CH643735A5 - Emulsion grasse pour l'injection intraveineuse. - Google Patents
Emulsion grasse pour l'injection intraveineuse. Download PDFInfo
- Publication number
- CH643735A5 CH643735A5 CH337880A CH337880A CH643735A5 CH 643735 A5 CH643735 A5 CH 643735A5 CH 337880 A CH337880 A CH 337880A CH 337880 A CH337880 A CH 337880A CH 643735 A5 CH643735 A5 CH 643735A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- emulsion
- fatty
- soybean oil
- fatty acid
- Prior art date
Links
- 238000010253 intravenous injection Methods 0.000 title claims description 6
- 239000002960 lipid emulsion Substances 0.000 title description 2
- 239000000839 emulsion Substances 0.000 claims description 55
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 22
- 210000002969 egg yolk Anatomy 0.000 claims description 22
- 150000003904 phospholipids Chemical class 0.000 claims description 20
- 235000012424 soybean oil Nutrition 0.000 claims description 18
- 239000003549 soybean oil Substances 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 150000004665 fatty acids Chemical class 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 13
- 235000012000 cholesterol Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000005642 Oleic acid Substances 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 3
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 3
- 229960004488 linolenic acid Drugs 0.000 claims description 3
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- 235000021313 oleic acid Nutrition 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 238000000889 atomisation Methods 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 235000008935 nutritious Nutrition 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 239000003995 emulsifying agent Substances 0.000 description 8
- 235000019197 fats Nutrition 0.000 description 7
- 241000700159 Rattus Species 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000037396 body weight Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000021588 free fatty acids Nutrition 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 2
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000007951 isotonicity adjuster Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- 241001137251 Corvidae Species 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54055476A JPS6030652B2 (ja) | 1979-05-07 | 1979-05-07 | 静脈注射用脂肪乳剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH643735A5 true CH643735A5 (fr) | 1984-06-29 |
Family
ID=12999653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH337880A CH643735A5 (fr) | 1979-05-07 | 1980-05-01 | Emulsion grasse pour l'injection intraveineuse. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4280996A (enExample) |
| JP (1) | JPS6030652B2 (enExample) |
| AU (1) | AU518087B2 (enExample) |
| BE (1) | BE885844A (enExample) |
| CA (1) | CA1142089A (enExample) |
| CH (1) | CH643735A5 (enExample) |
| DE (1) | DE2938807C2 (enExample) |
| FI (1) | FI70137C (enExample) |
| FR (1) | FR2455888A1 (enExample) |
| GB (1) | GB2050799B (enExample) |
| HK (1) | HK66685A (enExample) |
| IT (1) | IT1146936B (enExample) |
| NL (1) | NL189899C (enExample) |
| SU (1) | SU1311604A3 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS609726B2 (ja) * | 1980-05-15 | 1985-03-12 | 株式会社 ミドリ十字 | ステロイド製剤 |
| JPS5924132B2 (ja) * | 1980-12-02 | 1984-06-07 | 株式会社 林原生物化学研究所 | 栄養補給用乳剤の製法 |
| DE3131460A1 (de) * | 1981-08-08 | 1983-02-24 | B. Braun Melsungen Ag, 3508 Melsungen | Fettemsulsion fuer parenterale ernaehrung |
| FR2520253A1 (fr) * | 1982-01-28 | 1983-07-29 | Oreal | Nouveau systeme emulsionnant a base d'un condensat de proteines, d'un sterol polyoxyethylene et de phosphatide et son utilisation en cosmetique |
| JPS58222014A (ja) * | 1982-06-18 | 1983-12-23 | Taisho Pharmaceut Co Ltd | プロスタグランジンｅ↓１脂肪乳剤 |
| DE3228629A1 (de) * | 1982-07-31 | 1984-02-02 | Reifenrath, Rainer Richard Otto, Dr., 3104 Unterlüß | Pharmazeutisches erzeugnis zur behandlung der atemwege und verfahren zu seiner herstellung |
| DE3230103A1 (de) * | 1982-08-13 | 1984-02-16 | Mletzko, Armin von, Dr., 4520 Melle | Diaetetikum |
| JPS59152348A (ja) * | 1983-02-19 | 1984-08-31 | Kaken Pharmaceut Co Ltd | ビフエニリルプロピオン酸エステル誘導体およびその製造法 |
| FR2539324B1 (fr) * | 1983-01-19 | 1989-11-17 | Oreal | Nouveau systeme emulsionnant a base d'un acide gras, de sterol polyoxyethylene et de phosphatide et son utilisation pour l'obtention de compositions cosmetiques ou pharmaceutiques |
| JPS59141518A (ja) * | 1983-02-03 | 1984-08-14 | Taisho Pharmaceut Co Ltd | プロスタグランジン脂肪乳剤 |
| JPS59216820A (ja) * | 1983-05-20 | 1984-12-06 | Taisho Pharmaceut Co Ltd | プロスタグランジン脂肪乳剤 |
| JPS601122A (ja) * | 1983-06-20 | 1985-01-07 | Green Cross Corp:The | ビフエニリルプロピオン酸誘導体脂肪乳剤 |
| US4551449A (en) * | 1983-11-16 | 1985-11-05 | The Regents Of The University Of California | Avoidance of the immunosuppressive and antiproliferative effects of lipid emulsions |
| JPS60130519A (ja) * | 1983-12-16 | 1985-07-12 | Terumo Corp | 脂肪輸液剤 |
| JPH0818989B2 (ja) * | 1984-01-12 | 1996-02-28 | 株式会社ミドリ十字 | 脂肪乳剤中のプロスタグランジンの安定化方法 |
| CA1257131A (en) * | 1984-07-27 | 1989-07-11 | John Y. Park | Total parenteral and enteral nutrition composition |
| US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
| JPS6284028A (ja) * | 1985-07-26 | 1987-04-17 | イエダ・リサ−チ・アンド・デイベロツプメント・カンパニ−・リミテツド | 膜流動化のための脂質混合物 |
| IL78929A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
| US4760096A (en) * | 1985-09-27 | 1988-07-26 | Schering Corporation | Moisturizing skin preparation |
| US5461037A (en) * | 1985-10-15 | 1995-10-24 | Clintec Nutrition Company | Lipid emulsion |
| US4678808A (en) * | 1985-10-15 | 1987-07-07 | Baxter Travenol Laboratories, Inc. | Rapid acting intravenous emulsions of omega-3 fatty acid esters |
| SE8505047L (sv) * | 1985-10-25 | 1987-04-26 | Nutritional Int Res Inst | Fettemulsion |
| WO1988008301A1 (en) * | 1987-04-22 | 1988-11-03 | Baxter Travenol Laboratories, Inc. | Lipid emulsion and method for intravenous infusion |
| JPS6431072A (en) * | 1987-07-27 | 1989-02-01 | Nec Corp | Microwave landing system ground apparatus having monitor check function |
| US5807572A (en) * | 1988-02-18 | 1998-09-15 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| DE68914929T2 (de) * | 1988-09-29 | 1994-08-11 | Shiseido Co Ltd | Emulgierte Zusammensetzung. |
| CH677886A5 (enExample) * | 1989-06-26 | 1991-07-15 | Hans Georg Prof Dr Weder | |
| US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5221535A (en) * | 1989-11-13 | 1993-06-22 | Nova Pharmaceutical Corporation | Sustained release formulations of insect repellent |
| IE904098A1 (en) * | 1989-11-13 | 1991-05-22 | Nova Pharm Corp | Lipospheres for controlled delivery of substances |
| US5227165A (en) * | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5089268A (en) * | 1990-05-02 | 1992-02-18 | Katz David P | Egg phosphatide lipid emulsions altered for a specific therapeutic fatty acid composition |
| JP3273785B2 (ja) * | 1990-08-13 | 2002-04-15 | ダブリュー． イェスエア，デービッド | 薬物または熱源送達用混合脂質―重炭酸塩コロイド粒子 |
| US5891466A (en) * | 1990-08-13 | 1999-04-06 | Yesair; David W. | Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories |
| US5571517A (en) * | 1990-08-13 | 1996-11-05 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
| SE470086B (sv) * | 1991-04-23 | 1993-11-08 | Kabi Pharmacia Ab | Organspecifik emulsion |
| US5817646A (en) * | 1991-11-15 | 1998-10-06 | Laboratoires Inocosm | Polar lipid composition of plant origin |
| US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5310556A (en) * | 1993-06-09 | 1994-05-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic composition |
| US5554379A (en) * | 1994-06-20 | 1996-09-10 | Kv Pharmaceutical Company | Long acting GI and esophageal protectant |
| US5670163A (en) * | 1994-06-20 | 1997-09-23 | Kv Pharmaceuticals Company | Long acting GI and esophageal protectant |
| US5554380A (en) * | 1994-08-04 | 1996-09-10 | Kv Pharmaceutical Company | Bioadhesive pharmaceutical delivery system |
| US5635536A (en) * | 1994-12-07 | 1997-06-03 | Pharmacia & Upjohn Aktiebolag | Emulsion suitable for administering a sphingolipid |
| US5616342A (en) * | 1995-04-11 | 1997-04-01 | Pdt, Inc. | Emulsioin suitable for administering a poorly water-soluble photosensitizing compound and use thereof |
| KR100508910B1 (ko) | 1995-10-17 | 2006-04-20 | 알티피 파마 코포레이션 | 불용성약물방출 |
| US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| KR100509776B1 (ko) * | 1997-07-29 | 2005-08-24 | 파마시아 앤드 업존 캄파니 엘엘씨 | 친지성 화합물의 자가유화 제제 |
| DE69908304T2 (de) * | 1998-02-11 | 2004-02-19 | Rtp Pharma Corp. | Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen |
| WO1999043301A1 (en) | 1998-02-24 | 1999-09-02 | The Board Of Trustees Of The University Of Illinois | Lipid emulsions in the treatment of systemic poisoning |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| AU764001B2 (en) | 1998-05-29 | 2003-08-07 | Skyepharma Canada Inc. | Thermoprotected microparticle compositions and process for terminal steam sterilization thereof |
| ATE252889T1 (de) | 1998-08-19 | 2003-11-15 | Skyepharma Canada Inc | Injizierbare wässerige propofoldispersionen |
| EP0988857B8 (en) | 1998-08-31 | 2006-05-03 | Nipro Corporation | Nutrient infusion preparation |
| PL201578B1 (pl) | 1998-11-20 | 2009-04-30 | Skyepharma Canada Inc | Stała terapeutyczna postać dawkowania nierozpuszczalnego lub słabo rozpuszczalnego w wodzie związku |
| US7261903B1 (en) * | 1999-02-22 | 2007-08-28 | Guy Weinberg | Lipid emulsions in the treatment of systemic poisoning |
| JP3589904B2 (ja) * | 1999-06-17 | 2004-11-17 | 花王株式会社 | 酸性水中油型乳化組成物 |
| NZ522239A (en) | 2000-04-20 | 2004-03-26 | Skyepharma Canada Inc | Improved water-insoluble drug particle process |
| CA2420597C (en) | 2000-08-31 | 2011-05-17 | Rtp Pharma Inc. | Milled particles |
| US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
| DE60127457T2 (de) * | 2001-02-22 | 2007-11-29 | Jagotec Ag | Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen |
| EP2445472B1 (de) * | 2009-06-24 | 2017-12-27 | Lipoid GmbH | Zusammensetzung für kosmetische, pharmazeutische oder diätetische anwendungen |
| ES2981705T3 (es) * | 2013-12-11 | 2024-10-10 | Health Ever Biotech Co Ltd | Composiciones farmacéuticas de carotenoides |
| CN104368852B (zh) * | 2014-11-04 | 2016-08-24 | 重庆和剑机械制造有限公司 | 一种倒挡拨叉双平面一体加工设备 |
| JP2020503320A (ja) | 2017-01-08 | 2020-01-30 | レスキュー・ファーマ・インコーポレイテッドＲｅｓｑ Ｐｈａｒｍａ， Ｉｎｃ． | 術中低血圧に関連する損傷を減らす方法 |
| CN111417380A (zh) | 2017-10-27 | 2020-07-14 | 嘉吉公司 | 个人护理产品 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA615342A (en) * | 1961-02-28 | Armour And Company | Soybean phosphatide emulsifier | |
| US1939166A (en) * | 1930-07-21 | 1933-12-12 | Monsanto Chemicals | Treatment of intestinal tract |
| US2185969A (en) * | 1935-05-24 | 1940-01-02 | Winthrop Chem Co Inc | Clear aqueous solutions of lipins and process of preparing the same |
| US3004892A (en) * | 1959-03-27 | 1961-10-17 | Baxter Don Inc | Fat emulsion and process of producing same |
| CA725596A (en) * | 1960-08-26 | 1966-01-11 | J. Wretlind Arvid | Method of preparing intravenously injectable fat emulsions free from side reactions or complications |
| FR8014M (enExample) * | 1968-01-09 | 1970-07-27 | ||
| JPS537492B2 (enExample) * | 1973-02-12 | 1978-03-18 | ||
| CH588887A5 (enExample) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute |
-
1979
- 1979-05-07 JP JP54055476A patent/JPS6030652B2/ja not_active Expired
- 1979-09-13 US US06/075,684 patent/US4280996A/en not_active Expired - Lifetime
- 1979-09-25 DE DE2938807A patent/DE2938807C2/de not_active Expired
-
1980
- 1980-02-24 AU AU57809/80A patent/AU518087B2/en not_active Ceased
- 1980-04-24 CA CA000350542A patent/CA1142089A/en not_active Expired
- 1980-04-25 FI FI801336A patent/FI70137C/fi not_active IP Right Cessation
- 1980-05-01 CH CH337880A patent/CH643735A5/fr not_active IP Right Cessation
- 1980-05-02 GB GB8014624A patent/GB2050799B/en not_active Expired
- 1980-05-05 IT IT48587/80A patent/IT1146936B/it active
- 1980-05-05 SU SU802914601A patent/SU1311604A3/ru active
- 1980-05-06 FR FR8010074A patent/FR2455888A1/fr active Granted
- 1980-10-21 NL NLAANVRAGE8005797,A patent/NL189899C/xx not_active IP Right Cessation
- 1980-10-23 BE BE0/202570A patent/BE885844A/fr not_active IP Right Cessation
-
1985
- 1985-09-05 HK HK666/85A patent/HK66685A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL189899B (nl) | 1993-04-01 |
| CA1142089A (en) | 1983-03-01 |
| AU518087B2 (en) | 1981-09-10 |
| NL8005797A (nl) | 1982-05-17 |
| DE2938807C2 (de) | 1982-07-01 |
| FR2455888A1 (fr) | 1980-12-05 |
| FR2455888B1 (enExample) | 1983-07-29 |
| IT1146936B (it) | 1986-11-19 |
| AU5780980A (en) | 1980-11-13 |
| FI70137B (fi) | 1986-02-28 |
| DE2938807A1 (de) | 1980-11-13 |
| GB2050799A (en) | 1981-01-14 |
| HK66685A (en) | 1985-09-13 |
| SU1311604A3 (ru) | 1987-05-15 |
| US4280996A (en) | 1981-07-28 |
| GB2050799B (en) | 1983-07-20 |
| NL189899C (nl) | 1993-09-01 |
| FI70137C (fi) | 1990-12-28 |
| BE885844A (fr) | 1981-02-16 |
| JPS55147228A (en) | 1980-11-17 |
| IT8048587A0 (it) | 1980-05-05 |
| JPS6030652B2 (ja) | 1985-07-17 |
| FI801336A7 (fi) | 1980-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH643735A5 (fr) | Emulsion grasse pour l'injection intraveineuse. | |
| BE1001760A5 (fr) | Supports de médicaments. | |
| Klang et al. | Design and evaluation of submicron emulsions as colloidal drug carriers for intravenous administration | |
| DE3877595T2 (de) | Haltbare waesserige emulsionen aus fluorkohlenwasserstoffen. | |
| US7157099B2 (en) | Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds | |
| DE68919772T2 (de) | Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird. | |
| CN1091591C (zh) | 亲脂载体制剂 | |
| JPH0347527A (ja) | 水相中に油粒子のナノエマルジヨンを製造する方法、薬学および化粧品調剤の製法および細胞培養用栄養溶液の製法 | |
| JPS60149524A (ja) | プロスタグランジン脂肪乳剤 | |
| KR102565469B1 (ko) | 비타민 c가 포집된 리포좀 및 이의 제조방법 | |
| FR2531857A1 (fr) | Composition injectable pour prolonger la stabilite et la retention de particules enrobees, injectees dans le flux sanguin d'animaux et d'etres humains | |
| EP0491921B1 (fr) | Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile | |
| CH681275A5 (enExample) | ||
| FR2553661A1 (fr) | Nouvelles microemulsions pharmaceutiquement acceptables | |
| JP2930242B2 (ja) | 非経口投与用エマルジヨン | |
| FR2661331A1 (fr) | Composition cosmetique ou dermopharmaceutique contenant des vesicules formees par un melange phospholipides/glycolipides. | |
| EP2117510B1 (fr) | Composition pharmaceutique parentérale et son procede de preparation. | |
| EP0969871B1 (de) | Verfahren zur herstellung von homogenen, glycerophospholipide und polare oder lipophile substanzen enthaltenden, wasserfreien formulierungen | |
| US20250367117A1 (en) | Vitamin c-encapsulated liposome and preparation method therefor | |
| JP3611130B2 (ja) | 脂肪乳剤の調製方法 | |
| WO2009136084A2 (fr) | Composition cosmetique emulsionnante, preparation et utilisations | |
| CN119546281A (zh) | 阿法沙龙脂肪乳注射液及其制备方法 | |
| WO1992004886A1 (fr) | Emulsion grasse pour injection intraveineuse | |
| JPH0157095B2 (enExample) | ||
| FR2561101A1 (fr) | Procede de preparation de liposomes et liposomes ainsi obtenus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |