CH619932A5 - - Google Patents

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Publication number
CH619932A5
CH619932A5 CH1660475A CH1660475A CH619932A5 CH 619932 A5 CH619932 A5 CH 619932A5 CH 1660475 A CH1660475 A CH 1660475A CH 1660475 A CH1660475 A CH 1660475A CH 619932 A5 CH619932 A5 CH 619932A5
Authority
CH
Switzerland
Prior art keywords
formula
compound
pyrrolidinyl
radical
preparation
Prior art date
Application number
CH1660475A
Other languages
English (en)
French (fr)
Inventor
William John Welstead Jr
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of CH619932A5 publication Critical patent/CH619932A5/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CH1660475A 1974-12-26 1975-12-22 CH619932A5 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/536,708 US4002766A (en) 1974-12-26 1974-12-26 Antiarrhythmia methods

Publications (1)

Publication Number Publication Date
CH619932A5 true CH619932A5 (ko) 1980-10-31

Family

ID=24139598

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1660475A CH619932A5 (ko) 1974-12-26 1975-12-22

Country Status (18)

Country Link
US (1) US4002766A (ko)
JP (1) JPS5191255A (ko)
AU (1) AU498763B2 (ko)
BE (1) BE836974A (ko)
CA (1) CA1055396A (ko)
CH (1) CH619932A5 (ko)
DE (1) DE2558501A1 (ko)
DK (1) DK137751B (ko)
ES (1) ES443846A1 (ko)
FI (1) FI753607A (ko)
FR (1) FR2295745A1 (ko)
GB (1) GB1535770A (ko)
IE (1) IE43901B1 (ko)
NL (1) NL185620C (ko)
NO (1) NO754377L (ko)
PH (1) PH13483A (ko)
SE (1) SE428126B (ko)
ZA (1) ZA757974B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133881A (en) * 1977-04-27 1979-01-09 A. H. Robins Company, Incorporated Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
US4242261A (en) * 1979-07-19 1980-12-30 A. H. Robins Company, Inc. Production of methylene-cycloamines
US4260606A (en) * 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US4594343A (en) * 1984-10-19 1986-06-10 Shanklin Jr James R 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810703A (en) * 1984-10-19 1989-03-07 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
WO2004089892A2 (en) * 2003-04-01 2004-10-21 Theravance, Inc. Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US7071224B2 (en) * 2004-03-11 2006-07-04 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
US20070203221A1 (en) * 2005-12-27 2007-08-30 Valeriano Merli Processes for preparing darifenacin hydrobromide
EP2121594B1 (en) * 2007-02-23 2015-10-21 Theravance Biopharma R&D IP, LLC Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
CN101663270B (zh) * 2007-04-24 2013-07-17 施万制药 可用作蕈毒碱受体拮抗剂的季铵化合物
WO2012166909A1 (en) * 2011-06-03 2012-12-06 Galleon Pharmaceuticals, Inc. Compositions and methods for treating breathing control disorders or diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192210A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones
US3466321A (en) * 1965-05-17 1969-09-09 Ucb Sa Derivatives of phenyl-acetic acid
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives

Also Published As

Publication number Publication date
AU8754975A (en) 1977-06-23
IE43901B1 (en) 1981-07-01
DK137751C (ko) 1978-10-09
AU498763B2 (en) 1979-03-22
CA1055396A (en) 1979-05-29
NO754377L (ko) 1976-06-29
NL185620B (nl) 1990-01-02
DK137751B (da) 1978-05-01
JPS612658B2 (ko) 1986-01-27
DK589175A (ko) 1976-06-27
PH13483A (en) 1980-05-21
FR2295745B1 (ko) 1980-06-27
SE428126B (sv) 1983-06-06
NL185620C (nl) 1990-06-01
BE836974A (fr) 1976-04-16
FR2295745A1 (fr) 1976-07-23
DE2558501C2 (ko) 1987-07-16
DE2558501A1 (de) 1976-07-08
IE43901L (en) 1976-06-26
ES443846A1 (es) 1977-07-16
FI753607A (ko) 1976-06-27
NL7515071A (nl) 1976-06-29
SE7514375L (sv) 1976-06-28
US4002766A (en) 1977-01-11
JPS5191255A (en) 1976-08-10
GB1535770A (en) 1978-12-13
ZA757974B (en) 1976-12-29

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PL Patent ceased