/FI813937L/fi
Application granted granted Critical
Publication of FI73993B publication Critical patent/FI73993B/fi
Publication of FI73993C publication Critical patent/FI73993C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI813937A 1980-12-11 1981-12-08 Foerfarande foer framstaellning av radioaktivt maerkta 8-/4-/4-(2-pyrimidinyl)-1-piperazinyl/butyl/-8- azaspiro/4.5/dekan-7,9-dioner. FI73993C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21521480A 1980-12-11 1980-12-11
US21521480 1980-12-11

Publications (3)

Publication Number Publication Date
FI813937L FI813937L (fi) 1982-06-12
FI73993B true FI73993B (fi) 1987-08-31
FI73993C FI73993C (fi) 1987-12-10

Family

ID=22802113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI813937A FI73993C (fi) 1980-12-11 1981-12-08 Foerfarande foer framstaellning av radioaktivt maerkta 8-/4-/4-(2-pyrimidinyl)-1-piperazinyl/butyl/-8- azaspiro/4.5/dekan-7,9-dioner.

Country Status (18)

Country Link
JP (1) JPS57122082A (fi)
AT (1) AT380686B (fi)
AU (1) AU528067B2 (fi)
BE (1) BE891446A (fi)
CA (1) CA1172255A (fi)
CH (1) CH647518A5 (fi)
DE (1) DE3149011A1 (fi)
DK (1) DK154560C (fi)
FI (1) FI73993C (fi)
FR (1) FR2496105B1 (fi)
GB (1) GB2089341B (fi)
GR (1) GR76331B (fi)
IE (1) IE51948B1 (fi)
IT (1) IT1172073B (fi)
LU (1) LU83833A1 (fi)
NL (1) NL8105529A (fi)
SE (1) SE444438B (fi)
YU (1) YU42432B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2341925A1 (de) * 1973-08-20 1975-03-06 Thomae Gmbh Dr K Neue pyrimidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IT1172073B (it) 1987-06-18
JPH0113476B2 (fi) 1989-03-06
CH647518A5 (de) 1985-01-31
DK154560C (da) 1989-04-17
DE3149011A1 (de) 1982-07-15
GB2089341B (en) 1984-09-19
AT380686B (de) 1986-06-25
AU7604181A (en) 1982-07-15
SE8107446L (sv) 1982-06-12
SE444438B (sv) 1986-04-14
LU83833A1 (fr) 1982-07-07
IE812897L (en) 1982-06-11
BE891446A (fr) 1982-06-11
IT8149718A0 (it) 1981-11-16
AU528067B2 (en) 1983-04-14
JPS57122082A (en) 1982-07-29
FI813937L (fi) 1982-06-12
GB2089341A (en) 1982-06-23
DK154560B (da) 1988-11-28
FR2496105B1 (fr) 1985-12-13
DK548081A (da) 1982-06-12
NL8105529A (nl) 1982-07-01
FI73993C (fi) 1987-12-10
YU243681A (en) 1984-02-29
CA1172255A (en) 1984-08-07
GR76331B (fi) 1984-08-04
FR2496105A1 (fr) 1982-06-18
ATA529581A (de) 1985-11-15
DE3149011C2 (fi) 1988-08-25
IE51948B1 (en) 1987-04-29
YU42432B (en) 1988-08-31

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Legal Events

Date Code Title Description
MA Patent expired

Owner name: BRISTOL-MYERS CO