CH621115A5 - - Google Patents

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Publication number
CH621115A5
CH621115A5 CH234376A CH234376A CH621115A5 CH 621115 A5 CH621115 A5 CH 621115A5 CH 234376 A CH234376 A CH 234376A CH 234376 A CH234376 A CH 234376A CH 621115 A5 CH621115 A5 CH 621115A5
Authority
CH
Switzerland
Prior art keywords
formula
compounds
methyl
group
compound
Prior art date
Application number
CH234376A
Other languages
German (de)
English (en)
Inventor
Antony Marie Akkerman
Geertruida Cornelia Va Leeuwen
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Publication of CH621115A5 publication Critical patent/CH621115A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/26Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • One-Way And Automatic Clutches, And Combinations Of Different Clutches (AREA)
CH234376A 1975-02-25 1976-02-25 CH621115A5 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7891/75A GB1513961A (en) 1975-02-25 1975-02-25 6,7-benzomorphans method for their preparation and intermediates

Publications (1)

Publication Number Publication Date
CH621115A5 true CH621115A5 (no) 1981-01-15

Family

ID=9841801

Family Applications (2)

Application Number Title Priority Date Filing Date
CH234376A CH621115A5 (no) 1975-02-25 1976-02-25
CH1036579A CH623572A5 (no) 1975-02-25 1979-11-20

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH1036579A CH623572A5 (no) 1975-02-25 1979-11-20

Country Status (20)

Country Link
US (2) US4128548A (no)
JP (2) JPS51111550A (no)
AT (1) AT360663B (no)
AU (1) AU505939B2 (no)
BE (1) BE838708A (no)
CA (1) CA1080704A (no)
CH (2) CH621115A5 (no)
DE (1) DE2606267A1 (no)
DK (1) DK76176A (no)
ES (1) ES445494A1 (no)
FR (1) FR2302092A1 (no)
GB (1) GB1513961A (no)
HU (1) HU173571B (no)
IE (1) IE43450B1 (no)
IL (1) IL48990A (no)
IT (1) IT1057250B (no)
LU (1) LU74431A1 (no)
NL (1) NL7601924A (no)
PH (1) PH12974A (no)
SE (1) SE7602235L (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5381778A (en) * 1976-12-27 1978-07-19 Toshiharu Nakao Cloth loop forming apparatus in steaming apparatus
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
US5490436A (en) * 1994-03-17 1996-02-13 At&T Corp. Liquid-chamber apparatus for active, dynamic balancing of rotating machinery
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP5438250B2 (ja) 2002-05-17 2014-03-12 ジェンケン バイオサイエンスィズ,インコーポレイテッド オピオイド及びオピオイド様の化合物並びにそれらの使用
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
AR067673A1 (es) * 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5769970B2 (ja) * 2007-11-16 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
NZ588954A (en) 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5670440B2 (ja) 2009-06-02 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤
JP5456555B2 (ja) * 2010-04-23 2014-04-02 株式会社マキタ 電動工具
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
CA2813671A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138603A (en) * 1958-10-31 1964-06-23 Everette L May New benzomorphans (methanobenzazocines) and preparation thereof
US3372165A (en) * 1960-12-01 1968-03-05 Sterling Drug Inc 1, 2, 3, 4, 5, 6-hexahydro-8-hydroxy-2, 6-methano-3-benzazocine derivatives
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
NL156047B (nl) * 1969-06-04 1978-03-15 Acf Chemiefarma Nv Werkwijze voor de bereiding van farmaceutische preparaten met analgetische en/of morfine-antagonistische werking, gevormde preparaten, alsmede werkwijze voor de bereiding van daartoe geschikte nieuwe 6,7-benzomorfanen.
US3969468A (en) * 1972-10-31 1976-07-13 Kyowa Hakko Kogyo Co., Ltd. 2-Amino-1,2,3,4-tetrahydronaphthalene derivatives
US4010164A (en) * 1973-03-28 1977-03-01 Boehringer Ingelheim Gmbh N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof
SU510999A3 (ru) * 1973-10-27 1976-04-15 К.Х.Берингер Зон, (Фирма) Способ получени (метоксиметил-фурилметил)6,7-бензоморфанов илиморфинанов
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
US4032529A (en) * 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates

Also Published As

Publication number Publication date
IL48990A0 (en) 1976-04-30
IE43450L (en) 1976-08-25
LU74431A1 (no) 1976-08-13
FR2302092B1 (no) 1978-11-10
FR2302092A1 (fr) 1976-09-24
ATA137276A (de) 1980-06-15
AU505939B2 (en) 1979-12-06
ES445494A1 (es) 1977-11-01
AU1085676A (en) 1977-08-11
CA1080704A (en) 1980-07-01
NL7601924A (nl) 1976-08-27
DK76176A (da) 1976-08-26
US4128548A (en) 1978-12-05
AT360663B (de) 1981-01-26
BE838708A (fr) 1976-08-19
DE2606267A1 (de) 1976-09-30
GB1513961A (en) 1978-06-14
IT1057250B (it) 1982-03-10
JPS51111550A (en) 1976-10-01
SE7602235L (sv) 1976-08-26
IE43450B1 (en) 1981-02-25
HU173571B (hu) 1979-06-28
JPS51118767A (en) 1976-10-18
IL48990A (en) 1980-01-31
CH623572A5 (no) 1981-06-15
US4268673A (en) 1981-05-19
PH12974A (en) 1979-10-24

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PL Patent ceased