CH643457A5 - Pharmazeutische praeparate zur behandlung der hypertonie. - Google Patents
Pharmazeutische praeparate zur behandlung der hypertonie. Download PDFInfo
- Publication number
- CH643457A5 CH643457A5 CH178579A CH178579A CH643457A5 CH 643457 A5 CH643457 A5 CH 643457A5 CH 178579 A CH178579 A CH 178579A CH 178579 A CH178579 A CH 178579A CH 643457 A5 CH643457 A5 CH 643457A5
- Authority
- CH
- Switzerland
- Prior art keywords
- active ingredients
- preparations according
- weight ratio
- occur
- preparations
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title description 3
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 13
- 230000003276 anti-hypertensive effect Effects 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- BFAKENXZKHGIGE-UHFFFAOYSA-N bis(2,3,5,6-tetrafluoro-4-iodophenyl)diazene Chemical compound FC1=C(C(=C(C(=C1F)I)F)F)N=NC1=C(C(=C(C(=C1F)F)I)F)F BFAKENXZKHGIGE-UHFFFAOYSA-N 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- JZQKKSLKJUAGIC-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CN2 JZQKKSLKJUAGIC-UHFFFAOYSA-N 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- ALAXZYHFVBSJKZ-UHFFFAOYSA-N endralazine Chemical compound C1CC=2N=NC(NN)=CC=2CN1C(=O)C1=CC=CC=C1 ALAXZYHFVBSJKZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000012458 free base Substances 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000003826 tablet Substances 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 208000001871 Tachycardia Diseases 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000008119 colloidal silica Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 230000001631 hypertensive effect Effects 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000006794 tachycardia Effects 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- WRLKLPDTRUYBBV-UHFFFAOYSA-N 4-chloro-3-sulfamoylbenzamide Chemical compound NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 WRLKLPDTRUYBBV-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000054 salidiuretic effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH178579A CH643457A5 (de) | 1979-02-22 | 1979-02-22 | Pharmazeutische praeparate zur behandlung der hypertonie. |
| DE19803005029 DE3005029A1 (de) | 1979-02-22 | 1980-02-11 | Antihypertensive pharmazeutische zubereitungen |
| SE8001121A SE8001121L (sv) | 1979-02-22 | 1980-02-13 | Antihypertensiva farmaceutiska beredningar |
| GB8005245A GB2044101B (en) | 1979-02-22 | 1980-02-15 | Antihypertensive pharmaceutical compositions |
| BE1/9727A BE881763A (fr) | 1979-02-22 | 1980-02-18 | Nouvelles compositions pharmaceutiques utilisables pour le traitement de l'hypertension |
| NL8001000A NL8001000A (nl) | 1979-02-22 | 1980-02-19 | Werkwijzen voor het bereiden van een geneesmiddel tegen hypertensie en voor het behandelen van hypertensie daarmede. |
| PT70855A PT70855A (fr) | 1979-02-22 | 1980-02-20 | Procede pour la preparation d'une composition pharmaceutique |
| IE336/80A IE49073B1 (en) | 1979-02-22 | 1980-02-20 | Antihypertensive pharmaceutical compositions |
| IT47950/80A IT1145433B (it) | 1979-02-22 | 1980-02-20 | Composizione farmaceutiche impiegabili per il trattamento dell'ipertensione |
| NZ19978380A NZ199783A (en) | 1979-02-22 | 1980-02-20 | Sustained release compositions containing endralazine embedded in a wax matrix |
| NZ192924A NZ192924A (en) | 1979-02-22 | 1980-02-20 | Anti-hypertensive compositions containing endralazine, pendolol and a salidiuretic |
| CA000346083A CA1147657A (en) | 1979-02-22 | 1980-02-20 | Antihypertensive pharmaceutical compositions |
| IL59432A IL59432A (en) | 1979-02-22 | 1980-02-20 | Anti-hypertensive compositions containing endralazin,a salidiuretic and pindolol |
| FR8003669A FR2449450A1 (fr) | 1979-02-22 | 1980-02-20 | Nouvelles compositions pharmaceutiques utilisables pour le traitement de l'hypertension |
| AU55742/80A AU538599B2 (en) | 1979-02-22 | 1980-02-20 | Compositions and treatment for hypertension |
| AT0095580A AT378915B (de) | 1979-02-22 | 1980-02-21 | Verfahren zur herstellung von antihypertensiven pharmazeutischen zubereitungen |
| JP1980480A JPS55115823A (en) | 1979-02-22 | 1980-02-21 | Antihypertensive pharmaceutic composition |
| PH23672A PH17118A (en) | 1979-02-22 | 1980-02-21 | Antihypertensive pharmaceutical compositions and its method of use |
| HU80402A HU187271B (en) | 1979-02-22 | 1980-02-21 | Process for producing of medical preparates effecting fall in blood-pressure |
| ZA00801018A ZA801018B (en) | 1979-02-22 | 1980-02-22 | Antihypertensive pharmaceutical compositions |
| SE8202357A SE8202357L (en) | 1979-02-22 | 1982-04-15 | Antihypertensive compsns. free from side effects - contg. endralazine, a salidiuretic, esp. clopamide, and pindolol |
| MY619/85A MY8500619A (en) | 1979-02-22 | 1985-12-30 | Antihypertensive pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH178579A CH643457A5 (de) | 1979-02-22 | 1979-02-22 | Pharmazeutische praeparate zur behandlung der hypertonie. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH643457A5 true CH643457A5 (de) | 1984-06-15 |
Family
ID=4218544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH178579A CH643457A5 (de) | 1979-02-22 | 1979-02-22 | Pharmazeutische praeparate zur behandlung der hypertonie. |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS55115823A (nl) |
| AT (1) | AT378915B (nl) |
| AU (1) | AU538599B2 (nl) |
| BE (1) | BE881763A (nl) |
| CA (1) | CA1147657A (nl) |
| CH (1) | CH643457A5 (nl) |
| DE (1) | DE3005029A1 (nl) |
| FR (1) | FR2449450A1 (nl) |
| GB (1) | GB2044101B (nl) |
| HU (1) | HU187271B (nl) |
| IE (1) | IE49073B1 (nl) |
| IL (1) | IL59432A (nl) |
| IT (1) | IT1145433B (nl) |
| MY (1) | MY8500619A (nl) |
| NL (1) | NL8001000A (nl) |
| NZ (1) | NZ192924A (nl) |
| PH (1) | PH17118A (nl) |
| PT (1) | PT70855A (nl) |
| SE (2) | SE8001121L (nl) |
| ZA (1) | ZA801018B (nl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2537434A1 (fr) * | 1982-12-09 | 1984-06-15 | Sandoz Sa | Composition pharmaceutique d'endralazine sous forme retard |
| GB2367242B (en) * | 2000-09-21 | 2004-07-28 | Henderson Morley Res & Dev Ltd | Antiviral treatment |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2458155A1 (de) * | 1973-12-19 | 1975-07-03 | Sandoz Ag | Neue pharmazeutische praeparate |
-
1979
- 1979-02-22 CH CH178579A patent/CH643457A5/de not_active IP Right Cessation
-
1980
- 1980-02-11 DE DE19803005029 patent/DE3005029A1/de active Granted
- 1980-02-13 SE SE8001121A patent/SE8001121L/ not_active Application Discontinuation
- 1980-02-15 GB GB8005245A patent/GB2044101B/en not_active Expired
- 1980-02-18 BE BE1/9727A patent/BE881763A/fr not_active IP Right Cessation
- 1980-02-19 NL NL8001000A patent/NL8001000A/nl not_active Application Discontinuation
- 1980-02-20 IL IL59432A patent/IL59432A/xx unknown
- 1980-02-20 CA CA000346083A patent/CA1147657A/en not_active Expired
- 1980-02-20 FR FR8003669A patent/FR2449450A1/fr active Granted
- 1980-02-20 NZ NZ192924A patent/NZ192924A/en unknown
- 1980-02-20 IT IT47950/80A patent/IT1145433B/it active
- 1980-02-20 IE IE336/80A patent/IE49073B1/en unknown
- 1980-02-20 PT PT70855A patent/PT70855A/pt unknown
- 1980-02-20 AU AU55742/80A patent/AU538599B2/en not_active Ceased
- 1980-02-21 PH PH23672A patent/PH17118A/en unknown
- 1980-02-21 JP JP1980480A patent/JPS55115823A/ja active Pending
- 1980-02-21 AT AT0095580A patent/AT378915B/de not_active IP Right Cessation
- 1980-02-21 HU HU80402A patent/HU187271B/hu unknown
- 1980-02-22 ZA ZA00801018A patent/ZA801018B/xx unknown
-
1982
- 1982-04-15 SE SE8202357A patent/SE8202357L/xx not_active Application Discontinuation
-
1985
- 1985-12-30 MY MY619/85A patent/MY8500619A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU187271B (en) | 1985-12-28 |
| CA1147657A (en) | 1983-06-07 |
| NZ192924A (en) | 1984-05-31 |
| IE800336L (en) | 1980-08-22 |
| ZA801018B (en) | 1981-09-30 |
| AU5574280A (en) | 1980-08-28 |
| DE3005029A1 (de) | 1980-09-04 |
| SE8001121L (sv) | 1980-08-23 |
| FR2449450A1 (fr) | 1980-09-19 |
| IL59432A0 (en) | 1980-05-30 |
| GB2044101B (en) | 1983-09-07 |
| PT70855A (fr) | 1980-03-01 |
| IT1145433B (it) | 1986-11-05 |
| DE3005029C2 (nl) | 1987-02-12 |
| FR2449450B1 (nl) | 1983-07-22 |
| IE49073B1 (en) | 1985-07-24 |
| BE881763A (fr) | 1980-08-18 |
| PH17118A (en) | 1984-06-01 |
| GB2044101A (en) | 1980-10-15 |
| MY8500619A (en) | 1985-12-31 |
| IT8047950A0 (it) | 1980-02-20 |
| ATA95580A (de) | 1985-03-15 |
| NL8001000A (nl) | 1980-08-26 |
| AU538599B2 (en) | 1984-08-23 |
| SE8202357L (en) | 1982-04-15 |
| IL59432A (en) | 1984-08-31 |
| JPS55115823A (en) | 1980-09-06 |
| AT378915B (de) | 1985-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |